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The Genetics Podcast

Sano Genetics
Gene Therapy
Genomics
Precision Medicine
Genetic Testing
Genetics
Clinical Trials
Alzheimer's Disease
Rare Diseases
Sano Genetics
Biotechnology
Aging
UK Biobank
Personalized Medicine
Drug Discovery
FDA
Neurodevelopmental Disorders
Artificial Intelligence
Breast Cancer
Neurodegenerative Diseases
Parkinson's Disease

Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com

PublishesWeeklyEpisodes250Founded7 years ago
Number of ListenersCategories
Natural SciencesScience

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Artwork for The Genetics Podcast

Latest Episodes

This week on The Genetics Podcast, Patrick is joined by Sharon Terry, President & CEO of Genetic Alliance. They discuss how Sharon established a layperson-led biobank, her long-term work on rare diseases and patient advocacy, and her program to bring... more

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This week on The Genetics Podcast, Patrick is joined by Dr. Carl Anderson, Senior Group Leader and Head of the Human Genetics Programme at the Wellcome Sanger Institute, where he leads the Genomics of Inflammation and Immunity Group. They discuss IBD... more

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This week on The Genetics Podcast, Patrick is joined by Dr. Pradeep Natarajan, Director of Preventive Cardiology at Massachusetts General Hospital and Associate Professor of Medicine at Harvard Medical School. They discuss the discovery of clonal hem... more

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This week on The Genetics Podcast, Patrick is joined by Dr. Christopher Walsh, Professor of Pediatrics and Neurology at Harvard Medical School, Chief of Genetics and Genomics at Boston Children's Hospital, and HHMI Investigator. They discuss his path... more

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Recent Guests

Pradeep Natarajan
Preventive Cardiologist and Cardiovascular Geneticist at Mass General Hospital
Mass General Hospital
Episode: EP 248: The blood mutations rewriting cardiovascular risk: Clonal hematopoiesis and polygenic risk with Pradeep Natarajan of Massachusetts General Hospital
Christopher Walsh
Bullard Professor of Pediatrics and Neurology at Harvard Medical School; Chief of Genetics and Genomics at Boston Children's Hospital; HHMI Investigator
Harvard Medical School; Boston Children's Hospital; Howard Hughes Medical Institute
Episode: EP 247: Why neurons accumulate mutations like clockwork: Somatic mosaicism and neurodegeneration with Christopher Walsh of Boston Children's Hospital
Yentli Soto Albrecht
MD PhD trainee, carrier of C9orf72 expansion, focused on accelerating cure research
CureC9 (biorepository initiatives with BrainX cell)
Episode: EP 246: Turning a fatal diagnosis into a cure strategy: Accelerating C9orf72 ALS research with Yentli Soto Albrecht of CureC9
Eric Green
CEO and founder of Trace Neuroscience; former co-founder of Maze Therapeutics
Trace Neuroscience
Episode: EP 245: Developing targeted therapies for ALS with Eric Green of Trace Neuroscience [Re-run]
Timothy Yu
Physician-scientist focusing on personalized genetic medicine and N-of-1 therapies
Boston Children's Hospital, Harvard Medical School
Episode: EP 244: Building the first n-of-1 ASO: The new frontier of rare disease with Timothy Yu of Boston Children’s Hospital
Cara Altimus
CEO of BD², a bipolar research initiative
BD²
Episode: EP 243: How BD² is using genetics and deep phenotyping to transform bipolar research with Cara Altimus and Ben Neale
Ben Neale
Statistical geneticist; associate professor at Harvard Medical School and Broad Institute
Harvard Medical School; Broad Institute
Episode: EP 243: How BD² is using genetics and deep phenotyping to transform bipolar research with Cara Altimus and Ben Neale
Sal Rico
Chief Medical Officer, Encoded Therapeutics
Encoded Therapeutics
Episode: EP 241: The hard-won lessons behind Encoded Therapeutics’ Dravet syndrome gene therapy with Salvador Rico [Re-run]
Vincent Dion
Group leader at the UK Dementia Research Institute, Cardiff University
UK Dementia Research Institute, Cardiff University
Episode: EP 240: Hijacking DNA repair machinery to treat Huntington’s disease with Vincent Dion of the UKDRI

Host

Patrick Short
Host of The Genetics Podcast

Reviews

4.9 out of 5 stars from 163 ratings
  • Great Experience!

    Thank you for the opportunity to share our story from a parent led perspective about finding treatments for Usher syndrome. Patrick was an amazing host.

    Apple Podcasts
    5
    Jp knows
    United States9 months ago
  • Love the solo episode!

    Super informative. More please!

    Apple Podcasts
    5
    whirlaway25
    United States10 months ago
  • Smart, thoughtful, and always worth a listen

    The Genetics Podcast consistently delivers engaging, well-researched conversations with leading scientists and innovators. It is one of the best ways to stay informed about the discoveries shaping the field of genetics

    Apple Podcasts
    5
    moyavie
    United States10 months ago
  • Review

    Fascinating and awesome!! Thanks!

    Apple Podcasts
    5
    Polowonder
    United Statesa year ago
  • Super interesting content

    Great to see where precision medicine is heading and hear more about the companies that are working on new therapies

    Apple Podcasts
    5
    shwkdk
    United Kingdom2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some episodes feel highly technical but remain understandable with context.
Shows are well-edited, with clear takeaways for practitioners and researchers.
Listeners praise accessible explanations of complex science.
Guests are high-caliber and topics stay relevant to precision medicine.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

EP 247: Why neurons accumulate mutations like clockwork: Somatic mosaicism and neurodegeneration with Christopher Walsh of Boston Children's Hospital
Q: What therapeutic implications might arise from somatic mosaicism findings?
Therapies could target microglial inflammation or somatic mutations themselves, and cancer-targeted strategies may be repurposed to address the somatic mutations driving neurodegenerative processes.
EP 247: Why neurons accumulate mutations like clockwork: Somatic mosaicism and neurodegeneration with Christopher Walsh of Boston Children's Hospital
Q: What has changed in how we think about the brain with respect to mosaicism?
We shifted from viewing mosaicism as a rare curiosity to recognizing it as a widespread, age-related process that can influence disease risk, particularly through somatic mutations in microglia and neurons.
EP 248: The blood mutations rewriting cardiovascular risk: Clonal hematopoiesis and polygenic risk with Pradeep Natarajan of Massachusetts General Hospital
Q: What makes Tet2 especially compelling as a therapeutic target in CHIP-related cardiovascular disease?
Tet2 mutations consistently associate with inflammation-driven atherogenesis in models and human data; this has guided exploration of anti-inflammatory strategies (e.g., NLRP3 inflammasome inhibitors) as a therapeutic route.
EP 237: How genetics and environment shape neurodegeneration in Alzheimer's and Parkinson's with Sarah Marzi of King’s College London
Q: What are the most promising therapeutic angles given the multi-cell type cascade in neurodegenerative diseases?
The most promising approach may be a cocktail that modulates upstream causal pathways, preserves synaptic function, and supports neuronal survival, rather than targeting a single gene. This includes strategies to influence microglial states, lipid handling, and possibly modulation of vitamin D receptor signaling to mitigate APOE4-related dysfunctions.
EP 237: How genetics and environment shape neurodegeneration in Alzheimer's and Parkinson's with Sarah Marzi of King’s College London
Q: What do we know about how environmental risks and genetics interact, and is the interaction additive or multiplicative?
It's clear there is at least an additive effect of genetics and environment, but determining whether interactions are multiplicative is hard. The evidence suggests gene-environment interactions exist, but the precise nature of these interactions—whether certain environments amplify genetic risk more than others—remains an active area of research.

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Frequently Asked Questions About The Genetics Podcast

What is The Genetics Podcast about and what kind of topics does it cover?

This program consistently covers cutting-edge genetics, translating complex research into practical implications for patients, clinicians, and industry. Episodes frequently feature researchers, clinicians, and biotech leaders who discuss topics like long-read sequencing, polygenic risk, biomarker development, gene therapies, and AI-driven health data. Notably, the show often bridges basic science with clinical translation, regulatory considerations, and patient advocacy, offering a broad view of how genetic insights are shaping precision medicine, diagnostics, and therapeutics. A standout strength is diverse guest selection—from university scientists to industry executives and policy experts—providing a well-rounded perspective for listener... more

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1. Ground Truths
2. BioCentury This Week
3. The Readout Loud
4. Biotech Hangout
5. Nature Podcast

How many episodes of The Genetics Podcast are there?

The Genetics Podcast launched 7 years ago and published 250 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Genetics Podcast?

Recent guests on The Genetics Podcast include:

1. Pradeep Natarajan
2. Christopher Walsh
3. Yentli Soto Albrecht
4. Eric Green
5. Timothy Yu
6. Cara Altimus
7. Ben Neale
8. Sal Rico

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