UC术后辅助免疫治疗路向何方
RuiyunTALK瑞赟说特邀专家：
四川大学华西医院 鲍一歌 教授
南京鼓楼医院 邓永明 教授
主持：
上海交通大学医学院附属仁济医院 张瑞赟 教授
| Publishes | Daily | Episodes | 6 | Founded | 20 days ago |
|---|---|---|---|---|---|
| Language |  ZH-CN | Number of Listeners | Categories | MedicineHealth & FitnessLife SciencesScience |
Listen to this Podcast
Latest Episodes
导语：UTUC与MIBC虽同属尿路上皮癌，但在病理特征、治疗耐受性尤其是肾功能影响方面存在显著差异。UTUC患者缺乏专门的临床研究证据，辅助治疗方案多参考MIBC数据，导致临床决策困难。如何基于肾功能状态、病理分期制定UTUC患者的个体化辅助治疗方案，是当前未被满足的临床需求。
张瑞赟 教授：UTUC与MIBC存在本质差异，不能简单套用MIBC的辅助治疗证据。基于现有研究和临床实践，UTUC术后辅助治疗应如何决策？需重点关注哪些因素？
邓永明 教授：UTUC术后辅助治疗的核心考量是肾功能状态，因... more
导语：国内部分中心因患者拒绝、顺铂不耐受或医疗条件限制，仍有部分MIBC患者未接受新辅助治疗直接手术。这类患者的辅助治疗决策缺乏统一标准，需结合现有研究证据和临床实践经验综合判断。
张瑞赟 教授：对于未接受新辅助治疗直接手术的MIBC患者，术后辅助治疗应如何决策？针对pT2N0患者，传统视为器官局限性疾病，多数辅助治疗研究未纳入，这类患者是否需要辅助治疗？pT3/pT4患者应优先选择化疗还是免疫治疗？
邓永明 教授：pT2N0患者的辅助治疗需个体化，化疗时代缺乏高级别证据支持常规辅助治疗，若存在... more
导语：ctDNA作为反映微小残留病灶（MRD）的核心指标，在CheckMate 274、IMvigor011等研究中已展现出重要的预后与预测价值。但ctDNA检测的最佳时机、频率，结果解读的标准化，以及如何与病理分期、临床因素结合指导决策，仍缺乏统一标准，限制了其临床转化应用。
张瑞赟 教授：ctDNA是否应常规用于辅助治疗决策？最佳检测间隔与频率如何设定？对于术后ctDNA阴性的患者，是否可直接豁免辅助治疗，无需考虑病理分期？此外，ctDNA结果存在交界性情况，如何解读这类结果以指导临床实践？... more
导语：新辅助治疗后仍为≥ypT2或淋巴结阳性的无应答者，是复发风险最高的人群，辅助治疗的必要性已达成共识，但方案选择存在争议。传统化疗时代多会更换未使用过的药物，而EV-303、NIAGARA等研究采用固定方案延续治疗。对于病理高分期但ctDNA阴性的特殊病例，如何平衡治疗强度与过度治疗风险，成为临床决策的难点。
张瑞赟 教授：对于新辅助治疗后仍为≥ypT2或淋巴结阳性的无应答患者，辅助治疗方案应延续新辅助方案还是更换方案？EV-303等研究采用固定方案的设计逻辑是什么？此外，若患者病理分期为≥... more
导语：新辅助治疗后达到PR的患者，即降期至ypTis或ypT1且淋巴结阴性，属于病理缓解的“灰色地带”，这类患者预后介于pCR与无应答者之间。如何基于初始分期、高危因素及生物标志物对这类患者进行风险分层，制定个体化辅助治疗方案，是临床面临的重要挑战。
张瑞赟 教授：对于新辅助治疗后降期至ypTis或ypT1且淋巴结阴性的PR患者，其辅助治疗应如何决策？
邓永明 教授：这类患者的决策核心是风险分层，多数临床研究将其视为相对低复发风险人群，未纳入辅助治疗的核心队列，但临床实践中需结合具体情况调整。若... more
导语：病理完全缓解（pCR）是MIBC新辅助治疗的理想目标，传统认知中此类患者预后良好，辅助治疗的必要性存疑。但随着EV-303、NIAGARA等围手术期研究采用固定治疗模式，以及ctDNA等液态活检技术的发展，pCR患者是否需要进一步辅助治疗、如何区分真性与假性pCR、不同诱导方式带来的pCR是否预后一致，成为临床决策的核心难题。本部分围绕pCR患者的辅助治疗策略展开深入探讨。
张瑞赟 教授：对于接受新辅助治疗后达到ypT0N0（病理完全缓解，pCR）的MIBC患者，是否需要继续进行辅助治疗？... more
Key Facts
Chart Rankings
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #125 | China/Health & Fitness/Medicine |
Top Medicine Podcasts
Audience Metrics
Listeners, social reach, demographics and more for this podcast.
| Listeners per Episode | Gender Skew | Location | |||
|---|---|---|---|---|---|
| Interests | Professions | Age Range | |||
| Household Income | Social Media Reach | ||||
Frequently Asked Questions About UC术后辅助免疫治疗路向何方
Where can I find podcast stats for UC术后辅助免疫治疗路向何方?
Rephonic provides a wide range of podcast stats for UC术后辅助免疫治疗路向何方. We scanned the web and collated all of the information that we could find in our comprehensive podcast database. See how many people listen to UC术后辅助免疫治疗路向何方 and access YouTube viewership numbers, download stats, audience demographics, chart rankings, ratings, reviews and more.
How many listeners does UC术后辅助免疫治疗路向何方 get?
Rephonic provides a full set of podcast information for three million podcasts, including the number of listeners. View further listenership figures for UC术后辅助免疫治疗路向何方, including podcast download numbers and subscriber numbers, so you can make better decisions about which podcasts to sponsor or be a guest on. You will need to upgrade your account to access this premium data.
What are the audience demographics for UC术后辅助免疫治疗路向何方?
Rephonic provides comprehensive predictive audience data for UC术后辅助免疫治疗路向何方, including gender skew, age, country, political leaning, income, professions, education level, and interests. You can access these listener demographics by upgrading your account.
How many subscribers and views does UC术后辅助免疫治疗路向何方 have?
To see how many followers or subscribers UC术后辅助免疫治疗路向何方 has on Spotify and other platforms such as Castbox and Podcast Addict, simply upgrade your account. You'll also find viewership figures for their YouTube channel if they have one.
How many episodes of UC术后辅助免疫治疗路向何方 are there?
UC术后辅助免疫治疗路向何方 launched 20 days ago and published 6 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
How do I contact UC术后辅助免疫治疗路向何方?
Our systems regularly scour the web to find email addresses and social media links for this podcast. We scanned the web and collated all of the contact information that we could find in our podcast database. But in the unlikely event that you can't find what you're looking for, our concierge service lets you request our research team to source better contacts for you.
Where can I see ratings and reviews for UC术后辅助免疫治疗路向何方?
Rephonic pulls ratings and reviews for UC术后辅助免疫治疗路向何方 from multiple sources, including Spotify, Apple Podcasts, Castbox, and Podcast Addict.
View all the reviews in one place instead of visiting each platform individually and use this information to decide if a show is worth pitching or not.
How do I access podcast episode transcripts for UC术后辅助免疫治疗路向何方?
Rephonic provides full transcripts for episodes of UC术后辅助免疫治疗路向何方. Search within each transcript for your keywords, whether they be topics, brands or people, and figure out if it's worth pitching as a guest or sponsor. You can even set-up alerts to get notified when your keywords are mentioned.