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Solving the Puzzle with Dr. Datis Kharrazian

Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN
Functional Medicine
Mood Disorders
Breast Implant Illness
Nutrition
Autoimmunity
Gut Health
Chronic Bacterial Infections
Neurological Health
Anemia
Aging
Depression
Antibiotic Resistance
Exercise
Lyme Disease
Biofilms
Chronic Inflammation
Longevity Medicine
Environmental Factors
Hormone Therapy
Metabolic Health

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases.

Dr. Kharrazian discusses evidence-based models incorporating diet, nutr... more

PublishesWeeklyEpisodes86Founded5 years ago
Number of ListenersCategory
Health & Fitness

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Artwork for Solving the Puzzle

Latest Episodes

In this episode, functional medicine clinician Dr. Rajka Milanovic Galbraith dive into the world of peptides for recovery, exploring both oral and injectable options. She breaks down the latest clinical insights on popular peptides like BPC157, KPV, ... more

In this episode, Rajka Milanovic Galbraith, MD, dives into nutrigenetics and its transformative impact on mental health and chronic conditions. Using real-life patient stories, Dr. Galbraith illustrates how genetic insights and targeted nutrient supp... more

In this episode, we dive into the world of oxidative stress, GST gene patterns, and hormone genetics, uncovering how these factors influence chronic illness and overall health. You'll hear about innovative testing strategies, gene patterns seen in ch... more

In this episode with Dr. Datis Kharrazian, we dive into the mechanisms that underlie pain, exploring key terms like nociception, hyperalgesia, allodynia, and sensitization. You'll learn how pain signals travel through first, second, and third order n... more

Key Facts

Contact Information
Podcast Host
Number of Listeners
Find out how many people listen to this podcast per episode and each month.

Recent Guests

Darla Booth
Chiropractor turned functional medicine clinician specializing in autoimmunity
Private practice in Los Gatos, California
Episode: Episode 80: Dr. Darla Booth DC, AFMC, Managing Autoimmune Patients Successfully
Danielle Valores
Certified physician assistant with a focus on breast implant health
Episode: Episode 71: The Hidden Risks of Breast Implants
Dr. Yousef Elyaman
Expert on ketogenic diets and fasting
Episode: Episode 69: Ketogenic Diets and Fasting for Liver Health with Dr. Yousef Elyaman
Unnamed guest (wife of Dr. Kharrazian)
Wife of Dr. Datis Kharrazian, subject of a personal health case related to neurodegeneration and autoimmunity
Episode: Episode 60: The Power of Laser Therapy in Neurodegeneration and Autoimmunity
Dr. Joseph Pizzorno
Co-founder of Bastyr University and a leading expert in functional medicine
Bastyr University
Episode: Episode 57: Dr. Joseph Pizzorno’s Insights on Functional Medicine and Environmental Health
Randy Vawdry
A nurse practitioner with a focus on neurological health and complex patient care.
Episode: Episode 48: Neurological Health and Interventions with Randy Vawdry, NP-C

Host

Dr. Datis Kharrazian
Host known for autoimmune and brain-health expertise; develops and shares evidence-based functional medicine protocols.

Reviews

4.9 out of 5 stars from 189 ratings
  • My Best Health Resource!!

    I listen to this podcast all the time, it is the best way to consume the most information to help your healing. Today I was looking for guidance to navigate a big flare up and episode 1 came up 10 Reasons Your Autoimmune Doesn’t Get Better and wow that list helps me so much right now truly the heavy hitters and back to basics advice that I needed to remember today!! So grateful for this podcast.

    Apple Podcasts
    5
    lam19@@
    United States2 years ago
  • 🌟🌟🌟🌟🌟 Stars!

    Dr. K is sharing such solid well researched information. I am always confident about the information I receive here as being accurate. Thank you. Please keep teaching us! ♥️

    Apple Podcasts
    5
    K Car1234
    United States3 years ago
  • One of my favorites

    Fantastic info!

    Apple Podcasts
    5
    whisper56
    United States4 years ago
  • Fabulous Doctor- incredibly knowledgeable

    I have learned more from this Doctor that all over 20 Doctors I’ve seen in the past 25 years! Thank you Dr. Datis, I’m looking forward to looking at some of your courses.

    Apple Podcasts
    5
    Cindy Syy
    United States4 years ago
  • Dr. K is a life saver

    Legit the smartest doctor in the country

    Apple Podcasts
    5
    hfdjksdf
    United States5 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners praise the host's depth of clinical knowledge and clear explanations.
Audience consistently values evidence-based, practical guidance for autoimmune health.
Fans appreciate the actionable protocols and patient-centered approach, including group programs.

Top Health & Fitness Podcasts

Talking Points

Recent interactions between the hosts and their guests.

Episode 80: Dr. Darla Booth DC, AFMC, Managing Autoimmune Patients Successfully
Q: Which testing and dietary strategies are central to your approach?
Testing like Cyrex arrays to assess gut permeability and pathogen burden, along with an autoimmune paleo framework, staged reintroduction of foods, and a focus on gluten and dairy elimination as initial steps.
Episode 80: Dr. Darla Booth DC, AFMC, Managing Autoimmune Patients Successfully
Q: What role does a group program play in treating autoimmunity?
A group program provides scalability, peer support, shared accountability, and practical guidance, reducing clinician burnout and helping patients stay engaged with lifestyle changes that impact gut health and immune function.
Episode 74: Practitioner Spotlight: Dr. Dave Boynton on Why Hypoglycemia Destroys Healing, Neurological Exams Save Lives & Cookie-Cutter Protocols Don't Work
Q: How do you stay excited about your practice and involved?
I love going to work every day and helping people.
Episode 74: Practitioner Spotlight: Dr. Dave Boynton on Why Hypoglycemia Destroys Healing, Neurological Exams Save Lives & Cookie-Cutter Protocols Don't Work
Q: What would you say is the most overlooked in care with other practitioners?
A lot of the neurological components to people's conditions are left out.
Episode 51: Dr. Joseph Pizzorno’s Insights on Functional Medicine and Environmental Health
Q: Are there any other big ones for practitioners that are focused on other things?
Diabetes is a key concern, but cardiovascular disease and cancer are also significantly impacted by environmental toxins.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
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Interests
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Age Range
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Social Media Reach

Frequently Asked Questions About Solving the Puzzle

What is Solving the Puzzle about and what kind of topics does it cover?

This show centers on autoimmune and brain health, exploring how nutrition, genetics, and lifestyle interventions can influence conditions like Hashimoto's, chronic fatigue, pain, and neurodevelopmental issues. Episodes frequently layer practical clinical workflows, case studies, and patient-centered strategies—ranging from nutrigenomics and methylation to mitochondrial health and detox pathways—into actionable protocols for practitioners and motivated patients. A notable throughline is the emphasis on personalized, root-cause approaches rather than one-size-fits-all protocols, with episodes often grounded in biochemical mechanisms and real-world outcomes. The host combines deep clinical experience with accessible explanations, and there's a... more

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Solving the Puzzle launched 5 years ago and published 86 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Solving the Puzzle?

Recent guests on Solving the Puzzle include:

1. Darla Booth
2. Danielle Valores
3. Dr. Yousef Elyaman
4. Unnamed guest (wife of Dr. Kharrazian)
5. Dr. Joseph Pizzorno
6. Randy Vawdry

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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