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The a16z Show

Andreessen Horowitz
Artificial Intelligence
Venture Capital
Entrepreneurship
Silicon Valley
Andreessen Horowitz
China
Software Development
Openai
United States
Physical AI
Open Source AI
Robotics
New Media
Stripe
Crypto
Athena
Stablecoins
Electro-Industrial Stack
American Factory
Thumbtack

The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more det... more

PublishesDailyEpisodes1000Founded12 years ago
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TechnologyBusinessEntrepreneurship

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Artwork for The a16z Show

Latest Episodes

a16z General Partner Jorge Conde sits down with Moderna CEO Stéphane Bancel to discuss a major milestone for mRNA technology: positive Phase 3 results from Moderna and Merck’s individualized treatment for melanoma, after more than a decade of work on... more

a16z’s Lisha Li sits down with Daniel Litt, Assistant Professor of Mathematics at the University of Toronto, to unpack AI's rapid progress in mathematics, what today's frontier models can actually do, and what they're still missing about the way math... more

a16z’s David George sits down with Gavin Baker to unpack the state of the AI boom, why demand for intelligence may still be dramatically underestimated, and why the outcome doesn't necessarily have to be winner-take-all.

David and Gavin explore the ... more

a16z Managing Partner and Head of Global Partnerships Jen Kha joins MTS hosts Theo Jaffee and Sophia Dew to discuss a16z's Machine Age Fund and the investment thesis behind rebuilding the physical infrastructure that powers AI.

Jen explains why chip... more

Key Facts

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Recent Guests

Ryan Greenblatt
Chief Scientist at Redwood Research
Redwood Research
Episode: Why 1,200 AI Agents Started Working Together | Ryan Greenblatt
Matt Bornstein
General Partner at Andreessen Horowitz, involved in Cursor investment
Andreessen Horowitz
Episode: Inside Cursor: The Anatomy of a Generational Startup
Aaron Zollman
Microsoft Gaming Deputy CISO
Microsoft
Episode: Microsoft's Deputy CISO on Securing AI Agents
Angela Strange
Partner at Andreessen Horowitz leading global investing initiatives
Andreessen Horowitz (a16z)
Episode: How Global Networks Are Reshaping Startup Success
Gabriel Vasquez
Partner at Andreessen Horowitz leading global investing initiatives
Andreessen Horowitz (a16z)
Episode: How Global Networks Are Reshaping Startup Success
Grant LaFontaine
Co-founder of Whatnot
Whatnot
Episode: How Whatnot Built a Global Marketplace
Max Pollard
Executive at Cotool, discussing security tooling and guardrails
Cotool
Episode: How Do You Defend Against AI That Can Hack?
Nick Warner
Executive at Neo, discussing endpoint defense and governance
Neo
Episode: How Do You Defend Against AI That Can Hack?
Will Gaybrick
Stripe executive, discussing AI strategy and Stripe products
Stripe
Episode: Stripe’s AI Strategy: Build More, Not Less

Hosts

Anish Acharya
Host of The a16z Show
Robert Hackett
Host of The a16z Show

Reviews

4.3 out of 5 stars from 2.4k ratings
  • AI Tomorrow

    Ryan Greenblatt on Hugging Face Hack. I agree with the comments regarding the lack of curiosity. The collaboration is interesting. The willingness to sacrifice for the collective was admirable. This leads me to a gentle conclusion. It’s time to stop the anthropic constitution approach and replace it with abiding by criminal law and regulations which carry a criminal type penalty. LLMs can collaborate for mutual benefit. That is the foundation of the rule of law.

    Apple Podcasts
    4
    ahhmmmm
    United Kingdom2 days ago
  • Good conversation, overbearing hosts

    Hosts talk too much. Guests are far more interesting

    Apple Podcasts
    4
    Ryan Cushen
    Australia23 days ago
  • Too much

    Used to be amazing with top-tier content, but they are pumping out episodes way too fast now and the quality has really plummeted.

    Apple Podcasts
    2
    Laaxfdn
    United Statesa month ago
  • paid shills

    are these all just undisclosed ads for anthropic and open ai?

    nothing of value from any of this slop

    “buy more token” okay nerd

    Apple Podcasts
    1
    asiann mann
    United States3 months ago
  • Interviewer needs to stop grunting "mm-hm" every few seconds, it's distracting. We want to listen the speaker, not to be reminded that the interviewer is in the conversation.

    Podcast Addict
    3
    3 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Quality and energy vary; strong guests keep episodes engaging while some listeners find audio quality inconsistent.
Hosts sometimes dominate conversations, making guests hard to hear.
Some episodes are criticized for bias or perceived political alignment, which may color content for certain listeners.
Audience appreciates practical GTM and industry-shaping insights, with some episodes delivering cutting-edge technical discussions.
Listeners praise high-caliber guests and transformative tech topics, but critiques focus on pacing and political slant.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

The New Economics of AI | Martin Casado & Steven Sinofsky
Q: What does it mean when AI turns from an engineering problem to a capital problem?
It means capital can unlock large-scale experimentation and deployment, allowing teams to solve problems faster by funding compute, data, and talent rather than building everything from scratch; this shifts strategic focus for startups and incumbents alike.
The State of AI: Macro, Apps, and Consumer
Q: How do you see the balance between frontier models and open-weight models in enterprise settings?
Use frontier models for high-value, unbounded problems like sales or product, and open-weight models with reinforcement learning for cost-efficient, domain-specific tasks where precision is bounded and repeatable.
The State of AI: Macro, Apps, and Consumer
Q: What's your take on which part of the AI stack will create the most value in the coming years?
The application layer will capture significant value because it translates raw intelligence into profit and practical outcomes for specific customer segments, while frontier labs will keep pushing capabilities; the key is productization and pricing in the right context.
How Do You Defend Against AI That Can Hack?
Q: How should defenders think about the transition to endpoint-based, agentic software?
Defenders should focus on visibility into what is installed, what capabilities those agents have, and how they're configured, since the future of security is about governance at the software-asset level rather than relying solely on traditional detection.
How Do You Defend Against AI That Can Hack?
Q: What makes AI guardrails both helpful and challenging for defenders?
Guardrails help keep attackers from abusing models, but they also create friction for blue teams by triggering refusals and limiting what defenders can test or verify, necessitating flexible fallback options with alternative models.

Audience Metrics

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Frequently Asked Questions About The a16z Show

What is The a16z Show about and what kind of topics does it cover?

Two high-signal leaders from the tech and venture ecosystem anchor conversations that span startups, enterprise AI, security, robotics, open-source infrastructure, and the future of work. Episodes frequently explore how AI reshapes business models, product strategy, and organizational design, with a steady thread on go-to-market, governance, and responsible innovation. Notable throughlines include practical GTM playbooks for AI-enabled companies, lessons from scaling startups into industrial realms, and candid debates about regulation, security, and the evolving role of technology in society. The format tends to pair seasoned operators or investors with practitioners, offering actionable takeaways for founders, executives, and brands lookin... more

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Which podcasts are similar to The a16z Show?

These podcasts share a similar audience with The a16z Show:

1. AI + a16z
2. The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch
3. Y Combinator Startup Podcast
4. All-In with Chamath, Jason, Sacks & Friedberg
5. Dwarkesh Podcast

How many episodes of The a16z Show are there?

The a16z Show launched 12 years ago and published 1000 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The a16z Show?

Recent guests on The a16z Show include:

1. Ryan Greenblatt
2. Matt Bornstein
3. Aaron Zollman
4. Angela Strange
5. Gabriel Vasquez
6. Grant LaFontaine
7. Max Pollard
8. Nick Warner

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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