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Artwork for The Lancet HIV in conversation with

The Lancet HIV in conversation with

The Lancet Group
HIV
Parkinsonism
Vertical Transmission Of HIV
Insomnia
Obstructive Sleep Apnea
Positive Voices Survey
REPRIEVE Trial
Mental Health Disparities Among Transgender Women Living With HIV
Sleep Health
HIV Prevention
Non-Communicable Diseases In HIV
Uganda Population HIV Impact Assessment (UPHIA)
Antiretroviral Therapy (ART)
Circadian Rhythm Sleep Disorder
Africa
Donor Funding
United Kingdom
Mental Health
Substance Use
Broadly Neutralizing Antibodies

Peter Hayward, Editor-in-Chief, and Adrian Gonzalez-Lopez, Senior Editor at The Lancet HIV, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy.A monthly audio companion to the journal, this podcast covers a broad range of topics, from treatments of children with HIV to COVID-19 and chemsex, the experiences of H... more

PublishesMonthlyEpisodes83Founded6 years ago
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Artwork for The Lancet HIV in conversation with

Latest Episodes

Transgender women and transfeminine people living with HIV face layers of stigma and multiple challengers that contribute to high levels of mental ill health and substance use—new research quantifies this burden, and we discuss the findings with the ... more

Non-communicable diseases (NCDs) increasingly represent a leading cause of morbidity and mortality among people with HIV. People with HIV are at high risk of developing NCDs, often at younger ages and more severely than people without HIV.

Esteban M... more

People living with HIV often have many health needs beyond their antiretroviral medication. Editor in Chief Peter Hayward talks to Colette Smith of the Institute for Global Health at University College London about results of the Positive Voices surv... more

Ageing with HIV brings new challenges. Even with effective ART, people ageing with HIV face increased risk of parkinsonism. Eran F Shorer from the Icahn School of Medicine at Mount Sinai joins us to explore the latest research on brain changes, motor... more

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Recent Guests

David Coelho
From the Division of Public and Community Psychiatry, Massachusetts General Hospital
Massachusetts General Hospital
Episode: David Coelho and Arjee Restar on mental health disparities among transgender women and transfeminine people living with HIV
Arjee Restar
From Yale University School of Public Health
Yale University
Episode: David Coelho and Arjee Restar on mental health disparities among transgender women and transfeminine people living with HIV
Steven Grinspoon
Guest discussing REPRIEVE-based analyses of cardiovascular risk in HIV
Massachusetts General Hospital; Harvard Medical School
Episode: Esteban Martinez and Steven Grinspoon on non-communicable diseases and the REPRIEVE trial
Esteban Martinez
Guest discussing non-communicable diseases in people with HIV
Hospital, Clinic and University of Barcelona
Episode: Esteban Martinez and Steven Grinspoon on non-communicable diseases and the REPRIEVE trial
Colette Smith
A researcher from the Institute of Global Health at University College London
University College London
Episode: Colette Smith on the Positive Voices UK survey recording health needs of people living with HIV
Eran Shorer
Neurology resident at Mount Sinai West; former postdoc at Johns Hopkins
Mount Sinai West; Johns Hopkins
Episode: Eran Shorer on Parkinsonism in people with virally suppressed HIV
Solange Baptiste
International Treatment Preparedness Coalition representative
International Treatment Preparedness Coalition (ITPC)
Episode: Solange Baptiste, Charles Holmes, and Kenneth Ngure on sustainable HIV prevention in Africa
Charles Holmes
Center of Innovation in Global Health, Georgetown University
Georgetown University
Episode: Solange Baptiste, Charles Holmes, and Kenneth Ngure on sustainable HIV prevention in Africa
Kenneth Ngure
School of Public Health, Jomo Kenyatta University of Agriculture and Technology
Jomo Kenyatta University of Agriculture and Technology
Episode: Solange Baptiste, Charles Holmes, and Kenneth Ngure on sustainable HIV prevention in Africa

Hosts

Adrian Gonzalez
Deputy Editor, The Lancet HIV; Host of The Lancet HIV podcast in conversation with
Peter Hayward
Host and Editor-in-Chief of The Lancet HIV; in conversation with authors

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Talking Points

Recent interactions between the hosts and their guests.

Richard Wu on a phase 1 trial of a broadly neutralising antibody for HIV
Q: What then is next for the development of N6LS?
Further trials are needed, including phase 2 studies and exploration of combinations with other BNABs or long-acting antiretrovirals to determine the most effective regimens and dosing strategies for broader and longer-lasting protection or treatment.
Richard Wu on a phase 1 trial of a broadly neutralising antibody for HIV
Q: Can you take us back to basics here and explain what broadly neutralizing antibodies are, and why there is so much interest in them in the HIV field?
BNABs are rare antibodies that can neutralize a wide spectrum of HIV-1 strains by targeting conserved regions of the viral envelope, which creates the potential for both prevention and therapy, particularly in light of the diverse and evolving HIV population.
Maggie Walters and Michelle Bulterys on the probability of vertical transmission of HIV
Q: What were the main findings regarding the timing of ART initiation and its effect on vertical transmission?
Earlier ART initiation before delivery reduces vertical transmission risk, with each additional week of ART before delivery reducing the odds by about 5.6 percent, and early ART initiation improves maternal viral load suppression at delivery.
Maggie Walters and Michelle Bulterys on the probability of vertical transmission of HIV
Q: Could you tell us what has changed since the 2018 review and why there was a need for an update?
The update builds on earlier reviews to incorporate new data, especially the impact of universal test and treat and the introduction of Dolutegravir, and uses meta-regression to better capture uncertainties and continuous factors like timing of ART initiation and duration before delivery.
Esteban Martinez and Steven Grinspoon on non-communicable diseases and the REPRIEVE trial
Q: What should clinicians take away from these findings for everyday practice, especially for patients over 40 living with HIV?
Metabolic risk factors should receive closer attention in HIV care, cardiovascular prevention should start earlier, and guidelines now support statin therapy for patients over 40 with HIV, with practical tools to implement these recommendations in routine care.

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Frequently Asked Questions About The Lancet HIV in conversation with

What is The Lancet HIV in conversation with about and what kind of topics does it cover?

The series features in-depth conversations with leading researchers, clinicians, and policymakers who publish in or collaborate with a major HIV-focused journal. Episodes commonly center on the latest HIV science—ranging from non-communicable diseases in people with HIV to prevention, treatment innovations, and health systems research—and explore clinical implications, implementation in care settings, and policy considerations. Many installments pair long-form interviews with authors, highlighting methodological nuances, data interpretation, and practical takeaways for clinicians, program managers, and decision-makers. A distinctive strength is the collaboration between editorial leadership and contributing researchers, producing content th... more

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What guests have appeared on The Lancet HIV in conversation with?

Recent guests on The Lancet HIV in conversation with include:

1. David Coelho
2. Arjee Restar
3. Steven Grinspoon
4. Esteban Martinez
5. Colette Smith
6. Eran Shorer
7. Solange Baptiste
8. Charles Holmes

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