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Behind the Breakthroughs

Inside Precision Medicine
Precision Medicine
Artificial Intelligence
CRISPR
CAR T-Cell Therapy
Genomics
Oncology
Biotechnology
Clinical Trials
Molecular Diagnostics
Emily Whitehead Foundation
Cancer Detection
Molecular Pathology
Drug Discovery
Allogene Therapeutics
Car-T
Xenotransplantation
Diabetes
Natural Killer Cells
Patient Care
Immunotherapy

Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine, as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and c... more

PublishesTwice monthlyEpisodes46Founded2 years ago
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Artwork for Behind the Breakthroughs

Latest Episodes

For decades, psychiatry has relied on symptom-based diagnosis and trial-and-error treatment, but precision medicine is set to transform mental health care by using objective biological measures—such as EEG, sleep and circadian rhythm data, and cognit... more

AI is transforming biomedical research, but meaningful advances in drug discovery require more than just increasingly powerful algorithms—they depend on combining machine learning with physics-based simulations, mechanistic models, and rigorous exper... more

Philippe Pouletty, MD, is one of Europe’s most successful life sciences entrepreneurs, having spent more than 30 years building category-leading biotechnology and medical technology companies from breakthrough scientific innovations. His most notable... more

While growing up during the polio era, Arthur Caplan, PhD, saw doctors hide painful truths from families and children, which sparked his lifelong questions about power, protection, and inequality in medicine. In this episode, Caplan claims that bioet... more

Brain-computer interfaces have gained widespread attention largely for assistive applications, but Carolina Aguilar sees their greatest potential in directly treating neurological disease. Through INBRAIN Neuroelectronics, she is developing graphene-... more

Matthew Rabinowitz, PhD, moved from engineering to medicine after his Human Genome Project work, motivated by both scientific insight and personal loss that exposed the limits of existing genetic diagnostics. He founded Natera and later Myome, buildi... more

Precision medicine promises individualized care through data, but progress remains fragmented. Clinical, genomic, and imaging data are siloed, limiting real-world use. Jurgi Camblong, PhD, founded SOPHiA Genetics to integrate multimodal data into act... more

As an Origination Partner at Flagship Pioneering, Molly Gibson, PhD, co-founded her first company, Generate:Biomedicines, in 2018, where she made her mark by developing models that design novel proteins—work that has already led to a Phase 3 asthma d... more

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Recent Guests

Philippe Pouletty
Co-founder and CEO of Truffle Capital; entrepreneur behind Abivax and Carvolix
Truffle Capital
Episode: Philippe Pouletty: Turning Europe’s Life Science Startups Into World Leaders
Arthur Caplan
Renowned bioethicist, professor, and commentator
New York University (professional affiliation cited in dialogue)
Episode: Arthur Caplan: The Right to Life, Liberty, and Pursuit of Health
Carolina Aguilar
Co-founder and CEO of INBRAIN Neuroelectronics
INBRAIN Neuroelectronics
Episode: Carolina Aguilar: Brain-Computer Interfaces that Heal Neural Circuits
Matthew Rabinowitz
Founder of Natera and Myome
Natera, Myome
Episode: Matthew Rabinowitz: Engineering a New Era of Diagnosis
Jurgi Camblong
Founder and CEO of SOPHiA Genetics
SOPHiA Genetics
Episode: Jurgi Camblong: Data-Driven Doctors Without Borders
Molly Gibson
Origination partner at Flagship Pioneering; founder of Generate Biomedicines; founder of Expedition Medicines; founder of Lila Biosciences
Flagship Pioneering
Episode: Molly Gibson: Superintelligence and the Future of Drug Development
Mike Curtis
President and CEO of eGenesis
eGenesis
Episode: Mike Curtis: Pig Organs as a Bridge to Human Transplants
Markus Warmuth
CEO of Monte Rosa Therapeutics
Monte Rosa Therapeutics
Episode: Markus Warmuth: Eliminating Pathogenic Proteins with Molecular Glue Degraders
Zachary Roberts
Physician-scientist, Executive Vice President of Research and Development and Chief Medical Officer at Allogene Therapeutics
Allogene Therapeutics
Episode: Zachary Roberts: Building a Viable Off-the-Shelf CAR T

Host

Jonathan Grinstein
Host of Behind the Breakthroughs (North American Editor for Inside Precision Medicine)

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Talking Points

Recent interactions between the hosts and their guests.

Philippe Pouletty: Turning Europe’s Life Science Startups Into World Leaders
Q: What is your long-term legacy goal for reshaping European life sciences?
The aim is to enable radical, novel innovations that significantly improve patients' lives, not just to achieve multiple IPOs. The focus is on creating a pipeline of breakthrough products and building an ecosystem where Europe consistently yields global science and healthcare leaders through disciplined execution and ambitious science.
Philippe Pouletty: Turning Europe’s Life Science Startups Into World Leaders
Q: What are the regulatory and payer considerations that shape European vs. US commercialization?
Regulatory paths differ (FDA in the US; CE marking via notified bodies in Europe), but the core requirements—robust data, manufacturing quality, and proven safety and efficacy—are similar. Payer and pricing dynamics differ, with Europe generally favoring lower pricing and reimbursement scopes, influencing how companies plan market access and sustainability.
Philippe Pouletty: Turning Europe’s Life Science Startups Into World Leaders
Q: How is Carvolix positioned to compete with US and Chinese players in AI-driven interventional medicine?
Carvolix integrates hardware, software, imaging, and AI to create an autonomous or semi-autonomous system for valve replacement and thrombectomy. The plan emphasizes launching in the US first, maintaining platform-agnostic compatibility with major valve systems, and expanding through Europe with a careful, multi-market strategy and potential partnerships, while ensuring strong regulatory and manufacturing foundations.
Philippe Pouletty: Turning Europe’s Life Science Startups Into World Leaders
Q: What sets Abivax apart and how did you approach growth to avoid being scooped up by larger players?
Abivax grew by merging several biotech entities to reach critical mass, pursuing an early IPO on Euronext, and leveraging a management team capable of steering complex development paths. The approach balanced science with strategic leadership to weather setbacks and ultimately advance promising candidates to late-stage trials.
Philippe Pouletty: Turning Europe’s Life Science Startups Into World Leaders
Q: Can you tell me a bit about your story and what inspired you to move from medicine to building companies?
I started with residency in Paris, moved to Stanford for research, developed a patent for a gene amplification technique, and chose to pursue entrepreneurship to bring innovations to patients rather than stay in academia. This led to founding Truffle Capital and backing biotech and medtech ventures like Abivax and Carvolix, with a focus on translating science into globally competitive, independent European companies.

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Frequently Asked Questions About Behind the Breakthroughs

What is Behind the Breakthroughs about and what kind of topics does it cover?

A tech-forward, biotech-forward interview series that centers on the people and ideas driving precision medicine. Conversations span bioethics, neural interfaces, genomic diagnostics, AI-enabled drug discovery, and transformative therapies like xenotransplantation and allogeneic CAR-T. Across episodes, the host surfaces personal journeys, regulatory and reimbursement hurdles, and the practical realities of bringing cutting-edge science to patients, including data sharing, privacy, equity, and global access. Noteworthy threads include the maturation of AI in biology, the shift toward platform-based biotech entrepreneurship, and the push to democratize access to advanced therapies, diagnostics, and personalized care. The show often features s... more

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1. Touching Base
2. The Readout Loud
3. The Long Run with Luke Timmerman
4. The a16z Show
5. Huberman Lab

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Behind the Breakthroughs launched 2 years ago and published 46 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Behind the Breakthroughs?

Recent guests on Behind the Breakthroughs include:

1. Philippe Pouletty
2. Arthur Caplan
3. Carolina Aguilar
4. Matthew Rabinowitz
5. Jurgi Camblong
6. Molly Gibson
7. Mike Curtis
8. Markus Warmuth

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