Rephonic
Artwork for Touching Base
CRISPR
Gene Therapy
Human Genome Project
Artificial Intelligence
Gene Editing
Nanoparticles
DNA
Eli Lilly
AI In Drug Discovery
Mrna Therapeutics
Rosalind Franklin
Biotechnology
FDA
Nvidia
Drug Discovery
Autism
Genealogy
Moderna
AACR
Genetic Engineering

Touching Base is the dynamic podcast series from the editors of GEN (Genetic Engineering & Biotechnology News). Each episode features a rotating cast of senior editors including John Sterling, Kevin Davies, Julianna LeMieux, Alex Philippidis, Uduak Thomas, Corinna Singleman and Fay Lin who delve into emerging stories, exchange ideas, and debate the latest trends in biotech. Additionally, they talk... more

PublishesTwice monthlyEpisodes54Founded3 years ago
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ScienceNews CommentaryLife SciencesNews

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Latest Episodes

Promise hits Parkinson’s disease therapy, as a Phase I/II clinical study has demonstrated the feasibility of transplanting stem-cell-derived dopamine progenitor cells into the brain. In preclinical research, a new platform uses the brain’s fluid tran... more

More big biotech deals on the docket this week. First, Merck KGaA is buying Bio-Techne for $11.3 billion to expand its presence in high-growth life science markets. We dive into the details of this deal and then turn our attention to a $2.5 million c... more

We are still talking about big pharma deals and biotech fundraising in this episode. The big news this week was Parabilis Medicines’s history-making IPO. We dive into the drug developer’s plans for the eye-popping $770.5 million that it raised. Next,... more

In this week’s episode, we start with news that Fulcrum Therapeutics is scrapping its lead pipeline program for sickle cell disease following concerns from the FDA about the drug’s risks and benefits. Also on the docket, news of Eli Lilly’s latest sp... more

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Recent Guests

Alex Zavronkov
CEO, Insilico Medicine
Insilico Medicine
Episode: Merck and Insilico Make Deals, Claude Science’s Debut, Vaccines for Neglected Diseases
John Sterling
Editor-in-chief of GEN
GEN
Episode: Remembering J. Craig Venter, PhD
Kevin Davies
Editor/author with deep knowledge of genomics history
GEN
Episode: Remembering J. Craig Venter, PhD
Mark Tesse-Lavigne
CEO, Xaira
Xaira
Episode: Agentic AI, Virtual Cell, LNP Vaccine Boosters, Engineered Organs, and Mergers
Bo Wang
Senior Vice President and Head of Biomedical AI
Xaira
Episode: Agentic AI, Virtual Cell, LNP Vaccine Boosters, Engineered Organs, and Mergers
Michelle Lee
CEO of Medra
Medra
Episode: Women in Science, Robotics, Automation, SLAS, and Lilly Updates
Scott Ripley
Vice President and General Manager of Nucleic Acids and Nanomedicines at Cytiva
Cytiva
Episode: Navigating Biotech’s New Normal, Applying AI to Cas9 Enzymes, and Sequencing Generations
Francis Collins
Former Director of the NIH
National Institutes of Health
Episode: Genetic Engineering at Asilomar, Stand Up for Science, and Francis Collins

Hosts

Corinna Singleman
Host of Touching Base, GEN editor
Alex Philippidis
GEN editor, Editor/author with deep genomics knowledge

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Talking Points

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Agentic AI, Virtual Cell, LNP Vaccine Boosters, Engineered Organs, and Mergers
Q: What are the practical implications of agentic AI for life sciences and pharma pipelines?
Agentic AI offerings, when designed with strong safety controls and federated data approaches, can accelerate hypothesis generation, model-driven design, and collaborative drug discovery while allowing companies to share data without compromising proprietary information.
uniQure Staggers at FDA, Recursion's Microglia Map, and Leadership Transitions
Q: Were there any really great takeaways from the summit for future looking?
The summit emphasized the need for more proof points in AI drug discovery to balance hype with reality.
uniQure Staggers at FDA, Recursion's Microglia Map, and Leadership Transitions
Q: What could impact Unicure's efforts here with FDA leadership changes?
The ongoing leadership instability at the FDA could impact Unicure's interactions and regulatory outcomes.
Sarepta Under Scrutiny, AstraZeneca’s Big Bet, and AI vs. IDRs
Q: Does that $50 billion, with a B, which is crazy to me, in dollar investment, is that just for the Virginia location or is that for all of these improvements?
The $50 billion is across all of AstraZeneca's projects, not just the Virginia location.
Sarepta Under Scrutiny, AstraZeneca’s Big Bet, and AI vs. IDRs
Q: Is there any indication that you've heard of at all that patients are worried about just stopping the treatment?
Concerns exist broadly in the patient community regarding the FDA's demands to halt shipments and the implications for patient safety.

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Frequently Asked Questions About Touching Base

What is Touching Base about and what kind of topics does it cover?

Biotech news and analysis with a rotating slate of senior editors who dissect the latest dealmaking, scientific breakthroughs, and policy shifts shaping the life sciences landscape. Episodes frequently cover large industry transactions, AI-enabled drug discovery, vaccine research, and the practical implications of new technologies like CRISPR, regenerative medicine, and open-science movements. The discussion style blends historical context, market dynamics, and strategic perspectives from industry reporters, with a willingness to arena-switch from high-stakes finance to technical science. A notable strength is the breadth of coverage—from blockbuster mergers and AI partnerships to vaccine updates and neglected-disease research—delivered thr... more

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1. Behind the Breakthroughs
2. The Readout Loud
3. BioCentury This Week
4. Nature Podcast
5. Ground Truths

How many episodes of Touching Base are there?

Touching Base launched 3 years ago and published 54 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Touching Base?

Recent guests on Touching Base include:

1. Alex Zavronkov
2. John Sterling
3. Kevin Davies
4. Mark Tesse-Lavigne
5. Bo Wang
6. Michelle Lee
7. Scott Ripley
8. Francis Collins

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