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This Week in Startups

Jason Calacanis
Artificial Intelligence
Openclaw
Openai
Startups
Venture Capital
Google
Bittensor
Automation
Japan
Nvidia
E-Commerce
Entrepreneurship
Anthropic
Generative AI
AI Technology
Spacex
Uber
AI Models
Technology
AI Agents

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.

PublishesDailyEpisodes1468Founded17 years ago
Number of ListenersCategory
Technology

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This Week In Startups is made possible by:

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Today's show:

Hugging Face's $399 Microduck and t... more

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This Week In Startups is made possible by:

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Today's show:

*Nvidia agreed to buy Hugging Face for $12.9 billion, just days after quietly licensing Pool... more

This Week In Startups is made possible by:

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Today's show:

*Bill Gates dropped a 6,000 word w... more

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Today's show:

Can a founder actually fire a board member? Short answer: almost never. And the reason why may surprise a lot of founders.

On this edition of Legal Basics, Wilson Sonsini partner Becki DeGraw joins Jason for a deep dive into who rea... more

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Recent Guests

Allan Guo
Co-founder and CEO of Willow, an AI-powered voice dictation app
Willow
Episode: Open source is going to win it all: Harvey proves it | E2328
Ethan Goodhart
Stanford Computer Science student, designer of the self-driving Robo taxi golf cart
Stanford University
Episode: Open source is going to win it all: Harvey proves it | E2328
Amir Sadeghian
Founder and CEO of Astrocade
Astrocade
Episode: Taste is the new programming language (w/ Astrocade CEO Amir Sadeghian) | AI Basics
Ashi Dissanayake
CEO and co-founder, Spaceium
Spaceium
Episode: Neurosymbolic AI outperforms chatbots and product search | E2327
Jacob Steeves
Founder/engineer known as Const on Bittensor
Bittensor
Episode: Bittensor creator Const on Affine, dTAO, "mining reasoning," and more | E2326
Sami Khoreibi
CEO and co-founder of Wisewell, water-purification startup
Wisewell
Episode: What we'll learn from Anthropic's $2-$3T IPO | E2325
Puneet Puri
Co-founder of Gritt Robotics, AI infrastructure for solar panel installation
Gritt Robotics
Episode: What we'll learn from Anthropic's $2-$3T IPO | E2325
Kevin Gibbon
Co-founder and CEO of Cytronic
Cytronic
Episode: These robots could cut delivery costs by 80% | Next Unicorns
Matthias Hofmann
CEO and co-founder of Eyebot
Eyebot
Episode: These robots could cut delivery costs by 80% | Next Unicorns

Hosts

Jason Calacanis
Host known for driving deep founder-focused conversations; frequently sets the agenda, challenges assumptions, and steers strategic discussions.
Lon Harris
Co-host and interviewer; contributes market context and synthesizes topics for scalable storytelling.
Alex Wilhelm
Host and discussion facilitator for Twist segments and startup insights; often introduces topics and guides conversation.

Reviews

4.3 out of 5 stars from 3k ratings
  • Audio only option

    I really like this podcast and have been listening to it for more than a decade. But recent changes to the iPod version require me to download the video version. I just want the audio version so I can listen to it on the go. Recent changes that force me to download a 8GB video file to my iPhone is frustrating.

    Apple Podcasts
    1
    JSVentures
    Japana month ago
  • Alpaka bag is now $155

    Thanks to Ja Cal the Alpaka back is $155 not $133. Great episode.

    Apple Podcasts
    5
    Alaskariverguy
    United States3 months ago
  • 10min contents + 30min ads

    As title lol

    Apple Podcasts
    1
    Ruedhdhejej
    Taiwan4 months ago
  • So annoying

    I can’t listen to this guy, can’t stand his voice, he’s just so annoying and a disgusting host

    Apple Podcasts
    1
    Projomni78
    United States6 months ago
  • Not actually about startups!

    Check out the episode titles. They are related to diverse popular topics of the day (big tech, new tech, news), but not really about startups.

    Apple Podcasts
    1
    hhsuey
    United States6 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Shows high utility for founders and investors with practical startup playbooks.
Ad-heavy episodes sometimes detract from listening experience for some listeners.
Audience often praises founders'-first perspective and market savvy.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Spotify
#47
United States/Technology
Apple Podcasts
#52
United States/Technology
Apple Podcasts
#59
Canada/Technology
Apple Podcasts
#98
United Kingdom/Technology
Apple Podcasts
#37
Australia/Technology
Apple Podcasts
#69
Italy/Technology

Talking Points

Recent interactions between the hosts and their guests.

Neurosymbolic AI outperforms chatbots and product search | E2327
Q: Could you start by giving people the basics as to why this is a problem that needs to be solved now?
The problem is that traditional LLMs struggle with hallucinations and lack transparency; by layering neuro-symbolic techniques, Onton can learn in real time, explain its results, and adapt the search index to user contexts without constant retraining.
These robots could cut delivery costs by 80% | Next Unicorns
Q: What role do doctors play in Eyebot's model, and could AI eventually replace the need for clinicians in prescription decisions?
Eyebot uses licensed tele-doctors who review data collected by the kiosk and issue prescriptions, ensuring safety and clinical judgment. While AI may assist in the future, the experts emphasize that doctor oversight is essential for now and likely will remain a part of care delivery for the foreseeable future.
These robots could cut delivery costs by 80% | Next Unicorns
Q: How do the economics of Cytronic's system compare to traditional 3PL fulfillment today, and what order volumes are required to break even?
Cytronic claims fulfillment costs can drop from around $3-$3.50 per order to about $0.50 per order with their robotic-plus-software stack, with per-pick costs around $0.10. Break-even and profitability come from high-volume throughput and compact, city-centered facilities that shorten distance to customers.
While other cultivated meat companies are collapsing, this one turned a profit | E2317
Q: What was the impact of the open source angle when you were raising from VCs?
VCs cared more about the ability to generate and scale IP within the company rather than the open source origins, and open source facilitated credibility but was not the primary driver of funding decisions.
While other cultivated meat companies are collapsing, this one turned a profit | E2317
Q: Hi, I'm Natalie, building PlayPin, so we make anyone easy to build robots. How did the open source community react to your commercialization?
The open source community accepted the separation of the open source framework from the for-profit IP development; the model was clear, with a governance structure that differentiated community activities from the company's proprietary development, and ongoing communication helped align expectations.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
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Frequently Asked Questions About This Week in Startups

What is This Week in Startups about and what kind of topics does it cover?

A sharp-tanged look at the startup world, with conversations that thread through venture capital, product strategy, and market dynamics. Episodes frequently dissect how AI, data, and growth metrics reshape the SaaS landscape, featuring deep dives with founders, investors, and operators who share practical lessons on fundraising, go-to-market, and building resilient companies. Notable standouts include guests exploring frontier tech (robotics, quantum hardware, cellular agriculture) and live, candid takes on funding ecosystems, liquidity, and the evolving role of AI in startups. The show often balances founder-first interviews with roundtable VC analyses, and maintaining sponsor-friendly ad reads is a recurring, visible element. This mix mak... more

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Which podcasts are similar to This Week in Startups?

These podcasts share a similar audience with This Week in Startups:

1. This Week in AI
2. All-In with Chamath, Jason, Sacks & Friedberg
3. The a16z Show
4. The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch
5. Y Combinator Startup Podcast

How many episodes of This Week in Startups are there?

This Week in Startups launched 17 years ago and published 1468 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on This Week in Startups?

Recent guests on This Week in Startups include:

1. Allan Guo
2. Ethan Goodhart
3. Amir Sadeghian
4. Ashi Dissanayake
5. Jacob Steeves
6. Sami Khoreibi
7. Puneet Puri
8. Kevin Gibbon

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