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Mind & Matter

Nick Jikomes
Human Evolution
Ancient DNA
Cannabis
Metabolic Diseases
Human Migration
Mitochondria
Agricultural Revolution
Dietary Adaptation
Type 2 Diabetes
Aging
Climate Change
Genetic Diversity
Neuroscience
Stress Response
Cell Biology
Metabolism
Insulin Resistance
Metabolic Health
Skin Color Evolution
Glucose Metabolism

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.

Not medical advice.At M&M, we are interested in trying to figure out how t... more

PublishesTwice weeklyEpisodes291Founded5 years ago
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Society & CultureScience

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Artwork for Mind & Matter

Latest Episodes

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How the vagus nerve regulates inflammation; bioelectronic therapies to treat inflammatory conditions.

Nick speaks with Dr. Kevin Tracey about inflammation as a major driver of modern diseases, the vagus nerve’s role in balancing im... more

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How light regulate circadian rhythms, mitochondrial function, hormones, and appetite.

Nick & Dr. Alexis Cowan discuss non-image-forming effects of light on the body, from melanopsin-driven circadian signaling in the eye to UV-stimu... more

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Is the fundamental purpose of sleep to remove oxidized fats from the brain?

Nick & Dr. Amita Sehgal talk about the latest science on why animals sleep. Using fruit flies, her lab shows that waking generates oxidized lipids in neuro... more

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The science, hype, and unknowns surrounding popular peptides like BPC-157 & TB-500 ("Wolverine stack") for injury recovery & tissue repair.

Nick & Dr. Flynn McGuire discuss the surge in peptide use for injury recovery. They cover p... more

Key Facts

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Recent Guests

Amita Sehgal
Professor of neuroscience at the University of Pennsylvania; HHMI investigator; circadian rhythms and sleep expert
University of Pennsylvania
Episode: Sleep, Brain Fat & Oxidative Stress | Amita Sehgal | 286
Flynn McGuire
Clinician and researcher discussing peptides and musculoskeletal biology
Episode: Peptides for Tissue Repair: BPC-157, TB-500 & the "Wolverine Stack"
Jens Lund
Researcher focused on obesity resistance and body weight regulation
University of Copenhagen; Novo Nordisk Foundation Center for Basic Metabolic Research
Episode: Obesity Resistance & Leanness | 284
Douglas Wallace
Director of the Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia
Center for Mitochondrial and Epigenomic Medicine, CHOP
Episode: Mitochondria Genetics & Human Metabolic Variation in Health & Disease | Douglas Wallace | 283
Rebecca Haeusler
Associate professor, Columbia University; studies insulin signaling and metabolism
Columbia University
Episode: Bile Acids in Health & Metabolic Disease | Ep. 282
Dr. Joseph Bass
Chief of Endocrinology Metabolism and Molecular Medicine at Northwestern University
Northwestern University
Episode: Circadian Rhythms, Metabolism & Why Timing Your Meals Matters | Dr. Joseph Bass | Ep. 281
Stephanie Daws
Associate Professor at Temple University specializing in substance abuse research.
Temple University
Episode: Opioid Addiction: RNA Biology, Brain Inflammation & Psychedelic Therapy | Ep 280
Dr. Potter
Expert in nutrition and adipose tissue research from the FitFat lab.
University of New Hampshire and University of Illinois Urbana-Champaign
Episode: Estrogen & Body Fat: Menopause, Puberty, Females vs. Males | 279
Stephan Van Vliet
Director of the Center for Human Nutrition Studies at Utah State University
Utah State University
Episode: Nutrition Content of Animal & Plant Foods: Beef, Plant-Based Meat, Raw vs. Processed Milk | Stephan Van Vliet | 273

Host

Nick
Host of discussions with leading scientists and thinkers in health and wellness, focusing on bridging the gap between complex scientific ideas and practical insights for listeners.

Reviews

4.8 out of 5 stars from 285 ratings
  • Never a dull moment

    Before he began podcasting, Nick was introduced to me throughout respective work in cannabis. In fact, he was a guest on my show - SetSet Show - and it was clear that he had a knack for distilling complicated topics for those without a scientific background. If you’re curious how our bodies and minds can be optimized, subscribe to this show!

    Apple Podcasts
    5
    April Pride
    United States2 years ago
  • Amazing

    An informative podcast from a knowledgeable host with awesome guests! And he’s so handsome ;)

    Apple Podcasts
    5
    Emmmmyyyy!!!!
    United States2 years ago
  • Favorite

    One of my go to podcasts. I always learn something with his quality guests. He also makes sure to rephrase and/or have his guests explain the more technical or hard to grasp ideas so that the information is more easily absorbed. Great teaching skills. Much appreciated!

    Apple Podcasts
    5
    Vg2468
    United States4 years ago
  • Best.Science.Podcast

    My favourite podcast: insightful, good production, interresting.

    Apple Podcasts
    5
    Hurdigurd
    Sweden4 years ago
  • Mind and Matter Podcast

    Excellent podcast. Nick clearly does his homework and his questions serve to bring out further detailed information. He is respectful and provides encouraging cues which seem to encourage his guests to talk. I learn a lot from each episode. Thanks and keep up the good work.

    Apple Podcasts
    5
    Sri Lathabai
    Australia4 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Many comment on the host's respectfulness and ability to create a welcoming atmosphere for discussions.
Reviews highlight the high-quality guests featured on the show, providing expert insights into contemporary issues.
The host's ability to ask insightful questions and distill information makes difficult subjects accessible.
Listeners appreciate the informative and engaging conversations that simplify complex scientific topics.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#167
New Zealand/Science
Apple Podcasts
#220
Taiwan/Science
Apple Podcasts
#242
Denmark/Science

Talking Points

Recent interactions between the hosts and their guests.

Bile Acids in Health & Metabolic Disease | Ep. 282
Q: What happens to bile acid dynamics after bariatric surgery?
Bariatric surgeries, especially malabsorptive ones, tend to increase plasma bile acids significantly, due to altered intestinal sensing and reduced feedback inhibition on bile acid synthesis.
Bile Acids in Health & Metabolic Disease | Ep. 282
Q: How does insulin resistance affect bile acid production and transport?
Insulin resistance is associated with increased synthesis of certain bile acids, particularly 12-hydroxylated species, and impaired transport across hepatocytes, which can disrupt homeostasis and signaling.
Bile Acids in Health & Metabolic Disease | Ep. 282
Q: Do bile acids only help with digestion, or do they also act as signaling molecules?
Bile acids are well known for emulsifying fats to aid digestion, but they also act as signaling molecules that activate various receptors and signaling pathways, influencing metabolism beyond digestion.
Mitochondria Genetics & Human Metabolic Variation in Health & Disease | Douglas Wallace | 283
Q: What is heteroplasmy and why is it important for disease and aging?
Heteroplasmy is when a cell contains a mixture of mitochondria with different mitochondrial DNA mutations. If a high fraction of mutant mitochondria accumulates, energy production drops, leading to cellular dysfunction. Heteroplasmy thresholds in critical tissues like brain and heart can drive neurological and metabolic diseases, and age-related accumulation of heteroplasmy is linked to functional decline.
Mitochondria Genetics & Human Metabolic Variation in Health & Disease | Douglas Wallace | 283
Q: Why is mitochondrial DNA inherited maternally rather than biparentally?
Maternal inheritance minimizes potential 'short-circuiting' problems that could arise if mitochondrial components from two parents with different energetic efficiencies mixed in the zygote. The maternal lineage maintains a consistent mitochondrial background, allowing selective transmission of advantageous mutations along radiating maternal lineages.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About Mind & Matter

What is Mind & Matter about and what kind of topics does it cover?

The focus is on exploring the interplay between food, drugs, and ideas, and how they shape individual experiences and health. The episodes prominently feature conversations with leading scientists, thinkers, and entrepreneurs, emphasizing scientific inquiry over consensus or pre-existing beliefs. Unique to this discourse is the commitment to understanding and distilling complex scientific ideas into actionable insights for listeners, ultimately fostering a health-conscious approach to information consumption. Each episode connects the dots between modern research and traditional wisdom, promoting a deeper understanding of the mind-body connection and the importance of questioning established norms.

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How many subscribers and views does Mind & Matter have?

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Which podcasts are similar to Mind & Matter?

These podcasts share a similar audience with Mind & Matter:

1. The Metabolic Link
2. Metabolic Mind
3. The Metabolic Classroom with Dr. Ben Bikman
4. STEM-Talk
5. The Jesse Chappus Show

How many episodes of Mind & Matter are there?

Mind & Matter launched 5 years ago and published 291 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact Mind & Matter?

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Where can I see ratings and reviews for Mind & Matter?

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What guests have appeared on Mind & Matter?

Recent guests on Mind & Matter include:

1. Amita Sehgal
2. Flynn McGuire
3. Jens Lund
4. Douglas Wallace
5. Rebecca Haeusler
6. Dr. Joseph Bass
7. Stephanie Daws
8. Dr. Potter

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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