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JTO Insights

JTO Insights
Lung Cancer
Stage I Non-Small Cell Lung Cancer
Pulmonology
Trastuzumab Derastuzine
Lung Cancer Screening
Thoracic Surgery
Circulating Tumor DNA
Low-Dose CT Lung Cancer Screening
Journal Of Thoracic Oncology
KRAS G12C
Destiny Lung 03
Non-Small Cell Lung Cancer
Cardio-Oncology
Liquid Biopsy
Immune Signature Classifier
Bronchoscopy
TTF1
Interventional Radiology
Ablation (radiofrequency, Microwave, Cryoablation, Irreversible Electroporation)
Olamoracib

Welcome to JTO Insights, the official podcast of the International Association for the Study of Lung Cancer (IASLC) Journal of Thoracic Oncology (JTO). In each episode, hosts Dr. Alex Adjei and Dr. Tom John deliver concise, accessible insights from the latest JTO research. Each episode features expert discussions with authors, highlighting key studies, clinical implications, and future directions ... more

PublishesTwice monthlyEpisodes10Founded5 months ago
Number of ListenersCategory
Science

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Latest Episodes

Episode 9: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John speak with authors of two articles published in the August issue of the Journal of Thoracic Oncology. Michael J. Grant, MD, Assistant Profess... more

Episode Summary Episode 8: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John highlight two articles published in the JTO 20th Anniversary Series. Dr. David Ryan of Royal Brompton & Harefield Hospitals, ... more

Episode 7: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host Dr. Masahiro Torasawa, the corresponding author of "Tumor Inflammation–Associated Neurotoxicity Masquerading as Severe Immune Effector C... more

Episode 6: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host the corresponding author of an article published in the JTO 20th Anniversary Series. Dr. Emily Stone, a Conjoint Professor at the UNSW S... more

Episode 5: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host authors of two articles published in the Journal of Thoracic Oncology June issue. Dr. Natasha B. Leighl, Head of Division of Medical Onc... more

In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host authors of two articles published in the JTO 20th Anniversary Series. Dr. Stephen Lam, Director of the MDS-Rix Early Lung Cancer Detection and Tran... more

In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host authors of two articles published in the May issue of the Journal of Thoracic Oncology. Dr. Bonnie Ky, Founder’s Professor of Cardio-Oncology at th... more

In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host authors of two articles published in the JTO 20th Anniversary Series. Dr. Michele Carbone, Director of the Thoracic Oncology Program at the Univers... more

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Recent Guests

Michael Grant
Corresponding author; Assistant Professor of Medicine, Medical Oncology, Yale University
Yale University School of Medicine
Episode: JTO Insights: August 2026
Christian Rolfo
Professor of Internal Medicine; Director of the Division of Medical Oncology
Ohio State University James Comprehensive Cancer Center
Episode: JTO Insights: August 2026
David Ryan
Physician from the Department of Radiology, Royal Brompton & Harefield Hospitals
Royal Brompton & Harefield Hospitals, London
Episode: JTO Insights: 20 Years of Advances in Imaging and Interventional Radiology
Masahiro Torasawa
Corresponding author of the case report; Assistant Professor, Department of Respiratory Medicine, John Tendo University School of Medicine, Tokyo, Japan
John Tendo University School of Medicine, Tokyo
Episode: JTO Insights: July 2026
Dr. Emily Stone
Conjoined professor, UNSW; consultant respiratory physician; head of the Department of Thoracic Medicine and Lung Transplantation at St Vincent's Hospital, Sydney; board chair of the Thoracic Oncology Group of Australasia
University of New South Wales / St Vincent's Hospital, Sydney
Episode: JTO Insights: 20 Years of Advances in Pulmonology
Dr. Natasha Leighl
Corresponding author of the first study discussed, medical oncologist
Princess Margaret Cancer Centre / University Health Network / Sinai Health System; University of Toronto
Episode: JTO Insights: June 2026
Dr. Gabriella Sozzi
Corresponding author of the second study discussed, biomarker researcher
National Cancer Institute, Milan, Italy
Episode: JTO Insights: June 2026
Dr. Stephen Lam
Professor of Medicine, Director of MDS-Rix Early Lung Cancer Detection and Translational Research Program
University of British Columbia
Episode: JTO Insights: 20 Years of Advances in Screening & Surgery
Dr. Paul Van Schil
Past president of ISLC and thoracic/vascular surgeon
Antwerp University Faculty of Medicine
Episode: JTO Insights: 20 Years of Advances in Screening & Surgery

Hosts

Dr. Alex Adjei
Editor-in-Chief of JTO and Chief of the Cleveland Clinic Cancer Institute; host of the podcast.
Dr. Tom John
Co-host of the podcast; thoracic oncologist with affiliations at Peter MacCallum Cancer Centre and JTO.

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Talking Points

Recent interactions between the hosts and their guests.

JTO Insights: April 2026
Q: Looking into the future, do you think olamoracib will be a leading KRAS G12C inhibitor in first-line settings, or might other on/off inhibitors outperform it?
The experts express cautious optimism about olamoracib being a leading option in certain contexts, but acknowledge that other KRAS inhibitors (including pan-KRAS and combination strategies) may compete; overall, improvements in first-line outcomes may come from combinations with immunotherapy or chemoimmunotherapy, and there is a sense that no single agent will dominate across all patient subgroups.
JTO Insights: April 2026
Q: From your perspective, is there a mechanistic difference that explains the ability to combine KRAS G12C inhibitors with checkpoint inhibitors where other examples have not shown the same synergy?
The discussion emphasizes that while inhibitors are covalent and target KRAS in its active or inactive forms, olamoracib appears more potent and selective, potentially accounting for better safety and efficacy signals when combined with pembrolizumab; however, the exact off-target or mechanistic reasons for the improved combination remain under investigation.
JTO Insights: 20 Years of Advances in Basic Science & Radiotherapy
Q: How is oligometastatic disease defined today and how has its management evolved?
Today, synchronous disease is defined as five or fewer metastatic lesions; metacronous refers to recurrence with five or fewer lesions. Management has evolved with better imaging, trials showing mixed results, and focus on biomarkers and targeted local therapies to potentially improve outcomes.
JTO Insights: 20 Years of Advances in Basic Science & Radiotherapy
Q: Can you briefly explain how SBRT has revolutionized lung cancer care?
SBRT delivers very high doses to small tumor volumes with precise targeting, enabled by four-dimensional CT and real-time imaging, allowing high local control with acceptable toxicity and dramatically changing the standard of care.

Audience Metrics

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Frequently Asked Questions About JTO Insights

What is JTO Insights about and what kind of topics does it cover?

A concise, clinically focused discussion style centers on thoracic oncology research and its real-world implications. Episodes typically feature hosts who guide conversations with leading researchers and study authors, covering the latest JTO findings, diagnostic and treatment advances, and emerging biomarker- and AI-driven approaches. Real-world clinical insights, trial design considerations, and multidisciplinary care are recurring themes, with an emphasis on practical implications for clinicians, researchers, and healthcare professionals. Notable strengths include access to high-profile experts, clear explanations of complex science, and a steady cadence that makes cutting-edge oncology research approachable for a busy medical audience.

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Which podcasts are similar to JTO Insights?

These podcasts share a similar audience with JTO Insights:

1. Lung Cancer Considered
2. The Daily
3. The Rest Is Politics
4. The Rest Is Politics: US

How many episodes of JTO Insights are there?

JTO Insights launched 5 months ago and published 10 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on JTO Insights?

Recent guests on JTO Insights include:

1. Michael Grant
2. Christian Rolfo
3. David Ryan
4. Masahiro Torasawa
5. Dr. Emily Stone
6. Dr. Natasha Leighl
7. Dr. Gabriella Sozzi
8. Dr. Stephen Lam

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