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Retina Synthesis

Retina Synthesis
Geographic Atrophy
Neovascular AMD
Diabetic Macular Edema
Diabetic Retinopathy
Aflibercept
Clinical Trials
Gene Therapy
Artificial Intelligence
Retinopathy Of Prematurity
Tyrosine Kinase Inhibitors
Intravitreal Gene Therapy
Stanford University
Photobiomodulation
Age-Related Macular Degeneration
Optogenetics
Ophthalmology
Visual Acuity
PRIMA Retinal Implant
Retina Specialists
Intravitreal Injections

Retina Synthesis is a data-focused resource exploring therapies in development for retinal diseases.

PublishesWeeklyEpisodes178Founded5 years ago
Number of ListenersCategory
Education

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Artwork for Retina Synthesis

Latest Episodes

In this episode we discuss the results of a phase 2 trial using subcutaneous elamipretide for the treatment of geographic atrophy with Dr. Mark Barakat.

In this episode, we discuss the 3 year results of the Phase 2 trial of the Adverum intravitreal gene therapy with Dr. Dilsher Dhoot, California Retina Consultants, Adjunct Clinical Professor Ophthalmology, Keck School of Medicine of USC.

In this episode we discuss the impressive Phase 4 results of the Belvedere Trial for treatment of neovascular AMD with Dr. Michael Klufas of Wills Eye Hospital.

In our latest episode with the discuss the promising results of a Phase I clinical trial looking at kamuvidine 8 an inflammasome inhibitor in the treatment of geographic atrophy with Dr. Jayakrishna Ambati, Guerry Professor of Ophthalmology at the Un... more

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Recent Guests

Dr. Mark Barakat
Guest expert discussing the Reclaim-2 trial and related developments
Independent retinal pharmacotherapy expert
Episode: Elamipretide in the Treatment of Geographic Atrophy
Dilsher Dhoot
Eye surgeon with focus on retinal therapies
Santa Barbara, California
Episode: Long Term Followup of Intravitreal Gene Therapy for Neovascular AMD
Dr. Michael Klufas
Ophthalmologist at Wills Eye Hospital
Wills Eye Hospital
Episode: The Port Delivery Stem for Treatment of Neovascular AMD
Jayakrishna Ambati
Gary Professor at the University of Virginia Medical School
University of Virginia
Episode: Jayakrishna Ambati
Adrienne Scott
Professor at Wilmer Eye Institute, Johns Hopkins University
Wilmer Eye Institute, Johns Hopkins University
Episode: Treatment of Proliferative Diabetic Retinopathy After Protocol S
Roger Goldberg
Retina specialist discussing CNTF implant for MacTel
Northern California
Episode: Encapsulated Cell Therapy for MacTel2
Glenn Yiu
Professor of Ophthalmology, UC Davis; Director of Teleophthalmology
University of California, Davis
Episode: Teleretinology - Update on Screening and Artificial Intelligence
Dr. Harry Flynn
J. Gass Distinguished Chair in Ophthalmology, Bascom Palmer Eye Institute
Bascom Palmer Eye Institute
Episode: Endophthalmitis after Intravitreal Injection
Phil Rosenfeld
Interventional neuroradiologist / Retina specialist
Bascom Palmer Eye Institute
Episode: Ophthalmic Artery Angioplasty for Geographic Atrophy

Host

Carmen Puliofito
Host of Retina Synthesis

Reviews

4.8 out of 5 stars from 19 ratings
  • MD PhD

    Great

    Apple Podcasts
    5
    Retina Physician
    United States5 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Engaging hosts with strong clinical credibility.
High-quality synthesis of complex data for practitioners.
Guests provide practical trial insights with real-world relevance.

Talking Points

Recent interactions between the hosts and their guests.

Long Term Followup of Intravitreal Gene Therapy for Neovascular AMD
Q: Can you tell us a little bit about the drug, the gene therapy approach, and then discuss the trial?
Ixavec uses an engineered AAV7MA vector to deliver flibrocept to ocular tissues, aiming to convert the eye into a production factory for the anti-VEGF protein and reduce the need for repeated injections while monitoring safety in a two-dose Optic study, with the extension showing sustained expression and a favorable safety profile.
Elamipretide in the Treatment of Geographic Atrophy
Q: What is the significance of topical Bevameprotein in this program?
Bevameprotein is being explored as a topical delivery alternative to subcutaneous administration, with preclinical data showing similar ocular tissue exposure and levels in the RPE and choroid, which could reduce treatment burden if clinical results mirror preclinical findings.
Elamipretide in the Treatment of Geographic Atrophy
Q: What is the Reclaim-2 trial and what was it testing?
The Reclaim-2 trial tested a mitochondria-targeting peptide, L-ametpretide, in geographic atrophy to see if it could slow degeneration by improving mitochondrial function and ATP production; while the primary endpoint was not met, there was observed preservation of ellipsoid zone and some improvement in visual acuity metrics, indicating potential biologic activity.
Treatment of Proliferative Diabetic Retinopathy After Protocol S
Q: How often were patients receiving anti-VEGF treatments in the real world?
Real-world practice showed wide variation, with only about 30-40% of patients following Protocol S-style regimens and many receiving combination therapies or individualized plans.
Treatment of Proliferative Diabetic Retinopathy After Protocol S
Q: What was Protocol S's recommended anti-VEGF treatment modality?
Protocol S used ranibizumab with an induction loading phase followed by a treat-and-extend or as-needed approach based on activity, with randomization to panretinal photocoagulation for comparison.

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Frequently Asked Questions About Retina Synthesis

What is Retina Synthesis about and what kind of topics does it cover?

Retina Synthesis delivers data-driven conversations focused on therapies in retinal disease development, with frequent deep dives into trial results, mechanisms, and real-world practice. Episodes spotlight geographic atrophy, neovascular AMD, DME, gene therapies, implantable devices, and AI-enabled screening, often pairing clinicians with researchers to unpack what the data implies for patient care, treatment burdens, and future directions. A notable strength is the blend of practical surgical and clinical perspectives with translational science, offering listeners concrete takeaways on trial outcomes, safety signals, and deployment considerations across the retinal field.

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Which podcasts are similar to Retina Synthesis?

These podcasts share a similar audience with Retina Synthesis:

1. New Retina Radio by Eyetube
2. ASRS’s Journal of Vitreoretinal Diseases (JVRD) Author’s Forum
3. The Retina Channel Podcast
4. RETINA Journal Podcasts
5. Talking Euretina

How many episodes of Retina Synthesis are there?

Retina Synthesis launched 5 years ago and published 178 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Retina Synthesis?

Recent guests on Retina Synthesis include:

1. Dr. Mark Barakat
2. Dilsher Dhoot
3. Dr. Michael Klufas
4. Jayakrishna Ambati
5. Adrienne Scott
6. Roger Goldberg
7. Glenn Yiu
8. Dr. Harry Flynn

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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