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The Stem Cell Report with Janet Rossant

ISSCR
Stem Cell Research
Neuroscience
Lung Development
Stem Cells
Regenerative Medicine
Glioblastoma
Cell Differentiation
Tumor Organoids
Induced Pluripotent Stem Cells
Aging
Parkinson's Disease
Pluripotent Stem Cells
Cholinergic Neurons
Patient-Derived Models
Blood-Brain Barrier
Epigenetics
Alzheimer's Disease
Retinal Regeneration
Neurogenesis
Alveolar Cells

Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Janet Rossant, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. ... more

PublishesMonthlyEpisodes52Founded6 years ago
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Artwork for The Stem Cell Report

Latest Episodes

In 2006, Kazutoshi Takahashi and Shinya Yamanaka at Kyoto University published their landmark paper showing that mouse skin cells could be reprogrammed to an embryonic-like state using just four transcription factors. Over the past two decades, this ... more

The enteric nervous system (ENS) is an intricate network of neurons and glia lining the gastrointestinal tract, regulating digestion and overall health. Loss of ENS neurons, as occurs in Hirschsprung disease, leads to intestinal obstruction, and trea... more

Bosma arhinia microphthalmia syndrome (BAMS) is a rare genetic disorder resulting in babies born without a nose, along with eye and reproductive anomalies. Our guests today investigated the developmental basis of this distinct defect using induced pl... more

Acute respiratory distress syndrome (ARDS) induced by COVID-19 was a leading cause of severe illness and death during the pandemic, driven by an intense innate immune response, hyperinflammation, and a decrease in lymphocytes. Mesenchymal stromal cel... more

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Recent Guests

Laurent David
Associate Professor at University of Nantes; leads the Nantes Pluripotent Stem Cell Core Facility
University of Nantes
Episode: Two Decades of iPS Cells: Perspectives from the Field
Wei Li
Professor and director of the State Key Laboratory of Organ Regeneration and Reconstruction
Institute of Zoology, Chinese Academy of Sciences
Episode: Two Decades of iPS Cells: Perspectives from the Field
Sonja Schrepfer
Professor of Surgery and Regenerative Medicine; scientific founder of SANA Biotechnology
Cedars-Sinai Medical Center / SANA Biotechnology
Episode: Two Decades of iPS Cells: Perspectives from the Field
Julia Ganz
Associate Professor, Michigan State University; ENS development and regeneration in zebrafish
Michigan State University
Episode: Repair the Second Brain
Mujahid Ali Shah
Postdoctoral researcher in Julia Ganz's lab; lead author on the zebrafish ENS paper
Michigan State University
Episode: Repair the Second Brain
Marlene Hao
Senior research fellow; ENS development and regeneration research in Melbourne
University of Melbourne
Episode: Repair the Second Brain
Lincon Stamp
Associate professor; NHMRC fellow at University of Melbourne; ENS development and therapy discussions
University of Melbourne
Episode: Repair the Second Brain
Eve Rowland
Graduate student; lead author on iPSC-derived ENS neurons paper
University of Melbourne
Episode: Repair the Second Brain
Shifeng Xue
Assistant Professor in the Department of Biological Sciences at the National University of Singapore
National University of Singapore
Episode: Born Without a Nose

Host

Janet Elizabeth Rossant
Editor-in-Chief of Stem Cell Reports; affiliated with Stem Cell Reports / ISSCR and The Stem Cell Report

Reviews

4.8 out of 5 stars from 26 ratings
  • Fun conversation

    I enjoy learning about the breadth of research happening in the stem cell field on this podcast and how different areas of research connect. It was also fun to see how the researchers interact with one another and hear their personal stories.

    Apple Podcasts
    5
    DianaDu1212
    United States2 months ago

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Talking Points

Recent interactions between the hosts and their guests.

Two Decades of iPS Cells: Perspectives from the Field
Q: Wei, what is your major piece of advice to someone entering the IPS field?
Stay open‑minded and retain plasticity, especially as technology evolves rapidly with AI and other tools; maintain flexibility in approach.
Two Decades of iPS Cells: Perspectives from the Field
Q: Laurent, is your best piece of advice to make sure you have a good stem cell facility around to help you?
Yes, having a well‑run core facility and proper training is essential to avoid lab failures and to ensure access to quality cell banks and standardized practices.
Repair the Second Brain
Q: How mature are the iPSC-derived ENS neurons compared to in vivo human ENS neurons?
iPSC-derived ENS neurons show maturation markers and functional responses to neurotransmitters, with spontaneous network activity emerging in culture, indicating progress toward recapitulating human ENS development in vitro.
Repair the Second Brain
Q: What are the main advantages of the zebrafish model for ENS regeneration studies?
Zebrafish allow precise genetic ablation with minimal collateral damage, rapid development, and the capacity to study regeneration in hundreds of larvae, enabling robust analysis of neuron subtypes and gut function recovery.
Repair the Second Brain
Q: Where do you see the future of ENS therapies, especially regarding timelines for clinical translation?
There is optimism for first-in-human trials within about five years, contingent on safety, immunomodulation, and successful integration after transplantation, with parallel development of stem cell–based models to refine approaches.

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Frequently Asked Questions About The Stem Cell Report

What is The Stem Cell Report about and what kind of topics does it cover?

This program centers on cutting-edge stem cell science, featuring conversations that go beyond published papers to explore the questions, methods, and translational potential driving the field. Episodes typically mix researchers at the bench with clinicians and policy experts to discuss topics like organoids, iPSC models, cell therapies, disease modeling, and regulatory considerations. A standout aspect is the host's emphasis on practical insights, mentorship, and the broader implications of research for therapy and policy, often weaving in historical context and future directions. The show is likely to attract researchers, clinicians, and science-minded listeners who want accessible, expert-led conversations about how basic discoveries tra... more

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3. Science Magazine Podcast
4. Economist Podcasts
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The Stem Cell Report launched 6 years ago and published 52 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Stem Cell Report?

Recent guests on The Stem Cell Report include:

1. Laurent David
2. Wei Li
3. Sonja Schrepfer
4. Julia Ganz
5. Mujahid Ali Shah
6. Marlene Hao
7. Lincon Stamp
8. Eve Rowland

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