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The Jesse Chappus Show

Jesse Chappus
Insulin Resistance
Nutrition
Metabolic Health
Gut Health
Ketogenic Diet
Weight Loss
Carnivore Diet
Fasting
Microbiome
Intermittent Fasting
Exercise
Alzheimer's Disease
Chronic Disease
Aging
Visceral Fat
Mitochondria
Fructose
Inflammation
Gut Microbiome
Cholesterol

Long-form conversations on what actually drives health.

PublishesWeeklyEpisodes723Founded12 years ago
Number of ListenersCategories
NutritionAlternative HealthHealth & Fitness

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Artwork for The Jesse Chappus Show

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Dr. Dominic D’Agostino is a tenured Associate Professor at the University of South Florida whose research focuses on ketogenic nutrition, metabolism, neuroscience, and metabolic therapies.

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Dr. Matthew Phillips is a neurologist and researcher studying metabolic therapies for Alzheimer’s, Parkinson’s, ALS and glioblastoma.

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Show notes:

jessechappus.com/722

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Robb Wolf is a former research biochemist, New York Times bestselling author, and co-founder of LMNT.

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Dr. Anthony Jay is a biochemist, author, and the president of AJ Consulting Company, where he provides health consulting.

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Show notes:

jessechappus.com/720

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Recent Guests

Dominic D'Agostino
Scientific expert discussing sardine fasting and ketosis
University/Research (as referenced in discussion)
Episode: 723: What Happens to Your Body on a Sardine Fast? | Dr. Dominic D’Agostino
Matthew Phillips
Neurologist, researcher focused on mitochondria and terrain theory
Researcher/Neurologist
Episode: 722: Neurologist: The Hidden Root Cause of Alzheimer’s, Parkinson’s & Brain Cancer | Dr. Matthew Phillips
Robert Wolf
Robb Wolf, paleo advocate, author, and health educator
The Paleo Movement advocate, former CrossFit affiliate owner
Episode: 721: Modern Life Is a Disease — Here’s How to Opt Out | Robb Wolf
Anthony Jay
Dr. Anthony Jay, author and metabolic health expert
Author of books on plaque and metabolism
Episode: 720: What's Really Destroying Your Arteries & The New Science of Reversing Plaque | Dr. Anthony Jay
Bella Ma
Bella Ma, aka Steak and Butter Gal, Carnivore diet educator and content creator
Steak and Butter Gang / Carnivore community
Episode: 719: She Went From Vegan to Carnivore Overnight — Here’s What Happened | Bella Ma (Steak and Butter Gal)
Nicole Laurent
Ketogenic metabolic therapy expert and researcher discussed in detail by host
Functional nutrition and ketogenic metabolism practitioner
Episode: 718: The Most Harmful Foods for Your Mental Health (Eat This Instead) | Nicole Laurent
David Perlmutter
Neurologist and author of Brain Defenders, Brain Maker, Grain Brain, Drop Acid
University/Medical practice not explicitly named in transcript
Episode: 717: Neurologist: The Real Cause of Brain Disease — and How to Protect Yourself | Dr. David Perlmutter
Michael Breus
Sleep Doctor, sleep psychologist and author
Sleep Doctor brand / clinical practice
Episode: 716: Sleep Doctor: If You Wake Up at 3AM, Do Not Make This Mistake (What Actually Works) | Dr. Michael Breus
Sten Ekberg
Doctor and expert guest on metabolic health
Dr. Ekberg Health
Episode: 715: The Exact Formula to Reverse Insulin Resistance (Doctors Won’t Tell You This) | Dr. Sten Ekberg

Host

Jesse Chappus
Host of The Jesse Chappus Show

Reviews

4.6 out of 5 stars from 3k ratings
  • Fabulous interviewer

    I listen to these interviews because they are no- nonsense, just the facts, deep interviews. This is now one of my favorite podcasts. His choices of who to interview is spot on. I always get some gem of an insight. Thank you Jesse..

    Apple Podcasts
    5
    Esmithart
    United Statesa month ago
  • My favorite podcast

    This is my favorite podcast bc Jesse is my favorite podcast host. Do you know why? bc he asks good questions and most importantly he lets his guests speak everything they need to say without being interrupted!! There’s no fluff just information. I wish I could give more than 5 stars! More podcasters need to learn from him!

    Apple Podcasts
    5
    My.app.Reviews
    United States3 months ago
  • Top Notch Guests

    Jesse is a great interviewer. Love this show.

    Apple Podcasts
    5
    Eyedeal02
    United States4 months ago
  • Exceptional host

    Jesse is one of the best podcast hosts on this platform. Regardless of kookiness or competence of guests, Jesse handles it deftly. Keep up the great work!

    Apple Podcasts
    5
    Horst McElroy
    United States5 months ago
  • This podcast used to be decent but lately he has a parade of whack jobs pimping their "alternative medicine" - not evidence based at all.

    Podcast Addict
    2
    Plants Rock
    5 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some listeners praise the high quality questions and the practical takeaways, while a few criticize perceived pseudoscience or fringe viewpoints.
Overall, feedback points to strong production quality and valuable health-focused insights.
Guests are described as knowledgeable and the discussions as in-depth and informative.
Listener feedback consistently highlights the host's preparation and ability to give guests space to speak.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

723: What Happens to Your Body on a Sardine Fast? | Dr. Dominic D’Agostino
Q: What exactly is a sardine fast and why sardines?
The sardine fast is a three-day caloric restriction using sardines as the primary protein and fat source, chosen for their high omega-3 content, protein quality, micronutrients, and satiety. It aims to induce nutritional ketosis without severe protein restriction and to leverage the anti-inflammatory and anti-catabolic properties of sardines.
721: Modern Life Is a Disease — Here’s How to Opt Out | Robb Wolf
Q: How quickly did you start to regain health after shifting your diet dramatically?
He notes immediate improvements in physical well-being and a rapid stabilization of energy and digestion, though he humorously acknowledges becoming a zealot during the recovery and the companion mental health effects.
721: Modern Life Is a Disease — Here’s How to Opt Out | Robb Wolf
Q: What might a typical day look like back then when you were healing food wise?
He describes a very low-carb, highly cooked, minimally processed diet with fatty meats, some fruit, and careful carbohydrate management, along with trying to cook most food at home and avoid gut irritants.
721: Modern Life Is a Disease — Here’s How to Opt Out | Robb Wolf
Q: Robb, you were one of the people years back that helped bring the paleo movement to the mainstream. When you look back at that time, what core values and principles have changed and what ones have stuck?
Robb explains that his core motivation was to give people a choice and that some principles persist (like focusing on real foods, circadian biology, and individual variability) while others have evolved as the field has learned more about gut health and metabolic complexity.
718: The Most Harmful Foods for Your Mental Health (Eat This Instead) | Nicole Laurent
Q: What role do micronutrients play in this process?
Micronutrient sufficiency is essential; magnesium is a must, along with a good multivitamin, trace minerals, potassium, calcium where needed, and omega-3s from fish or supplements, because these support enzymatic function and neurotransmitter synthesis critical for mood and cognitive function.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About The Jesse Chappus Show

What is The Jesse Chappus Show about and what kind of topics does it cover?

The show features long-form conversations with experts who dissect what actually drives health, frequently challenging mainstream narratives and offering practical, evidence-based guidance. Episodes commonly center on metabolic health, sleep, cardiovascular risk, nutrition, and the body's response to lifestyle factors, with guests including physicians, researchers, and thought leaders who push for deeper scientific understanding and actionable takeaways. A standout is the breadth of topics—from insulin resistance and gut health to melatonin, brain health, and environmental influences—that appeals to listeners seeking rigorous, data-driven insights and real-world strategies. The host pulls well-prepared questions and allows guests to articul... more

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Which podcasts are similar to The Jesse Chappus Show?

These podcasts share a similar audience with The Jesse Chappus Show:

1. The Primal Podcast
2. The Ben Azadi Show
3. Nutrition with Judy | Carnivore Diet
4. Low Carb MD Podcast
5. The Metabolic Classroom with Dr. Ben Bikman

How many episodes of The Jesse Chappus Show are there?

The Jesse Chappus Show launched 12 years ago and published 723 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Jesse Chappus Show?

Recent guests on The Jesse Chappus Show include:

1. Dominic D'Agostino
2. Matthew Phillips
3. Robert Wolf
4. Anthony Jay
5. Bella Ma
6. Nicole Laurent
7. David Perlmutter
8. Michael Breus

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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