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The Stem Cell Report with Janet Rossant

ISSCR
Stem Cell Research
Neuroscience
Lung Development
Stem Cells
Regenerative Medicine
Glioblastoma
Cell Differentiation
Tumor Organoids
Aging
Parkinson's Disease
Pluripotent Stem Cells
Cholinergic Neurons
Patient-Derived Models
Blood-Brain Barrier
Epigenetics
Alzheimer's Disease
Neurogenesis
Retinal Regeneration
Alveolar Cells
Vascular Biology

Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Janet Rossant, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. ... more

PublishesMonthlyEpisodes49Founded5 years ago
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Artwork for The Stem Cell Report

Latest Episodes

Acute respiratory distress syndrome (ARDS) induced by COVID-19 was a leading cause of severe illness and death during the pandemic, driven by an intense innate immune response, hyperinflammation, and a decrease in lymphocytes. Mesenchymal stromal cel... more

Five years ago, The Stem Cell Report set out with a simple goal: to bring the science, the people, and the stories behind stem cell research into one conversation. Since then, the field has advanced at an extraordinary pace—transforming our understan... more

Our guests today created new lab models to study Merkel cells using mouse whisker tissue cultures, mouse skin organoids, and human skin organoids. These models allowed them to study Merkel cells as they develop, validate the role of known signaling p... more

Human pluripotent stem cells (hPSCs) are transforming the study of biology and disease by enabling scientists to grow large amounts of specific cell types in the lab that were once difficult to obtain. Our guests today focus on improving the derivati... more

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Recent Guests

Duncan Stewart
Senior Clinician Scientist, Regenerative Medicine Program, Ottawa Hospital Research Institute; Professor, Department of Medicine, University of Ottawa
Ottawa Hospital Research Institute; University of Ottawa
Episode: Therapeutic Strategy for COVID-19-Induced Acute Respiratory Distress Syndrome
Elmira Safaie
PhD student in Duncan Stewart's lab; background in medical immunology
Ottawa Hospital Research Institute
Episode: Therapeutic Strategy for COVID-19-Induced Acute Respiratory Distress Syndrome
Chuck Murray
Chair of the Department of Stem Cell Biology and Regenerative Medicine; Director of the Eli and Edith Broad Center at USC; founder in industry
University of Southern California
Episode: Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations
Larry Goldstein
distinguished professor and policy advocate; former policy leader in stem cell research
University of California, San Diego; ISSCR Policy Committee
Episode: Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations
Clare Parish
Professor and Deputy Director of Science; leader of Stem Cell and Neurodevelopment Group
Florey Institute of Neuroscience and Mental Health, Melbourne
Episode: Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations
Martin Pera
Professor at The Jackson Laboratory; former Editor-in-Chief and Founder of The Stem Cell Report podcast
The Jackson Laboratory
Episode: Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations
Ying Xiao
Principal Investigator at Sir Run Run Shaw Hospital, Zhejiang University
Zhejiang University
Episode: Making Sense of Touch
Chaochen Wang
Associate Professor, Zhejiang University
Zhejiang University
Episode: Making Sense of Touch
Huipu Yuan
Research Associate, Sir Run Run Shaw Hospital/ Zhejiang University
Zhejiang University
Episode: Making Sense of Touch

Host

Janet Rossant
Editor-in-Chief of Stem Cell Reports; host of the show; affiliated with Stem Cell Reports and ISSCR.

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Talking Points

Recent interactions between the hosts and their guests.

Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations
Q: Martin, as you step away from editorial leadership, what would you like to see in future Stem Cell Reports podcast episodes and journal coverage?
A balance between deep-dive discussions on specific papers and broader conversations about policy, data science, organoids, and AI-driven data mining, with a continued emphasis on unproven stem cell therapies to guard against over-optimism, and a cadence that highlights the latest journal publications alongside thoughtful expert commentary.
Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations
Q: Larry, given your long-standing advocacy for fetal tissue research, how has NIH policy change impacted the field and what is your response to those shifts?
Policy shifts have caused a yo-yo effect, with restrictions tied to political cycles. Despite NIH funding fluctuations, fetal tissue remains crucial for understanding human development and validating stem cell-derived therapies; a comprehensive Stem Cell Reports review and advocacy by the Goldstein fellows helps illustrate the ongoing importance and applications.
Illuminating hPSC-derived Sensory Neurons
Q: What advice would you give your younger self?
Joriene would advise her younger self to spend more time reading literature to inspire better experimental design and build confidence.
Illuminating hPSC-derived Sensory Neurons
Q: What are the real roadblocks you see to clinical translation going forward?
Joriene expresses skepticism about using in vitro-derived neurons directly for treatment due to the challenges in achieving meaningful functional restoration, favoring their use as model systems to explore sensory neuropathy mechanisms instead.
Illuminating hPSC-derived Sensory Neurons
Q: How does that trajectory shape the kind of questions that your lab asks today?
Joriene explains how her early training in developmental biology informs her current research questions focused on the intrinsic and extrinsic mechanisms that allow sensory neurons to assume different phenotypes and functions.

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Frequently Asked Questions About The Stem Cell Report

What is The Stem Cell Report about and what kind of topics does it cover?

Across recent episodes, the show centers on translating stem cell science into real-world therapies and diagnostics, with deep dives into regenerative medicine, organoid and organ-on-chip models, and the regulatory and manufacturing hurdles that accompany clinical translation. Conversations weave clinical insight, basic biology, and policy context, often featuring researchers who bridge academia and industry, clinicians pushing trials, and leaders shaping funding and regulation. A standout trait is the frequent focus on practical pathways from benchtop findings to patient care, including safety considerations, standardized assays, and collaboration across disciplines. The host's background as a field editor and clinician-scientist tends to ... more

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1. Nature Podcast
2. Science Magazine Podcast
3. The Daily
4. Unexpected Elements
5. ASGCT Podcast Network

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The Stem Cell Report launched 5 years ago and published 49 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Stem Cell Report?

Recent guests on The Stem Cell Report include:

1. Duncan Stewart
2. Elmira Safaie
3. Chuck Murray
4. Larry Goldstein
5. Clare Parish
6. Martin Pera
7. Ying Xiao
8. Chaochen Wang

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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