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Behind the Breakthroughs

Inside Precision Medicine
Precision Medicine
Artificial Intelligence
CRISPR
CAR T-Cell Therapy
Genomics
Oncology
Biotechnology
Clinical Trials
Molecular Diagnostics
Emily Whitehead Foundation
Molecular Pathology
Drug Discovery
Allogene Therapeutics
Car-T
Cancer Detection
Xenotransplantation
Diabetes
Natural Killer Cells
Patient Care
Immunotherapy

Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine, as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and c... more

PublishesTwice monthlyEpisodes43Founded2 years ago
Number of ListenersCategories
ScienceTechnology

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Artwork for Behind the Breakthroughs

Latest Episodes

While growing up during the polio era, Arthur Caplan, PhD, saw doctors hide painful truths from families and children, which sparked his lifelong questions about power, protection, and inequality in medicine. In this episode, Caplan claims that bioet... more

Brain-computer interfaces have gained widespread attention largely for assistive applications, but Carolina Aguilar sees their greatest potential in directly treating neurological disease. Through INBRAIN Neuroelectronics, she is developing graphene-... more

Matthew Rabinowitz, PhD, moved from engineering to medicine after his Human Genome Project work, motivated by both scientific insight and personal loss that exposed the limits of existing genetic diagnostics. He founded Natera and later Myome, buildi... more

Precision medicine promises individualized care through data, but progress remains fragmented. Clinical, genomic, and imaging data are siloed, limiting real-world use. Jurgi Camblong, PhD, founded SOPHiA Genetics to integrate multimodal data into act... more

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Recent Guests

Carolina Aguilar
Co-founder and CEO of INBRAIN Neuroelectronics
INBRAIN Neuroelectronics
Episode: Carolina Aguilar: Brain-Computer Interfaces that Heal Neural Circuits
Matthew Rabinowitz
Founder of Natera and Myome
Natera, Myome
Episode: Matthew Rabinowitz: Engineering a New Era of Diagnosis
Jurgi Camblong
Founder and CEO of SOPHiA Genetics
SOPHiA Genetics
Episode: Jurgi Camblong: Data-Driven Doctors Without Borders
Molly Gibson
Origination partner at Flagship Pioneering; founder of Generate Biomedicines; founder of Expedition Medicines; founder of Lila Biosciences
Flagship Pioneering
Episode: Molly Gibson: Superintelligence and the Future of Drug Development
Mike Curtis
President and CEO of eGenesis
eGenesis
Episode: Mike Curtis: Pig Organs as a Bridge to Human Transplants
Markus Warmuth
CEO of Monte Rosa Therapeutics
Monte Rosa Therapeutics
Episode: Markus Warmuth: Eliminating Pathogenic Proteins with Molecular Glue Degraders
Zachary Roberts
Physician-scientist, Executive Vice President of Research and Development and Chief Medical Officer at Allogene Therapeutics
Allogene Therapeutics
Episode: Zachary Roberts: Building a Viable Off-the-Shelf CAR T
Boyang Wang
Founder of Immortal Dragons, longevity investor
Immortal Dragons
Episode: Boyang Wang: Organ Swaps and Mass Preventative Gene Therapy to Extend Lifespan
Kevin Davies
Director of Professional Media Content Development at Sage Publications; CRISPR authority; author
Sage Publications
Episode: Year In Review: My Personal Genomics Journey Redux

Host

Jonathan D. Grinstein
Host of Behind the Breakthroughs, insights on precision medicine from experts and innovators.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#231
Israel/Technology
Apple Podcasts
#238
Finland/Technology

Talking Points

Recent interactions between the hosts and their guests.

Matthew Rabinowitz: Engineering a New Era of Diagnosis
Q: Why is regulation such a bottleneck, and how does it affect patient access to these advances?
Regulatory pathways and differing approvals (e.g., NY State, FDA, CE) slow deployment; even with strong performance, reimbursement and guidelines lag, limiting patient access and uptake.
Matthew Rabinowitz: Engineering a New Era of Diagnosis
Q: What were the key breakthroughs that allowed you to apply deep learning to high-volume genetic testing?
We balanced explainable statistical methods with neural networks, starting with microdeletion detection in 22Q11, and showed that AI could learn from vast data to improve sensitivity and specificity beyond traditional statistics.
Matthew Rabinowitz: Engineering a New Era of Diagnosis
Q: How did your background in electrical engineering and physics lead you to diagnostics?
A drive to apply signal processing and machine learning to biology, sparked by a personal tragedy and the potential for impactful change, led to founding and building technologies at Natera and later Myome.
Jurgi Camblong: Data-Driven Doctors Without Borders
Q: What is SOPHiA's core value proposition as a 'clinical operating system' for precision medicine?
SOPHiA provides a web-based platform that ingests heterogeneous data (genomics, transcriptomics, radiology, and clinical data), processes it with AI and empirical models, and presents actionable mutation- and treatment-related insights tailored to each hospital's workflows.
Hervé Affagard: Creating Microbiomes to Fight Cancer, ALS, and More
Q: Could you explain MaaT 13 vs MaaT 33, and what you expect in terms of regulatory timelines?
MaaT 13 is donor-derived and has shown pivotal results in GVHD with the potential to be the first microbiome product approved in Europe and possibly the US via SPU and future filings. MaaT 33 is an oral form designed for stem cell transplant patients with a large ongoing trial; regulatory timelines will depend on trial outcomes and agency reviews.

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Frequently Asked Questions About Behind the Breakthroughs

What is Behind the Breakthroughs about and what kind of topics does it cover?

This podcast presents an engaging exploration of the individuals shaping the future of precision medicine. It features insightful interviews with both seasoned experts and emerging innovators who share their personal and professional journeys in advancing healthcare through cutting-edge technologies. Key topics often include the role of AI in patient care, molecular diagnostics, and the development of novel genetic therapies like cell and gene therapies. Each episode provides a nuanced understanding of how these advancements are not only changing medical practices but also aiming to make treatments more equitable and accessible on a global scale. The discussions bridge the gap between complex scientific concepts and their real-world applica... more

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1. Touching Base
2. BioCentury This Week
3. The Long Run with Luke Timmerman
4. The Readout Loud
5. Core Memory

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Behind the Breakthroughs launched 2 years ago and published 43 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Behind the Breakthroughs?

Recent guests on Behind the Breakthroughs include:

1. Carolina Aguilar
2. Matthew Rabinowitz
3. Jurgi Camblong
4. Molly Gibson
5. Mike Curtis
6. Markus Warmuth
7. Zachary Roberts
8. Boyang Wang

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