Rephonic
Artwork for Knife Down
Cardiovascular Disease
Cholesterol
Insulin Resistance
Heart Disease
Alzheimer's Disease
Detour Procedure
Menopausal Hormone Therapy
Apob
Hypertension
Metabolic Health
Lipoprotein(a)
Statins
Lp(a)
HDL Cholesterol
Lipoprotein Little A
Peripheral Arterial Disease
Nattokinase
APOE4
PCSK9 Inhibitors
Diabetes

"Knife Down" is what a surgeon says in the OR when she puts her scalpel down so no one gets hurt — and it’s the mission here: put the knife down, long before anyone needs to use it.

Knife Down is a podcast about how to actually invest in your health so you can live longer, stronger, and with less time in doctors’ offices. The core focus is the world’s leading cause of death—cardiovascular disease... more

PublishesDailyEpisodes44Founded4 months ago
Number of ListenersCategories
MedicineHealth & FitnessNutrition

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Artwork for Knife Down

Latest Episodes

The nattokinase video clearly hit a nerve. Your comments were sharp, occasionally feisty, and worth a real answer. So this is the follow-up Q&A: natto the food versus nattokinase the isolated capsule, whether CIMT is a test I actually trust, the dosi... more

Nattokinase is one of the most hyped supplements in cardiovascular health — claimed to lower blood pressure, shrink arterial plaque by 36%, and drop LDL cholesterol without a statin. I put a patient on it. Then I looked closer at the data. Now I've s... more

Can you take too much vitamin K2? In this video, I answer the most common follow-up questions about vitamin K2, including dose, safety, testing, interactions, and whether more is actually better.

Here's the original video on the K2 clinical trial: h... more

Can vitamin K2 slow coronary artery calcium? A new JAMA Cardiology randomized trial found that MK-7 may reduce CAC progression over 2 years — but the real story is more complicated.

TL;DR: In this randomized trial, people with symptomatic coronary a... more

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Recent Guests

Dr Boz
Physician and health educator featured in the episode
Episode: Can THIS Supplement Prevent Heart Disease? Surgeon Reacts to Dr Boz
Nick Norwitz
MDPhD discussing ezetimibe and Alzheimer's disease, based on his video and research
Physician-Scientist, likely independent/academic
Episode: Is Ezetimibe the Secret to Preventing Dementia? Surgeon Reacts to Nick Norwitz MDPhD ​
Dr. Ford Brewer
Preventive medicine expert and former emergency medicine physician
none
Episode: When "Healthy" Is a Lie: @DrFordBrewer on Insulin Resistance, Hidden Plaque & His Prevention Pivot

Host

Dr. Lily Johnston
Board-certified vascular surgeon and cardiometabolic health specialist; host of Knife Down; focused on prevention and metabolic health.

Reviews

5.0 out of 5 stars from 1 ratings
  • Jackpot

    So happy I somehow found this podcast. I have so much respect when a doctor questions some of the traditional theories.

    Very easy and enjoyable to listen to.

    Apple Podcasts
    5
    Babser 100
    United Statesa month ago

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Talking Points

Recent interactions between the hosts and their guests.

AMA #2: Why a 'Perfect' LDL Won't Save You--Plaque, Statins & Metabolic Health
Q: Is erectile dysfunction reversible with statins, PCSK9 inhibitors, or vascular surgery?
Vascular health improvement can help vascular ED, with therapies like PDE5 inhibitors, and in some cases adjunctive vascular interventions or shockwave therapy; overall stabilization of plaque and improved nitric oxide pathways contribute.
AMA #2: Why a 'Perfect' LDL Won't Save You--Plaque, Statins & Metabolic Health
Q: What should I look for when taking statins and how to objectively measure their effectiveness and side effects?
Monitor lipid panels (LDL-C, ApoB) and HbA1c, watch for muscle symptoms, and consider gradual dosing with re-challenges; if intolerance occurs, discuss alternatives like non-statin therapies.
AMA #2: Why a 'Perfect' LDL Won't Save You--Plaque, Statins & Metabolic Health
Q: Tron asks, how do I actually find a prevention metabolic cardiologist to help out with these extra concerns?
The field includes integrative and preventive cardiology specialists; look for provider directories (e.g., Bale-Doneen) and verify they focus on metabolic health and prevention rather than only traditional lipid targets.
Surgery for Alzheimer's...Is It Real? (and other questions)
Q: What are your thoughts on testosterone or other hormone replacement therapies reducing LP little a, and how should patients think about menopausal hormone therapy in relation to lipid risk?
HRT can influence certain lipid parameters and may shift risk in some postmenopausal individuals, particularly by affecting estradiol levels and potentially bringing Lp(a) back toward baseline in some cases. However, it is not a primary strategy to lower Lp(a); the decision to use MHT should consider broader benefits (bone health, GSM, vasomotor symptoms) and risks, with a focus on methods (e.g., transdermal estradiol with micronized progesterone) that may carry a more favorable cardiovascular risk profile for many patients. The overall cardiovascular benefit is not guaranteed for everyone, and shared decision-making with a clinician is essential.
The Biggest Walking Mistake I See: PAD Q&A
Q: What is the surgery like for vascular disease in PAD, and how long is recovery?
Surgery and recovery vary by disease location and severity; some patients undergo minimally invasive angioplasty or stenting, while others require open bypass with vein or grafts, and recovery can range from days to a week or more depending on overall health and the extent of the procedure.

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Frequently Asked Questions About Knife Down

What is Knife Down about and what kind of topics does it cover?

This show consistently translates cutting-edge science on prevention, metabolic health, and longevity into practical, real-world guidance for avoiding cardiovascular disease. Episodes often center on rigorous evaluation of supplements, lipidology, hormones, and emerging therapies, with a clear emphasis on evidence-based strategies, safety, and personalized risk. The host—a vascular surgeon—explains complex medical concepts in accessible terms, frequently debunking marketing hype and highlighting how lifestyle, testing, and targeted interventions can reduce cardiovascular risk long before symptoms appear. A notable strength is its rigorous, no-nonsense approach to prevention, balanced with timely discussions of new therapies and diagnostic t... more

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Which podcasts are similar to Knife Down?

These podcasts share a similar audience with Knife Down:

1. Boundless Life
2. The Dr. Gabrielle Lyon Show
3. The Peter Attia Drive
4. Heart Doc VIP with Dr. Joel Kahn
5. LEVELS – A Whole New Level

How many episodes of Knife Down are there?

Knife Down launched 4 months ago and published 44 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Knife Down?

Recent guests on Knife Down include:

1. Dr Boz
2. Nick Norwitz
3. Dr. Ford Brewer

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