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Retina Synthesis

Retina Synthesis
Geographic Atrophy
Neovascular AMD
Diabetic Macular Edema
Diabetic Retinopathy
Aflibercept
Clinical Trials
Gene Therapy
Artificial Intelligence
Retinopathy Of Prematurity
Tyrosine Kinase Inhibitors
Intravitreal Gene Therapy
Stanford University
Photobiomodulation
Age-Related Macular Degeneration
Optogenetics
Ophthalmology
Visual Acuity
PRIMA Retinal Implant
Retina Specialists
Intravitreal Injections

Retina Synthesis is a data-focused resource exploring therapies in development for retinal diseases.

PublishesWeeklyEpisodes181Founded5 years ago
Number of ListenersCategory
Education

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Artwork for Retina Synthesis

Latest Episodes

In our latest episode we discuss the results of a novel approach to the treatment of geographic atrophy using Xelafaslatide a Fas inhibitor with Dr. David Zacks, Professor of Ophthalmology at the Kellogg Eye Center at the University of Michigan.

In our latest episode, we discuss the use of inhibitors of IL-6 in the treatment of retinal disease with Dr. Steven M. Yeh, Stanley M. Truhlsen, Jr. , Chair of Ophthalmology a the University of Nebraska.

In this episode, we discuss the use of aflibercept 8mg for the management of retinal vein occlusion and the results of the QUASAR study with Dr. Sunir Garg, Co Director of Retina Research at the Wills Eye Hospital and Professor of Ophthalmology at Th... more

In this episode we discuss the results of a phase 2 trial using subcutaneous elamipretide for the treatment of geographic atrophy with Dr. Mark Barakat.

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Recent Guests

Dr. Steven Yeh
Truhlsen Professor at the Truhlsen Eye Institute
University of Nebraska Medical Center
Episode: Inhibition of IL-6 in the Treatment of Retinal Disease
Dr. Mark Barakat
Guest expert discussing the Reclaim-2 trial and related developments
Independent retinal pharmacotherapy expert
Episode: Elamipretide in the Treatment of Geographic Atrophy
Dilsher Dhoot
Eye surgeon with focus on retinal therapies
Santa Barbara, California
Episode: Long Term Followup of Intravitreal Gene Therapy for Neovascular AMD
Dr. Michael Klufas
Ophthalmologist at Wills Eye Hospital
Wills Eye Hospital
Episode: The Port Delivery Stem for Treatment of Neovascular AMD
Jayakrishna Ambati
Gary Professor at the University of Virginia Medical School
University of Virginia
Episode: Kamuvudine 8 in the Treatment of Geographic Atrophy
Adrienne Scott
Professor at Wilmer Eye Institute, Johns Hopkins University
Wilmer Eye Institute, Johns Hopkins University
Episode: Treatment of Proliferative Diabetic Retinopathy After Protocol S
Roger Goldberg
Retina specialist discussing CNTF implant for MacTel
Northern California
Episode: Encapsulated Cell Therapy for MacTel2
Glenn Yiu
Professor of Ophthalmology, UC Davis; Director of Teleophthalmology
University of California, Davis
Episode: Teleretinology - Update on Screening and Artificial Intelligence
Dr. Harry Flynn
J. Gass Distinguished Chair in Ophthalmology, Bascom Palmer Eye Institute
Bascom Palmer Eye Institute
Episode: Endophthalmitis after Intravitreal Injection

Host

Carmen Puliofito
Host of Retina Synthesis

Reviews

4.8 out of 5 stars from 19 ratings
  • MD PhD

    Great

    Apple Podcasts
    5
    Retina Physician
    United States5 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Engaging hosts with strong clinical credibility.
High-quality synthesis of complex data for practitioners.
Guests provide practical trial insights with real-world relevance.

Chart Rankings

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Apple Podcasts
#241
Argentina/Education

Talking Points

Recent interactions between the hosts and their guests.

Aflibercept 8mg for Retinal Vein Occlusion
Q: In real-world practice, how long do BRVO patients typically require treatment?
BRVO patients often need treatment for six months to a couple of years, with some requiring several years depending on the eye and individual response; the goal is to dry the retina and then extend treatment intervals as tolerated over time.
Aflibercept 8mg for Retinal Vein Occlusion
Q: Tell us about the Quasar study.
The Quasar study was a phase 3 trial evaluating aflibercept 8 mg for retinal vein occlusion, including CRVO, BRVO, and HRVO, with three dosing regimens (2 mg monthly; 8 mg with three loading doses and then every eight weeks; and 8 mg with five loading doses and then every eight weeks), showing comparable efficacy with fewer injections in the higher-dose groups.
Long Term Followup of Intravitreal Gene Therapy for Neovascular AMD
Q: Can you tell us a little bit about the drug, the gene therapy approach, and then discuss the trial?
Ixavec uses an engineered AAV7MA vector to deliver flibrocept to ocular tissues, aiming to convert the eye into a production factory for the anti-VEGF protein and reduce the need for repeated injections while monitoring safety in a two-dose Optic study, with the extension showing sustained expression and a favorable safety profile.
Elamipretide in the Treatment of Geographic Atrophy
Q: What is the significance of topical Bevameprotein in this program?
Bevameprotein is being explored as a topical delivery alternative to subcutaneous administration, with preclinical data showing similar ocular tissue exposure and levels in the RPE and choroid, which could reduce treatment burden if clinical results mirror preclinical findings.
Elamipretide in the Treatment of Geographic Atrophy
Q: What is the Reclaim-2 trial and what was it testing?
The Reclaim-2 trial tested a mitochondria-targeting peptide, L-ametpretide, in geographic atrophy to see if it could slow degeneration by improving mitochondrial function and ATP production; while the primary endpoint was not met, there was observed preservation of ellipsoid zone and some improvement in visual acuity metrics, indicating potential biologic activity.

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Frequently Asked Questions About Retina Synthesis

What is Retina Synthesis about and what kind of topics does it cover?

Retina Synthesis delivers data-driven conversations focused on therapies in retinal disease development, with frequent deep dives into trial results, mechanisms, and real-world practice. Episodes spotlight geographic atrophy, neovascular AMD, DME, gene therapies, implantable devices, and AI-enabled screening, often pairing clinicians with researchers to unpack what the data implies for patient care, treatment burdens, and future directions. A notable strength is the blend of practical surgical and clinical perspectives with translational science, offering listeners concrete takeaways on trial outcomes, safety signals, and deployment considerations across the retinal field.

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Which podcasts are similar to Retina Synthesis?

These podcasts share a similar audience with Retina Synthesis:

1. New Retina Radio by Eyetube
2. ASRS’s Journal of Vitreoretinal Diseases (JVRD) Author’s Forum
3. RETINA Journal Podcasts
4. Talking Euretina
5. Ophthalmology Journal

How many episodes of Retina Synthesis are there?

Retina Synthesis launched 5 years ago and published 181 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Retina Synthesis?

Recent guests on Retina Synthesis include:

1. Dr. Steven Yeh
2. Dr. Mark Barakat
3. Dilsher Dhoot
4. Dr. Michael Klufas
5. Jayakrishna Ambati
6. Adrienne Scott
7. Roger Goldberg
8. Glenn Yiu

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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