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Artwork for The Optispan Podcast

The Optispan Podcast with Matt Kaeberlein

Optispan
Aging
Rapamycin
Periodontal Disease
Healthspan
Oral Health
Longevity
Healthcare System
Preventive Medicine
Adhesive Capsulitis
Aging Biology
Sirtuins
TOR Pathway
Sleep Quality
Exercise
Longevity Medicine
Chronic Disease
Vitamin D
Healthy Diet
Intermittent Fasting
Diabetes

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We bel... more

PublishesTwice weeklyEpisodes164Founded2 years ago
Number of ListenersCategory
Science

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Artwork for The Optispan Podcast

Latest Episodes

What does over 18 months of precision medicine actually look like in practice? In this episode of the Optispan Success Story Series, Dr. Matt Kaeberlein sits down with Carlos Pinto, a tech executive and early Optispan client, to trace his longitudina... more

YouTube

Peptides are everywhere in longevity and functional medicine, but what does the law actually say? In this episode, Dr. Matt Kaeberlein breaks down what a peptide is and the complex regulatory landscape governing peptides in the United States, from FD... more

YouTube

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Recent Guests

Nicki Byrne
Clinical Director at Optispan
Optispan
Episode: THIS Helps Detect Heart Disease Before It Happens
Kim Brockenbrough
CEO and founder of CardiaVision LLC; cardiovascular radiologist
CardiaVision
Episode: THIS Helps Detect Heart Disease Before It Happens
Carlos Pinto
Optispan client with long-running healthspan program participation
Optispan
Episode: Optispan Success Story: What 18 Months of Real Biomarker Data Actually Looks Like (With Carlos Pinto)
Dr. Ben Blue
Chief Executive Officer of Ora Biomedical
Ora Biomedical
Episode: New Discovery: This Molecule Could Beat Rapamycin in Longevity
Brad Stanfield
Primary care physician and YouTuber focusing on longevity and health.
YouTube Channel, Doctor
Episode: Dr. Stanfield Mortgaged His House For $150k To Prove Longevity Drug Works
Alexandru Ardélion
Lead Physician at the YEARS Clinic
YEARS Clinic
Episode: Longevity Lie: Doctor Reveals Why Anti-Aging Supplements Don’t Work
Jan Hennigs
Medical Director of YEARS Clinic
YEARS Clinic
Episode: Longevity Lie: Doctor Reveals Why Anti-Aging Supplements Don’t Work
Erik Nelson
Expert in brain health and co-developer of a new program for cognitive decline
HumanSync
Episode: A Scientific-Backed Discussion On Fighting Cognitive Decline
Dr. Nicole Byrne
A medical professional with a focus on healthspan medicine
Optispan
Episode: Doctors Reveal Their Blueprint for Lifelong Health (4 Pillars & Key Blood Tests) | 118

Host

Matt Kaeberlein
Host of The Optispan Podcast; focuses on longevity science, healthspan, and evidence-based wellness.

Reviews

4.7 out of 5 stars from 88 ratings
  • Dr. K is great!

    So knowledgeable. We saw him speak live and have been big fans of his work. He definitely cuts through the noise and is truly doing ground breaking research in the longevity space, without a lot of the fluff quick fix advice that has muddied the field.

    Apple Podcasts
    5
    Nisha pat
    United States5 months ago
  • Science to sale pitch

    I used to like listening to Matt and his very science informed opinions and would caveat his ‘takes’ vs ‘research baked’. But the most recent episode on cognitive improvements was nothing more than n=1 case study and what seemed to be poorly educated in the space guests opinions.

    Apple Podcasts
    1
    StrengthScience
    United States6 months ago
  • Latest podcast with Dr Seager

    Dr Seager stated that for MD’s, knowledge ceases once we finish medical school. There was no pushback from Matt.

    I’ve heard ridiculous comments from guests, but that one tops the list.

    I’ve been a physician for 34 years and like every physician I have ever known, we obviously know that medical school is simply a springboard towards the goal for knowledge.

    Physicians read scientific, peer-reviewed journals, we have journal club to discuss recent articles, we attend scientific meetings, we are ... more

    Apple Podcasts
    1
    ruuningdoc
    United Statesa year ago
  • Fantastic - should be in charge of the NHS

    Great information clearly delivered. I wish you were running the NHS in the UK or other equivalents around the world. Maybe with Peter Attia as well. Thank you Matt

    Apple Podcasts
    5
    George Russell 1982
    United Kingdoma year ago
  • Smartest and most ethical Dr in longevity

    Matt is the best. I have been taking rapamycin for 4 years and love his passion for the topic. He's an honest and trustworthy source for longevity news and information.

    Apple Podcasts
    5
    Jmichael68
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some episodes attract critique for guest viewpoints or treatment claims that feel anecdotal.
Many listeners value practical healthspan strategies and data-driven decision making.
Audience appreciates transparency about limitations and risks in longevity therapies and supplements.
Listeners praise rigorous science-based discussions and clear explanations of aging research.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#158
Ireland/Science
Apple Podcasts
#178
Philippines/Science
Apple Podcasts
#217
Singapore/Science

Talking Points

Recent interactions between the hosts and their guests.

How Fighting Gives You A Bulletproof Mind with Noah Neiman
Q: What would be one piece of advice for that person who's going through what you went through?
It's only when you've lost everything are you free to do anything. You got nothing to lose, so use it to propel yourself to create.
Optispan Success Story: How I Got Strong Without Living at the Gym
Q: What do you want people who have listened to this episode to take away?
If you feel good and you have health from the inside, you will look good; it's about inner health leading to outer beauty.
Optispan Success Story: How I Got Strong Without Living at the Gym
Q: What has worked for you to recognize when you're starting to go down that path?
One of the greatest gifts for me was aging, as it made the internal issues manifest externally, prompting me to work on my health from within.
Preventive Failure: How Modern Healthcare Misses Disease Early
Q: What does preventing that first crisis really look like in practice?
It's a more holistic view, focusing on how we can increase resilience and treat patients as a whole, rather than just addressing specific disease processes.
Preventive Failure: How Modern Healthcare Misses Disease Early
Q: Was there a moment for you when you sort of realized that traditional health care isn't addressing a lot of what matters most for people's health?
I think it was just very obvious quickly as you're working in the hospital that all of our attention and energy and money is going towards the wrong area.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
Location
Interests
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Age Range
Household Income
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Frequently Asked Questions About The Optispan Podcast

What is The Optispan Podcast about and what kind of topics does it cover?

The show centers on evidence-based longevity, healthspan, and practical biology-driven wellness. Across episodes, listeners encounter deep dives into biomarkers, pharmacology, and dietary science, alongside critical reviews of trends like peptides, aging clocks, and hormone therapies. The hosts emphasize data-driven decisions, cautious use of supplements, and holistic prevention over reactive disease management, often featuring clinicians and researchers who challenge conventional medical norms. A standout is the blend of personal health journeys with rigorous science, plus candid conversations about the risks and realities of emerging therapies and wellness fads, making it a strong fit for listeners who value rigor and long-term health str... more

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Which podcasts are similar to The Optispan Podcast?

These podcasts share a similar audience with The Optispan Podcast:

1. FoundMyFitness
2. Boundless Life
3. The Dr. Gabrielle Lyon Show
4. The Human Upgrade: Biohacking for Longevity & Performance
5. The Matt Walker Podcast

How many episodes of The Optispan Podcast are there?

The Optispan Podcast launched 2 years ago and published 164 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Optispan Podcast?

Recent guests on The Optispan Podcast include:

1. Nicki Byrne
2. Kim Brockenbrough
3. Carlos Pinto
4. Dr. Ben Blue
5. Brad Stanfield
6. Alexandru Ardélion
7. Jan Hennigs
8. Erik Nelson

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