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Artwork for Signal and Symptoms Podcast
Artificial Intelligence
Healthcare
AI In Healthcare
Healthcare AI
Digital Transformation
Patient Care
Clinical Decision Support
Microsoft
FDA
Radiology
Regulation
Guardrails In AI
Artificial Intelligence In Healthcare
Segmed
Governance
Digital Twins
AI Models
Generative AI
Digital Doctor
Data Drift

Three healthcare AI experts who've watched millions wasted on failed projects. Dr. Harvey Castro, Dr. Junaid Kalia, Edward Marx, and guest experts cover all things healthcare AI - from digital transformation to clinical reality. Every Tuesday, we diagnose real failures, reveal what actually works, and help you avoid the expensive mistakes we've seen repeated everywhere. Because when AI decisions a... more

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Latest Episodes

The same software engine can run a 400-megawatt power plant and simulate whether a cancer drug will survive a real-world patient population. That’s not two companies — it’s one engine, built by a founder who came up not in medicine but in gas turbine... more

For a generation, your medical record has lived behind the hospital’s firewall. What happens the day the patient walks in holding it — already read, already interpreted by AI, on their own phone?

In this episode, Dr. Harvey Castro hosts — with co-ho... more

Somewhere in Oxford, there’s an AI that can produce a contrast-enhanced cardiac MRI without ever injecting the contrast. No needle, no gadolinium, no risk. It works — and it has for years. Walk into a community hospital in Dallas tomorrow, and you st... more

The hardest part of a pediatric visit now happens before the appointment even begins.

In this episode, Dr. Isha Mannering — a board-certified pediatrician with 16 years in the Dallas–Fort Worth area and founder of InTuneMD — joins Dr. Junaid Kalia, ... more

The foundation of tomorrow's diagnostics is being rebuilt — and it starts in biology, not silicon.

In this episode, Edmund White, biomedical innovator and bestselling author, joins the conversation to challenge an assumption quietly embedded in ever... more

We built a healthcare system engineered for sick care, but the future of medicine belongs to those who seek health.

In this episode, global Digital Health Futurist Philippe Gerwill joins the panel to unpack the real bottlenecks stalling clinical inn... more

What does it actually cost when a diagnosis comes six months too late, a test gets ordered twice, or a treatment decision gets made without the best information available?

In this special recap episode of Signal & Symptoms, we synthesize the stronge... more

Will AI eliminate primary care — or finally give primary care physicians their time back?

That's the central question driving this episode, as Dr. Junaid Kalia, Dr. Harvey Castro, and Ed Marx sit down with Dr. John Dayton — an ER physician who has e... more

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Recent Guests

Stephen Rouse
Co-founder and Head of Growth at Savva AI
Savva AI
Episode: Who Owns Your Medical Record Now? — Stephen Rouse, Co-Founder, Savva
Yeshe Kway
Guest expert from Oxford, researching imaging-based precision phenotyping
Oxford University, Radcliffe Department of Medicine
Episode: Can Medicine Keep Up with AI? — Dr. Yeshe Kway (Oxford)
Isha Mannering
Board-certified pediatrician, AI advocate
Episode: AI Won’t Replace Your Pediatrician — But It Will Change the Visit
Edmund White
Biomedicine/Organioid expert from Germany
Organized Intelligence (OI Tomorrow)
Episode: How Brain Organoids Work (And Why They Could Replace Silicon)
Philippe Gerwill
Futurist for AI with background in pharma and chemicals
Independent futurist; formerly Novartis
Episode: Why AI Isn't the Tech Hype Hospital Leaders Think It Is
John Dayton
Physician, Stanford faculty, physician-entrepreneur involved in venture activities
Former Stanford/Medical community, VC-related work
Episode: What Hospitals Actually Need Before They'll Deploy Your AI
Edward Marx
Healthcare executive and advisor with clinical background
Healthcare leadership
Episode: What Hospitals Actually Need Before They'll Deploy Your AI
Hansa Bhargava
Dr. Bhargava, expert on trust in medical literature
Healio / medical literature expert
Episode: The Hidden Risk of AI-Powered Clinical Decisions
Sara Rana
Physician turned venture capitalist, advisor to the host, and advocate for physicians in entrepreneurship
Advisor to host, venture investor
Episode: The Business Playbook for Physicians Who Want to Win Beyond the Clinic

Hosts

Dr. Junaid Kalia
Co-host of the Signal and Symptoms Podcast
Harvey Castro
Co-host of the Signal and Symptoms Podcast; host with focus on healthcare topics and AI
Edward Marx
Co-host of Signal and Symptoms Podcast; healthcare technology leader

Talking Points

Recent interactions between the hosts and their guests.

Why Are Junior Researchers Outperforming Gene Editing Experts?
Q: How can Nebius help me with CRISPR-GPT, Alpha-14-14 and everything?
By combining specialized AI models with scalable cloud infrastructure and expert handholding, Nebius lowers the barrier to entry for advanced gene-editing workflows, enabling researchers to design and execute complex experiments with higher efficiency and reliability.
Why Are Junior Researchers Outperforming Gene Editing Experts?
Q: Just help me understand the landscape of drug discovery and how Nebius and you are helping companies in terms of drug development. Do you have something for that, or is it in the planning?
Nebius provides the infrastructure and cloud-native platform to run complex, high-throughput experiments with AI-guided decision-making, enabling faster iteration cycles and closer alignment between research and clinical outcomes. The discussion emphasizes that there is no single system that does everything, but Nebius enables the ecosystem and hardware/software integration to accelerate drug discovery.
Why Will Digital Twins Change the Way We Treat Patients?
Q: How do we address data privacy and implementation costs when building healthcare digital twins?
The approach is to keep data on secure personal or local servers, use locked-down personal clouds, and push for on-device or edge processing to minimize centralized risk and costs, while acknowledging the need for scalable infrastructure and governance.
AI vs. Your Brain: Preserving Clinical Expertise in the Age of AI
Q: How are you protecting yourself from the cognitive impact of AI?
I ensure that my solutions and ideas are grounded in my own experience and knowledge, using AI as a tool rather than letting it replace my judgment.
AI vs. Your Brain: Preserving Clinical Expertise in the Age of AI
Q: How are you using AI to decrease your cognitive load for stupid work?
I see AI as a streamline workflow, using it for tasks like retrieving emails for presentations quickly and creating frameworks on paper before inputting into AI.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
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Frequently Asked Questions About Signal and Symptoms Podcast

What is Signal and Symptoms Podcast about and what kind of topics does it cover?

This show centers on healthcare AI, digital transformation, and practical outcomes in clinical settings. Episodes feature physicians, technologists, and healthcare leaders discussing real-world failures and what actually works when implementing AI in care delivery. Common threads include governance, patient experience, cost, and how to integrate AI responsibly without losing the human touch. A standout element is the recurring emphasis on avoiding costly mistakes through candid lessons learned, making it valuable for executives, clinicians, and technologists evaluating AI initiatives in healthcare. The format often blends strategic leadership discussion with concrete examples from hospital systems, startups, and technology vendors, offering... more

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1. CareTalk: Healthcare. Unfiltered.

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Signal and Symptoms Podcast launched 10 months ago and published 48 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Signal and Symptoms Podcast?

Recent guests on Signal and Symptoms Podcast include:

1. Stephen Rouse
2. Yeshe Kway
3. Isha Mannering
4. Edmund White
5. Philippe Gerwill
6. John Dayton
7. Edward Marx
8. Hansa Bhargava

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