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Lifespan with Dr. David Sinclair

Lifespan Communications LLC
Aging
Lifespan
Longevity
Caloric Restriction
Fasting and Calorie Restriction
Eye Health
David Sinclair
Biological Aging
Lifespan.com
Ketone-Iq
Chrono-Nutrition
Autophagy
Longevity and Aging Biology
Exercise
Epigenetic Reprogramming
Information Theory Of Aging
LCA (lithocholic Acid)
Ketones
DNA Methylation Age

Lifespan with Dr. David Sinclair is a health and science show on how to live longer and stay healthier - grounded in the latest longevity research. A Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, Dr. Sinclair breaks down the latest studies into clear, applicable insights so that you can perform at your best and live your longest,... more

PublishesTwice monthlyEpisodes17Founded5 years ago
Number of ListenersCategory
Health & Fitness

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Artwork for Lifespan

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At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at lif... more

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at lif... more

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives - while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at l... more

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at lif... more

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Recent Guests

Bruce Cassander
Co-director, Ocular Oncology Center of Excellence
Harvard Medical School
Episode: Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
Wan Cheng Lu
Pioneer in lab work on OSK-based aging reversal
Life Biosciences
Episode: Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
Xiao Chan
Life Biosciences
Episode: Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
Sharon Rosenzweig-Lipson
Researcher running ER100 trial
Life Biosciences
Episode: Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4

Host

David Sinclair
Host of the series and a professor researching aging biology at Harvard Medical School.

Reviews

4.9 out of 5 stars from 13.3k ratings
  • The ad approach is offensive

    There is no break in the podcast to indicate an ad. Instead, they are woven into the discussion. That practice is a complete turnoff and seriously undermines any advice or message. I refuse to listen to any more episodes of Season 2 as a result

    Apple Podcasts
    1
    TheHesitantReviewer
    United States8 days ago
  • New favourite podcast

    Mind blown with every episode! As an intermittent faster I have found every episode a powerhouse in my intermittent life. I been fasting now for three years and just had a health check. My results in my biometrics displayed my body is three years younger than my age!!

    Apple Podcasts
    5
    Dragon*lee
    United Kingdom13 days ago
  • Unqualified statements make Dr David less credible

    Dr David really needs to qualify his statements more

    Because he is in a position of privilege. People will blindly follow even his vague hints and it’s important to protect them. More importantly, he is selling hope, and for that reason he needs to ensure he doesn’t skate close to a snake oil salesman . (For example, NMN).

    Apple Podcasts
    3
    So cello
    Australiaa month ago
  • Actionable Health Advice

    One of my top podcasts! Science backed, understandable and actionable health advice for a healthier longer life. Fantastic show, great delivery, enjoyable to listen to and take away some useful advice to act upon. Feeling the benefits, learning the ways to a very long, healthy and happy life. Thank you sincerely x

    Apple Podcasts
    5
    Bennes909
    United Kingdoma month ago
  • Love the Show

    I absolutely love these shows and David is so informative 🤩

    Apple Podcasts
    5
    Donnac71
    Australiaa month ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Mostly praising evidence-based longevity insights and practical takeaways
Some listeners wish for more skepticism and broader representation in topics
Many fans want season 2 updates and more topics like menopause and new therapies

Chart Rankings

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Talking Points

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The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind
Q: What is the potential of future therapies like cellular reprogramming for aging?
Research has identified a safe subset of Yamanaka factors that can reset aging in cells and some tissues without causing cancer, with early animal data showing tissue-specific rejuvenation, such as in the eye, suggesting a path toward reversing aspects of aging in humans.
The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind
Q: What are the main longevity pathways and how can lifestyle choices modulate them?
Key pathways include mTOR, AMPK, and sirtuins. Caloric restriction, fasting, and certain diets activate these pathways, promoting autophagy and mitochondrial health, while exercise and sleep also modulate them to support healthier aging.
The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind
Q: Why is aging considered malleable rather than fixed, and what evidence supports this view?
Aging is driven by conserved biological programs that can be influenced by stress, metabolism, and interventions; studies across yeast, worms, flies, mice, and humans show that longevity genes and pathways respond to energy and stress signals, enabling slower aging and even reversal in some models.

Audience Metrics

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Frequently Asked Questions About Lifespan

What is Lifespan about and what kind of topics does it cover?

A health and science show focused on extending healthy lifespan through the latest longevity research. Episodes blend foundational biology with practical guidance, covering topics like caloric restriction, fasting, epigenetic reprogramming, and how consumer tech and wearables can help monitor aging-related health metrics. Noteworthy elements include high-profile updates on clinical trials, accessible explanations of complex biology, and a steady cadence of actionable takeaways for listeners who want to apply science to real life. The format tends to pair rigorous science with personal anecdotes and partnerships that illustrate current developments in aging research.

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How many subscribers and views does Lifespan have?

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Which podcasts are similar to Lifespan?

These podcasts share a similar audience with Lifespan:

1. Huberman Lab
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3. The Dr. Gabrielle Lyon Show
4. Perform with Dr. Andy Galpin
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How many episodes of Lifespan are there?

Lifespan launched 5 years ago and published 17 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Lifespan?

Recent guests on Lifespan include:

1. Bruce Cassander
2. Wan Cheng Lu
3. Xiao Chan
4. Sharon Rosenzweig-Lipson

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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