Carbocisteine or Hypertonic Saline for Acute Respiratory Failure
N Engl J Med 2026; DOI: 10.1056/NEJMoa2603406
本研究は、人工呼吸器管理を必要とする急性呼吸不全患者において、気道分泌物の排出を助けるための去痰薬(カルボシステインおよび高張食塩水)の有効性と安全性を検証した多施設共同ランダム化比較試験である。英国の71施設において、分泌物の排出が困難と判断された16歳以上の重症患者1,... more
Vasopressors or Fluids in Early Septic Shock
N Engl J Med. 2026. DOI: 10.1056/NEJMoa2516225
敗血症性ショックの初期蘇生において、十分な輸液による循環回復を図る従来の戦略と、輸液を制限しつつ早期に昇圧薬を開始する戦略のどちらが最適かは不明である。本研究(ARISE FLUIDS試験)は、オーストラリア、ニュージーランド、アイルランドの51施設において、救急外来を受診した敗血症性ショックの成人患者963名... more
Conservative Oxygen for Unresponsive Patients after Cardiac Arrest
N Engl J Med. 2026. doi: 10.1056/NEJMoa2513814
心停止後の自発循環再開後、意識が回復しない患者においては、虚血再灌流障害による脳損傷が課題となる。高濃度の酸素曝露が酸化ストレスを増大させ、神経予後を悪化させる可能性が指摘されていた。本研究(LOGICAL試験)は、ICUで人工呼吸器管理を受けるこれらの成人患者を対象... more
Association Between Emergency Department Undertriage or Overtriage With Timeliness of Care and Patient Outcomes
Ann Emerg Med. 2026;87:723-734.
本研究は、救急外来(ED)におけるトリアージュの不正確さ(ミストリアージ)が、診療のタイムラインや患者の予後にどのような影響を与えるかを調査した、大規模な後方視的コホート研究である。米国のカイザー・パーマネン... more
The hemodynamics of tracheal intubation in critically ill patients: a narrative review
Journal of Intensive Care (2026) 14:42
集中治療室(ICU)における気管挿管は、重度の低酸素血症やショック、代謝性アシドーシスを伴う患者に対して行われる日常的かつ高リスクな手技である。大規模な国際研究では、ICUでの挿管の40%以上で循環不全が発生し、約3%で心停止を伴うことが示され... more
Biofilms in clinical infection: pathophysiology, diagnosis, and the evolving therapeutic landscape
Journal of Clinical Microbiology. Published online December 17, 2025. doi: 10.1128/jcm.01168-24
バイオフィルムは、微生物が自己産生した細胞外ポリマー(EPS)の行列に包まれ、表面に付着(または非付着の凝... more
The Majority of Bacillus subtilis Strains Isolated From Blood Cultures Were Derived From Traditional Japanese Fermented Soybeans Natto: A Single-center Retrospective Study
Open Forum Infect Dis. 12(9), ofaf574 (2025)
本研究は、血液培養から検出されるバシラス・サブチリス(Baci... more
Speech-based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts
Alzheimer’s & Dementia. 2026;22:e71462.
本研究は、早期アルツハイマー病(AD)の検出を目的とした、完全に自動化された音声ベースのデジタル認知評価指標(S... more
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #190 |










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