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JTO Insights

JTO Insights
Lung Cancer
Stage I Non-Small Cell Lung Cancer
Pulmonology
Trastuzumab Derastuzine
Lung Cancer Screening
Thoracic Surgery
Circulating Tumor DNA
Low-Dose CT Lung Cancer Screening
Journal Of Thoracic Oncology
KRAS G12C
Destiny Lung 03
Non-Small Cell Lung Cancer
Cardio-Oncology
Liquid Biopsy
Immune Signature Classifier
Bronchoscopy
Olamoracib
Radiotherapy
Thoracic Oncology
International Association For the Study Of Lung Cancer

Welcome to JTO Insights, the official podcast of the International Association for the Study of Lung Cancer (IASLC) Journal of Thoracic Oncology (JTO). In each episode, hosts Dr. Alex Adjei and Dr. Tom John deliver concise, accessible insights from the latest JTO research. Each episode features expert discussions with authors, highlighting key studies, clinical implications, and future directions ... more

PublishesTwice monthlyEpisodes9Founded4 months ago
Number of ListenersCategory
Science

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Latest Episodes

Episode Summary Episode 8: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John highlight two articles published in the JTO 20th Anniversary Series. Dr. David Ryan of Royal Brompton & Harefield Hospitals, ... more

Episode 7: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host Dr. Masahiro Torasawa, the corresponding author of "Tumor Inflammation–Associated Neurotoxicity Masquerading as Severe Immune Effector C... more

Episode 6: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host the corresponding author of an article published in the JTO 20th Anniversary Series. Dr. Emily Stone, a Conjoint Professor at the UNSW S... more

Episode 5: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host authors of two articles published in the Journal of Thoracic Oncology June issue. Dr. Natasha B. Leighl, Head of Division of Medical Onc... more

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Recent Guests

Dr. Emily Stone
Conjoined professor, UNSW; consultant respiratory physician; head of the Department of Thoracic Medicine and Lung Transplantation at St Vincent's Hospital, Sydney; board chair of the Thoracic Oncology Group of Australasia
University of New South Wales / St Vincent's Hospital, Sydney
Episode: JTO Insights: 20 Years of Advances in Pulmonology
Dr. Natasha Leighl
Corresponding author of the first study discussed, medical oncologist
Princess Margaret Cancer Centre / University Health Network / Sinai Health System; University of Toronto
Episode: JTO Insights: June 2026
Dr. Gabriella Sozzi
Corresponding author of the second study discussed, biomarker researcher
National Cancer Institute, Milan, Italy
Episode: JTO Insights: June 2026
Dr. Stephen Lam
Professor of Medicine, Director of MDS-Rix Early Lung Cancer Detection and Translational Research Program
University of British Columbia
Episode: JTO Insights: 20 Years of Advances in Screening & Surgery
Dr. Paul Van Schil
Past president of ISLC and thoracic/vascular surgeon
Antwerp University Faculty of Medicine
Episode: JTO Insights: 20 Years of Advances in Screening & Surgery
Bonnie Ky
Founders Professor of Cardio-Oncology; Director of the Thalheimer Center for Cardio-Oncology; Penn Cardiovascular programs
University of Pennsylvania
Episode: JTO Insights: May 2026
David Planchard
Thoracic oncologist; head of the Thoracic Group at Institut Gustave Roussy; corresponding author of Destiny Lung 03
Institut Gustave Roussy
Episode: JTO Insights: May 2026
Michele Carbone
William and Ellen Mellon Chair in Cancer Biology and Human Genetics; Special Advisor on Health and Science to the Governor of Hawaii; Director of Thoracic Oncology at the University of Hawaii Cancer Center
University of Hawaii Cancer Center
Episode: JTO Insights: 20 Years of Advances in Basic Science & Radiotherapy
Jeffrey Bogart
Distinguished professor and chair of radiation oncology
State University of New York, Upstate Medical Center
Episode: JTO Insights: 20 Years of Advances in Basic Science & Radiotherapy

Hosts

Dr. Alex Adjei
Editor-in-Chief of JTO and Chief of the Cleveland Clinic Cancer Institute; host of the podcast.
Dr. Tom John
Co-host of the podcast; thoracic oncologist with affiliations at Peter MacCallum Cancer Centre and JTO.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#182
India/Science

Talking Points

Recent interactions between the hosts and their guests.

JTO Insights: April 2026
Q: Looking into the future, do you think olamoracib will be a leading KRAS G12C inhibitor in first-line settings, or might other on/off inhibitors outperform it?
The experts express cautious optimism about olamoracib being a leading option in certain contexts, but acknowledge that other KRAS inhibitors (including pan-KRAS and combination strategies) may compete; overall, improvements in first-line outcomes may come from combinations with immunotherapy or chemoimmunotherapy, and there is a sense that no single agent will dominate across all patient subgroups.
JTO Insights: April 2026
Q: From your perspective, is there a mechanistic difference that explains the ability to combine KRAS G12C inhibitors with checkpoint inhibitors where other examples have not shown the same synergy?
The discussion emphasizes that while inhibitors are covalent and target KRAS in its active or inactive forms, olamoracib appears more potent and selective, potentially accounting for better safety and efficacy signals when combined with pembrolizumab; however, the exact off-target or mechanistic reasons for the improved combination remain under investigation.
JTO Insights: 20 Years of Advances in Basic Science & Radiotherapy
Q: How is oligometastatic disease defined today and how has its management evolved?
Today, synchronous disease is defined as five or fewer metastatic lesions; metacronous refers to recurrence with five or fewer lesions. Management has evolved with better imaging, trials showing mixed results, and focus on biomarkers and targeted local therapies to potentially improve outcomes.
JTO Insights: 20 Years of Advances in Basic Science & Radiotherapy
Q: Can you briefly explain how SBRT has revolutionized lung cancer care?
SBRT delivers very high doses to small tumor volumes with precise targeting, enabled by four-dimensional CT and real-time imaging, allowing high local control with acceptable toxicity and dramatically changing the standard of care.

Audience Metrics

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Frequently Asked Questions About JTO Insights

What is JTO Insights about and what kind of topics does it cover?

A concise, clinically focused discussion style centers on thoracic oncology research and its real-world implications. Episodes typically feature hosts who guide conversations with leading researchers and study authors, covering the latest JTO findings, diagnostic and treatment advances, and emerging biomarker- and AI-driven approaches. Real-world clinical insights, trial design considerations, and multidisciplinary care are recurring themes, with an emphasis on practical implications for clinicians, researchers, and healthcare professionals. Notable strengths include access to high-profile experts, clear explanations of complex science, and a steady cadence that makes cutting-edge oncology research approachable for a busy medical audience.

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Which podcasts are similar to JTO Insights?

These podcasts share a similar audience with JTO Insights:

1. Lung Cancer Considered
2. ASCO Daily News

How many episodes of JTO Insights are there?

JTO Insights launched 4 months ago and published 9 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on JTO Insights?

Recent guests on JTO Insights include:

1. Dr. Emily Stone
2. Dr. Natasha Leighl
3. Dr. Gabriella Sozzi
4. Dr. Stephen Lam
5. Dr. Paul Van Schil
6. Bonnie Ky
7. David Planchard
8. Michele Carbone

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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