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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
Biohacking
Longevity
Stemregeneration
Plant-Based Stem Cell Enhancers
NAD+
Urolithin A
Mitochondrial Function
Health Supplements
Blue-Green Algae
Healing
Inflammation
Post-Biotics
Entrepreneurship
Christian Drapeau
Nutrition
Mitophagy
Immune Function
Cancer Research
Neurohacker Collective
ATP

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced te... more

PublishesDailyEpisodes1495Founded15 years ago
Number of ListenersCategories
EducationHealth & FitnessSelf-Improvement

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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes

Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet... more

What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor ... more

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is.

• Watch this episode on YouTube for the full video exp... more

Try TrueDark (with my discount): truedark.com/discount/DAVETUBE

I transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".

The retina is a metabolically hungry tissue that u... more

Key Facts

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Recent Guests

McCall McPherson
Thyroid expert and clinician
Modern Thyroid Clinic
Episode: Here's Why You Still Feel Like Sh*t After Doing Everything Right... : 1434
Jason Shurka
Author and philanthropist behind Unified Healing
Unified Healing / The Light System
Episode: The Awakening Within Cells: Healing Breakthroughs No One Can Ignore : 1433
Dr. Justin Houman
Physician, urology, male fertility, and sexual medicine specialist
Cedars-Sinai
Episode: Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430
Tom Griffiths
Professor at Princeton related to computational cognitive science
Princeton University
Episode: AI Expert Says: Humans Are Just Mystical Meat Robots : 1429
Josefine Musco
Founder of Olyxir Tea Strips
Olyxir Tea Strips
Episode: Your Brain Is 0.5% Plastic (Here’s How to Flush It) : 1426
Dr. Anil Bajnath
American Board of Precision Medicine
Precision Medicine / Epigenetics & Inflammation specialist
Episode: Why Are Hackers Microdosing “Sex Drugs” Now? : 1425
Josh Felber
Entrepreneur and podcast host (Making Bank) in health/peptide space
Making Bank
Episode: The Secret to Staying DANGEROUS After 50 : 1422
Lucy Goff
Founder of LYMA Lasers
LYMA Lasers
Episode: The Home Laser That Reverses Skin Age By 20 Years : 1421
Dylan Gemelli
Biohacker and speaker in the biohacking community
Episode: The Secret Peptides and Underground Compounds Doctors Won’t Talk About : 1413

Host

Dave Asprey
Host of The Human Upgrade and founder of Bulletproof Media. Renowned for biohacking advocacy and longevity discussions.

Reviews

4.6 out of 5 stars from 10.6k ratings
  • Boring

    This podcast has finally lost me when the host and guests start attacking others personally, whilst building each other up with big back pats. Not science but rather bro chat. Do better, this becomes boring to listen to.

    Apple Podcasts
    1
    Alexidel
    Australiaa month ago
  • Live longer if you can afford it. Nothing about us broke folk.

    Podcast Addict
    2
    Schmitty Bear
    a month ago
  • Too many unproven products

    He notes that Methylene Blue could hurt you. The nicotine podcast was also very alarming. These shows are a recipe for a lawsuit? The bro interactions are strange.

    Apple Podcasts
    2
    Interested bystander
    United States2 months ago
  • Long time student of health

    Keep going Dave, you’re doing a world of good for public health!

    Apple Podcasts
    5
    Velocity Raptor
    United States3 months ago
  • Too many unproven products

    Need to verify effectiveness. Oh, by the way, he notes the Methylene Blue could hurt you. Is this a recipe for a lawsuit?

    Apple Podcasts
    2
    Interested bystander
    United States4 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners praise deep, actionable longevity content and practical experiments.
Feedback is mixed on interview pacing and guest depth, with strong praise for high-profile guests and rigorous topics.
Some reviews criticize ads, ego, and perceived misinformation or promotional focus.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

This Popular Fat Loss Shortcut Destroys Your Youth : 1437
Q: What are GLP-1 drugs actually doing to the gut microbiome?
GLP-1 drugs slow gut transit, which can cause secondary dysbiosis and increased gut inflammation, potentially altering fat metabolism, blood sugar regulation, and mitochondrial health.
AI Expert Says: Humans Are Just Mystical Meat Robots : 1429
Q: Is AI conscious or not?
The guest suggests it depends on what problem consciousness would be needed for in a system; current AI can function with sophisticated processing without requiring conscious experience in the human sense.
Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430
Q: What's the balance between testosterone levels and fertility when using TRT?
Exogenous testosterone can suppress natural testosterone production and fertility, but options like Clomid, Enclomiphene, and HCG can help preserve fertility while treating low T.
Your Brain Is 0.5% Plastic (Here’s How to Flush It) : 1426
Q: How can one support detoxification and reduce microplastics absorption in the body?
Increase soluble fiber intake (25-50 grams), use prebiotic fibers like acacia gum, consume lactobacillus-rich foods, and support lymphatic drainage through gentle movement, rebounding, sauna use, and targeted supplements as discussed.
The Secret to Looking Younger is in Mushrooms (And Chocolate?) : 1417
Q: What does NAD do and how do people feel when their levels are raised?
NAD powers mitochondria and elevating its levels can lead to improved energy, cognition, better sleep, and overall vitality.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

A high-energy show focused on biohacking, longevity, and performance optimization, featuring deep dives into cutting-edge science, technology, and practical protocols. Guests span clinicians, researchers, and industry founders who share insights on mitochondria, hormones, peptides, sleep, cognitive enhancement, and real-world health hacks. The host blends data-backed discussion with bold ideas and personal experiments, often weaving product details and sponsor integrations into the conversation. Listeners likely include health enthusiasts, biohackers, and professionals seeking to upgrade energy, focus, and resilience, with a penchant for early-adopter tech and lifestyle experimentation. A standout aspect is the willingness to explore emergi... more

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These podcasts share a similar audience with this podcast:

1. Boundless Life
2. The Dr. Hyman Show
3. Dhru Purohit Show
4. The Dr. Gabrielle Lyon Show
5. The Genius Life

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this podcast launched 15 years ago and published 1495 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. McCall McPherson
2. Jason Shurka
3. Dr. Justin Houman
4. Tom Griffiths
5. Josefine Musco
6. Dr. Anil Bajnath
7. Josh Felber
8. Lucy Goff

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