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Lifespan with Dr. David Sinclair

Lifespan Communications LLC
Aging
Lifespan
Longevity
Caloric Restriction
Fasting and Calorie Restriction
Eye Health
Gut Microbiome
Glycine
David Sinclair
Biological Aging
Lifespan.com
Ketone-Iq
Chrono-Nutrition
Autophagy
Longevity and Aging Biology
Mitochondrial Dysfunction
Inflammation
Sugar Glycation Hba1c
Plant-Based Diet
Methionine Restriction

Lifespan with Dr. David Sinclair is a health and science show on how to live longer and stay healthier - grounded in the latest longevity research. A Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, Dr. Sinclair breaks down the latest studies into clear, applicable insights so that you can perform at your best and live your longest,... more

PublishesTwice monthlyEpisodes22Founded5 years ago
Number of ListenersCategory
Health & Fitness

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Artwork for Lifespan

Latest Episodes

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at lif... more

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at lif... more

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at lif... more

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at lif... more

Key Facts

Accepts Guests
Accepts Sponsors
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Recent Guests

Bruce Cassander
Co-director, Ocular Oncology Center of Excellence
Harvard Medical School
Episode: Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
Wan Cheng Lu
Pioneer in lab work on OSK-based aging reversal
Life Biosciences
Episode: Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
Xiao Chan
Life Biosciences
Episode: Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
Sharon Rosenzweig-Lipson
Researcher running ER100 trial
Life Biosciences
Episode: Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4

Hosts

David Sinclair
Host; scientist and professor focusing on aging biology; Harvard Medical School
Matthew LaPlante
Co-host; author; Lifespan series partner

Reviews

4.9 out of 5 stars from 13.6k ratings
  • Some caveats

    Dr Sinclair is an expert. Information is good, but some of the downsides & complexities of therapeutics and their uncertainty are not clearly flagged. To be fair, he does often mention that therapies are not proven as effective and explaining technicalities to lay listeners is a difficult task. A non scientist may draw some erroneous conclusions on efficacy, especially with some of the commercial adverts. Always triangulate information with other sources. Many ‘longevity pilgrims?’ do not prope... more

    Apple Podcasts
    5
    Llwynogarian
    United Kingdoma month ago
  • Easy for the laymen!

    I’ve been a fan of Dr. Sinclair since hearing him on Armchair Expert years ago. This pod is an excellent addition to his book. (One request: Please include a notice that an ad is incoming. Without a notification, it feels like we’re being tricked, which is disengenuine to the ethos of the podcast.)

    Apple Podcasts
    4
    Thelazyninja
    United Statesa month ago
  • The ad approach is offensive

    There is no break in the podcast to indicate an ad. Instead, they are woven into the discussion. That practice is a complete turnoff and seriously undermines any advice or message. I refuse to listen to any more episodes of Season 2 as a result

    Apple Podcasts
    1
    TheHesitantReviewer
    United States2 months ago
  • New favourite podcast

    Mind blown with every episode! As an intermittent faster I have found every episode a powerhouse in my intermittent life. I been fasting now for three years and just had a health check. My results in my biometrics displayed my body is three years younger than my age!!

    Apple Podcasts
    5
    Dragon*lee
    United Kingdom2 months ago
  • Unqualified statements make Dr David less credible

    Dr David really needs to qualify his statements more

    Because he is in a position of privilege. People will blindly follow even his vague hints and it’s important to protect them. More importantly, he is selling hope, and for that reason he needs to ensure he doesn’t skate close to a snake oil salesman . (For example, NMN).

    Apple Podcasts
    3
    So cello
    Australia2 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Credibility is noted by many, though some worry about promotional content and hype.
Ads integration is a common critique, with viewers wanting clear breaks.
Listeners praise science-backed, practical longevity insights and clear explanations.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#111
United States/Health & Fitness
Apple Podcasts
#57
Canada/Health & Fitness
Apple Podcasts
#106
United Kingdom/Health & Fitness
Apple Podcasts
#70
Australia/Health & Fitness
Apple Podcasts
#162
Germany/Health & Fitness
Apple Podcasts
#192
Italy/Health & Fitness

Talking Points

Recent interactions between the hosts and their guests.

The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind
Q: What is the potential of future therapies like cellular reprogramming for aging?
Research has identified a safe subset of Yamanaka factors that can reset aging in cells and some tissues without causing cancer, with early animal data showing tissue-specific rejuvenation, such as in the eye, suggesting a path toward reversing aspects of aging in humans.
The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind
Q: What are the main longevity pathways and how can lifestyle choices modulate them?
Key pathways include mTOR, AMPK, and sirtuins. Caloric restriction, fasting, and certain diets activate these pathways, promoting autophagy and mitochondrial health, while exercise and sleep also modulate them to support healthier aging.
The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind
Q: Why is aging considered malleable rather than fixed, and what evidence supports this view?
Aging is driven by conserved biological programs that can be influenced by stress, metabolism, and interventions; studies across yeast, worms, flies, mice, and humans show that longevity genes and pathways respond to energy and stress signals, enabling slower aging and even reversal in some models.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
Location
Interests
Professions
Age Range
Household Income
Social Media Reach

Frequently Asked Questions About Lifespan

What is Lifespan about and what kind of topics does it cover?

Two-paragraph overview of high-level themes across episodes: deep dives into longevity biology, practical health strategies, and how cutting-edge research translates to everyday life. Topics frequently center on fasting, caloric restriction, time-restricted eating, mitochondrial health, sirtuins, mTOR, AMPK signaling, and the role of lifestyle choices (exercise, sleep, wearables) in extending healthspan. The show often pairs scientific explanations with personal anecdotes and discusses emerging therapies, nutraceuticals, and doses when available, while highlighting the importance of skepticism and medical supervision for newer interventions. Noteworthy is a consistent emphasis on actionable day-to-day habits, accessible explanations of comp... more

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Which podcasts are similar to Lifespan?

These podcasts share a similar audience with Lifespan:

1. Huberman Lab
2. The Peter Attia Drive
3. The Human Upgrade: Biohacking for Longevity & Performance
4. The Dr. Hyman Show
5. The Dr. Gabrielle Lyon Show

How many episodes of Lifespan are there?

Lifespan launched 5 years ago and published 22 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Lifespan?

Recent guests on Lifespan include:

1. Bruce Cassander
2. Wan Cheng Lu
3. Xiao Chan
4. Sharon Rosenzweig-Lipson

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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