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Mind & Matter

Nick Jikomes
Obesity
Metabolism
Neuroscience
Mitochondria
Psilocybin
Metabolic Health
Gut Microbiome
Mental Health
Immune System
Diabetes
Nutrition
Genetics
Cholesterol
Insulin Resistance
Linoleic Acid
Psychedelics
Ketogenic Diet
Human Evolution
Type 2 Diabetes
Sleep

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.

Not medical advice.At M&M, we are interested in trying to figure out how t... more

PublishesTwice weeklyEpisodes299Founded5 years ago
Number of ListenersCategories
ScienceSociety & Culture

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Latest Episodes

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Fructose survival hypothesis: how fructose metabolism in the liver triggers ATP depletion, uric acid production, oxidative stress, lipogenesis & leptin resistance.

TOPICS DISCUSSED:

• Glucose vs Fructose Metabolism: Fructose is ra... more

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Deep-dive into a 2026 cardiology review paper claiming seed oils reduce inflammation, exposing misrepresentations of cited clinical trials, and detailing how oxidized Ω-6 fats trigger inflammation.

Companion article: Click HERE

TO... more

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Human genetic variation in dietary fat metabolism and its implications for health & disease.

TOPICS DISCUSSED:

• Linoleic Acid Rise: Linoleic acid now comprises 6-8% or more of energy in Western diets.

• Metabolic Pathways: Omega-... more

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Pregnenolone, a neurosteroid derived from cholesterol, affects brain activity and shows promise for treating mood and substance abuse disorders.

TOPICS DISCUSSED:

• Steroid Biosynthesis: Cholesterol converted to pregnenolone, the ... more

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Recent Guests

Richard Johnson
Professor of Medicine; expert on sugar metabolism and fructose
Episode: Fructose Metabolism in Obesity, Dementia, Evolution | Richard Johnson | Episode 295
Tucker Goodrich
Researcher and writer focusing on nutrition and seed oils
Episode: How to Lie With Science: Seed Oils & Inflammation | Livestream 1
Sherwood Brown
Vice Chair for Clinical Research in the Department of Psychiatry at UT Southwestern Medical Center; researcher focusing on mood disorders and corticosteroids
UT Southwestern Medical Center
Episode: Pregnenolone & Corticosteroids in Brain Health | Sherwood Brown | Episode 293
Bill Harris
Dr. Bill Harris, OmegaQuant founder and researcher focused on fatty acids and cardiovascular health
OmegaQuant / Fatty Acid Research Institute
Episode: Omega Fats & ω-3 Supplements in Human Health | Bill Harris | Episode 292
Philip Calder
Professor of Nutritional Immunology
University of Southampton
Episode: Omega Polyunsaturated Fats in Inflammation | Philip Calder | Episode 291
Andrew Pieper
Psychiatrist and neuroscientist directing Brain Health Medicine Center at Harrington Discovery Institute; Case Western Reserve University and University Hospitals of Cleveland Medical Center
Case Western Reserve University / University Hospitals of Cleveland / Harrington Discovery Institute
Episode: Reversing Alzheimer's & Neurodegeneration: Latest Science | Andrew Pieper | Episode 290
Kristin Stanford
Professor, Department of Surgery, The Ohio State University
The Ohio State University
Episode: How Parental Exercise Effects Offspring Health | Kristin Stanford | Episode 289
Kevin Tracey
President of the Feinstein Institute at Northwell Health; neurosurgeon focusing on inflammation and the vagus nerve; co-founder of SetPoint Medical
The Feinstein Institute at Northwell Health; SetPoint Medical
Episode: Vagus Nerve Stimulation & Inflammation | Kevin Tracey | Episode 288
Alexis Cowan
Scientist researching light biology and circadian systems
Independent researcher / founder of related platform
Episode: Light, Hunger & Mitochondria: Non-Image Forming Effects of Sunlight | Alexis Cowan | Episode 287

Host

Nick
Host of Mind & Matter guiding the interview and synthesis of scientific literature

Reviews

4.8 out of 5 stars from 287 ratings
  • Superb

    Great in-depth interviews and discussion on a wide range of health topics

    Apple Podcasts
    5
    Dani Woodward
    Canada2 months ago
  • Never a dull moment

    Before he began podcasting, Nick was introduced to me throughout respective work in cannabis. In fact, he was a guest on my show - SetSet Show - and it was clear that he had a knack for distilling complicated topics for those without a scientific background. If you’re curious how our bodies and minds can be optimized, subscribe to this show!

    Apple Podcasts
    5
    April Pride
    United States2 years ago
  • Amazing

    An informative podcast from a knowledgeable host with awesome guests! And he’s so handsome ;)

    Apple Podcasts
    5
    Emmmmyyyy!!!!
    United States2 years ago
  • Favorite

    One of my go to podcasts. I always learn something with his quality guests. He also makes sure to rephrase and/or have his guests explain the more technical or hard to grasp ideas so that the information is more easily absorbed. Great teaching skills. Much appreciated!

    Apple Podcasts
    5
    Vg2468
    United States4 years ago
  • Best.Science.Podcast

    My favourite podcast: insightful, good production, interresting.

    Apple Podcasts
    5
    Hurdigurd
    Sweden4 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Production is high quality with accessible explanations and strong synthesis.
The host asks great questions and clarifies complex topics clearly.
Guests are top-notch and well-chosen for deep-dives into science.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#168
Philippines/Science
Apple Podcasts
#179
New Zealand/Science
Apple Podcasts
#186
Finland/Science
Apple Podcasts
#243
Taiwan/Science

Talking Points

Recent interactions between the hosts and their guests.

How to Lie With Science: Seed Oils & Inflammation | Livestream 1
Q: What is CRP and why should we care about it in nutrition research?
CRP is a marker of inflammation that responds to cellular damage and oxidized lipids, not just pathogens. It can indicate the body's reaction to rancid fats and oxidized omega-6 fatty acids, and its level can be affected by dietary fat composition.
Fructose Metabolism in Obesity, Dementia, Evolution | Richard Johnson | Episode 295
Q: What is the liver's central role in the metabolic consequences of fructose ingestion, and how does this relate to brain signaling?
The liver acts as the primary site where fructose metabolism triggers ATP depletion and uric acid production, initiating oxidative stress and fat synthesis. This liver signal then communicates with the brain, influencing appetite and satiety pathways (including leptin resistance) and potentially altering brain energy use, contributing to a cycle of increased intake and metabolic disruption.
Omega Fats & ω-3 Supplements in Human Health | Bill Harris | Episode 292
Q: What is the Omega-3 Index and how is it measured and used by individuals?
The Omega-3 Index is the percentage of EPA and DHA in red blood cell membranes relative to total fatty acids. It is measured via a home blood spot test, with results guiding intake changes and providing a calculator to estimate how much to add to reach a target like 8%.
Omega Fats & ω-3 Supplements in Human Health | Bill Harris | Episode 292
Q: How much Omega-3 EPA, DHA should people be getting per day, and what about supplementation?
The expert suggests that for many, a practical target is roughly 1,400 mg of EPA+DHA daily to move an average person's Omega-3 index toward 8%, with 1-2 grams per day often being optimal for higher levels; he emphasizes preferring preformed EPA/DHA rather than relying on conversion from ALA, and cautions that supplement quality and oxidation are considerations but not a dominant risk at typical doses.
Omega Polyunsaturated Fats in Inflammation | Philip Calder | Episode 291
Q: What is parenteral nutrition and when is it used?
Parenteral nutrition is intravenous nutrition used when patients cannot receive nutrition through the gut, such as after major surgery, in intensive care, after significant GI tract loss, or in severe malnutrition, with the plan to tailor components including lipids, amino acids, carbohydrates, vitamins and minerals.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About Mind & Matter

What is Mind & Matter about and what kind of topics does it cover?

A science-forward interview series featuring leading researchers and clinicians who discuss how biology and behavior shape the mind and body. Episodes cover brain health, metabolism, sleep, circadian biology, nutrition, inflammation, and cutting-edge translational science, with a strong emphasis on clear explanations of complex mechanisms and practical implications. The host curates primary literature, presents diverse expert perspectives, and often connects basic science to real-world health outcomes, making challenging topics more accessible without oversimplifying. A notable strength is the guest mix—from mitochondrial biology and neurodegeneration to sleep, photobiology, and parental biology—providing a broad, interconnected view of how... more

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Which podcasts are similar to Mind & Matter?

These podcasts share a similar audience with Mind & Matter:

1. Metabolic Mind
2. The Metabolic Link
3. The Jesse Chappus Show
4. Boundless Life
5. The Metabolic Classroom with Dr. Ben Bikman

How many episodes of Mind & Matter are there?

Mind & Matter launched 5 years ago and published 299 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Mind & Matter?

Recent guests on Mind & Matter include:

1. Richard Johnson
2. Tucker Goodrich
3. Sherwood Brown
4. Bill Harris
5. Philip Calder
6. Andrew Pieper
7. Kristin Stanford
8. Kevin Tracey

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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