
Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine, as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and c... more
| Publishes | Twice monthly | Episodes | 46 | Founded | 2 years ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | TechnologyScience | |||

For decades, psychiatry has relied on symptom-based diagnosis and trial-and-error treatment, but precision medicine is set to transform mental health care by using objective biological measures—such as EEG, sleep and circadian rhythm data, and cognit... more
AI is transforming biomedical research, but meaningful advances in drug discovery require more than just increasingly powerful algorithms—they depend on combining machine learning with physics-based simulations, mechanistic models, and rigorous exper... more
Philippe Pouletty, MD, is one of Europe’s most successful life sciences entrepreneurs, having spent more than 30 years building category-leading biotechnology and medical technology companies from breakthrough scientific innovations. His most notable... more
While growing up during the polio era, Arthur Caplan, PhD, saw doctors hide painful truths from families and children, which sparked his lifelong questions about power, protection, and inequality in medicine. In this episode, Caplan claims that bioet... more
Brain-computer interfaces have gained widespread attention largely for assistive applications, but Carolina Aguilar sees their greatest potential in directly treating neurological disease. Through INBRAIN Neuroelectronics, she is developing graphene-... more
Matthew Rabinowitz, PhD, moved from engineering to medicine after his Human Genome Project work, motivated by both scientific insight and personal loss that exposed the limits of existing genetic diagnostics. He founded Natera and later Myome, buildi... more
Precision medicine promises individualized care through data, but progress remains fragmented. Clinical, genomic, and imaging data are siloed, limiting real-world use. Jurgi Camblong, PhD, founded SOPHiA Genetics to integrate multimodal data into act... more
As an Origination Partner at Flagship Pioneering, Molly Gibson, PhD, co-founded her first company, Generate:Biomedicines, in 2018, where she made her mark by developing models that design novel proteins—work that has already led to a Phase 3 asthma d... more
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A tech-forward, biotech-forward interview series that centers on the people and ideas driving precision medicine. Conversations span bioethics, neural interfaces, genomic diagnostics, AI-enabled drug discovery, and transformative therapies like xenotransplantation and allogeneic CAR-T. Across episodes, the host surfaces personal journeys, regulatory and reimbursement hurdles, and the practical realities of bringing cutting-edge science to patients, including data sharing, privacy, equity, and global access. Noteworthy threads include the maturation of AI in biology, the shift toward platform-based biotech entrepreneurship, and the push to democratize access to advanced therapies, diagnostics, and personalized care. The show often features s... more
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Behind the Breakthroughs launched 2 years ago and published 46 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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Recent guests on Behind the Breakthroughs include:
1. Philippe Pouletty
2. Arthur Caplan
3. Carolina Aguilar
4. Matthew Rabinowitz
5. Jurgi Camblong
6. Molly Gibson
7. Mike Curtis
8. Markus Warmuth
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