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Artwork for The Science, Microbes & Health Podcast
Microbiome
Probiotics
Gut Microbiome
Gut-Brain Axis
Gut Health
Fermented Foods
Prebiotics
Stress
Gastroenterology
Colorectal Cancer
Inflammatory Bowel Disease
Precision Fermentation
Obesity
Chronic Diseases
Mental Health
Dietary Interventions
Urinary Tract Infections
Human Milk Oligosaccharides
Fiber Intake
Vaginal Microbiome

This podcast covers emerging topics and challenges in the science of probiotics, prebiotics, synbiotics, postbiotics and fermented foods. This is the podcast of The International Scientific Association for Probiotics and Prebiotic (ISAPP), a nonprofit scientific organization dedicated to advancing the science of these fields.

PublishesTwice monthlyEpisodes95Founded4 years ago
Number of ListenersCategories
Life SciencesHealth & FitnessMedicineScience

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Artwork for The Science, Microbes & Health Podcast

Latest Episodes

This episode features Dr. Mingyang Song ScD from Harvard University (USA), speaking about epidemiological evidence connecting the gut microbiota to colorectal cancer (CRC) and whether the evidence supports the gut microbiota as a ‘driver’ or a ‘passe... more

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This episode features Prof. Alberto Martin from University of Toronto (Canada), speaking about the molecular mechanisms by which certain bacteria – namely, pks+ E. coli – influence colorectal cancer development. pks+ E. coli secretes a toxin that cau... more

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This episode features Dr. Georg Zeller PhD from Leiden University Medical Center (the Netherlands), speaking about gut microbiome signatures of colorectal cancer across global populations. An early study Dr. Zeller completed in Peer Bork’s lab sugges... more

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This episode features Prof. Cynthia L. Sears, MD from the Johns Hopkins University School of Medicine and the Bloomberg School of Public Health (USA), speaking about both biofilms and specific gut microorganisms that may contribute to colorectal canc... more

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Recent Guests

Mingyang Song
Associate Professor of Clinical Epidemiology and Nutrition, Harvard
Harvard Medical School / Harvard T.H. Chan School of Public Health
Episode: Epidemiological insights on the gut microbiota in colorectal cancer, with Dr. Mingyang Song ScD
Alberto Martin
Professor, Department of Immunology, University of Toronto
University of Toronto
Episode: Molecular mechanisms of colorectal cancer development, with Prof. Alberto Martin PhD
Georg Zeller
Researcher focusing on microbiome and cancer; University of Leiden Medical Center
Leiden University Medical Center (LUMC)
Episode: Gut microbiome signatures of colorectal cancer, with Dr. Georg Zeller PhD
Cindy Sears
Professor of medicine, oncology, molecular microbiology, and immunology at Johns Hopkins
Johns Hopkins School of Medicine and Bloomberg School of Public Health
Episode: Biofilms and specific bacteria in colorectal cancer development, with Prof. Cynthia L. Sears, MD
Anne Salonen
Professor, Principal Investigator and Director of the Human Microbiome Research Program at the Medical Faculty of the University of Helsinki, Finland
University of Helsinki
Episode: The early life gut microbiota in the developmental origins of health & disease, with Dr. Anne Salonen PhD
Christopher Stewart
Professor and lead researcher in infant gut microbiome
Newcastle University (implied from bio)
Episode: Factors affecting infant gut microbiota development, with Prof. Christopher Stewart PhD
Rihua Xie
A researcher involved in the study of vaginal microbiota transfer and skin-brain axis
Episode: A mechanism linking the newborn skin microbiota to neurodevelopment, with Prof. Rihua Xie and Dr. Yuhang Zhang
Yuhang Zhang
Co-researcher contributing to the mechanistic study of skin microbiota and neurodevelopment
Episode: A mechanism linking the newborn skin microbiota to neurodevelopment, with Prof. Rihua Xie and Dr. Yuhang Zhang
Marie-Claire Arrieta
Associate Professor at the University of Calgary, focusing on early-life microbiome development
University of Calgary
Episode: Gut microbiota development in preterm and non-preterm infants, with Dr. Marie-Claire Arrieta PhD

Hosts

Colin Hill
Host of the series; ISAPP affiliation; frequently engages in interviews on probiotic and prebiotic science.
Dan Tancredi
Co-host; ISAPP board member; active in interview discussions across microbiome topics.
Marla Cunningham
Executive Director of ISAPP; frequent host with focus on defining gut health and related metrics.

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Talking Points

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Gut microbiome signatures of colorectal cancer, with Dr. Georg Zeller PhD
Q: What are the clinical translation challenges you see for microbiome-based CRC diagnostics?
Current classifiers don't reach sufficient accuracy alone; integrating microbiome data with existing tests like FIT and exploring multi-marker approaches could improve screening, but robust, high-performance models are still needed.
Gut microbiome signatures of colorectal cancer, with Dr. Georg Zeller PhD
Q: How do you view the microbiome—taxonomic vs functional readouts—in terms of explaining cancer signals?
Both views are valuable: taxa provide strong predictive power for diagnostics, while functional analyses reveal mechanisms such as bile acid metabolism and genotoxic factors like colibactin, helping to prioritize mechanistic follow-up studies.
Gut microbiome signatures of colorectal cancer, with Dr. Georg Zeller PhD
Q: What was the approach you took in Peer Bork's lab that led you to colorectal cancer as a subject of analysis?
I started with a strong computational background and a biological focus, joining Peer Bork's lab to apply machine learning and statistical methods to microbiome data, which gradually pointed toward cancer discrimination using fecal readouts, eventually expanding to large meta-analyses and cross-study validations.
Gut microbiota development in preterm and non-preterm infants, with Dr. Marie-Claire Arrieta PhD
Q: What are the main factors that influence microbiome trajectories in preterm infants and how do they relate to immune development?
Key drivers include mode of birth (cesarean vs. vaginal), antibiotic exposure, feeding (breastmilk vs. formula), and the introduction of complementary foods; these factors together shape the pace of maturation and subsequent immune responses, with dysbiosis linked to altered allergy and infection risk.
The skin microbiome’s role in atopic dermatitis, with Dr. Maria Teresa García-Romero, MD MPH
Q: What is being observed about the microbiome after biologic or steroid treatments for atopic dermatitis?
There are studies showing that the skin microbiome changes after biologics, steroids, or antibiotics, but more work is needed to understand how to manipulate the microbiome effectively without relying solely on biologics; probiotics are increasingly being explored as adjuncts with some products showing good data in atopic dermatitis.

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Frequently Asked Questions About The Science, Microbes & Health Podcast

What is The Science, Microbes & Health Podcast about and what kind of topics does it cover?

A rigorous, science-forward program focused on probiotics, prebiotics, synbiotics, postbiotics, and fermented foods. Episodes consistently center on how the microbiome influences health across the life course—from colorectal cancer and infant gut development to skin health and neurodevelopment—often anchoring discussions in mechanistic biology, clinical translation, and regulatory considerations. Noteworthy episodes spotlight microbiome signatures in cancer, biofilm roles in colorectal cancer, maternal and infant microbiome trajectories, and skin-gut axes, frequently featuring leading researchers and clinicians as guests. The show appears to balance foundational microbiology with translational insights, highlighting diagnostic, preventive, ... more

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1. The Doctor's Kitchen Podcast
2. ZOE Science & Nutrition
3. The Proof with Simon Hill
4. Huberman Lab
5. The Metabolic Classroom with Dr. Ben Bikman

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The Science, Microbes & Health Podcast launched 4 years ago and published 95 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Science, Microbes & Health Podcast?

Recent guests on The Science, Microbes & Health Podcast include:

1. Mingyang Song
2. Alberto Martin
3. Georg Zeller
4. Cindy Sears
5. Anne Salonen
6. Christopher Stewart
7. Rihua Xie
8. Yuhang Zhang

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