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Behind the Breakthroughs

Inside Precision Medicine
Precision Medicine
Artificial Intelligence
CAR T-Cell Therapy
CRISPR
Oncology
Genomics
Biotechnology
Clinical Trials
Molecular Diagnostics
Emily Whitehead Foundation
Cancer Detection
Molecular Pathology
Drug Discovery
Allogene Therapeutics
Car-T
Xenotransplantation
Diabetes
Natural Killer Cells
Patient Care
Immunotherapy

Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine, as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and c... more

PublishesTwice monthlyEpisodes40Foundeda year ago
Number of ListenersCategories
TechnologyScience

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Artwork for Behind the Breakthroughs

Latest Episodes

Precision medicine promises individualized care through data, but progress remains fragmented. Clinical, genomic, and imaging data are siloed, limiting real-world use. Jurgi Camblong, PhD, founded SOPHiA Genetics to integrate multimodal data into act... more

As an Origination Partner at Flagship Pioneering, Molly Gibson, PhD, co-founded her first company, Generate:Biomedicines, in 2018, where she made her mark by developing models that design novel proteins—work that has already led to a Phase 3 asthma d... more

Xenotransplantation has long been a scientifically promising but ethically complex field, overshadowed by its limited practicality despite the growing shortage of transplantable organs and the urgent needs of patients. Recent breakthroughs, including... more

Traditional drugs usually inhibit specific protein sites, but many disease-causing proteins lack accessible or unique motifs, leaving them “undruggable.” Targeted Small-molecule drugs have long been the quiet workhorses of modern medicine, slipping i... more

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Recent Guests

Mike Curtis
President and CEO of eGenesis
eGenesis
Episode: Mike Curtis: Pig Organs as a Bridge to Human Transplants
Markus Warmuth
CEO of Monte Rosa Therapeutics
Monte Rosa Therapeutics
Episode: Markus Warmuth: Eliminating Pathogenic Proteins with Molecular Glue Degraders
Zachary Roberts
Physician-scientist, Executive Vice President of Research and Development and Chief Medical Officer at Allogene Therapeutics
Allogene Therapeutics
Episode: Zachary Roberts: Building a Viable Off-the-Shelf CAR T
Boyang Wang
Founder of Immortal Dragons, longevity investor
Immortal Dragons
Episode: Boyang Wang: Organ Swaps and Mass Preventative Gene Therapy to Extend Lifespan
Kevin Davies
Director of Professional Media Content Development at Sage Publications; CRISPR authority; author
Sage Publications
Episode: Year In Review: My Personal Genomics Journey Redux
David Fischel
CEO of Stereotaxis
Stereotaxis
Episode: David Fischel: Surgical Robotics for Superhuman and Remote Operations
Katherine Stueland
CEO of GeneDx
GeneDx
Episode: Katherine Stueland: The Diagnostic Odyssey Era Ends with Early Genomics
Rahul Gupta
Dr. Rahul Gupta, former director of the Office of National Drug Control Policy
GATC Health (CEO/leader role referenced)
Episode: Rahul Gupta: Can Biotech Fix U.S. Healthcare Faster than Policy?
Michael Langer
Investor, head of T.Rex Capital
T.Rex Capital
Episode: Michael Langer: Biotech Investing in the Data Age

Host

Jonathan D. Grinstein
Host of Behind the Breakthroughs, insights on precision medicine from experts and innovators.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#176
South Korea/Technology

Talking Points

Recent interactions between the hosts and their guests.

Mike Curtis: Pig Organs as a Bridge to Human Transplants
Q: What were the pivotal shifts in the field that made xenotransplantation more feasible, and how has CRISPR changed what you can do?
The guest points to CRISPR as a turning point that unlocked multiple edits across the porcine genome, enabling inactivation of retroviruses and better immunomodulation. He contrasts early single-gene edits with the now scalable, multiplexed genome engineering that makes safe, clinically viable donor pigs possible.
Mike Curtis: Pig Organs as a Bridge to Human Transplants
Q: So how did you end up at eGenesis, and what drew you to xenotransplantation given your background in neuroscience and cancer drug development?
Curtis explains that the field offered a unique convergence of unmet medical need, a collaborative transplant community, and a compelling opportunity to apply decades of drug development experience to a brand-new modality. He highlights the chance to work with surgeons who have long sought better organ availability and to bridge dialysis patients to eventual human transplants.
Rahul Gupta: Can Biotech Fix U.S. Healthcare Faster than Policy?
Q: Can you explain what a digital twin is and how it applies to drug discovery and patient care?
A digital twin is an integrated computational model that simulates human biology and drug interactions by aggregating genomic, proteomic, metabolic, and clinical data, enabling in silico testing of how molecules behave in the body and potentially predicting efficacy and safety before clinical trials.
Rahul Gupta: Can Biotech Fix U.S. Healthcare Faster than Policy?
Q: What were the core issues you faced when you first started in this field, and have they evolved over time?
The guest describes poverty-level barriers in rural settings, the high cost of medications, and the challenge of delivering effective treatments to patients with limited resources, noting that these core issues have persisted even as policy and medical knowledge have evolved.
David Liu: Performing Chemistry on DNA to Unlock Personalized Gene Editing
Q: What initially inspired your focus on gene editing, and how did your early experiences shape your approach?
A mix of curiosity-driven exploration and the desire to address real biological problems; childhood experiences with questions and experiments, coupled with supportive mentors, steered me toward chemistry-based problem solving in biology.

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Frequently Asked Questions About Behind the Breakthroughs

What is Behind the Breakthroughs about and what kind of topics does it cover?

This podcast presents an engaging exploration of the individuals shaping the future of precision medicine. It features insightful interviews with both seasoned experts and emerging innovators who share their personal and professional journeys in advancing healthcare through cutting-edge technologies. Key topics often include the role of AI in patient care, molecular diagnostics, and the development of novel genetic therapies like cell and gene therapies. Each episode provides a nuanced understanding of how these advancements are not only changing medical practices but also aiming to make treatments more equitable and accessible on a global scale. The discussions bridge the gap between complex scientific concepts and their real-world applica... more

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1. Touching Base
2. The Readout Loud
3. The Long Run with Luke Timmerman
4. BioCentury This Week
5. The Ezra Klein Show

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Behind the Breakthroughs launched a year ago and published 40 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Behind the Breakthroughs?

Recent guests on Behind the Breakthroughs include:

1. Mike Curtis
2. Markus Warmuth
3. Zachary Roberts
4. Boyang Wang
5. Kevin Davies
6. David Fischel
7. Katherine Stueland
8. Rahul Gupta

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