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The Genetics Podcast

Sano Genetics
Gene Therapy
Genomics
Precision Medicine
Genetic Testing
Genetics
Clinical Trials
Alzheimer's Disease
Rare Diseases
Sano Genetics
Biotechnology
Aging
UK Biobank
Drug Discovery
Personalized Medicine
FDA
Neurodevelopmental Disorders
Artificial Intelligence
Breast Cancer
Neurodegenerative Diseases
Parkinson's Disease

Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com

PublishesWeeklyEpisodes253Founded7 years ago
Number of ListenersCategories
Natural SciencesScience

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Artwork for The Genetics Podcast

Latest Episodes

This week on The Genetics Podcast, Patrick is joined by Dr. Andrew Jackson, Programme Leader at the MRC Human Genetics Unit at the University of Edinburgh. They discuss how his lab discovered that gain-of-function DNMT3A mutations cause both microcep... more

YouTube

This week on The Genetics Podcast, Patrick is joined by Stevie Ringel, co-founder of Nome and founder of the Kizuna Foundation. They discuss Stevie's own ultra-rare disease diagnosis and shaped his path to founding Kizuna Foundation and Nome, how Nom... more

YouTube

This week on The Genetics Podcast, Patrick is joined by Dr. Jagesh Shah, Chief Scientific Officer at Mirai Bio. They discuss why delivery is a central bottleneck holding back nucleic acid medicines, how Mirai's lipid nanoparticle (LNP) platform is bu... more

YouTube

This week on The Genetics Podcast, Patrick is joined by Sharon Terry, President & CEO of Genetic Alliance. They discuss how Sharon established a layperson-led biobank, her long-term work on rare diseases and patient advocacy, and her program to bring... more

YouTube

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Recent Guests

Jagesh Shah
Chief Scientific Officer at Mirai Bio
Mirai Bio
Episode: EP 251: Cracking the delivery barrier in genetic medicine with Jagesh Shah of Mirai Bio
Carl Anderson
Head of the Human Genetics Programme, Wellcome Sanger Institute
Wellcome Sanger Institute
Episode: EP 249: Building the world's most detailed genetic map of inflammatory bowel disease with Carl Anderson of the Wellcome Sanger Institute
Pradeep Natarajan
Preventive Cardiologist and Cardiovascular Geneticist at Mass General Hospital
Mass General Hospital
Episode: EP 248: The blood mutations rewriting cardiovascular risk: Clonal hematopoiesis and polygenic risk with Pradeep Natarajan of Massachusetts General Hospital
Christopher Walsh
Bullard Professor of Pediatrics and Neurology at Harvard Medical School; Chief of Genetics and Genomics at Boston Children's Hospital; HHMI Investigator
Harvard Medical School; Boston Children's Hospital; Howard Hughes Medical Institute
Episode: EP 247: Why neurons accumulate mutations like clockwork: Somatic mosaicism and neurodegeneration with Christopher Walsh of Boston Children's Hospital
Yentli Soto Albrecht
MD PhD trainee, carrier of C9orf72 expansion, focused on accelerating cure research
CureC9 (biorepository initiatives with BrainX cell)
Episode: EP 246: Turning a fatal diagnosis into a cure strategy: Accelerating C9orf72 ALS research with Yentli Soto Albrecht of CureC9
Eric Green
CEO and founder of Trace Neuroscience; former co-founder of Maze Therapeutics
Trace Neuroscience
Episode: EP 245: Developing targeted therapies for ALS with Eric Green of Trace Neuroscience [Re-run]
Timothy Yu
Physician-scientist focusing on personalized genetic medicine and N-of-1 therapies
Boston Children's Hospital, Harvard Medical School
Episode: EP 244: Building the first n-of-1 ASO: The new frontier of rare disease with Timothy Yu of Boston Children’s Hospital
Cara Altimus
CEO of BD², a bipolar research initiative
BD²
Episode: EP 243: How BD² is using genetics and deep phenotyping to transform bipolar research with Cara Altimus and Ben Neale
Ben Neale
Statistical geneticist; associate professor at Harvard Medical School and Broad Institute
Harvard Medical School; Broad Institute
Episode: EP 243: How BD² is using genetics and deep phenotyping to transform bipolar research with Cara Altimus and Ben Neale

Host

Patrick Short
Host of The Genetics Podcast

Reviews

4.9 out of 5 stars from 163 ratings
  • Great Experience!

    Thank you for the opportunity to share our story from a parent led perspective about finding treatments for Usher syndrome. Patrick was an amazing host.

    Apple Podcasts
    5
    Jp knows
    United States10 months ago
  • Love the solo episode!

    Super informative. More please!

    Apple Podcasts
    5
    whirlaway25
    United States10 months ago
  • Smart, thoughtful, and always worth a listen

    The Genetics Podcast consistently delivers engaging, well-researched conversations with leading scientists and innovators. It is one of the best ways to stay informed about the discoveries shaping the field of genetics

    Apple Podcasts
    5
    moyavie
    United Statesa year ago
  • Review

    Fascinating and awesome!! Thanks!

    Apple Podcasts
    5
    Polowonder
    United Statesa year ago
  • Super interesting content

    Great to see where precision medicine is heading and hear more about the companies that are working on new therapies

    Apple Podcasts
    5
    shwkdk
    United Kingdom2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some episodes feel highly technical but remain understandable with context.
Shows are well-edited, with clear takeaways for practitioners and researchers.
Listeners praise accessible explanations of complex science.
Guests are high-caliber and topics stay relevant to precision medicine.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

EP 251: Cracking the delivery barrier in genetic medicine with Jagesh Shah of Mirai Bio
Q: What is the role of ML in your platform, and how does the feedback loop between in vivo results and formulation guide the next experiments?
ML uses in vivo results to guide formulation and chemistry choices, creating an iterative flywheel where each round informs the next, balancing exploration and exploitation to broaden biodistribution while maintaining tolerability.
EP 251: Cracking the delivery barrier in genetic medicine with Jagesh Shah of Mirai Bio
Q: Can you compare lipid nanoparticles to viral vectors and describe why Mirai focuses on LNPs for in vivo delivery?
Lipid nanoparticles offer tunable biodistribution, reduced immunogenicity with careful formulation, and the possibility of systemic delivery, whereas viral vectors have strong tropism but higher immunogenicity and cargo-size limitations; Mirai aims to decouple targeting from cargo via modular LNPs and ML-driven optimization.
EP 251: Cracking the delivery barrier in genetic medicine with Jagesh Shah of Mirai Bio
Q: For people who are not as in the details, could you frame the delivery challenge and what exactly people mean when they say delivery is the bottleneck?
Delivery is about getting nucleic acids into the right cells without degradation, avoiding immune clearance, and achieving meaningful tissue-level distribution; it's about translating a biological target into a therapeutic delivery that can reach- and act on- the intended cells.
EP 249: Building the world's most detailed genetic map of inflammatory bowel disease with Carl Anderson of the Wellcome Sanger Institute
Q: How have the advances in single-cell data changed our view of disease subtypes and potential therapies?
The discussion highlights that subtypes are challenging due to sample size and disease progression differences, but larger cohorts and finer cell-type resolution are enabling identification of disease subtypes and potentially tailoring therapies.
EP 249: Building the world's most detailed genetic map of inflammatory bowel disease with Carl Anderson of the Wellcome Sanger Institute
Q: Could you talk a little about the resource you built and the recent findings you shared?
Carl explains that IBD-Verse is a cohort with gut biopsies and blood samples from Crohn's patients and controls, enabling single-cell maps of gene regulation in gut tissues across many cell types, which helps identify genes perturbed by IBD GWAS signals.

Audience Metrics

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Frequently Asked Questions About The Genetics Podcast

What is The Genetics Podcast about and what kind of topics does it cover?

This program consistently covers cutting-edge genetics, translating complex research into practical implications for patients, clinicians, and industry. Episodes frequently feature researchers, clinicians, and biotech leaders who discuss topics like long-read sequencing, polygenic risk, biomarker development, gene therapies, and AI-driven health data. Notably, the show often bridges basic science with clinical translation, regulatory considerations, and patient advocacy, offering a broad view of how genetic insights are shaping precision medicine, diagnostics, and therapeutics. A standout strength is diverse guest selection—from university scientists to industry executives and policy experts—providing a well-rounded perspective for listener... more

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Which podcasts are similar to The Genetics Podcast?

These podcasts share a similar audience with The Genetics Podcast:

1. Ground Truths
2. Nature Podcast
3. The Readout Loud
4. Biotech Hangout
5. DNA Today: A Genetics Podcast

How many episodes of The Genetics Podcast are there?

The Genetics Podcast launched 7 years ago and published 253 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Genetics Podcast?

Recent guests on The Genetics Podcast include:

1. Jagesh Shah
2. Carl Anderson
3. Pradeep Natarajan
4. Christopher Walsh
5. Yentli Soto Albrecht
6. Eric Green
7. Timothy Yu
8. Cara Altimus

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