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Artwork for Retina Synthesis

Retina Synthesis

Retina Synthesis
Geographic Atrophy
Diabetic Macular Edema
Neovascular AMD
Aflibercept
Diabetic Retinopathy
Clinical Trials
Artificial Intelligence
Gene Therapy
Retinopathy Of Prematurity
Tyrosine Kinase Inhibitors
Intravitreal Gene Therapy
Stanford University
Home OCT
Neovascular Age-Related Macular Degeneration
Photobiomodulation
Age-Related Macular Degeneration
Optogenetics
Ophthalmology
Prima Retinal Implant
Visual Acuity

Retina Synthesis is a data-focused resource exploring therapies in development for retinal diseases.

PublishesWeeklyEpisodes198Founded6 years ago
Number of ListenersCategory
Education

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Artwork for Retina Synthesis

Latest Episodes

Can a drop replace the needle in diabetic macular edema? Dr. Veeral Sheth returns to Retina Synthesis to walk through DIAMOND-1 and DIAMOND-2, Oculis's twin Phase 3 trials of OCS-01, a high-concentration (15 mg/mL) topical dexamethasone formulated to... more

We welcome back Dr. Roger Goldberg from Bay Area Retina Associates, in our latest episode to discuss the BARDENAS trial (NCT05151744) a global Phase 2 clinical study evaluating the efficacy and safety of vamikibart (RO7200220), an IL-6 inhibitor, com... more

In this episode, we discuss the surgical technique and complications associated with implantation of an encapsulated cell therapy for MacTel 2 with Dr. Lloyd Clark from North Carolina Retina Association.

In this episode, we discuss the results of the Phase 3 Lugano Trial from Eyepoint Pharmaceuticals with Dr. Carl Regillo of Wills Eye Hospital.

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Recent Guests

Lloyd Clark
Physician discussing NeuroTech Encapsulated Cell Device
NeuroTech (MacTel program)
Episode: Surgery for Encapsulated Cell Therapy
Dr. Carl Regillo
Ophthalmologist at Wills Eye Hospital, expert in retinal diseases
Wills Eye Hospital
Episode: Results of the Eyepoint LUGANO Trial
Anat Loewenstein
Professor and pioneer in home OCT
Episode: Home OCT in Management of Neovascular AMD
Dr. Veeral Sheth
ophthalmologist discussing the Rhone-X study
Chicago
Episode: Faricimab in the Treatment of DME: Long Term 'Results
David Zacks
Professor, Kellogg Eye Center, University of Michigan
Kellogg Eye Center, University of Michigan
Episode: Xelafaslatide for the Treatment of Geographic Atrophy
Dr. Steven Yeh
Truhlsen Professor at the Truhlsen Eye Institute
University of Nebraska Medical Center
Episode: Inhibition of IL-6 in the Treatment of Retinal Disease
Dr. Mark Barakat
Guest expert discussing the Reclaim-2 trial and related developments
Independent retinal pharmacotherapy expert
Episode: Elamipretide in the Treatment of Geographic Atrophy
Dilsher Dhoot
Eye surgeon with focus on retinal therapies
Santa Barbara, California
Episode: Long Term Followup of Intravitreal Gene Therapy for Neovascular AMD
Dr. Michael Klufas
Ophthalmologist at Wills Eye Hospital
Wills Eye Hospital
Episode: The Port Delivery Stem for Treatment of Neovascular AMD

Host

Dr. Carmen Puliofido
Host of Retina Synthesis

Reviews

4.8 out of 5 stars from 19 ratings
  • MD PhD

    Great

    Apple Podcasts
    5
    Retina Physician
    United States6 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

The show consistently delivers nuanced, evidence-backed insights for real-world eye care.
Practical takeaways on implementation and payer considerations stand out.
The breadth of topics—from gene therapy to AI-enabled monitoring—helps stakeholders spot cross-cutting opportunities.
Listeners appreciate the rigorous, data-driven discussions.
Guests bring high-level clinical and translational depth.

Talking Points

Recent interactions between the hosts and their guests.

Surgery for Encapsulated Cell Therapy
Q: What's the surgical technique like?
The technique mirrors other intraocular implants: a pars plana approach with a four-millimeter incision, insertion into the vitreous cavity, and suturing closed with the conjunctiva over the sutures; the implant is fully housed within the vitreous, with some exposed sutures but no intraocular dislocation observed in trials.
5 Year Results of Pegacetacoplan Treatment of Geographic Atrophy
Q: Tell us a little about the differences between the every other month and the monthly doses in the crossover.
The differences between dosing regimens in crossover were small, with only a few percentage points separating monthly from every-other-month schedules, and data suggest that six-to-eight week intervals may be optimal to balance efficacy and safety while maintaining similar outcomes.
5 Year Results of Pegacetacoplan Treatment of Geographic Atrophy
Q: So what were the key findings?
The key findings include strong retention in the open-label extension, significant reductions in GA progression over five years, and a clear benefit for early treatment with substantial tissue preservation, along with a stable safety profile showing a decreasing incidence of retinal vasculitis over time.
Faricimab in the Treatment of DME: Long Term 'Results
Q: What is the protocol for starting dose and extension in the current practice?
Historically loading injections were common, but in practice many clinicians now start with monthly injections until dry and then extend by four weeks at a time, extending to 8, 12, or 16 weeks based on response.
Faricimab in the Treatment of DME: Long Term 'Results
Q: How many injections on average do patients have in years three and four of the rollover extension?
Patients received around seven to eight injections across years three and four, roughly three to four injections in year three and about three in year four.

Audience Metrics

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Frequently Asked Questions About Retina Synthesis

What is Retina Synthesis about and what kind of topics does it cover?

The show consistently centers on cutting-edge retinal therapies, with episodes covering intravitreal gene therapy, home OCT and AI-enabled monitoring, long-term trial results for ferrisamab (Ferrisomab), and multi-faceted treatment strategies for geographic atrophy and inflammatory retinal diseases. Practical discussions often address clinical implementation, regulatory considerations, payer impacts, and real-world treatment patterns, making the content valuable for clinicians, researchers, and device/biotech professionals evaluating new approaches and partnerships. A notable strength is the data-driven, translational focus—bridging trial results, surgical technique, and care system integration to illuminate how emerging therapies could res... more

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Which podcasts are similar to Retina Synthesis?

These podcasts share a similar audience with Retina Synthesis:

1. New Retina Radio by Eyetube
2. RETINA Journal Podcasts
3. ASRS’s Journal of Vitreoretinal Diseases (JVRD) Author’s Forum
4. MedEdTalks - Ophthalmology
5. Ophthalmology Journal

How many episodes of Retina Synthesis are there?

Retina Synthesis launched 6 years ago and published 198 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Retina Synthesis?

Recent guests on Retina Synthesis include:

1. Lloyd Clark
2. Dr. Carl Regillo
3. Anat Loewenstein
4. Dr. Veeral Sheth
5. David Zacks
6. Dr. Steven Yeh
7. Dr. Mark Barakat
8. Dilsher Dhoot

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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