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The RTW Podcast

RTW Investments, LP
Psilocybin
Treatment-Resistant Depression
Compass Pathways
RTW Investments
Biotech
Gene Editing
Hormone Replacement Therapy
Gene Therapy
Global Sleep Epidemic
Beam Therapeutics
FDA
Akero Therapeutics
Perimenopause
New York City
MASH
REM Sleep
Dreaming
Elly's Team
Urogen Pharma
Glp-1 Drugs

We’re witnessing a healthcare revolution, as medical and science innovations transform the lives of millions. Join as we speak to bright scientific minds, inspiring company founders and healthcare champions that are driving this exciting period of scientific discovery.

Subscribe to catch each episode as it goes live.

The content of this podcast does not constitute investment advice, an offer to pr... more

PublishesMonthlyEpisodes16Founded2 years ago
Number of ListenersCategories
Life SciencesScienceBusinessInvesting

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Artwork for The RTW Podcast

Latest Episodes

Treatment-resistant depression affects four million Americans, and until now, patients have had almost no options. Dr. Steve Levine of Compass Pathways joins RTW's Stephanie Sirota to discuss COMP360, a psilocybin-based therapy for treatment-resistan... more

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Are psychedelics poised to transform mental health treatment? Connor Williams joins Stephanie Sirota for a deep dive into psilocybin, the science behind its effects on the brain, and its potential in treatment-resistant depression, PTSD, and other se... more

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For decades, some cancers were a near-certain death sentence. Now, a new generation of cancer drugs—many coming from biotech, not big pharma—is changing that. RTW’s Chris Liu discusses ASCO 2026, and breakthroughs in pancreatic cancer, lung cancer, a... more

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Menopause, perimenopause, and hormone replacement therapy (HRT) are reshaping the conversation around women’s health and longevity. OB/GYN Dr. Stephanie Lam explains the science, symptoms, and why women’s healthcare may represent a major investing wh... more

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Key Facts

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Recent Guests

Steve Levine
Chief Patient Officer
Compass Pathways
Episode: Psilocybin on the Verge: Treating Depression at Compass Pathways
Connor Williams
Senior Research Analyst covering disorders of the nervous system
RTW Investments
Episode: Psilocybin: Counterculture to Cutting-Edge Psychiatry
Dr. Stephanie Lam
Board-certified OB-GYN, Carnegie Women's Health, New York
Carnegie Women's Health
Episode: Women's Health: An Investing Whitespace
John Evans
CEO of Beam Therapeutics
Beam Therapeutics
Episode: Gene Editing: From CRISPR to Curative Medicine
Rod Wong
Managing partner, chief investment officer, founder of RTW Investments
RTW Investments
Episode: Biotech’s Next Era: Innovation and Commercialization
Liz Barrett
CEO of UroGen Pharma
UroGen Pharma
Episode: The Split Vote: UroGen and the FDA
Michelle Krueger
Managing Director at Alvarez and Marsal Transaction Advisory Group; Co-Founder of Elly's Team
Elly's Team / RTW Foundation
Episode: 14 Months to Treatment: Breaking Records in Rare Disease Therapy
Matthew Walker
Professor of neuroscience and psychology, UC Berkeley; founder and director of the Center for Human Sleep Science
University of California, Berkeley; Center for Human Sleep Science
Episode: Losing Sleep and Lives: Matthew Walker on the Global Sleep Epidemic
Andrew Cheng
CEO of Akero Therapeutics (Acero Therapeutics in transcript)
Akero Therapeutics
Episode: From drop to double: Akero’s surging stock

Host

Stephanie Sirota
Partner and Chief Business Officer at RTW Investments; Host of The RTW Podcast

Reviews

5.0 out of 5 stars from 17 ratings
  • Informative

    Podcast are clean understandable & informative. All under a half hour

    Apple Podcasts
    5
    FODW12
    United States10 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Consistently strong lineup of industry guests
High-quality, accessible discussions of complex biotech topics
Investing-focused angle adds practical relevance for sponsors
Clear takeaways that are easy to act on for guests and sponsors
Concise episodes with strong, expert guests

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Talking Points

Recent interactions between the hosts and their guests.

Psilocybin on the Verge: Treating Depression at Compass Pathways
Q: How is Compass planning to deliver Comp360 at scale while balancing incentives for clinicians and patients?
Compass is aligning reimbursement infrastructure with clinical care by creating dedicated CPT codes, leveraging a Spravato-like room setup, training staff, and coordinating with payers to ensure clinicians are reimbursed fairly for time and expertise.
Psilocybin on the Verge: Treating Depression at Compass Pathways
Q: I'm curious, what's the path of a patient?
Patients with treatment-resistant depression are often managed in primary care until they reach the point where interventional psychiatry or specialized care is engaged; the collaboration aims to move patients into targeted, supervised treatments with monitoring, safety checks, and follow-up discussions about their experience.
Psilocybin: Counterculture to Cutting-Edge Psychiatry
Q: What is the future infrastructure look like for delivering COMP360 at scale?
The infrastructure would likely involve interventional clinics with medical supervision, similar to current models like Spravato, optimized to efficiently deliver treatment while ensuring safety and appropriate patient monitoring.
Psilocybin: Counterculture to Cutting-Edge Psychiatry
Q: How do you view the safety profile and durability of the effects seen with COMP360?
So far, safety data in controlled settings are favorable with manageable acute effects; durability of the antidepressant response can last for weeks to months, and some patients may require only a few doses over a year or two, depending on individual response.
Psilocybin: Counterculture to Cutting-Edge Psychiatry
Q: What differentiates COMP360 from earlier efforts from a clinical and regulatory perspective?
COMP360 aims to be accessible to as many patients as possible by fitting into a scalable regulatory framework, showing robust results across three large trials, and aligning its delivery with clinical infrastructure similar to other interventional psychiatry approaches.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About The RTW Podcast

What is The RTW Podcast about and what kind of topics does it cover?

This show centers on healthcare innovation and biotech investing, with in-depth conversations that connect scientific advances to company strategy and patient impact. Across episodes, topics range from gene editing and novel therapies to regulatory hurdles, financing dynamics, and the evolving biotech landscape, often through the lens of investors and industry leaders. Noteworthy are long-form discussions that bridge science, business, and policy, plus a recurring emphasis on practical implications for patients and markets. The format tends to mix technical detail with clear takeaways for listeners interested in how discoveries move from lab to market, and how investment perspectives shape development timelines and access.

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Which podcasts are similar to The RTW Podcast?

These podcasts share a similar audience with The RTW Podcast:

1. Biotech Hangout
2. The Readout Loud
3. BioCentury This Week
4. The a16z Show
5. Invest Like the Best with Patrick O'Shaughnessy

How many episodes of The RTW Podcast are there?

The RTW Podcast launched 2 years ago and published 16 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The RTW Podcast?

Recent guests on The RTW Podcast include:

1. Steve Levine
2. Connor Williams
3. Dr. Stephanie Lam
4. John Evans
5. Rod Wong
6. Liz Barrett
7. Michelle Krueger
8. Matthew Walker

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