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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
Biohacking
Mitochondria
Longevity
Testosterone
Aging
Creatine
Nutrition
Metabolism
Cognitive Enhancement
Fasting
Nicotine
Health
Alzheimer's Disease
Diet
Methylene Blue
Peptides
Cortisol
Mental Health
Mitochondrial Health
Autophagy

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced te... more

PublishesDailyEpisodes1563Founded15 years ago
Number of ListenersCategories
Health & FitnessEducationSelf-Improvement

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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes

You’ve probably tried everything to sleep better. Magnesium. Melatonin. Blackout curtains. Maybe even expensive sleep gadgets. But what if the real reason your sleep feels broken has nothing to do with any of those things?

In this video, Dave Asprey... more

Artificial Sweeteners & Cognitive Decline, Myosteatosis on Coronary CT, Merck's Oral PCSK9 Inhibitor, Cyclospora Outbreak, Gut-Brain Synchronization, and the Banana Smoothie Mistake Explained

Artificial Sweeteners Linked To 62% Faster Cognitive Decl... more

Fix Leaky Gut, Boost Testosterone & Slash Endotoxins with Spore-Based Probiotics | Kiran Krishnan

Your bad gut bacteria might be the reason your testosterone, your immune system, and even your sperm count are struggling, and most probiotics never su... more

Visceral fat, subcutaneous fat, Prenuvo MRI scans, and the truth about belly fat

Your gut and your face are telling on you. This episode reveals why the fat under your skin might be protecting you while the fat around your organs is quietly wrecking... more

Key Facts

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Recent Guests

Peter McCullough
Physician, author, internal medicine and cardiology expert
Texas A&M College of Medicine (as referenced in conversation)
Episode: Peter McCullough: Spike Protein Detected 3.6 Years After the Shot (Detox Protocol) : 1501
Jordan Harbinger
Host of The Art of Charm, relationship, networking, and self-confidence expert
The Art of Charm
Episode: Jordan Harbinger: Fight-or-Flight, Two Kidnappings, and the Wallet Ruining Your Spine : 1499
David Perlmutter
Six-time New York Times bestselling author, neurologist, Brain Defenders author
Brain Health Associates / author
Episode: The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498
Brian Richards
Founder of SaunaSpace
SaunaSpace
Episode: The 1910 Secret: How Light Turns Water Into Medicine | Brain Richards : 1497
Dr. Anna Cabeca
Triple Board Certified OB-GYN, Author, and expert on oxytocin and longevity
Dr. Anna Cabeca, DO
Episode: Oxytocin: How To Naturally Induce Your MIRACLE Hormone | Anna Cabeca : 1493
Dr. Elie Abirached
Dubai-based biohacking and healthy aging strategist, founder of Limitless Human and Restore Fitness
Limitless Human; Restore Fitness
Episode: The Biohacking Secrets of Dubai | Dr. Elie Abirached : 1489
Michael Christopher
Board-certified dermatologist researching dermoscopy and melanoma detection
MD, Dermatology
Episode: The Skin Mistakes That Age You Fast and Kill You Slow | Dr. Michael Christopher : 1485
Majid Fotuhi
MD, PhD, Johns Hopkins/Harvard trained neurologist and author
The Invincible Brain
Episode: Brain Fog, Memory Loss, and Alzheimer's Prevention | Dr. Majid Fotuhi : 1482
William Li
Physician, founder of the Angiogenesis Foundation
Angiogenesis Foundation
Episode: The Foods That Starve Cancer | William Li : 1481

Host

Dave Asprey
Host of The Human Upgrade, a leading voice in biohacking and longevity education

Reviews

4.6 out of 5 stars from 10.6k ratings
  • I’m Obsessed

    Love this podcast, Daive and his guests. Valuable information. Health is Wealth

    Apple Podcasts
    5
    Jen_Zen
    United Statesa month ago
  • DAVE!!!!

    The creatine guy was hard to follow. Too many acronyms. I don’t know all these doctoral terms and if I’m DRIVING…

    I can’t read the transcript.

    Apple Podcasts
    5
    The Truth is Beauty
    United States2 months ago
  • Chapter markers are off

    It would be nice if the chapter markers were added after the ads because it seems they were added before the ad ads are added, and so the chapter markers are not accurate.

    Apple Podcasts
    3
    r0ck37
    United States2 months ago
  • Great solo episode!

    Very informative episode on creatine 🧠 💪 I like both the solo and interview formats.

    Apple Podcasts
    5
    Debbie (M)
    United States3 months ago
  • We are Bio-individuals

    This information is interesting and there are some good points; however speaking as if the same nutrition advice is right for every BODY is misleading. There are nuances to every point made about food - fruits, veggies, grains, animal protein, etc and every individual needs to understand what works for their own body. Intermittent fasting and butter in the coffee is not a solution for weight loss or optimal health for every person. As a very smart doctor once said, “You can’t fool Mother Nature... more

    Apple Podcasts
    2
    rox1999
    United States3 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners praise actionable insights and deep-dive topics from leading experts.
Fans appreciate a wide array of guests but note mixed pacing and occasional promotional emphasis.
Some criticism centers on host-led monologue and promotional segments.
Feedback highlights the show's impact on practical health protocols and biohacking discussions.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Jordan Harbinger: Fight-or-Flight, Two Kidnappings, and the Wallet Ruining Your Spine : 1499
Q: What are the three most important pieces of advice you have for someone who wants to kick more ass at everything they do?
Focus on relationships and network generously (ABG), avoid keeping score in those relationships, and develop scalable ways to help others (e.g., making introductions) so you build mutual value without transactional baggage.
Jordan Harbinger: Fight-or-Flight, Two Kidnappings, and the Wallet Ruining Your Spine : 1499
Q: Tell me the story, we'll just go there.
Harbinger recounts the first kidnapping in Mexico City, including his struggle to escape, the intense adrenaline, and the clever tactics he used to break free and survive until help arrived.
The 'Secret Sauce' To A 10/10 Morning Routine : 1490
Q: Tell me your why behind MTE.
The why is that the current energy paradigm relies on a tsunami of stimulation that harms foundational biology. MTE is designed to energize in a foundational, balanced way by combining prebiotics, adaptogens, and nootropics to support stress response, sleep, mood, and gut health so people can sustain energy without the typical crashes.
The Biohacking Secrets of Dubai | Dr. Elie Abirached : 1489
Q: What challenges do you face when treating patients in Dubai given the extreme heat and light exposure?
The core approach is optimizing lifestyle and environment. Focus on caregiving around timings of sun exposure, adjusting routines to the local climate, and controlling the indoor environment—like room temperature, darkness, air quality—and aligning activities with circadian rhythms.
How to Get Microplastics Out of Your Body | Mara Labs : 1478
Q: Is there evidence BrocElite affects BPA or heavy metals excretion?
Yes, BrocElite engages all three major detox routes, increasing glucuronidation and glutathione pathways, which supports excretion of BPA metabolites and heavy metals.

Audience Metrics

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

The show leans into biohacking, longevity, and performance optimization, often featuring scientists, physicians, and tech founders who discuss mitochondria, gut health, NAD biology, epigenetics, and cutting-edge wellness technologies. Episodes frequently weave practical protocols with critical scrutiny of supplements, devices, and controversial therapies, while spotlighting real-world applications and product integrations. A notable strength is its ability to translate complex science into actionable takeaways for high-achievement listeners, though some episodes divide attention between host monologue, guest insight, and sponsor promotions. This mix of rigorous science, bold claims, and hands-on optimization makes it appealing to health-min... more

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. Boundless Life
2. The Dr. Hyman Show
3. Dhru Purohit Show
4. The Dr. Gabrielle Lyon Show
5. LONGEVITY with Nathalie Niddam

How many episodes of this podcast are there?

this podcast launched 15 years ago and published 1563 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Peter McCullough
2. Jordan Harbinger
3. David Perlmutter
4. Brian Richards
5. Dr. Anna Cabeca
6. Dr. Elie Abirached
7. Michael Christopher
8. Majid Fotuhi

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