The Genetics Podcast

Sano Genetics

Gene Therapy

Genomics

Precision Medicine

Genetic Testing

Genetics

Clinical Trials

Alzheimer's Disease

Rare Diseases

Sano Genetics

Biotechnology

Aging

UK Biobank

Drug Discovery

Personalized Medicine

FDA

Neurodevelopmental Disorders

Artificial Intelligence

Breast Cancer

Parkinson's Disease

Machine Learning

Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com

162 ratings

Publishes	Weekly	Episodes	246	Founded	7 years ago
Number of Listeners		Categories	Natural SciencesScience

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Latest Episodes

EP 246: Turning a fatal diagnosis into a cure strategy: Accelerating C9orf72 ALS research with Yentli Soto Albrecht of CureC9

This week on The Genetics Podcast, Patrick is joined by Yentli Soto Albrecht, physician-scientist in training and founder of CureC9. They discuss how losing her father to C9orf72 ALS, and later learning her own genetic risk, reshaped the direction of... more

2 Jul 2026 • 34 min • Popular

YouTube

EP 245: Developing targeted therapies for ALS with Eric Green of Trace Neuroscience [Re-run]

This week on The Genetics Podcast, we're re-airing our conversation with Eric Green, Founder and CEO of Trace Neuroscience, Co-Founder and Chief Scientific Officer at Maze Therapeutics, and Adjunct Clinical Assistant Professor at Stanford University ... more

25 Jun 2026 • 43 min • Most popular

YouTube

EP 244: Building the first n-of-1 ASO: The new frontier of rare disease with Timothy Yu of Boston Children’s Hospital

This week on The Genetics Podcast, Patrick is joined by Dr. Timothy Yu, Associate Professor of Pediatrics at Harvard Medical School and Physician/Researcher at Boston Children’s Hospital. They discuss how one child’s hidden genetic mutation led Tim i... more

18 Jun 2026 • 44 min

YouTube

EP 243: How BD² is using genetics and deep phenotyping to transform bipolar research with Cara Altimus and Ben Neale

This week on The Genetics Podcast, Patrick is joined by Dr. Cara Altimus, CEO of BD², and Dr. Benjamin Neale, Associate Professor at Harvard Medical School and Massachusetts General Hospital. They discuss how rare variant discovery is opening new rou... more

11 Jun 2026 • 47 min

YouTube

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Recent Guests

Timothy Yu

Physician-scientist focusing on personalized genetic medicine and N-of-1 therapies

Boston Children's Hospital, Harvard Medical School

Episode: EP 244: Building the first n-of-1 ASO: The new frontier of rare disease with Timothy Yu of Boston Children’s Hospital

Cara Altimus

CEO of BD², a bipolar research initiative

BD²

Episode: EP 243: How BD² is using genetics and deep phenotyping to transform bipolar research with Cara Altimus and Ben Neale

Ben Neale

Statistical geneticist; associate professor at Harvard Medical School and Broad Institute

Harvard Medical School; Broad Institute

Episode: EP 243: How BD² is using genetics and deep phenotyping to transform bipolar research with Cara Altimus and Ben Neale

Sal Rico

Chief Medical Officer, Encoded Therapeutics

Encoded Therapeutics

Episode: EP 241: The hard-won lessons behind Encoded Therapeutics’ Dravet syndrome gene therapy with Salvador Rico [Re-run]

Vincent Dion

Group leader at the UK Dementia Research Institute, Cardiff University

UK Dementia Research Institute, Cardiff University

Episode: EP 240: Hijacking DNA repair machinery to treat Huntington’s disease with Vincent Dion of the UKDRI

Paul Valdmanis

Associate Professor at the University of Washington

University of Washington

Episode: EP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul Valdmanis of the University of Washington

Bin Yu

Chancellor's Distinguished Professor at UC Berkeley, pioneer in interpretable machine learning

UC Berkeley

Episode: EP 238: Uncovering epistatic interactions in complex disease with machine learning with Bin Yu of UC Berkeley

Sarah Marzi

Senior lecturer at King's College London and group leader at the UK Dementia Research Institute

King's College London; UK Dementia Research Institute

Episode: EP 237: How genetics and environment shape neurodegeneration in Alzheimer's and Parkinson's with Sarah Marzi of King’s College London

Suzanne Schindler

Associate Professor of Neurology

Washington University in St. Louis

Episode: EP 235: Inside Alzheimer’s disease: Blood biomarkers and predicting symptoms with Suzanne Schindler of Washington University

Host

Patrick Short

Host of The Genetics Podcast

Reviews

4.9 out of 5 stars from 162 ratings

Great Experience!
Thank you for the opportunity to share our story from a parent led perspective about finding treatments for Usher syndrome. Patrick was an amazing host.
Apple Podcasts
5
Jp knows
United States8 months ago
Love the solo episode!
Super informative. More please!
Apple Podcasts
5
whirlaway25
United States9 months ago
Smart, thoughtful, and always worth a listen
The Genetics Podcast consistently delivers engaging, well-researched conversations with leading scientists and innovators. It is one of the best ways to stay informed about the discoveries shaping the field of genetics
Apple Podcasts
5
moyavie
United States9 months ago
Review
Fascinating and awesome!! Thanks!
Apple Podcasts
5
Polowonder
United Statesa year ago
Super interesting content
Great to see where precision medicine is heading and hear more about the companies that are working on new therapies
Apple Podcasts
5
shwkdk
United Kingdom2 years ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some episodes feel highly technical but remain understandable with context.

Shows are well-edited, with clear takeaways for practitioners and researchers.

Listeners praise accessible explanations of complex science.

Guests are high-caliber and topics stay relevant to precision medicine.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#75	United States/Science/Natural Sciences
Apple Podcasts	#27	United Kingdom/Science/Natural Sciences
Apple Podcasts	#190	Canada/Science/Natural Sciences
Apple Podcasts	#239	United Kingdom/Science
Apple Podcasts	#51	Australia/Science/Natural Sciences
Apple Podcasts	#78	Italy/Science/Natural Sciences

Talking Points

Recent interactions between the hosts and their guests.

EP 237: How genetics and environment shape neurodegeneration in Alzheimer's and Parkinson's with Sarah Marzi of King’s College London

Q: What are the most promising therapeutic angles given the multi-cell type cascade in neurodegenerative diseases?

The most promising approach may be a cocktail that modulates upstream causal pathways, preserves synaptic function, and supports neuronal survival, rather than targeting a single gene. This includes strategies to influence microglial states, lipid handling, and possibly modulation of vitamin D receptor signaling to mitigate APOE4-related dysfunctions.

EP 237: How genetics and environment shape neurodegeneration in Alzheimer's and Parkinson's with Sarah Marzi of King’s College London

Q: What do we know about how environmental risks and genetics interact, and is the interaction additive or multiplicative?

It's clear there is at least an additive effect of genetics and environment, but determining whether interactions are multiplicative is hard. The evidence suggests gene-environment interactions exist, but the precise nature of these interactions—whether certain environments amplify genetic risk more than others—remains an active area of research.

EP 237: How genetics and environment shape neurodegeneration in Alzheimer's and Parkinson's with Sarah Marzi of King’s College London

Q: Just before we get into the details of some of your interesting recent work, can you share a couple of concrete examples to help make this real?

I highlighted work on microglia and how APOE variants shape their function, showing that APOE4 microglia are more pro-inflammatory and less migratory, which likely affects how they clear debris and respond to disease signals in Alzheimer's. I also described how we use xenotransplantation to study human microglia with different APOE backgrounds in an Alzheimer's mouse model to observe functional consequences.

EP 244: Building the first n-of-1 ASO: The new frontier of rare disease with Timothy Yu of Boston Children’s Hospital

Q: How has the field evolved to enable more patients and collaboration?

Expansion to dozens of patients across programs, the formation of the N-of-1 Collaborative, and partnerships with industry and nonprofits have created a scalable ecosystem to share learnings and resources while maintaining patient focus.

EP 244: Building the first n-of-1 ASO: The new frontier of rare disease with Timothy Yu of Boston Children’s Hospital

Q: Could you walk us through Mila's story and how it catalyzed the n-of-1 approach?

The Mila case showed that a deep intronic mutation could be therapeutically targeted by antisense oligonucleotides after standard tests failed, turning a diagnostic breakthrough into a potential treatment and inspiring the broader N-of-1 framework.

Audience Metrics

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Frequently Asked Questions About The Genetics Podcast

What is The Genetics Podcast about and what kind of topics does it cover?

This program consistently covers cutting-edge genetics, translating complex research into practical implications for patients, clinicians, and industry. Episodes frequently feature researchers, clinicians, and biotech leaders who discuss topics like long-read sequencing, polygenic risk, biomarker development, gene therapies, and AI-driven health data. Notably, the show often bridges basic science with clinical translation, regulatory considerations, and patient advocacy, offering a broad view of how genetic insights are shaping precision medicine, diagnostics, and therapeutics. A standout strength is diverse guest selection—from university scientists to industry executives and policy experts—providing a well-rounded perspective for listener... more

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Which podcasts are similar to The Genetics Podcast?

These podcasts share a similar audience with The Genetics Podcast:

1. The Long Run with Luke Timmerman
2. The Readout Loud
3. Raging Moderates with Scott Galloway and Jessica Tarlov
4. The Prof G Pod with Scott Galloway
5. Ground Truths

How many episodes of The Genetics Podcast are there?

The Genetics Podcast launched 7 years ago and published 246 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Genetics Podcast?

Recent guests on The Genetics Podcast include:

1. Timothy Yu
2. Cara Altimus
3. Ben Neale
4. Sal Rico
5. Vincent Dion
6. Paul Valdmanis
7. Bin Yu
8. Sarah Marzi

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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