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The Genetics Podcast

Sano Genetics
Gene Therapy
Genomics
Precision Medicine
Genetic Testing
Genetics
Clinical Trials
Alzheimer's Disease
Rare Diseases
Sano Genetics
Biotechnology
Aging
UK Biobank
Personalized Medicine
Drug Discovery
FDA
Neurodevelopmental Disorders
Artificial Intelligence
Breast Cancer
Machine Learning
Neurodegenerative Diseases

Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com

PublishesWeeklyEpisodes241Founded7 years ago
Number of ListenersCategories
ScienceNatural Sciences

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Artwork for The Genetics Podcast

Latest Episodes

This week on The Genetics Podcast, Patrick is joined by Salvador Rico, Chief Medical Officer at Encoded Therapeutics. With Encoded’s Dravet syndrome gene therapy program recently reaching major clinical and regulatory milestones, we’re revisiting thi... more

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This week on The Genetics Podcast, Patrick is joined by Dr. Vincent Dion, Group Leader at the UK Dementia Research Institute at Cardiff University. They discuss how repeat expansions drive Huntington’s disease and other neurological disorders, why DN... more

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This week on The Genetics Podcast, Patrick is joined by Dr. Paul Valdmanis, Associate Professor at the University of Washington. They discuss the impact of APOE4 on risk in Alzheimer’s disease, how long-read sequencing is uncovering hidden genetic va... more

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This week on The Genetics Podcast, Patrick is joined by Dr. Bin Yu, CDSS Chancellor’s Distinguished Professor at UC Berkeley. They discuss how different statistical approaches, from linear models to random forests, can be used to study complex geneti... more

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Recent Guests

Vincent Dion
Group leader at the UK Dementia Research Institute, Cardiff University
UK Dementia Research Institute, Cardiff University
Episode: EP 240: Hijacking DNA repair machinery to treat Huntington’s disease with Vincent Dion of the UKDRI
Paul Valdmanis
Associate Professor at the University of Washington
University of Washington
Episode: EP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul Valdmanis of the University of Washington
Bin Yu
Chancellor's Distinguished Professor at UC Berkeley, pioneer in interpretable machine learning
UC Berkeley
Episode: EP 238: Uncovering epistatic interactions in complex disease with machine learning with Bin Yu of UC Berkeley
Suzanne Schindler
Associate Professor of Neurology
Washington University in St. Louis
Episode: EP 235: Inside Alzheimer’s disease: Blood biomarkers and predicting symptoms with Suzanne Schindler of Washington University
Derek Ansel
Global vice president and therapeutic strategy lead for rare disease and oncology at Worldwide Clinical Trials
Worldwide Clinical Trials
Episode: EP 234: Inside rare disease trial operations: The role of CROs in an evolving landscape with Derek Ansel of Worldwide Clinical Trials
Tim Jobson
Medical Director of Predictive Health Intelligence and Consultant Physician at Somerset NHS Foundation Trust
Predictive Health Intelligence; Somerset NHS Foundation Trust
Episode: EP 233: Unlocking early detection in liver disease with data and genetics with Tim Jobson of Predictive Health Intelligence
Glenn Cohen
Professor of Law and Deputy Dean, Harvard Law School
Harvard Law School
Episode: EP 232: How ethics and law shape reproductive technology and AI in medicine with Glenn Cohen of Harvard Law School
Andrea Ganna
Associate Professor, Institute for Molecular Medicine Finland (FIMM); research associate at MGH and HMS
Institute for Molecular Medicine Finland (FIMM) / Massachusetts General Hospital / Harvard Medical School
Episode: EP 231: From polygenic scores to AI-driven medicine with Andrea Ganna of the Institute for Molecular Medicine Finland
Anna Lindstrand
Professor and consultant in clinical genetics and genomics at the Karolinska Institute and Karolinska University Hospital; directs the clinical genetics and genomics diagnostic laboratory and leads the rare disease research group
Karolinska Institute / Karolinska University Hospital
Episode: EP 230: From short reads to long reads in clinical genomics with Anna Lindstrand of Karolinska Institute

Host

Patrick Short
Host of The Genetics Podcast, focused on translating genetic science into actionable healthcare and industry insights.

Reviews

4.9 out of 5 stars from 162 ratings
  • Great Experience!

    Thank you for the opportunity to share our story from a parent led perspective about finding treatments for Usher syndrome. Patrick was an amazing host.

    Apple Podcasts
    5
    Jp knows
    United States7 months ago
  • Love the solo episode!

    Super informative. More please!

    Apple Podcasts
    5
    whirlaway25
    United States8 months ago
  • Smart, thoughtful, and always worth a listen

    The Genetics Podcast consistently delivers engaging, well-researched conversations with leading scientists and innovators. It is one of the best ways to stay informed about the discoveries shaping the field of genetics

    Apple Podcasts
    5
    moyavie
    United States8 months ago
  • Review

    Fascinating and awesome!! Thanks!

    Apple Podcasts
    5
    Polowonder
    United Statesa year ago
  • Super interesting content

    Great to see where precision medicine is heading and hear more about the companies that are working on new therapies

    Apple Podcasts
    5
    shwkdk
    United Kingdom2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Audience-friendly show with clear explanations of cutting-edge genetics topics.
Balanced guest mix delivers diverse perspectives from science to industry.
Guests are top experts; discussions are accessible without dumbing down complex topics.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

EP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul Valdmanis of the University of Washington
Q: What is the significance of studying PSEN1/PSEN2 with long-read sequencing?
Long-read sequencing reveals intron retention and cryptic exons that are enriched in sporadic Alzheimer's and may reflect novel mechanisms of disease beyond classic coding mutations, offering new biomarkers and therapeutic angles.
EP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul Valdmanis of the University of Washington
Q: How do these findings inform potential therapeutic approaches?
They highlight the value of understanding cell-type-specific regulatory elements and how enhancer disruption could be targeted or mimicked, and they point to gene therapy and precision medicine approaches tailored to specific genetic backgrounds.
EP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul Valdmanis of the University of Washington
Q: What is the main finding around APOE region variants using long-read sequencing?
A deletion near APOE disrupts a microglial enhancer region, affecting SPI-1 binding and APOE expression, which can reduce Alzheimer's risk, especially on an APOE4 background, and this protective effect is more evident in individuals of African ancestry.
EP 229: Turning personal tragedy into a movement for preventive genetics with Matthew Goldstein of jscreen
Q: What is the role of the nonprofit model in advancing preventive genetics?
By prioritizing patient access and subsidizing testing with philanthropic support, the nonprofit model reduces the pressure to prioritize margins, enabling broader testing, education, and equitable care across communities.
EP 229: Turning personal tragedy into a movement for preventive genetics with Matthew Goldstein of jscreen
Q: What are the biggest barriers to widespread adoption of carrier screening today?
Payor reimbursement, misaligned incentives, and the disconnect between powerful genetics capabilities and real-world clinical workflows. Addressing these requires education, streamlined implementation, and community-based strategies that make testing routine and accessible.

Audience Metrics

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Frequently Asked Questions About The Genetics Podcast

What is The Genetics Podcast about and what kind of topics does it cover?

The show centers on the latest in genetics and precision medicine, featuring interviews with researchers, biotech leaders, and clinicians who are pushing the boundaries of how genetic knowledge is translated into therapies, diagnostics, and scalable healthcare solutions. Episodes span carrier screening, viral genetics, gene therapy, de-extinction, newborn screening, and cutting-edge technologies like engineered tRNAs, RNAi, and large-scale biobanks, often highlighting practical challenges such as payor coverage, regulatory pathways, and patient advocacy. A notable strength is the diverse mix of researchers and industry executives who illuminate how fundamental science translates into real-world impact, making complex topics accessible for p... more

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Which podcasts are similar to The Genetics Podcast?

These podcasts share a similar audience with The Genetics Podcast:

1. The Long Run with Luke Timmerman
2. The Readout Loud
3. Biotech Hangout
4. BioCentury This Week
5. Ground Truths

How many episodes of The Genetics Podcast are there?

The Genetics Podcast launched 7 years ago and published 241 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Genetics Podcast?

Recent guests on The Genetics Podcast include:

1. Vincent Dion
2. Paul Valdmanis
3. Bin Yu
4. Suzanne Schindler
5. Derek Ansel
6. Tim Jobson
7. Glenn Cohen
8. Andrea Ganna

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