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The Genetics Podcast

Sano Genetics
Gene Therapy
Genomics
Precision Medicine
Genetic Testing
Genetics
Clinical Trials
Alzheimer's Disease
Rare Diseases
Sano Genetics
Biotechnology
Aging
UK Biobank
Drug Discovery
Personalized Medicine
FDA
Neurodevelopmental Disorders
Artificial Intelligence
Breast Cancer
Machine Learning
Neurodegenerative Diseases

Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com

PublishesWeeklyEpisodes244Founded7 years ago
Number of ListenersCategories
ScienceNatural Sciences

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Artwork for The Genetics Podcast

Latest Episodes

This week on The Genetics Podcast, Patrick is joined by Dr. Timothy Yu, Associate Professor of Pediatrics at Harvard Medical School and Physician/Researcher at Boston Children’s Hospital. They discuss how one child’s hidden genetic mutation led Tim i... more

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This week on The Genetics Podcast, Patrick is joined by Dr. Cara Altimus, CEO of BD², and Dr. Benjamin Neale, Associate Professor at Harvard Medical School and Massachusetts General Hospital. They discuss how rare variant discovery is opening new rou... more

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This week on The Genetics Podcast, Patrick is joined by Dr. Angela Bradshaw, Director for Research at Alzheimer Europe and honorary lecturer at the University of Glasgow. Following a series of recent episodes exploring Alzheimer’s disease research, w... more

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This week on The Genetics Podcast, Patrick is joined by Salvador Rico, Chief Medical Officer at Encoded Therapeutics. With Encoded’s Dravet syndrome gene therapy program recently reaching major clinical and regulatory milestones, we’re revisiting thi... more

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Recent Guests

Cara Altimus
CEO of BD², a bipolar research initiative
BD²
Episode: EP 243: How BD² is using genetics and deep phenotyping to transform bipolar research with Cara Altimus and Ben Neale
Ben Neale
Statistical geneticist; associate professor at Harvard Medical School and Broad Institute
Harvard Medical School; Broad Institute
Episode: EP 243: How BD² is using genetics and deep phenotyping to transform bipolar research with Cara Altimus and Ben Neale
Sal Rico
Chief Medical Officer, Encoded Therapeutics
Encoded Therapeutics
Episode: EP 241: The hard-won lessons behind Encoded Therapeutics’ Dravet syndrome gene therapy with Salvador Rico [Re-run]
Vincent Dion
Group leader at the UK Dementia Research Institute, Cardiff University
UK Dementia Research Institute, Cardiff University
Episode: EP 240: Hijacking DNA repair machinery to treat Huntington’s disease with Vincent Dion of the UKDRI
Paul Valdmanis
Associate Professor at the University of Washington
University of Washington
Episode: EP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul Valdmanis of the University of Washington
Bin Yu
Chancellor's Distinguished Professor at UC Berkeley, pioneer in interpretable machine learning
UC Berkeley
Episode: EP 238: Uncovering epistatic interactions in complex disease with machine learning with Bin Yu of UC Berkeley
Suzanne Schindler
Associate Professor of Neurology
Washington University in St. Louis
Episode: EP 235: Inside Alzheimer’s disease: Blood biomarkers and predicting symptoms with Suzanne Schindler of Washington University
Derek Ansel
Global vice president and therapeutic strategy lead for rare disease and oncology at Worldwide Clinical Trials
Worldwide Clinical Trials
Episode: EP 234: Inside rare disease trial operations: The role of CROs in an evolving landscape with Derek Ansel of Worldwide Clinical Trials
Tim Jobson
Medical Director of Predictive Health Intelligence and Consultant Physician at Somerset NHS Foundation Trust
Predictive Health Intelligence; Somerset NHS Foundation Trust
Episode: EP 233: Unlocking early detection in liver disease with data and genetics with Tim Jobson of Predictive Health Intelligence

Host

Patrick Short
Host of The Genetics Podcast

Reviews

4.9 out of 5 stars from 162 ratings
  • Great Experience!

    Thank you for the opportunity to share our story from a parent led perspective about finding treatments for Usher syndrome. Patrick was an amazing host.

    Apple Podcasts
    5
    Jp knows
    United States8 months ago
  • Love the solo episode!

    Super informative. More please!

    Apple Podcasts
    5
    whirlaway25
    United States8 months ago
  • Smart, thoughtful, and always worth a listen

    The Genetics Podcast consistently delivers engaging, well-researched conversations with leading scientists and innovators. It is one of the best ways to stay informed about the discoveries shaping the field of genetics

    Apple Podcasts
    5
    moyavie
    United States9 months ago
  • Review

    Fascinating and awesome!! Thanks!

    Apple Podcasts
    5
    Polowonder
    United Statesa year ago
  • Super interesting content

    Great to see where precision medicine is heading and hear more about the companies that are working on new therapies

    Apple Podcasts
    5
    shwkdk
    United Kingdom2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some episodes feel highly technical but remain understandable with context.
Shows are well-edited, with clear takeaways for practitioners and researchers.
Listeners praise accessible explanations of complex science.
Guests are high-caliber and topics stay relevant to precision medicine.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

EP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul Valdmanis of the University of Washington
Q: What is the significance of studying PSEN1/PSEN2 with long-read sequencing?
Long-read sequencing reveals intron retention and cryptic exons that are enriched in sporadic Alzheimer's and may reflect novel mechanisms of disease beyond classic coding mutations, offering new biomarkers and therapeutic angles.
EP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul Valdmanis of the University of Washington
Q: How do these findings inform potential therapeutic approaches?
They highlight the value of understanding cell-type-specific regulatory elements and how enhancer disruption could be targeted or mimicked, and they point to gene therapy and precision medicine approaches tailored to specific genetic backgrounds.
EP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul Valdmanis of the University of Washington
Q: What is the main finding around APOE region variants using long-read sequencing?
A deletion near APOE disrupts a microglial enhancer region, affecting SPI-1 binding and APOE expression, which can reduce Alzheimer's risk, especially on an APOE4 background, and this protective effect is more evident in individuals of African ancestry.
EP 229: Turning personal tragedy into a movement for preventive genetics with Matthew Goldstein of jscreen
Q: What is the role of the nonprofit model in advancing preventive genetics?
By prioritizing patient access and subsidizing testing with philanthropic support, the nonprofit model reduces the pressure to prioritize margins, enabling broader testing, education, and equitable care across communities.
EP 229: Turning personal tragedy into a movement for preventive genetics with Matthew Goldstein of jscreen
Q: What are the biggest barriers to widespread adoption of carrier screening today?
Payor reimbursement, misaligned incentives, and the disconnect between powerful genetics capabilities and real-world clinical workflows. Addressing these requires education, streamlined implementation, and community-based strategies that make testing routine and accessible.

Audience Metrics

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Frequently Asked Questions About The Genetics Podcast

What is The Genetics Podcast about and what kind of topics does it cover?

This program consistently covers cutting-edge genetics, translating complex research into practical implications for patients, clinicians, and industry. Episodes frequently feature researchers, clinicians, and biotech leaders who discuss topics like long-read sequencing, polygenic risk, biomarker development, gene therapies, and AI-driven health data. Notably, the show often bridges basic science with clinical translation, regulatory considerations, and patient advocacy, offering a broad view of how genetic insights are shaping precision medicine, diagnostics, and therapeutics. A standout strength is diverse guest selection—from university scientists to industry executives and policy experts—providing a well-rounded perspective for listener... more

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Which podcasts are similar to The Genetics Podcast?

These podcasts share a similar audience with The Genetics Podcast:

1. Science Friday
2. Nature Podcast
3. The Long Run with Luke Timmerman
4. The Readout Loud
5. The Joy of Why

How many episodes of The Genetics Podcast are there?

The Genetics Podcast launched 7 years ago and published 244 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Genetics Podcast?

Recent guests on The Genetics Podcast include:

1. Cara Altimus
2. Ben Neale
3. Sal Rico
4. Vincent Dion
5. Paul Valdmanis
6. Bin Yu
7. Suzanne Schindler
8. Derek Ansel

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