Rephonic
Artwork for HeadWise
Migraine
Headache Disorders
Chronic Pain
Mental Health
Migraine Disease
Sleep
Chronic Migraine
Cluster Headache
Exercise
National Headache Foundation
Idiopathic Intracranial Hypertension
Chronic Illness
Cognophobia
Cognitive Behavioral Therapy
Fibromyalgia
Depression
Self-Care
Headache
Menstrual Migraine
Anxiety

A podcast about the latest news on migraine disease and headache disorders.

PublishesTwice monthlyEpisodes253Founded6 years ago
Number of ListenersCategory
Education

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Artwork for HeadWise

Latest Episodes

Meet Hope O’Brien, MD, MBA, the new president of the National Headache Foundation’s Board of Directors. In this episode of HeadWise™, Dr. O’Brien shares what led her to headache medicine, the challenges facing headache care today and her vision for t... more

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What happens when headache, migraine-like symptoms or other symptoms persist after a concussion? In this episode, host Lindsay Weitzel, PhD, is joined by neurologist Shae Datta, MD, to discuss concussion, post-traumatic headache and the recovery proc... more

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Nausea and vomiting are common symptoms associated with migraine, but they can look very different from one person to another. Some people experience mild nausea, while others may have vomiting that makes it difficult to eat, drink or take medication... more

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What role could psychedelics play in the future of headache medicine? In this episode of HeadWise, host Lindsay Weitzel, PhD, is joined by Emmanuelle Schindler, MD, PhD, to discuss the latest research on psilocybin and other psychedelics in migraine,... more

In this episode of HeadWise™, host Lindsay Weitzel, PhD, is joined by Amelia Barrett, MD to explore how emerging research on biological pathways may help explain why some people experience treatment-resistant migraine. The conversation focuses on sev... more

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In this episode, host Lindsay Weitzel, PhD, is joined by neurologist Amelia Barrett, MD, to explore the role histamine may play in migraine and headache disorders. Dr. Barrett explains what histamine is, how it functions in the immune system, and why... more

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In this episode, host Lindsay Weitzel, PhD, is joined by headache specialist Fred Cohen, MD, to explore one of the most common questions people ask about headache disorders: What does it mean if my head hurts in a specific location?

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In this episode, host Lindsay Weitzel, PhD is joined by Tim Smith, MD and migraine clinical trial participant Tierra Lillard to explore how migraine clinical trials help advance treatment options and improve care for people living with migraine.

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Key Facts

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Recent Guests

Fred Cohen
Headache medicine specialist
Episode: Understanding Nausea and Vomiting With Migraine
Dr. Emmanuelle Schindler
Medical Director of the Headache Center of Excellence at the VA Connecticut Health Care System; Associate Professor of Neurology at Yale School of Medicine
VA Connecticut Health Care System; Yale School of Medicine
Episode: Psychedelics and Headache Disorders
Dr. Fred Cohen
Headache Medicine Specialist, repeat guest, Director of Headache Intervention in New York City, Assistant Professor at Icahn School of Medicine at Mount Sinai
Headache Medicine Specialist; Mount Sinai Icahn School of Medicine
Episode: Understanding Headache Locations ft. Fred Cohen, MD
Dr. Tim Smith
CEO of Study Medtrix Research; migraine clinical trials expert
Study Medtrix Research
Episode: Migraine Clinical Trials Explained
Tierra Lillard
Patient with lived experience in migraine clinical trials
Episode: Migraine Clinical Trials Explained
Tim Smith
CEO of Study Metrics Research, migraine clinician
Study Metrics Research
Episode: April Migraine Research News: PACAP Treatments, Exercise & Cannabis Studies ft. Tim Smith, MD
Dawn Buse
Psychologist specializing in headache and migraine; clinical professor of neurology
Albert Einstein College of Medicine
Episode: Behavioral Therapies for Migraine ft. Dawn Buse, PhD
Laurel Short
Nurse practitioner with advanced qualification in headache medicine
Episode: Blood Sugar and Migraine ft. Laurel Short, DNP
Sam Kelokates
Founder of Kelos Physical Therapy in Philadelphia and a doctor of physical therapy focusing on headache disorders.
Kelos Physical Therapy
Episode: Exercise Tips for Migraine and Headache Disorders ft. Sam Kelokates

Host

Dr. Lindsay Weitzel
Host of HeadWise; physician specializing in migraine disorders; affiliated with the National Headache Foundation and founder of Migraine Nation

Talking Points

Recent interactions between the hosts and their guests.

Psychedelics and Headache Disorders
Q: Can you summarize how psychedelics might help headache disorders even when patients do not experience psychedelic effects?
The data suggest that clinical benefits can occur without a full psychedelic experience, indicating that the mechanism may involve pharmacology and receptor activity beyond the conscious psychedelic experience, though more research is needed.
Histamine as a Migraine and Headache Trigger ft. Amelia Barrett
Q: So what is histamine?
Histamine is a chemical messenger used by immune cells, involved in allergy responses, and it signals other cells to respond; antihistamines can help some people by reducing this signaling, especially in those with a histamine-processing issue.
Tyramine and Headache: Foods, Triggers, and What to Know ft. Amelia Barrett
Q: Are there medical or genetic factors that affect tyramine sensitivity?
Yes, MAO inhibitors can worsen tyramine-related headaches because they reduce the enzyme that metabolizes tyramine; genetic testing for MAO-A activity can indicate whether someone metabolizes tyramine more slowly or quickly, informing risk assessments and management strategies.
Tyramine and Headache: Foods, Triggers, and What to Know ft. Amelia Barrett
Q: Which foods are typically high in tyramine and how should people approach them?
Fermented and aged products (like certain cheeses), cured meats, wine and beer, and leftovers that have been stored can have high tyramine levels; the key is to recognize that processing increases tyramine, so individuals should observe their own responses and consider moderating or avoiding high-tyramine items, especially around times of headache sensitivity.
Tyramine and Headache: Foods, Triggers, and What to Know ft. Amelia Barrett
Q: What exactly is tyramine and how does it relate to headaches?
Tyramine is a biological amine found in foods; when the body cannot break it down efficiently, it can trigger the release of stress chemicals like norepinephrine, potentially leading to headache symptoms, which may resemble migraines in some people but can also be shorter or only involve a localized headache.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About HeadWise

What is HeadWise about and what kind of topics does it cover?

The show focuses on the latest developments in migraine disease and headache disorders, mixing clinical insights, research updates, and practical guidance for patients and providers. Across episodes, listeners encounter deep dives into pharmacology (including CGRP, PACAP, and other emerging targets), genetics and personalized treatment pathways, non-pharmacological options like behavioral therapies and exercise, and real-world topics such as trial design, safety, insurance access, and diet-related triggers. Notable strengths include a clinician-host-led format that translates complex science into actionable takeaways, hands-on tips for patients (diet, exercise, mood, and symptom tracking), and timely coverage of regulatory and clinical tria... more

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Which podcasts are similar to HeadWise?

These podcasts share a similar audience with HeadWise:

1. Spotlight on Migraine®
2. Science Vs
3. Psychology Unplugged
4. The Happiness Lab with Dr. Laurie Santos
5. Hidden Brain

How many episodes of HeadWise are there?

HeadWise launched 6 years ago and published 253 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on HeadWise?

Recent guests on HeadWise include:

1. Fred Cohen
2. Dr. Emmanuelle Schindler
3. Dr. Fred Cohen
4. Dr. Tim Smith
5. Tierra Lillard
6. Tim Smith
7. Dawn Buse
8. Laurel Short

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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