The Genetics Podcast

Sano Genetics

Gene Therapy

Genomics

Precision Medicine

Genetics

Genetic Testing

Clinical Trials

Alzheimer's Disease

Rare Diseases

Sano Genetics

Biotechnology

Aging

Drug Discovery

UK Biobank

Personalized Medicine

FDA

Artificial Intelligence

Neurodevelopmental Disorders

Breast Cancer

Neurodegenerative Diseases

Parkinson's Disease

Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com

168 ratings

Publishes	Weekly	Episodes	259	Founded	7 years ago
Number of Listeners		Categories	Natural SciencesScience

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Latest Episodes

EP 259: A patient community driving awareness and research for Danon disease with Jenny Hsieh of the Danon Foundation

Summary

This week on The Genetics Podcast, Patrick is joined by Jenny Hsieh, Co-Founder and President of the Danon Foundation. They discuss how Danon disease affects males and females, why it is so often misdiagnosed, the current therapy landscape a... more

1 Oct 2026 • 38 min

YouTube

EP 258: The mutations hiding in healthy tissues with Inigo Martincorena of the Wellcome Sanger Institute

This week on The Genetics Podcast, Patrick is joined by Dr. Inigo Martincorena, Group Leader at the Wellcome Sanger Institute. They discuss the discovery of widespread cancer-driver mutations in normal tissue, the role of somatic mutations in autoimm... more

24 Sep 2026 • 39 min • Most popular

YouTube

EP 257: Managing hereditary cancer risk and medical uncertainty with Marleah Dean Kruzel of the University of South Florida

This week on The Genetics Podcast, Patrick is joined by Dr. Marleah Dean Kruzel, Professor of Communication at the University of South Florida. They discuss her personal path from watching breast cancer move through her family to testing positive for... more

17 Sep 2026 • 39 min

YouTube

EP 256: Cutting through the AI hype in drug discovery with Dave Hallett of Recursion

This week on The Genetics Podcast, Patrick is joined by Dr. David Hallett, Chief Scientific Officer at Recursion. They discuss the biggest shifts in drug discovery over Dave's three-decade career, where AI is genuinely transforming the field today ve... more

10 Sep 2026 • 40 min

YouTube

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Recent Guests

Marleah Dean Kruzel

Professor of Communication at the University of South Florida

University of South Florida

Episode: EP 257: Managing hereditary cancer risk and medical uncertainty with Marleah Dean Kruzel of the University of South Florida

Dave Hallett

Chief Scientific Officer at Recursion

Recursion

Episode: EP 256: Cutting through the AI hype in drug discovery with Dave Hallett of Recursion

Danny E. Miller

Physician-scientist, assistant professor in Pediatrics and Genetic Medicine

University of Washington

Episode: EP 255: Turning long-read sequencing into a routine part of clinical care with Danny Miller of the University of Washington

Brent Richards

Professor of Medicine and Human Genetics at McGill University and CEO of 5PrimeSciences

McGill University; 5PrimeSciences

Episode: EP 254: Triangulating genetic evidence and dodging bias to pick winning drug targets with Brent Richards of 5 Prime Sciences

Andrew Jackson

Professor, MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh

University of Edinburgh

Episode: EP 253: The genetics of brain size, growth, and aging with Andrew Jackson of the University of Edinburgh

Stevie Ringel

Founder and CEO of Nome Therapeutics; founder of the Kizuna Foundation

Nome Therapeutics / Kizuna Foundation

Episode: EP 252: The diagnosis that became a mission to cure rare disease: Advancing genetic medicine using AI with Stevie Ringel of Nome

Jagesh Shah

Chief Scientific Officer at Mirai Bio

Mirai Bio

Episode: EP 251: Cracking the delivery barrier in genetic medicine with Jagesh Shah of Mirai Bio

Carl Anderson

Head of the Human Genetics Programme, Wellcome Sanger Institute

Wellcome Sanger Institute

Episode: EP 249: Building the world's most detailed genetic map of inflammatory bowel disease with Carl Anderson of the Wellcome Sanger Institute

Pradeep Natarajan

Preventive Cardiologist and Cardiovascular Geneticist at Mass General Hospital

Mass General Hospital

Episode: EP 248: The blood mutations rewriting cardiovascular risk: Clonal hematopoiesis and polygenic risk with Pradeep Natarajan of Massachusetts General Hospital

Host

Patrick Short

Host of The Genetics Podcast (Sano Genetics), focuses on genetics, translational science, and the biotech landscape.

Reviews

4.9 out of 5 stars from 168 ratings

Great Experience!
Thank you for the opportunity to share our story from a parent led perspective about finding treatments for Usher syndrome. Patrick was an amazing host.
Apple Podcasts
5
Jp knows
United Statesa year ago
Love the solo episode!
Super informative. More please!
Apple Podcasts
5
whirlaway25
United Statesa year ago
Smart, thoughtful, and always worth a listen
The Genetics Podcast consistently delivers engaging, well-researched conversations with leading scientists and innovators. It is one of the best ways to stay informed about the discoveries shaping the field of genetics
Apple Podcasts
5
moyavie
United Statesa year ago
Review
Fascinating and awesome!! Thanks!
Apple Podcasts
5
Polowonder
United States2 years ago
Super interesting content
Great to see where precision medicine is heading and hear more about the companies that are working on new therapies
Apple Podcasts
5
shwkdk
United Kingdom2 years ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

The host keeps discussions grounded and engaging for both scientists and patients.

Guests consistently bring cutting-edge insights from academia and industry.

Listeners appreciate accessible explanations of complex genetics topics.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#92	United States/Science/Natural Sciences
Apple Podcasts	#40	United Kingdom/Science/Natural Sciences
Apple Podcasts	#174	Canada/Science/Natural Sciences
Apple Podcasts	#45	France/Science/Natural Sciences
Apple Podcasts	#91	Italy/Science/Natural Sciences
Apple Podcasts	#126	Australia/Science/Natural Sciences

Talking Points

Recent interactions between the hosts and their guests.

EP 257: Managing hereditary cancer risk and medical uncertainty with Marleah Dean Kruzel of the University of South Florida

Q: How should healthcare systems adapt as more people learn about their genetic risks?

Healthcare should move beyond the initial disclosure to lifespan-oriented support, including psychosocial coping resources, family communication guidance, and co-design of tools with patients so information translates into real-world actions, not just data. This means empowering patients through ongoing support rather than treating genetics as a single encounter.

EP 257: Managing hereditary cancer risk and medical uncertainty with Marleah Dean Kruzel of the University of South Florida

Q: What are the key communication challenges when discussing genetic risk with family members, and how can people navigate them?

Communication is not a one-time event; it requires ongoing dialogue, follow-ups, and sensitivity to how relatives might react differently. Female relatives often bear a larger responsibility for disclosure. It's important to provide space for processing, reconnect after initial disclosure, and use shared decision-making with clinicians to guide conversations.

EP 257: Managing hereditary cancer risk and medical uncertainty with Marleah Dean Kruzel of the University of South Florida

Q: Can you walk us through the ART framework and give an example of how someone might apply it in a real situation?

The ART framework starts with assessing uncertainty as either dangerous or hopeful, identifying the type of uncertainty (healthcare, familial, financial, etc.), then reframing it to reduce fear, choosing information-seeking or avoidance strategies, and finally taking action with a plan and support from clinicians or loved ones. An example is a person with a positive genetic test facing ongoing MRI surveillance; they can reframe the test as an opportunity to gain actionable steps while rallying social support to manage the emotional load.

EP 255: Turning long-read sequencing into a routine part of clinical care with Danny Miller of the University of Washington

Q: How do you envision AI changing genetic data analysis and clinical practice in the near term?

AI will help synthesize large genomic and clinical datasets, accelerating insights, but we must balance optimism with safeguards to ensure learning and understanding aren't outsourced entirely; the goal is to use AI to augment clinicians and researchers, not replace critical thinking.

EP 254: Triangulating genetic evidence and dodging bias to pick winning drug targets with Brent Richards of 5 Prime Sciences

Q: Do you have a sense of how to weigh different types of genetic evidence when deciding which targets to pursue?

Yes. The approach is to triangulate across multiple, orthogonal lines of evidence so that biases in one line are countered by others. When different methods converge on the same direction and magnitude of effect, confidence in the target increases.

Audience Metrics

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Frequently Asked Questions About The Genetics Podcast

What is The Genetics Podcast about and what kind of topics does it cover?

Across recent episodes, the show centers on cutting-edge genetics, from rare disease therapy development and AI-enabled drug discovery to advances in gene delivery, somatic mutations, and precision medicine. Conversations frequently feature researchers, clinicians, and biotech leaders discussing mechanisms, translational challenges, regulatory pathways, and the business realities of bringing genetic therapies to patients. Notable threads include patient-centric approaches, scalable delivery platforms, data sharing and collaboration, and the evolving regulatory and manufacturing landscapes shaping next-gen genetic medicines. The program often blends technical depth with practical storytelling, helping listeners understand how scientific adva... more

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Which podcasts are similar to The Genetics Podcast?

These podcasts share a similar audience with The Genetics Podcast:

1. Biotech Hangout
2. The Long Run with Luke Timmerman
3. Ground Truths
4. The Readout Loud
5. NEJM AI Grand Rounds

How many episodes of The Genetics Podcast are there?

The Genetics Podcast launched 7 years ago and published 259 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Genetics Podcast?

Recent guests on The Genetics Podcast include:

1. Marleah Dean Kruzel
2. Dave Hallett
3. Danny E. Miller
4. Brent Richards
5. Andrew Jackson
6. Stevie Ringel
7. Jagesh Shah
8. Carl Anderson

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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