The Brain Podcast

Brain

Alzheimer's Disease

Neurodegeneration

Multiple Sclerosis

Neuroscience

Anti-Iglon 5 Disease

Human Leukocyte Antigens

Neuroimmunology

Academic Neurology

Pain Perception

Progressive Supranuclear Palsy

Clinical Practice

Autoimmunity

Hla-Dqb1*05

Parkinson's Disease

Congenital Myasthenic Syndromes

Nociception

Chronic Pain

Diagnosis

Dementia

Dopamine

A fascinating, informative and digestible podcast highlighting the rich and diverse neuroscience published in the Brain journals. The episodes will take the format of interviews with article authors and the aim is to produce an informal and enjoyable podcast that appeals to a broad audience including clinicians, researchers, students, neuroscientists, neurologists, neurosurgeons and psychiatrists

21 ratings

Publishes	Infrequently	Episodes	37	Founded	4 years ago
Number of Listeners		Categories	Life SciencesScience

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Latest Episodes

Propionic acid in Multiple Sclerosis: could a short chain fatty acid improve neuroinflammation and neurodegeneration?

Welcome to the 37th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author Dr Tobias Moser of the Brain article entitled: Propionic acid in multiple ... more

29 Jul 2026 • 25 min • Most popular

Distinct brain atrophy patterns in anti-IgLON5 disease

Welcome to the 36th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with senior author Dr Carsten Finke of the Brain article entitled: Brain atrophy patterns in... more

24 Jun 2026 • 22 min

Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity

Welcome to the 35th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author Dr Laetitia Marcadet and senior author Chantelle F Sephton of the Brain ar... more

22 Apr 2026 • 29 min

Brain connectivity as a new target for Alzheimer's disease therapy?

Welcome to the 34th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author Dr Lorenzo Pini of the Brain article entitled: Brain connectivity as a new... more

18 Feb 2026 • 25 min

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Recent Guests

Tobias Moser

First author of the paper; neurologist and associate professor of neurology

University Clinic of Salzburg

Episode: Propionic acid in Multiple Sclerosis: could a short chain fatty acid improve neuroinflammation and neurodegeneration?

Carsten Finke

Professor of Neurology

Charité – Universitätsmedizin Berlin

Episode: Distinct brain atrophy patterns in anti-IgLON5 disease

Dr. Chantelle Sephton

Senior author, professor, Laval University

Laval University

Episode: Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity

Laetitia Marcadet

Co-first author, research scientist in Sephton lab

Laval University

Episode: Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity

Dr. Lorenzo Pini

Researcher in the Department of Neuroscience

University of Padua

Episode: Brain connectivity as a new target for Alzheimer's disease therapy?

Dr. Tracy Young-Pearse

Associate Professor of Neurology

Brigham and Women's Hospital and Harvard Medical School

Episode: Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment

Dr. Courtney Benoit

Research Scientist

Anne Romney Center for Neurologic Diseases and the Neuroscience Institute

Episode: Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment

Philipp Koch

Neurology trainee at Charité Berlin

Charité Berlin

Episode: Neurotransmitter-informed connectivity maps and predicting stroke functional outcome

Ifrah Zawah

Assistant professor of neurology

University of Virginia

Episode: Do seizures drive the neuropathology of dementia? Insights from a post-mortem study

Host

Michael David

Host and co-host focused on neurology topics; clinical researcher

Reviews

4.5 out of 5 stars from 21 ratings

I can’t hear you.
Potentially valuable neurology BUT most of the authors use substandard microphones leading to pathetic audio quality.
Apple Podcasts
2
1111X
United States2 months ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Content is highly relevant and scientifically rigorous for neuroscience professionals.

Audio quality can be inconsistent due to microphone setup.

Discussions often bridge bench research and clinical applications, which is engaging.

Guests are well-credentialed and provide clear implications for practice and research.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#206	Canada/Science/Life Sciences
Apple Podcasts	#242	United Kingdom/Science/Life Sciences
Apple Podcasts	#19	Italy/Science/Life Sciences
Apple Podcasts	#33	Germany/Science/Life Sciences
Apple Podcasts	#138	Australia/Science/Life Sciences
Apple Podcasts	#194	France/Science/Life Sciences

Talking Points

Recent interactions between the hosts and their guests.

Distinct brain atrophy patterns in anti-IgLON5 disease

Q: Could you summarize what's known about IgLON5 functions in a healthy nervous system?

IgLON5 acts as a cell adhesion molecule; its exact physiological role is still being clarified, but antibodies against IgLON5 are linked to neuronal hyperexcitability and tau pathology, suggesting a mechanism that connects autoimmunity to neurodegeneration.

Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity

Q: Could you tell us a bit about the research questions and could you summarize the findings of your study?

The study investigates whether lipid dysregulation and lipid droplet accumulation contribute to cellular stress in neurons and astrocytes in FUS-related ALS, and whether promoting lipid utilization via beta-oxidation can mitigate this lipotoxicity. They found that lipid droplets accumulate and that Arimocromol can reduce droplets and acylcarnitins, likely by enhancing beta-oxidation, but long-term activation of lipid utilization may cause additional stress, indicating a need for balanced metabolic interventions.

Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment

Q: Can you tell us a little bit more about how you identify the phenotype and the implications, perhaps relating to autism spectrum disorders?

We identified premature radial glial specification as a phenotype through unbiased analyses, which suggests alterations in neural progenitor cell behavior can impact cortical development and relate to conditions such as autism spectrum disorders.

Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment

Q: What did you learn about the disruption of its function based on these results?

POU3F2 transcriptionally activates SOX13 and ADMP, which are involved in Wnt signaling regulation in neural progenitor cells, suggesting it plays a key role in controlling neurodevelopmental processes.

Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment

Q: Can you tell us a little bit about your gene of interest in the study POU3F2 and how you came to focus on this gene?

POU3F2, also called Brain2, is a neural transcription factor implicated in various neuropsychiatric and neurodevelopmental disorders. We began our work on it due to its consistent association with bipolar disorder and rare mutations linked to autism spectrum disorder.

Audience Metrics

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Frequently Asked Questions About The Brain Podcast

What is The Brain Podcast about and what kind of topics does it cover?

The show centers on interviews with authors of Brain journal articles, translating complex neuroscience research into accessible discussions. Recent episodes cover topics from propionic acid in neuroinflammation and MS to brain connectivity in Alzheimer's, autoimmune and neurodegenerative mechanisms, and neurodevelopmental genetics. Guests are typically senior researchers, clinicians, and professors who bring deep domain expertise, making the episodes valuable for clinicians, researchers, and students seeking practical insights and future directions in neuroscience. A notable strength is its ability to connect cutting-edge brain science to clinical implications, trial endpoints, and emerging therapeutic concepts, often with multi-center or ... more

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Which podcasts are similar to The Brain Podcast?

These podcasts share a similar audience with The Brain Podcast:

1. Neurology® Podcast
2. Practical Neurology Podcast
3. Continuum Audio
4. MDS Podcast
5. Nature Podcast

How many episodes of The Brain Podcast are there?

The Brain Podcast launched 4 years ago and published 37 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Brain Podcast?

Recent guests on The Brain Podcast include:

1. Tobias Moser
2. Carsten Finke
3. Dr. Chantelle Sephton
4. Laetitia Marcadet
5. Dr. Lorenzo Pini
6. Dr. Tracy Young-Pearse
7. Dr. Courtney Benoit
8. Philipp Koch

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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