Rephonic
Artwork for The Metabolic Link
Metabolic Health
Ketogenic Diet
Nutrition
Mental Health
Cancer
Metabolism
Obesity
Aging
Ultra-Processed Foods
Insulin Resistance
Mitochondria
Cancer Metabolism
Glioblastoma
Metabolic Dysfunction
Gut Microbiome
Metabolic Neurology
Cholesterol
Metabolic Syndrome
Fructose
Alzheimer's

Welcome to The Metabolic Link, a medical and science podcast that explores the common thread of metabolism in health and disease. Join Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field as they dive into the latest research on metabolic health and therapy alongside some of the world’s leading experts. They'll also discuss how this science is being applied in the real world. This i... more

PublishesTwice monthlyEpisodes95Founded3 years ago
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Health & FitnessMedicine

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Artwork for The Metabolic Link

Latest Episodes

In people with severe depression and cognitive decline, brain glucose metabolism has been shown in some studies to decline measurably. Ketone metabolism, by contrast, appears relatively preserved. That single observation is reshaping how researchers ... more

A gene mutation that reduces ketone production in the fasted state is associated with sudden infant death in modern populations. But in the ancestral context where it evolved alongside an omega-3-rich diet, it may have been part of what kept infants ... more

YouTube

In a 12-week clinical trial at The Ohio State University, every woman with PCOS who completed the intervention experienced a change in her menstrual status. One participant, who had never had a period in her life, began menstruating within a week. An... more

YouTube

A veteran walks into the clinic with a persistent migraine. Four minutes of vagal nerve stimulation later, the migraine is gone. This is not a one-off result. It is what Dr. Michael Hoffman has been observing for over seven years in the VA hospital s... more

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Recent Guests

Nicola Hale
Author of Inuit Metabolism Revisited; co-author Decolonizing the Diet
Independent researcher/author
Episode: Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94
Dr. Gideon Mailer
Professor of Early American History, University of Minnesota Duluth; author
University of Minnesota Duluth
Episode: Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94
Madison Kackley
Assistant Professor of Kinesiology at Ohio State University; Director of SHE Is Laboratory
The Ohio State University
Episode: Understanding Female Metabolism: PCOS, Postpartum, and Menopause | Madison Kackley, PhD | The Metabolic Link
Dr. Michael Hoffman
Neurologist and researcher focusing on stroke, TBI, neurodegenerative disease, and neurotoxic exposures
University of Central Florida; Ross Cardiovascular Institute
Episode: Vagal Nerve Stimulation, TBI, and Brain Health: Rethinking Neurological Care | Dr. Michael Hoffman, MD | The Metabolic Link Ep. 92
Johnny Pujol
Water chemist, co-founder of Simple Lab and Tap Score
Simple Lab; Tap Score
Episode: What's in Your Tap Water? Contaminants, Filtration, and How to Test It | Johnny Pujol | The Metabolic Link Ep. 91
Tommy Wood
Physician, neuroscientist, author of The Stimulated Mind
University of Washington
Episode: Rethinking Cognitive Decline: Stimulus, Exercise, and the Aging Brain | Dr. Tommy Wood, MD, PhD | The Metabolic Link Ep. 90
Mark Tarnopolsky
Clinician, scientist, MD and PhD, and an exercise physiologist with decades of experience in treating neuromuscular and mitochondrial disorders.
Episode: Mitochondria, Muscle, & Aging: What Longevity Drugs Miss | Dr. Mark Tarnopolsky | The Metabolic Link Ep. 88
Dr. Caesar Hernandez
Assistant professor focused on the role of metabolism in cognitive aging and neurodegeneration.
University of Alabama at Birmingham
Episode: Trauma, Inflammation, and Neurodegeneration: A New Framework for Alzheimer's | Dr. Caesar Hernandez, MS, PhD | The Metabolic Link Ep. 87
Dr. Lily Johnston
Board certified vascular and general surgeon with a focus on metabolic health and cardiovascular risk.
Episode: The Metabolic Roots of Cardiovascular Disease: A Vascular Surgeon's Perspective | Dr. Lily Johnston | The Metabolic Link Ep. 86

Hosts

Victoria Field
Host of The Metabolic Link
Dr. Dominic D'Agostino
Host of The Metabolic Link
Dr. Scott Sherr
Guest on The Metabolic Link podcast, expert in hyperbaric oxygen therapy

Reviews

4.7 out of 5 stars from 216 ratings
  • Metabolic migraines

    Excellent interview with Dr Elena Gross!

    Apple Podcasts
    5
    Kerry Berryyyyyyyy
    United States2 years ago
  • So valuable

    Always new and insightful information. Thank you!!

    Apple Podcasts
    5
    not comfortably online
    United States2 years ago
  • Great podcast but…

    I think some great topics are covered on this podcast and as an endocrinologist passionate about treating metabolic health I appreciate the progressive approach taken here. That being said I had to stop listening to the Andy Galpin talk 5 minutes in because the arrogance was just so toxic and grating. What a shame because I’ve heard him on many other podcasts and used to enjoy listening to him.

    Apple Podcasts
    5
    EndocrineMD
    United States2 years ago
  • Putting it together

    I work as a clinic pharmacist, and for years have seen the ills of medicating chronic illness while people stay, well, ill. The Metabolic Link provides excellent, evidence based information for helping reverse to many problems with chronic illness: From obesity and type 2 diabetes to the emerging world of mental health. If you are a lay person, practitioner, or just someone curious about how you can own your health with the latest evidence, the Metabolic Link is for you.

    Apple Podcasts
    5
    cubsfan2011
    United States2 years ago
  • Outstanding podcast in every way!

    I always learn new things from watching this cutting-edge podcast.

    The hosts are personable, knowledgable, eloquent, and brilliant. The guests are top-notch. This is one of my go-to podcasts/resources for all things Metabolic Psychiatry-related, and much more.

    Dyane Harwood, Author

    “Birth of a New Brain-Healing from Postpartum Bipolar Disorder”

    endorsed by Kay Redfield Jamison et al.

    “Birth of a Keto Brain-A Vegan’s Exploration of Metabolic Psychiatry” (Fall, 2025)

    Apple Podcasts
    5
    Dyane Harwood
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some feedback calls for more guest-focused episodes and less host monologue.
People appreciate the rigorous scientific approach and guest breadth.
Listeners note practical, evidence-based insights with strong clinical relevance.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94
Q: What are the implications for modern diets and public health messaging?
The episode emphasizes metabolic flexibility over strict ketosis, suggesting that diets should accommodate state-dependent shifts between glucose and fat use, and cautions against universal keto dogma.
Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94
Q: How do omega-3 fatty acids interact with this mutation?
Omega-3s increase CPT1A activity in the cell membrane, helping maintain adequate ketone production and offsetting the mutation's negative effects, which may explain better health outcomes in populations with high omega-3 intake.
Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94
Q: What is the CPT1A L479 Arctic Variant and why is it significant?
It is a genetic mutation that downregulates ketosis in the fasted state but upregulates ketosis at certain fed- or threshold states to conserve glucose; it represents a rapid selective sweep (~6,000 years ago) with potential benefits for metabolic flexibility in extreme environments.
Vagal Nerve Stimulation, TBI, and Brain Health: Rethinking Neurological Care | Dr. Michael Hoffman, MD | The Metabolic Link Ep. 92
Q: What tests do you find most underused in acute neurology, and what would you change about standard care to improve outcomes for brain injury patients?
He stresses the need for rapid cognitive and behavioral assessments, recommends short, targeted test batteries and computerized options like CNS Vital Signs to yield actionable results quickly, and argues against overlong, data-heavy notes.
What's in Your Tap Water? Contaminants, Filtration, and How to Test It | Johnny Pujol | The Metabolic Link Ep. 91
Q: What sample collection strategies are most important to get an accurate picture?
Morning first-draw samples show plumbing-derived contaminants, while representative samples reflect what people actually consume daily; fully purged samples show the source water after running through systems. Combining these insights helps identify both source risks and consumer exposure.

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Frequently Asked Questions About The Metabolic Link

What is The Metabolic Link about and what kind of topics does it cover?

A science-forward show centered on metabolism, with guests ranging from clinicians and researchers to practitioners who apply metabolic strategies in cancer, neurology, aging, cardiovascular health, and sports performance. Episodes commonly explore ketogenic approaches, fasting, HBOT, and other metabolic therapies, discussing mechanisms, translational potential, and real-world implementation for clinicians, researchers, and patients. A notable strength is the blend of rigorous science with practical applications, including policy critiques, surgical recovery tactics, and veterinary metabolism, making it useful for professionals evaluating metabolic interventions across disciplines. The format often features expert guests who bridge research... more

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Which podcasts are similar to The Metabolic Link?

These podcasts share a similar audience with The Metabolic Link:

1. Metabolic Mind
2. The Metabolic Classroom with Dr. Ben Bikman
3. Stay Off My Operating Table
4. Low Carb MD Podcast
5. The Primal Podcast

How many episodes of The Metabolic Link are there?

The Metabolic Link launched 3 years ago and published 95 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Metabolic Link?

Recent guests on The Metabolic Link include:

1. Nicola Hale
2. Dr. Gideon Mailer
3. Madison Kackley
4. Dr. Michael Hoffman
5. Johnny Pujol
6. Tommy Wood
7. Mark Tarnopolsky
8. Dr. Caesar Hernandez

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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