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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
Mitochondria
Longevity
Biohacking
Creatine
Aging
Testosterone
Fasting
Nutrition
Gut Microbiome
Sleep
Peptides
Intermittent Fasting
Mitophagy
Mental Health
Autophagy
Mitochondrial Health
Glutathione
Attachment Theory
Cognition
Urolithin A

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced te... more

PublishesDailyEpisodes1623Founded15 years ago
Number of ListenersCategories
Health & FitnessEducationSelf-Improvement

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Artwork for The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes

There's a 15 minute habit you can do every morning that kills insulin belly. That's the fat packed around your organs. It drains into your liver, forces your body to make more insulin, and insulin locks your fat cells shut so nothing can get out.

I ... more

Scientists Test Vibrating Mattress To Help Clear Alzheimer's-Related Proteins From The Brain

Researchers at the University of Oulu in Finland tested a vibrating mattress combined with nitroglycerin, a blood-vessel-relaxing drug, in 29 healthy adult... more

Get Roman Tsunder's book and learn more at pttow.com/

How to Master Any Skill, the Science of Peak Performance, Obsession, Deep Focus, Finding Your Purpose, Overcoming Failure, and Achieving Success Without Burnou

Host Dave Asprey sits down... more

YouTube

Triquetra Discount: Use code Dave20 at Triquetrahealth.com/dave

Multivitamin Mistakes, MTHFR Genetics, B Vitamins, Creatine & Prescription Drug Risks

Host Dave Asprey sits down with Phil Cowley, a pharmacist, founder of Cache Valley Pharmacy, and c... more

YouTube

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Recent Guests

Roman Tsunder
Entrepreneur, founder of PTTOW!, and author of Plan to Take On the World
PTTOW!
Episode: How to Get Really Good at Anything: The 3 Ingredients of Mastery | Roman Tsunder : 1569
Phil Cowley
Pharmacist, founder of Cache Valley Pharmacy, and creator of Phil's My Pharmacist
Phil's My Pharmacist
Episode: The Truth About Vitamins, Supplements & Prescription Drugs | Phil Cowley : 1567
Sarah Kennedy
CEO of Calocurb with a background in veterinary medicine and human nutrition
Calocurb
Episode: The No-Brainer Solution To Stop Overeating : 1565
Tim Cook
Physician and longevity medicine expert with 30 years of experience
House of Evolution
Episode: The Easiest Treatment That Made Me 15 Years Younger : 1563
Teri Cochrane
Integrative practitioner and pioneer in personalized healthcare
Global Sustainable Health Institute
Episode: Avoid THESE "Healthy" Superfoods : 1561
Steven Kotler
Bestselling author and researcher in the neuroscience of flow; founder of the Flow Research Collective
Flow Research Collective
Episode: How to Trigger Flow States From The 5 Brain Chemicals You Need : 1559
Hal Elrod
Bestselling author of The Miracle Morning and creator of its personal development method
The Miracle Morning
Episode: The 6-Minute Morning Routine That Can Change Your Life : 1558
John Gray
Relationship author and author of Men Are from Mars, Women Are from Venus
Episode: John Gray: Why Men Stop Wanting Their Wives : 1556
Michael Breus
Clinical psychologist, sleep specialist, and internationally recognized sleep expert
Episode: Sleep Expert: 80% of Sleep Problems Come From THIS : 1555

Host

Dave Asprey
Host of The Human Upgrade; pioneer in biohacking and longevity optimization; founder of Bulletproof brand.

Reviews

4.6 out of 5 stars from 10.6k ratings
  • Great discussion!

    This was a great overview discussion. I was obese on the White House staff in 2017-2019. Now 300% better following these protocols and more. Used the same White House Medical Unit for my care. Loved the deep dive on adipose fat. Well done, gents.

    Apple Podcasts
    5
    Doug and Kate
    United States2 months ago
  • This is truly an amazing message, and I really love what you’re sharing here. I believe these ideas have the potential to genuinely help a lot of people, which is why they deserve to reach a much wider audience.

    I’m a podcast promotion specialist myself, and I’d love to help bring this valuable message to more people through strategic, organic podcast promotion. Let’s work together to give this message the reach it deserves and create an even greater positive impact. 🙌

    Podchaser
    5
    anamulpodcastmarketing
    3 months ago
  • Amazing podcast

    Great experience with Dave Asprey!

    Dave’s passion for health, longevity, and helping people optimize their lives really comes through. I appreciate how he makes complex wellness topics interesting, approachable, and motivating. His insights have given me a fresh perspective on taking better care of my health and living with more intention. Highly recommend checking out his work!

    Apple Podcasts
    5
    Rsvl
    United States3 months ago
  • Amazing podcast Dave wanna thank you heath is wealth

    Thank you so much for your podcast Love everything you do appreciate all your hard work peace love, and light

    Apple Podcasts
    5
    Verde2525
    United States3 months ago
  • I’m Obsessed

    Love this podcast, Daive and his guests. Valuable information. Health is Wealth

    Apple Podcasts
    5
    Jen_Zen
    United States4 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Audience appreciates diverse guests and actionable takeaways for health optimization.
Some feedback calls for letting guests speak more and reducing ad/read frequency.
Listeners praise deep-dive science and practical biohacks, with some noting the host's strong hands-on approach.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

The Truth About Vitamins, Supplements & Prescription Drugs | Phil Cowley : 1567
Q: What's your take on the claim that creatine can cause damage to the kidneys?
Cowley says moderate creatine intake is generally safe for most people, while very high doses may raise concerns; he notes that creatine can affect related lab results and emphasizes hydration and individual differences.
The Truth About Vitamins, Supplements & Prescription Drugs | Phil Cowley : 1567
Q: Did they ever teach you about supplements when you were in school?
Cowley says pharmacy school devoted only a small portion of one class to nutraceuticals, teaching that they were ineffective and could cause drug interactions.
How to Get Really Good at Anything: The 3 Ingredients of Mastery | Roman Tsunder : 1569
Q: How do you know when it's fear to push through versus an intuitive warning that something actually is a bad idea?
Tsunder recommends noticing whether a choice feels expansive or contracting, while acknowledging that the mind can second-guess intuition and that practical judgment still matters in immediate danger.
How to Get Really Good at Anything: The 3 Ingredients of Mastery | Roman Tsunder : 1569
Q: What's the difference between a person who becomes a millionaire and a billionaire? I don't mean they have more money. I mean, attitude, abilities. What is it?
Tsunder says mastery is characterized by healthy obsession, putting in the hours, and sustained focus on a craft or goal.
The Easiest Treatment That Made Me 15 Years Younger : 1563
Q: You've had it, I've had it. And we saw some pretty interesting results because we're actually tracking Klotho in people's blood to see how well the gene therapy works. What do we find?
Cook says early MiniCircle trial participants showed an average klotho increase of about threefold, and he describes a client whose measured level rose from 0.9 to 10 after treatment.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

A rigorous exploration of biohacking, longevity, and human performance driven by a host who blends scientific detail with practical, real-world protocols. Across recent episodes, the conversations span artificial intelligence's impact on learning, cellular aging and NAD+/mitochondrial biology, breathwork and mindfulness, toxin-focused cancer theories, skin health delivery technologies, and gut-lung axis innovations. The show frequently threads in sponsor integrations and product recommendations, weaving a pro-optimization ethos with personal storytelling and cutting-edge research. It's notable for bringing together world-class researchers, physicians, and high-profile biohackers to translate complex science into actionable steps for better ... more

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These podcasts share a similar audience with this podcast:

1. Boundless Life
2. The Dr. Hyman Show
3. The Ultimate Human with Gary Brecka
4. Dhru Purohit Show
5. The Dr. Gabrielle Lyon Show

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this podcast launched 15 years ago and published 1623 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Roman Tsunder
2. Phil Cowley
3. Sarah Kennedy
4. Tim Cook
5. Teri Cochrane
6. Steven Kotler
7. Hal Elrod
8. John Gray

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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