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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
Mitochondria
Longevity
Biohacking
Creatine
Aging
Testosterone
Fasting
Nicotine
Nutrition
Metabolism
Methylene Blue
Gut Microbiome
Autophagy
Cortisol
Inflammation
Mitophagy
Microplastics
Urolithin A
Oxidative Stress
Mental Health

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced te... more

PublishesDailyEpisodes1599Founded15 years ago
Number of ListenersCategories
Health & FitnessEducationSelf-Improvement

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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes

Try TrueDark glasses: truedark.com

Try Danger Coffee: dangercoffee.com/discount/davetube

Try Suppgrade Labs: shopsuppgradelabs.com/

Try Longevity Gummies: www.timeline.com/partners/dave-asprey

This video explains t... more

Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion

Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause and addiction. The company has no... more

Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after e... more

Catharine Arnston on Spirulina, Chlorella, Mitochondria, Detox, Brain Energy, and Longevity

Visit energybits.com/ and use code HUMANUPGRADE for 20% off.

Could one of the oldest foods on Earth also be one of the most overlooked tools for mit... more

Key Facts

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Recent Guests

Michael Leon
Professor Emeritus of Neurobiology and Behavior, UC Irvine
University of California, Irvine
Episode: How to Hack Your Smell for Memory and Longevity WHILE YOU SLEEEP! : 1538
Josh Duhamel
Actor, founder of Gatlan Health
Gatlan Health
Episode: Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537
Carolina Reis de Oliveira
CEO and co-founder of OneSkin
OneSkin
Episode: The Peptide Secrets to a Youthful Face : 1536
Karan Rajan
Former NHS surgeon, GI surgeon, best-selling author
NHS / Author
Episode: Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533
Jenny McCarthy
Actress, comedian, and public figure discussing autism and related biohacking approaches
Jenny McCarthy Media
Episode: Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530
Jonny Miller
Host of the Inner Frontier Podcast, expert in nervous system mastery
Inner Frontier Podcast
Episode: Learn THIS And You’ll Become Impossible To Trigger : 1526
Jim Kwik
Top memory expert, founder of Kwik Learning
Kwik Learning
Episode: Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525
Gurudev Sri Sri Ravi Shankar
Founder of the Art of Living Foundation, breathwork and peace ambassador
Art of Living Foundation
Episode: The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523
Patrick Coles
Co-host / guest on the show, discussing toxin sequestration theory
Episode: The Wild New Theory of Cancer (It's GOOD For You?) : 1522

Host

Dave Asprey
Host of The Human Upgrade; pioneer in biohacking and longevity optimization; founder of Bulletproof brand.

Reviews

4.6 out of 5 stars from 10.6k ratings
  • Great discussion!

    This was a great overview discussion. I was obese on the White House staff in 2017-2019. Now 300% better following these protocols and more. Used the same White House Medical Unit for my care. Loved the deep dive on adipose fat. Well done, gents.

    Apple Podcasts
    5
    Doug and Kate
    United States15 days ago
  • This is truly an amazing message, and I really love what you’re sharing here. I believe these ideas have the potential to genuinely help a lot of people, which is why they deserve to reach a much wider audience.

    I’m a podcast promotion specialist myself, and I’d love to help bring this valuable message to more people through strategic, organic podcast promotion. Let’s work together to give this message the reach it deserves and create an even greater positive impact. 🙌

    Podchaser
    5
    anamulpodcastmarketing
    a month ago
  • Amazing podcast

    Great experience with Dave Asprey!

    Dave’s passion for health, longevity, and helping people optimize their lives really comes through. I appreciate how he makes complex wellness topics interesting, approachable, and motivating. His insights have given me a fresh perspective on taking better care of my health and living with more intention. Highly recommend checking out his work!

    Apple Podcasts
    5
    Rsvl
    United Statesa month ago
  • Amazing podcast Dave wanna thank you heath is wealth

    Thank you so much for your podcast Love everything you do appreciate all your hard work peace love, and light

    Apple Podcasts
    5
    Verde2525
    United States2 months ago
  • I’m Obsessed

    Love this podcast, Daive and his guests. Valuable information. Health is Wealth

    Apple Podcasts
    5
    Jen_Zen
    United States3 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Audience appreciates diverse guests and actionable takeaways for health optimization.
Some feedback calls for letting guests speak more and reducing ad/read frequency.
Listeners praise deep-dive science and practical biohacks, with some noting the host's strong hands-on approach.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

15g Every Morning for Anti-Aging Mitochondria : 1541
Q: What makes spirulina beneficial for brain health and mitochondria?
Spirulina contains superoxide dismutase to protect mitochondria and phycocyanin that acts as a natural facilitator for electron transport, improving energy production and reducing oxidative damage, which supports brain health.
Change Your Morning, Change Your Life! Hal Elrod : 1527
Q: Walk me through Hal's near-death experiences and how they shaped his work.
Hal describes surviving a head-on car crash at 20 with multiple fractures, brain injury, and a six-minute clinical death. He later faced a severe cancer diagnosis with a 20-30% survival rate, which compelled him to explore holistic and conventional treatments. These experiences reframed his purpose toward helping others through disciplined routines like The Miracle Morning and ongoing biohacking practices.
Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525
Q: What is the biggest brain training advice for people under 24?
The biggest lever is to manage attention and control inputs first thing in the morning, as attention hijackers like devices can derail learning and mental health.
The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523
Q: What is the role of community and group practice in amplifying individual transformation?
Group breathwork creates a multiplier effect—shared energy increases learning, compassion, and personal growth across thousands of participants.
The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523
Q: How do you maintain curiosity and openness to new ideas after decades of work?
By recognizing that science is an extension of spirituality and staying open to investigation, avoiding cynicism, and valuing the unknown as a source of growth.

Audience Metrics

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

A rigorous exploration of biohacking, longevity, and human performance driven by a host who blends scientific detail with practical, real-world protocols. Across recent episodes, the conversations span artificial intelligence's impact on learning, cellular aging and NAD+/mitochondrial biology, breathwork and mindfulness, toxin-focused cancer theories, skin health delivery technologies, and gut-lung axis innovations. The show frequently threads in sponsor integrations and product recommendations, weaving a pro-optimization ethos with personal storytelling and cutting-edge research. It's notable for bringing together world-class researchers, physicians, and high-profile biohackers to translate complex science into actionable steps for better ... more

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These podcasts share a similar audience with this podcast:

1. Boundless Life
2. The Dr. Hyman Show
3. Dhru Purohit Show
4. LONGEVITY with Nathalie Niddam
5. The Dr. Gabrielle Lyon Show

How many episodes of this podcast are there?

this podcast launched 15 years ago and published 1599 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Michael Leon
2. Josh Duhamel
3. Carolina Reis de Oliveira
4. Karan Rajan
5. Jenny McCarthy
6. Jonny Miller
7. Jim Kwik
8. Gurudev Sri Sri Ravi Shankar

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