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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
Biohacking
Longevity
Stemregeneration
Plant-Based Stem Cell Enhancers
NAD+
Mitochondrial Function
Urolithin A
Healing
Health Supplements
Blue-Green Algae
Inflammation
Post-Biotics
Entrepreneurship
Christian Drapeau
Nutrition
Immune Function
Cancer Research
Mitophagy
ATP
Neurohacker Collective

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced te... more

PublishesDailyEpisodes1507Founded15 years ago
Number of ListenersCategories
Self-ImprovementEducationHealth & Fitness

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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes

This week's stories:

***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer***

A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles... more

Your body already makes the most powerful wound-healing molecule on the planet, and now you can use it at home. This episode breaks down hypochlorous acid (HOCl), the compound your white blood cells produce naturally, and why it outperforms Neosporin... more

The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real s... more

My favorite creatine (discount code DAVETUBE): www.qualialife.com/ASPREYRECOMMENDS

Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy... more

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Recent Guests

Jason Earle
Indoor air quality expert
Got Mold
Episode: Superhuman Contact Lenses, Motivation Supplement Stack, Cat Scratches Cause Brain Fog, Amino Acid Shortening Lifespan, and more... : 1448
Dr. Sarah
Hormone health expert discussed on the show
Inner Balance (女性のホルモンケアなどを扱う機関)
Episode: Why Doctors Can't Fix Women in 2026 : 1446
Dr. Urzola
Co-founder of RMI clinic; neurology/biohacking expert referenced as leading clinician in stem-cell and neurotherapy protocols
RMI clinic
Episode: I Injected Stem Cells Into My Penis (Here's What Happened) : 1439
Arthur Brooks
Author and professor at Harvard Kennedy School
Harvard Kennedy School
Episode: Arthur Brooks | Why Your Life Has No Meaning : 1438
Bryce Applebaum
Dr
ScreenFit (professionally cited)
Episode: Arthur Brooks | Why Your Life Has No Meaning : 1438
McCall McPherson
Thyroid expert and clinician
Modern Thyroid Clinic
Episode: Here's Why You Still Feel Like Sh*t After Doing Everything Right... : 1434
Jason Shurka
Author and philanthropist behind Unified Healing
Unified Healing / The Light System
Episode: The Awakening Within Cells: Healing Breakthroughs No One Can Ignore : 1433
Dr. Justin Houman
Physician, urology, male fertility, and sexual medicine specialist
Cedars-Sinai
Episode: Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430
Tom Griffiths
Professor at Princeton related to computational cognitive science
Princeton University
Episode: AI Expert Says: Humans Are Just Mystical Meat Robots : 1429

Host

Dave Asprey
Host of The Human Upgrade and founder of Bulletproof Media. Renowned for biohacking advocacy and longevity discussions.

Reviews

4.6 out of 5 stars from 10.6k ratings
  • Too much Dave!

    I love this series but sometimes there’s just too much talking from Dave. I get that he’s an expert in his own right, but sometimes the person who he’s interviewing, doesn’t get a word in! EG the last episode I listened to about autism with Tracy Slepcevic probably would have been better if we started with her story and her journey with her son, but it sort of got thrown in at the end. Sometimes it feels a little muddled.

    Will still keep listening and following and supporting though because thi... more

    Apple Podcasts
    4
    Jolly poor
    Australia10 days ago
  • Let your guest speak

    I wish you let your guest talk more. You have very knowledgeable guests on but spend 75% of the episodes talking about yourself. We have heard your story over and over.

    Apple Podcasts
    2
    Nickname897$
    United States10 days ago
  • Good info. Hate the AI voice

    I like Dave and his information, but I find his recent switch to having an AI voice read his podcast to me annoying and unlistenable.

    Apple Podcasts
    4
    JRV332
    United Statesa month ago
  • Boring

    This podcast has finally lost me when the host and guests start attacking others personally, whilst building each other up with big back pats. Not science but rather bro chat. Do better, this becomes boring to listen to.

    Apple Podcasts
    1
    Alexidel
    Australia2 months ago
  • Live longer if you can afford it. Nothing about us broke folk.

    Podcast Addict
    2
    Schmitty Bear
    2 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners praise deep, actionable longevity content and practical experiments.
Feedback is mixed on interview pacing and guest depth, with strong praise for high-profile guests and rigorous topics.
Some reviews criticize ads, ego, and perceived misinformation or promotional focus.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

This Popular Fat Loss Shortcut Destroys Your Youth : 1437
Q: What are GLP-1 drugs actually doing to the gut microbiome?
GLP-1 drugs slow gut transit, which can cause secondary dysbiosis and increased gut inflammation, potentially altering fat metabolism, blood sugar regulation, and mitochondrial health.
AI Expert Says: Humans Are Just Mystical Meat Robots : 1429
Q: Is AI conscious or not?
The guest suggests it depends on what problem consciousness would be needed for in a system; current AI can function with sophisticated processing without requiring conscious experience in the human sense.
Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430
Q: What's the balance between testosterone levels and fertility when using TRT?
Exogenous testosterone can suppress natural testosterone production and fertility, but options like Clomid, Enclomiphene, and HCG can help preserve fertility while treating low T.
Your Brain Is 0.5% Plastic (Here’s How to Flush It) : 1426
Q: How can one support detoxification and reduce microplastics absorption in the body?
Increase soluble fiber intake (25-50 grams), use prebiotic fibers like acacia gum, consume lactobacillus-rich foods, and support lymphatic drainage through gentle movement, rebounding, sauna use, and targeted supplements as discussed.
The Secret to Looking Younger is in Mushrooms (And Chocolate?) : 1417
Q: What does NAD do and how do people feel when their levels are raised?
NAD powers mitochondria and elevating its levels can lead to improved energy, cognition, better sleep, and overall vitality.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
Location
Interests
Professions
Age Range
Household Income
Social Media Reach

Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

A high-energy show focused on biohacking, longevity, and performance optimization, featuring deep dives into cutting-edge science, technology, and practical protocols. Guests span clinicians, researchers, and industry founders who share insights on mitochondria, hormones, peptides, sleep, cognitive enhancement, and real-world health hacks. The host blends data-backed discussion with bold ideas and personal experiments, often weaving product details and sponsor integrations into the conversation. Listeners likely include health enthusiasts, biohackers, and professionals seeking to upgrade energy, focus, and resilience, with a penchant for early-adopter tech and lifestyle experimentation. A standout aspect is the willingness to explore emergi... more

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. Boundless Life
2. The Dr. Hyman Show
3. Dhru Purohit Show
4. The Dr. Gabrielle Lyon Show
5. The Genius Life

How many episodes of this podcast are there?

this podcast launched 15 years ago and published 1507 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Jason Earle
2. Dr. Sarah
3. Dr. Urzola
4. Arthur Brooks
5. Bryce Applebaum
6. McCall McPherson
7. Jason Shurka
8. Dr. Justin Houman

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