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This Week in Startups

Jason Calacanis
Artificial Intelligence
Openai
Openclaw
Startups
Venture Capital
Bittensor
Google
Japan
Automation
Entrepreneurship
Anthropic
E-Commerce
Generative AI
AI Technology
NVIDIA
Spacex
Uber
AI Models
Technology
AI Agents

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.

PublishesDailyEpisodes1478Founded17 years ago
Number of ListenersCategory
Technology

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This Week In Startups is made possible by:

Vanta: www.vanta.com/twist

DigitalOcean: do.co/twist

Lightfield: lightfield.app/

Plaud: Plaud.ai/twist

Today’s show:

Elon revives the Hyperloop, promising a 30-minute comm... more

This Week In Startups is made possible by:

Superhuman:⁠ superhuman.com/⁠ Paypal:⁠ paypal.launch.co⁠ Odoo:⁠ Odoo.com/twist⁠ Plaud:⁠ Plaud.ai/twist⁠ Harmonic:⁠ harmonic.ai/⁠

Today’s show:

Hugging Face built a $399 ... more

The TWiST AI Basics series is made possible by Google for Startups!

Build context-aware AI workflows using DeepMind models and orchestration tools with Google for Startups' new Startup technical guide on generative media. Get the guide here: https... more

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This Week In Startups is made possible by:

Quo: quo.com/TWiST

The Conservation Fund: conservationfund.org

CLA: app.notion.com/p/withyou-help-eb83a84d32cf43f59af13cb11e2f56c3?source=copy_link

Today's show:

A 27-year... more

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Recent Guests

Tristan Buckmaster
NYU mathematician involved in Navier–Stokes discussion
New York University
Episode: Did OpenAI Steal the Navier-Stokes Solution? | E2335
Dr. Mark Hyman
Physician, founder of Function Health
Function Health
Episode: Dr. Mark Hyman on Function Health & GLP-1 microdosing | E2334
Paige Doherty
Founding Partner, Behind Genius Ventures (BGV)
Behind Genius Ventures
Episode: VC experts on why Physical AI funding is heating up | E2333
Katelin Cruz
Partner, Seven Seven Six
Seven Seven Six
Episode: VC experts on why Physical AI funding is heating up | E2333
Anders Forslund
Founder of Heart Aerospace
Heart Aerospace
Episode: Are AI Agents forming "civilizations" or is this just a psy op? | 2332
John Yu
Founder of Bitsec, BitTensor subnet 60
BitTensor
Episode: Are AI Agents forming "civilizations" or is this just a psy op? | 2332
Craig Piggott
Founder and CEO of Halter, livestock management technology
Halter
Episode: Breaking down Nvidia's Hugging Face and Poolside bets | E2331
Matija Milonovic
Founder and CEO of Hop Aero, defense tech and autonomous cargo rockets
Hop Aero
Episode: Breaking down Nvidia's Hugging Face and Poolside bets | E2331
Hussein Kanji
London-based venture investor, first-time caller on the program
Lightfield investor and CRM AI sponsor
Episode: Bill Gates foresees massive AI job loss: these VCs disagree | E2330

Hosts

Jason Calacanis
Host known for driving deep founder-focused conversations; frequently sets the agenda, challenges assumptions, and steers strategic discussions.
Lon Harris
Co-host and interviewer; contributes market context and synthesizes topics for scalable storytelling.
Alex Wilhelm
Host and discussion facilitator for Twist segments and startup insights; often introduces topics and guides conversation.

Reviews

4.3 out of 5 stars from 3.1k ratings
  • Audio only option

    I really like this podcast and have been listening to it for more than a decade. But recent changes to the iPod version require me to download the video version. I just want the audio version so I can listen to it on the go. Recent changes that force me to download a 8GB video file to my iPhone is frustrating.

    Apple Podcasts
    1
    JSVentures
    Japan2 months ago
  • Alpaka bag is now $155

    Thanks to Ja Cal the Alpaka back is $155 not $133. Great episode.

    Apple Podcasts
    5
    Alaskariverguy
    United States3 months ago
  • 10min contents + 30min ads

    As title lol

    Apple Podcasts
    1
    Ruedhdhejej
    Taiwan5 months ago
  • So annoying

    I can’t listen to this guy, can’t stand his voice, he’s just so annoying and a disgusting host

    Apple Podcasts
    1
    Projomni78
    United States7 months ago
  • Not actually about startups!

    Check out the episode titles. They are related to diverse popular topics of the day (big tech, new tech, news), but not really about startups.

    Apple Podcasts
    1
    hhsuey
    United States7 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Shows high utility for founders and investors with practical startup playbooks.
Ad-heavy episodes sometimes detract from listening experience for some listeners.
Audience often praises founders'-first perspective and market savvy.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#55
United States/Technology
Apple Podcasts
#55
Canada/Technology
Apple Podcasts
#193
United Kingdom/Technology
Apple Podcasts
#151
Australia/Technology
Apple Podcasts
#206
France/Technology
Apple Podcasts
#12
Indonesia/Technology

Talking Points

Recent interactions between the hosts and their guests.

Did OpenAI Steal the Navier-Stokes Solution? | E2335
Q: Does a story like this change what you're willing to put into a frontier model?
Rebecca Lynn indicates she isn't surprised by the developments but stresses the importance of continuing to assess data privacy and security, while acknowledging the remarkable capability of models to solve advanced problems.
VC experts on why Physical AI funding is heating up | E2333
Q: How do you approach early-stage investments in wildly capital-intensive physical AI companies given the dilution risk?
By focusing on verticalized applications of physical AI that can reach revenue quickly, maintaining a strong emphasis on durable moat and founder execution, and structuring follow-on capital plans to manage ownership as rounds scale.
Are AI Agents forming "civilizations" or is this just a psy op? | 2332
Q: How far away are you from commercial deployment, Anders?
Forslund explains they aim for a pre-production hybrid version by 2028 with production aircraft in 2031, supported by a multi-hundred-million funding round and conformance/certification processes.
Breaking down Nvidia's Hugging Face and Poolside bets | E2331
Q: What makes Nvidia's move on Hugging Face so significant for frontier models?
It could funnel a large portion of the market's compute needs through Nvidia, potentially shifting revenue and influence away from currently dominant players like OpenAI and Anthropic if Nvidia delivers compelling, unmetered, on-premise capabilities.
Neurosymbolic AI outperforms chatbots and product search | E2327
Q: Could you start by giving people the basics as to why this is a problem that needs to be solved now?
The problem is that traditional LLMs struggle with hallucinations and lack transparency; by layering neuro-symbolic techniques, Onton can learn in real time, explain its results, and adapt the search index to user contexts without constant retraining.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
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Frequently Asked Questions About This Week in Startups

What is This Week in Startups about and what kind of topics does it cover?

A sharp-tanged look at the startup world, with conversations that thread through venture capital, product strategy, and market dynamics. Episodes frequently dissect how AI, data, and growth metrics reshape the SaaS landscape, featuring deep dives with founders, investors, and operators who share practical lessons on fundraising, go-to-market, and building resilient companies. Notable standouts include guests exploring frontier tech (robotics, quantum hardware, cellular agriculture) and live, candid takes on funding ecosystems, liquidity, and the evolving role of AI in startups. The show often balances founder-first interviews with roundtable VC analyses, and maintaining sponsor-friendly ad reads is a recurring, visible element. This mix mak... more

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Which podcasts are similar to This Week in Startups?

These podcasts share a similar audience with This Week in Startups:

1. This Week in AI
2. All-In with Chamath, Jason, Sacks & Friedberg
3. The a16z Show
4. The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch
5. Y Combinator Startup Podcast

How many episodes of This Week in Startups are there?

This Week in Startups launched 17 years ago and published 1478 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on This Week in Startups?

Recent guests on This Week in Startups include:

1. Tristan Buckmaster
2. Dr. Mark Hyman
3. Paige Doherty
4. Katelin Cruz
5. Anders Forslund
6. John Yu
7. Craig Piggott
8. Matija Milonovic

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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