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The Psych Commute with Dr. Brown

Brandon Lee Brown, MD

Thoughts on psychiatry, medicine, neuroscience, artificial intelligence, problem-solving, and decision-making from a practicing physician, psychiatrist, and neuroscientist recorded during his commute from work. brandonbrownmd.substack.com

PublishesDailyEpisodes32Founded5 months ago
Categories
Mental HealthLife SciencesScienceHealth & Fitness

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Latest Episodes

I write my notes backward.

Not in the traditional SOAP format (Subjective, Objective, Assessment, Plan), but essentially in reverse:

Assessment & Plan → Data (Subjective + Objective)

So instead of SOAP, it’s more like AP–SO.

This format isn’t unh... more

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On this episode of The Psych Commute, we try something a quite different.

Instead of discussing a random idea as I drive home as usual, we run a fully simulated inpatient consult using AI voice actors (but I wrote the script with no AI involvement).... more

Mapping Psychiatric Disorders with GWAS

I wanted to write record a brief episode about a paper I just read that came out in December 2025. The title is Mapping the genetic landscape across fourteen psychiatric disorders published in Nature.

At a hi... more

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I’ve worked in very high-volume settings. In a prior job, I did moonlighting where I would round on thirty-something patients per day, sometimes with ten or more admissions in a single day. Efficiency mattered a lot there, because otherwise you simpl... more

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I want to talk about focused ultrasound and its potential role in psychiatry. Right now, it is not an established psychiatric treatment, but it is being actively studied and I think there is a good chance it becomes part of our clinical toolkit in th... more

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Electroconvulsive therapy (ECT) is not FDA-approved for post-traumatic stress disorder (PTSD), and it doesn’t have an established clinical indication for PTSD in the way it does for severe depression, mania, catatonia, or treatment-resistant psychoti... more

I recently read the randomized controlled trial for a new neuromodulation device called ProlivRX. It’s an external nerve stimulator that is now FDA approved for major depressive disorder in patients who are already on antidepressants and haven’t bene... more

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In this episode, I break down one of the most interesting new developments in schizophrenia treatment: a medication that treats psychosis without dopamine blockade. And it also works for negative symptoms.

I’m talking about xanomeline–trospium, bran... more

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