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Vital Signs with Jacob Effron and Nikhil Krishnan

by Redpoint Ventures
Healthcare
Patient Empowerment
Large Language Models
Social Determinants Of Health
Generative AI
AI In Healthcare
Value-Based Care
Health Insurance
Data Privacy
Prompt Engineering
Telehealth
Maternal Health
Medicaid
Newborn Health
Oscar Health
Real-World Evidence
Digital Health
Artificial Intelligence
Clinical Notes
Sword Health

On Vital Signs, Jacob Effron and Nikhil Krishnan dig into cutting-edge trends in healthtech and the people shaping them. Every two weeks they’ll explore a new sub-sector and trend with policy leaders, startup founders and industry executives. Subscribe now to make sure you don’t miss any of it!

PublishesMonthlyEpisodes63Founded3 years ago
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Artwork for Vital Signs

Latest Episodes

This episode features Viren Shetty, Vice Chairman of Narayana Health, discussing how his father founded a cardiac surgery hospital in India 25 years ago that revolutionized healthcare delivery by applying manufacturing efficiency principles to drasti... more

This episode captures Walid Mehanna's perspective on how Merck KGaA has approached enterprise AI adoption through a federated strategy that prioritizes people over technology. The core message is that successful AI implementation requires building or... more

In this episode, Jacob sits down with Joshua Meier, co-founder of Chai Discovery and former Chief AI Officer at Absci, to explore the breakthrough moment happening in AI drug discovery. They discuss how the field has evolved through three distinct wa... more

Elliot Cohen—PillPack co-founder and now co-founder of General Medicine—joins Jacob Effron and Nikhil (Out-of-Pocket) to unpack what “best care” really means in 2025. He explains why General Medicine is building a broad front door to care. Elliot als... more

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Recent Guests

Viren Shetty
Vice Chairman of Narayana Health
Narayana Health
Episode: Ep 63: Narayana Health Vice Chairman on Scaling Quality Care in India and Tech’s Role
Walid Mehanna
Chief Data and AI Officer at Merck KGaA
Merck KGaA
Episode: Ep 62: Merck KGaA Chief Data and AI Officer on Scaling AI in Pharma and The Future of Enterprise Software
Joshua Meier
CEO and Co-Founder of Chai Discovery
Chai Discovery
Episode: Ep 61: Co-Founder of Chai Discovery Joshua Meier on 99% Faster Drug Discovery, BioTech’s AlphaGo Moment, Building Photoshop for Molecules
Elliot Cohen
Co-founder of PillPack and CEO of General Medicine
General Medicine
Episode: Ep 60: General Medicine's Elliot Cohen on Lessons from PillPack and Amazon and The Future of AI x Healthcare
Daniel Perez
Co-founder and CEO of Hinge Health
Hinge Health
Episode: Flashback: Hinge Health CEO Daniel Perez on Effective Employer Sales, Patient Engagement and His Top Advice to Founders
Rushika Fernandopulle
Former CEO of Iora Health, a pioneer in value-based care.
Harvard Medical School
Episode: Ep 58: Iora Health Former CEO Rushika Fernandopulle on Current State of Value Based Care Across Payer Types and AI’s Role in Primary Care
Frank Wu
CEO of Taro Health
Taro Health
Episode: Ep 57: Taro Health CEO Frank Wu on Direct Primary Care, The History of InsurTech and AI for Payers
Erik Wexler
CEO of Providence Health
Providence Health
Episode: Ep 56: Providence CEO Erik Wexler on Evaluating Partnerships, Policy and Leadership
Hemant Taneja
CEO of General Catalyst, involved in the creation of major healthcare companies.
General Catalyst
Episode: Ep 54: General Catalyst CEO Hemant Taneja on Buying a Health System, $100B Healthcare Companies and The Future of AI and Venture

Hosts

Jacob Effron
Co-host with expertise in health technology, actively engaging in conversations that shape the future of healthcare innovations.
Nikhil Krishnan
Co-host with a deep understanding of healthcare trends and technology, facilitating insightful discussions with industry leaders.

Reviews

4.9 out of 5 stars from 101 ratings
  • Must-listen for those in healthtech!

    Very well-researched interviewing which leads to thoughtful conversations from all types of perspectives in the healthtech industry.

    Apple Podcasts
    5
    amooradian
    United States2 years ago
  • Very well done

    Great guests that are a true conversation. I’d pick this podcast over many other healthcare industry podcasts out there. Keep up the great work!

    Apple Podcasts
    5
    andy4739(928:
    United States3 years ago
  • Clear, crisp insight

    Great discussion of past, present and future of value-based care start-ups and policy by two extremely knowledgeable and articulate participants in the space.

    Apple Podcasts
    5
    MoConnect
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Insightful and well-researched, offering thoughtful conversations from various perspectives in the healthtech sector.
Listeners appreciate the clarity and depth of insights into complex healthcare topics, positioning it as a standout among similar shows.
Hosts are praised for their ability to curate engaging guests that contribute to meaningful discussions.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#167
Hong Kong/Business/Investing
Apple Podcasts
#230
Chile/Business/Investing

Talking Points

Recent interactions between the hosts and their guests.

Ep 62: Merck KGaA Chief Data and AI Officer on Scaling AI in Pharma and The Future of Enterprise Software
Q: How realistic do you think that vision of digitally simulating drugs and the human body is over the next decade?
I think it's still a moonshot, but I focus more on the direction we need to go rather than obsessing over timelines.
Ep 62: Merck KGaA Chief Data and AI Officer on Scaling AI in Pharma and The Future of Enterprise Software
Q: How do you prioritize the set of things to go after as an organization?
We have set up our overall system very federated for a reason, allowing us to act fast and local when needed while capitalizing on innovation ecosystems.
Ep 60: General Medicine's Elliot Cohen on Lessons from PillPack and Amazon and The Future of AI x Healthcare
Q: Why is it essential to trust consumers in their healthcare decisions?
Consumers are often knowledgeable about their needs, and empowering them leads to better outcomes when provided with the right tools and resources.
Ep 60: General Medicine's Elliot Cohen on Lessons from PillPack and Amazon and The Future of AI x Healthcare
Q: What is General Medicine and how does it differ from traditional healthcare?
General Medicine simplifies healthcare access through consumer-directed services and a wide range of medical options, unlike traditional healthcare which can be convoluted and difficult.
Flashback: Hinge Health CEO Daniel Perez on Effective Employer Sales, Patient Engagement and His Top Advice to Founders
Q: What role do you think third-party validators play in healthcare?
They provide an unbiased perspective on what's working and add transparency and trust for customers.

Audience Metrics

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Frequently Asked Questions About Vital Signs

What is Vital Signs about and what kind of topics does it cover?

Focus is placed on the intersection of technology and healthcare, emphasizing innovative solutions, industry trends, and the evolution of healthcare systems. Frequent discussions with leaders in health technology cover diverse topics such as value-based care, artificial intelligence in healthcare, and consumer empowerment within the medical landscape. Listeners can expect insightful conversations that analyze the challenges and developments presented by industry pioneers, making it a valuable resource for those interested in modern healthtech dynamics and healthcare policy.

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Which podcasts are similar to Vital Signs?

These podcasts share a similar audience with Vital Signs:

1. a16z Podcast
2. The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch
3. ACQ2 by Acquired
4. Uncapped with Jack Altman
5. How I Invest with David Weisburd

How many episodes of Vital Signs are there?

Vital Signs launched 3 years ago and published 63 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Vital Signs?

Recent guests on Vital Signs include:

1. Viren Shetty
2. Walid Mehanna
3. Joshua Meier
4. Elliot Cohen
5. Daniel Perez
6. Rushika Fernandopulle
7. Frank Wu
8. Erik Wexler

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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