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The Optispan Podcast with Matt Kaeberlein

Optispan
Aging
Rapamycin
Periodontal Disease
Healthspan
Oral Health
Longevity
Healthcare System
Preventive Medicine
Adhesive Capsulitis
Aging Biology
TOR Pathway
Sirtuins
Exercise
Sleep Quality
Vitamin D
Chronic Disease
Longevity Medicine
Intermittent Fasting
Healthy Diet
Alzheimer's Disease

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We bel... more

PublishesTwice weeklyEpisodes168Founded2 years ago
Number of ListenersCategory
Science

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Artwork for The Optispan Podcast

Latest Episodes

What if you had more control over your brain's future than you think? Dr. Tommy Wood, neuroscientist, Associate Professor of Pediatrics at the University of Washington, and head of science for motorsport at Hintsa Performance, joins Dr. Matt Kaeberle... more

Dr. Matt Kaeberlein and Clinical Director Dr. Nicki Byrne tackle your most pressing supplement questions in this AMA episode, cutting through the hype to give you science-backed answers you can actually use. From CoQ10 and statins to sulforaphane inf... more

YouTube

The Galleri multi-cancer detection test made headlines when its landmark NHS trial failed to meet its primary endpoint, sending Grail's stock down nearly 50%. But does that mean Galleri is useless? Not exactly.

In this episode, Dr. Matt Kaeberlein ... more

YouTube

What if menopause is one of the most important longevity events in human biology, and we've been ignoring it?

Dr. Matt Kaeberlein sits down with Dr. Jennifer Pearlman, founder of PearlMD and pioneer in female-centric longevity medicine, to unpack wh... more

YouTube

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Recent Guests

Jennifer Pearlman
Founder, medical director of PearlMD Rejuvenation
PearlMD Rejuvenation
Episode: The Best Women’s Health Tips on the Planet with Dr. Jennifer Pearlman
Nicki Byrne
Clinical Director at Optispan
Optispan
Episode: THIS Helps Detect Heart Disease Before It Happens
Kim Brockenbrough
CEO and founder of CardiaVision LLC; cardiovascular radiologist
CardiaVision
Episode: THIS Helps Detect Heart Disease Before It Happens
Carlos Pinto
Optispan client with long-running healthspan program participation
Optispan
Episode: Optispan Success Story: What 18 Months of Real Biomarker Data Actually Looks Like (With Carlos Pinto)
Dr. Ben Blue
Chief Executive Officer of Ora Biomedical
Ora Biomedical
Episode: New Discovery: This Molecule Could Beat Rapamycin in Longevity
Brad Stanfield
Primary care physician and YouTuber focusing on longevity and health.
YouTube Channel, Doctor
Episode: Dr. Stanfield Mortgaged His House For $150k To Prove Longevity Drug Works
Alexandru Ardélion
Lead Physician at the YEARS Clinic
YEARS Clinic
Episode: Longevity Lie: Doctor Reveals Why Anti-Aging Supplements Don’t Work
Jan Hennigs
Medical Director of YEARS Clinic
YEARS Clinic
Episode: Longevity Lie: Doctor Reveals Why Anti-Aging Supplements Don’t Work
Unnamed Guest
Co-founder of MitoHealth, Medical Doctor specializing in preventive medicine
MitoHealth
Episode: AI Medicine: ChatGPT Reads Blood Tests Faster Than Your Doctor

Host

Matt Kaeberlein
Host of The Optispan Podcast; focuses on longevity science, healthspan, and evidence-based wellness.

Reviews

4.7 out of 5 stars from 89 ratings
  • Dr. K is great!

    So knowledgeable. We saw him speak live and have been big fans of his work. He definitely cuts through the noise and is truly doing ground breaking research in the longevity space, without a lot of the fluff quick fix advice that has muddied the field.

    Apple Podcasts
    5
    Nisha pat
    United States5 months ago
  • Science to sale pitch

    I used to like listening to Matt and his very science informed opinions and would caveat his ‘takes’ vs ‘research baked’. But the most recent episode on cognitive improvements was nothing more than n=1 case study and what seemed to be poorly educated in the space guests opinions.

    Apple Podcasts
    1
    StrengthScience
    United States7 months ago
  • Latest podcast with Dr Seager

    Dr Seager stated that for MD’s, knowledge ceases once we finish medical school. There was no pushback from Matt.

    I’ve heard ridiculous comments from guests, but that one tops the list.

    I’ve been a physician for 34 years and like every physician I have ever known, we obviously know that medical school is simply a springboard towards the goal for knowledge.

    Physicians read scientific, peer-reviewed journals, we have journal club to discuss recent articles, we attend scientific meetings, we are ... more

    Apple Podcasts
    1
    ruuningdoc
    United Statesa year ago
  • Fantastic - should be in charge of the NHS

    Great information clearly delivered. I wish you were running the NHS in the UK or other equivalents around the world. Maybe with Peter Attia as well. Thank you Matt

    Apple Podcasts
    5
    George Russell 1982
    United Kingdoma year ago
  • Smartest and most ethical Dr in longevity

    Matt is the best. I have been taking rapamycin for 4 years and love his passion for the topic. He's an honest and trustworthy source for longevity news and information.

    Apple Podcasts
    5
    Jmichael68
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some episodes attract critique for guest viewpoints or treatment claims that feel anecdotal.
Many listeners value practical healthspan strategies and data-driven decision making.
Audience appreciates transparency about limitations and risks in longevity therapies and supplements.
Listeners praise rigorous science-based discussions and clear explanations of aging research.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#173
United States/Science
Apple Podcasts
#79
United Arab Emirates/Science
Apple Podcasts
#84
Singapore/Science
Apple Podcasts
#93
Spain/Science
Apple Podcasts
#139
India/Science
Apple Podcasts
#169
Colombia/Science

Talking Points

Recent interactions between the hosts and their guests.

The Best Women’s Health Tips on the Planet with Dr. Jennifer Pearlman
Q: How should a woman approach hormone therapy during the menopause transition?
Approach hormone therapy with staged, personalized plans (cyclic, continuous, or sequential), starting low and slow, and tailor by stage, symptoms, biomarkers, and patient preferences, ensuring safety and monitoring for long-term implications.
The Best Women’s Health Tips on the Planet with Dr. Jennifer Pearlman
Q: What is FemSpan and why is it needed now?
FemSpan is a female-centric longevity framework that leverages unique biology to optimize healthspan during midlife, addressing menopause as a critical aging transition and mitigating systemic risks while leveraging advancements in diagnostics, biomarkers, and regenerative approaches.
How Fighting Gives You A Bulletproof Mind with Noah Neiman
Q: What would be one piece of advice for that person who's going through what you went through?
It's only when you've lost everything are you free to do anything. You got nothing to lose, so use it to propel yourself to create.
Optispan Success Story: How I Got Strong Without Living at the Gym
Q: What do you want people who have listened to this episode to take away?
If you feel good and you have health from the inside, you will look good; it's about inner health leading to outer beauty.
Optispan Success Story: How I Got Strong Without Living at the Gym
Q: What has worked for you to recognize when you're starting to go down that path?
One of the greatest gifts for me was aging, as it made the internal issues manifest externally, prompting me to work on my health from within.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
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Frequently Asked Questions About The Optispan Podcast

What is The Optispan Podcast about and what kind of topics does it cover?

The show centers on evidence-based longevity, healthspan, and practical biology-driven wellness. Across episodes, listeners encounter deep dives into biomarkers, pharmacology, and dietary science, alongside critical reviews of trends like peptides, aging clocks, and hormone therapies. The hosts emphasize data-driven decisions, cautious use of supplements, and holistic prevention over reactive disease management, often featuring clinicians and researchers who challenge conventional medical norms. A standout is the blend of personal health journeys with rigorous science, plus candid conversations about the risks and realities of emerging therapies and wellness fads, making it a strong fit for listeners who value rigor and long-term health str... more

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Which podcasts are similar to The Optispan Podcast?

These podcasts share a similar audience with The Optispan Podcast:

1. Longevity by Design
2. STEM-Talk
3. The Peter Attia Drive
4. The Metabolic Link
5. Huberman Lab

How many episodes of The Optispan Podcast are there?

The Optispan Podcast launched 2 years ago and published 168 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Optispan Podcast?

Recent guests on The Optispan Podcast include:

1. Jennifer Pearlman
2. Nicki Byrne
3. Kim Brockenbrough
4. Carlos Pinto
5. Dr. Ben Blue
6. Brad Stanfield
7. Alexandru Ardélion
8. Jan Hennigs

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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