Rephonic
Artwork for Moonshots

Moonshots with Peter Diamandis

PHD Ventures
Artificial Intelligence
Longevity
Healthcare
Bitcoin
Openai
Robotics
Artificial General Intelligence
China
Elon Musk
Google
Entrepreneurship
Education
Quantum Computing
Humanoid Robots
Space Exploration
Mental Health
Biotechnology
AGI
United States
Meta

Tracking the future of technology and how it impacts humanity. Named by Fortune as one of the “World’s 50 Greatest Leaders,” Peter H. Diamandis, MD, is a founder, investor, advisor, and best-selling author. Join Peter on his mission to uplift humanity through technology. Follow Peter on X - x.com/PeterDiamandis

PublishesTwice weeklyEpisodes258Founded4 years ago
Number of ListenersCategory
Business

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Artwork for Moonshots

Latest Episodes

In this episode, the mates welcome Blitzy CEO Brian Elliott to discuss Google’s blowout AI-driven earnings, White House model vetting, Pentagon deals with frontier labs, compute scarcity, the rise of private-equity-led enterprise AI, ocean and space ... more

This episode features a dynamic panel discussion on exponential technologies, AI advancements, robotics, and the future of humanity. Experts explore the implications of AI, robotics, biotech, and societal shifts, offering insights into what the next ... more

In this episode, the mates explore the rapid advancements in AI, the global AI race, new models like Kimi K 2.6 and GPT 5.5, and the implications for privacy, security, and the future of technology. The mates discuss the future of work, AI regulation... more

YouTube

This episode was filmed at the 2026 Abundance360 Summit. Learn more at www.abundance360.com/

This Q&A is about longevity, and especially how David Sinclair sees AI speeding up drug discovery, biological-age reversal, and the future of health... more

YouTube

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Recent Guests

David Sinclair
Leading longevity researcher, co-founder of Sinclair Lab
Life Biosciences / Sinclair Lab
Episode: David Sinclair on the Longevity Pill, Age Reversal Timelines, and Updated Protocols | EP #250
Sid Sibrandich
Founder of GitLab, discussed AI-driven medical breakthroughs
GitLab
Episode: Sam Altman’s Attack, Amazon vs. Starlink, and What Opus 4.7 Actually Means | #248
Mark Cuban
Entrepreneur and investor featured in discussion clips
Entrepreneur and investor
Episode: Elon Musk vs. Sam Altman, AI Job Loss, and OpenAI’s $852B Valuation | EP #247
Ben Lamm
CEO of Colossal
Colossal
Episode: How AI Is Bringing Extinct Animals Back (And What Comes Next) | Ben Lamm (Colossal) | EP #245
Dawn Musalam
Chief Medical Officer, Fountain Life
Fountain Life
Episode: NVIDIA's $1 Trillion Prediction, Anthropic Beats OpenAI, Tesla vs. TSMC & The CS Job Collapse | 240
Alex Wissner-Gross
AWG, resident genius
Moonshots panel
Episode: Meta Buys Moltbook, GPT 5.4, and Fruitfly Brain Upload | Moonshots Live at The Abundance Summit 238
Dara Khosrowshahi
CEO of Uber
Uber
Episode: Meta Buys Moltbook, GPT 5.4, and Fruitfly Brain Upload | Moonshots Live at The Abundance Summit 238
Jan LeCun
AI researcher, noted world-model advocate
Advanced Machine Intelligence Lab
Episode: Meta Buys Moltbook, GPT 5.4, and Fruitfly Brain Upload | Moonshots Live at The Abundance Summit 238
Dara Khorsrowshahi
CEO Uber
Uber
Episode: Meta Buys Moltbook, GPT 5.4, and Fruitfly Brain Upload | Moonshots Live at The Abundance Summit 238

Host

Peter Diamandis
Host with a track record of leading conversations on exponential tech and future-orientated topics.

Reviews

4.7 out of 5 stars from 1.5k ratings
  • Wildly optimistic futurism

    I listen to show for pure entertainment but only in small doses. They like to talk about all the ways AI will make our lives easier in the future I but take a lot of it with a grain of truth. “Don’t save for retirement as money won’t be needed”, “Humanoids living in data centers built on the moon”, “Data centers will push energy costs to zero for everyone” and “Elon is the great visionary who will solve all our problems”. I wish I had this level of optimism and/or whatever they are smoking.

    Apple Podcasts
    3
    Always be questioning
    United Statesa month ago
  • Must have pod

    Loved the new format of this pod, deep dives are so good, learned a lot. Appreciated your time & efforts.

    Apple Podcasts
    5
    Humanity & Peace
    Canada2 months ago
  • AI creates jobs IT Jobs

    Death of SaaS? A $15M Australian Company Swapped there HR app “Employment Hero" for AI in 4 Hours.

    We’ve all heard the doomsday predictions about AI and the job market. But for a $15 million Australian company (approx. $10M USD), the story isn't about redundancy—it's about a radical shift in how businesses are built and scaled.

    They didn't just tweak their workflow; they fired their HR software.

    The 4-Hour Software Revolution

    Using Anthropic’s latest code-generation tools, this small business m... more

    Apple Podcasts
    5
    GrillaBBQ
    Australia2 months ago
  • Enjoy the optimism. Beware the blind spots.

    I’ve become a regular listener to Moonshots. It’s a good place to tune in if you want to understand where technology is headed. The hosts seem genuinely enthusiastic and optimistic, which I appreciate.

    But the longer I’ve listened, the more a single, serious gap has become impossible to ignore.

    The running theme of “Abundance” is an appealing and optimistic framework, and in many ways very inspiring. The problem is that it functions more like a faith position than an argument. It doesn’t serio... more

    Apple Podcasts
    3
    benoftroy
    United States3 months ago
  • The most interesting and relevant podcast in my list today.

    I wish I had the time to listen and to relisten all the episodes.

    Podcast Addict
    5
    Frank Drebin
    3 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some listeners critique production quality or pacing and desire tighter moderation.
A subset feels the discussions sometimes lean toward promotional or bubbles of Silicon Valley.
Positive endorsements of the show's optimism and insightful guests.
Many praise the breadth of topics from AI to longevity and its practical implications.
Listeners frequently cite high-quality guests and actionable, future-focused ideas.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

David Sinclair on the Longevity Pill, Age Reversal Timelines, and Updated Protocols | EP #250
Q: When might we see broad access to longevity therapies, and what are the barriers?
The goal is to scale from tissue-by-tissue to whole-body approaches as delivery methods improve, with price reduction through scale-up and alternative modalities, aiming for widespread access within a couple of decades.
David Sinclair on the Longevity Pill, Age Reversal Timelines, and Updated Protocols | EP #250
Q: What are the economics of current gene therapy versus potential small-molecule approaches?
Current AAV-based therapies are expensive, but the team is pursuing cheaper small-molecule cocktails that could be mass-produced for a fraction of the cost, potentially down to metformin-like affordability.
David Sinclair on the Longevity Pill, Age Reversal Timelines, and Updated Protocols | EP #250
Q: Tell us about the eye trial and how OSK could cure blindness.
OSK genes are being delivered to the eye to reverse aging processes, with strong results in animals and monkeys and now initial human trials to see if blindness can be reversed.
David Sinclair: The GLP-1 Side Effect No One Talks About, What AI Found in His Lab, and Reversing Blindness | Q&A EP #251
Q: How should the field think about pharmacological muscle enhancement in the context of aging and metabolic health?
Balance the long-term systemic risks of anabolic approaches with the immediate need to prevent sarcopenia; evidence from endocrinology suggests testosterone can improve metabolic health and reduce falls, but longevity gains require a broader, multi-modal strategy.
David Sinclair: The GLP-1 Side Effect No One Talks About, What AI Found in His Lab, and Reversing Blindness | Q&A EP #251
Q: What biomarkers or KPIs should investors watch to identify genuine longevity companies?
Key indicators include the strength and track record of the management team, cash runway, how close a program is to the clinic, and the ability to raise capital; non-KPI factors like team quality often drive investment decisions.

Audience Metrics

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Frequently Asked Questions About Moonshots

What is Moonshots about and what kind of topics does it cover?

A high-velocity exploration of emerging technologies, AI, longevity, and how breakthrough science could reshape business and society. Episodes feature interviews with founders, researchers, and thinkers who offer optimistic yet pragmatic takes on the pace of innovation, its economic implications, and potential pathways to a better future. The show tends to connect technical advances to practical outcomes, from education and healthcare to productivity and global governance, often highlighting bold visions, scalable models, and the challenges of implementing rapid change. A few episodes stand out for their ambitious guest lineups and timely debates on policy, privacy, and the governance of powerful technologies, making it useful for listeners... more

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Which podcasts are similar to Moonshots?

These podcasts share a similar audience with Moonshots:

1. All-In with Chamath, Jason, Sacks & Friedberg
2. The a16z Show
3. The Pomp Podcast
4. No Priors: Artificial Intelligence | Technology | Startups
5. Cheeky Pint

How many episodes of Moonshots are there?

Moonshots launched 4 years ago and published 258 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Moonshots?

Recent guests on Moonshots include:

1. David Sinclair
2. Sid Sibrandich
3. Mark Cuban
4. Ben Lamm
5. Dawn Musalam
6. Alex Wissner-Gross
7. Dara Khosrowshahi
8. Jan LeCun

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