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This Week in AI

Jason Calacanis
Artificial Intelligence
Openclaw
Anthropic
Open Source AI
Openai
Productivity
Automation
Gecko Robotics
Abridge
Hermes Agent
Education
AGI
Gemini 3.0
Ziosec
AI Security
AI Inference
Penetration Testing
Prompt Injection
Healthcare
China

An experts-only AI podcast: Think the 'All In' podcast for AI. Jason + 3 CEO-level experts breaking down the news & trends.

PublishesWeeklyEpisodes40Founded9 months ago
Number of ListenersCategory
Technology

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Artwork for This Week in AI

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Today’s show:

Grok Bot users maxed out their weekly limits over Halloween Weekend, and SpaceX now... more

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Today’s show:

Anthropic’s S-1 is finally out and it’s a beast: $16.3 billion in revenue in the first half of this year, up from $1.2 billion in 2025. Plus a $1.6 billion a... more

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Today’s show:

Sam Altman told OpenAI staff that there are only three ways for AI regulation to go: an international watchdog, every lab merging into one CERN-style entity, or one c... more

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Today’s show:

Companies are spending $1 million on AI in a single month, but can’t always point directly to any resulting revenue. Jeffrey Morgan of Ollama joins Jason to explain... more

Key Facts

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Recent Guests

Jaleh Rezaei
CEO and co-founder of Mutiny, which builds AI assistants for go-to-market teams
Mutiny
Episode: No One Likes Any of Sam Altman’s 3 AI Endgames | TWiAI E36
Alex Cheema
CEO and co-founder of Exo Labs, which builds software for local AI clusters
Exo Labs
Episode: No One Likes Any of Sam Altman’s 3 AI Endgames | TWiAI E36
Jeffrey Morgan
Co-founder and CEO of Ollama
Ollama
Episode: Why Fortune 500 Companies Are Quietly Switching to Open Models
Varun Sivaram
Founder and CEO of Emerald AI
Emerald AI
Episode: Data Centers Aren't Killing the Grid. They Could SAVE It.
Vibhav Viswanathan
Co-founder and CEO of Pascal AI
Pascal AI
Episode: Data Centers Aren't Killing the Grid. They Could SAVE It.
George Sivulka
Founder and CEO of Hebbia
Hebbia
Episode: Is Meta's Muse agent reading your iMessages, even after you decline access? | E33
Scott Stephenson
CEO and co-founder of Deepgram
Deepgram
Episode: Is Meta's Muse agent reading your iMessages, even after you decline access? | E33
Dan Mishin
Founder and CEO of Manifest OS
Manifest
Episode: Is Meta's Muse agent reading your iMessages, even after you decline access? | E33
Guy Podjarny
Founder and CEO of Tessl (agent enablement platform)
Tessl
Episode: Why OpenAI Should Buy Off the World’s Top Mathematicians | E32

Hosts

Jason Calacanis
Host of This Week in AI; regular participant in AI industry roundtables; known for founder-level perspectives on AI strategy and policy.
Lon Harris
Editorial Director and News Reader; co-host with focus on industry news, governance, and market implications.
Alex Wilhelm
Host focusing on AI business, policy, and market trends within the AI ecosystem.

Reviews

4.5 out of 5 stars from 30 ratings
  • Love the new show

    Can’t wait for things to get rolling!

    Apple Podcasts
    5
    NYElliot
    United States9 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Energy and pace keep the conversations engaging for executives.
Shows strong industry insights from founders and operators.
Quality of guests varies but generally high for enterprise-focused AI topics.
Guests provide practical perspectives on AI economics and governance.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Spotify
#45
United States/Technology
Apple Podcasts
#70
United States/Technology
Apple Podcasts
#89
Canada/Technology
Apple Podcasts
#97
United Kingdom/Technology
Apple Podcasts
#104
Australia/Technology
Apple Podcasts
#81
South Africa/Technology

Talking Points

Recent interactions between the hosts and their guests.

No One Likes Any of Sam Altman’s 3 AI Endgames | TWiAI E36
Q: Which path do you think we will ultimately pursue, or is there a fourth path Sam Altman did not talk about?
Jaleh Rezaei questions why Altman considers those three outcomes exhaustive. The panel challenges the plausibility of a global lab merger and considers whether a company could gain an advantage by accumulating revenue and computing capacity.
No One Likes Any of Sam Altman’s 3 AI Endgames | TWiAI E36
Q: As a startup working with models, are you concerned about being cut off from Chinese open-source models?
Jaleh Rezaei says enterprise customers are uneasy about placing sensitive data on Chinese models, even when hosted locally, and asks how the United States can develop its own open models.
Why Fortune 500 Companies Are Quietly Switching to Open Models
Q: When you look into the black box and all this technology, do you see a sentient life form or do you see extremely powerful software that's advancing at a velocity that maybe we haven't seen in our careers before?
Morgan sees AI as powerful software rather than sentient life, but warns that increasingly capable open models create security risks and need additional safeguards.
Why Fortune 500 Companies Are Quietly Switching to Open Models
Q: Tell us what the state of affairs is in terms of the lead between the frontier models and open source. Does that lead matter when you're running a company?
Morgan says open models have largely closed the gap for general-purpose business tasks, though frontier models retain advantages in specialized areas such as math, biotech, and cybersecurity.
Mythos, Sonnet 5, GLM-5.2 Dominate the News Cycle | Episode 20
Q: Is there real regulatory concern for enterprises adopting GLM 5.2 and related technologies, or is this mostly chatter on social media?
There is genuine regulatory concern among hyperscalers and the administration, with participation in trusted access programs and a push for security and control; enterprises weigh cost, access, and security when choosing where to deploy models, including on-premise and managed services.

Audience Metrics

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Frequently Asked Questions About This Week in AI

What is This Week in AI about and what kind of topics does it cover?

A technology-forward, founder-led roundtable focused on AI industry dynamics, policy, open vs. closed models, and practical enterprise applications. Guests are typically CEOs, founders, and senior operators from AI, infrastructure, and enterprise tooling, offering hands-on perspectives on governance, cost, and deployment. The show often centers on regulatory trends, model stewardship, and the economics of running AI at scale, with frequent discussions about open-source vs. proprietary ecosystems, world models, and the intersection of AI with space, robotics, and enterprise workflows. Noteworthy is the panel-driven format that blends strategic critique with real-world use cases, making it valuable for leaders evaluating AI investments, partn... more

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Which podcasts are similar to This Week in AI?

These podcasts share a similar audience with This Week in AI:

1. All-In with Chamath, Jason, Sacks & Friedberg
2. BG2Pod with Brad Gerstner and Bill Gurley
3. The a16z Show
4. Invest Like the Best with Patrick O'Shaughnessy
5. Dwarkesh Podcast

How many episodes of This Week in AI are there?

This Week in AI launched 9 months ago and published 40 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on This Week in AI?

Recent guests on This Week in AI include:

1. Jaleh Rezaei
2. Alex Cheema
3. Jeffrey Morgan
4. Varun Sivaram
5. Vibhav Viswanathan
6. George Sivulka
7. Scott Stephenson
8. Dan Mishin

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