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RealTalk MS

Jon Strum
Multiple Sclerosis
Disease-Modifying Therapies
National MS Society
Vision Issues
Neurology
Optical Coherence Tomography
Optic Neuritis
Dunk MS
Diagnosis
Teaams Study
Exercise Programs
Clinical Trials
Aging and MS
Pacific Neuroscience Institute
Neurorehabilitation
Socioeconomic Disparities
General Health
Telehealth
Vitamin D
Patient Involvement

Jon Strum cuts through all the jargon and breaks down the latest multiple sclerosis news. You'll meet the scientists who are creating tomorrow's MS treatments today. You'll hear from the experts discussing how the latest tweaks and changes to our healthcare laws will impact your MS treatment. And we'll be talking to the courageous MS warriors who are out there advocating on behalf of the MS commun... more

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Artwork for RealTalk MS

Latest Episodes

Welcome back to Part Two of our coverage of the 2026 ACTRIMS Forum. This week, we shift our focus to emerging therapies and clinical insights that are re-shaping the future of MS care. From the latest information on stem cell transplantation to evolv... more

Last week, over 1,400 scientists and clinicians gathered in San Diego, California, at the 2026 Americas Committee for Treatment and Research in Multiple Sclerosis annual meeting, better known as the ACTRIMS Forum. This week, in Part One of our covera... more

This past December, the FDA issued a Complete Response Letter to drug manufacturer Sanofi in response to Sanofi's application seeking approval for Tolebrutinib, the first in a new category of investigational disease-modifying therapies to undergo FDA... more

The first coordinated global research strategy to prevent MS has been announced. This week, Dr. Bruce Bebo, the National MS Society's Executive Vice President and Chief Research & Medical Affairs Officer, joins me to explain what MS prevention looks ... more

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Recent Guests

Dr. Jeffrey Cohen
Neurologist at Cleveland Clinic's Mellon Center for Multiple Sclerosis and Director of Experimental Therapeutics Program
Cleveland Clinic
Episode: Episode 442: The 2026 ACTRIMS Forum (Part 2) with Dr. Jeffrey Cohen, Dr. Daniel Ontaneda, and Kristine Werner Ozug
Dr. Manuel Friese
Clinician-scientist at the Institute of Neuroimmunology and Multiple Sclerosis in Germany and winner of the Barancik Prize for Innovation in MS Research.
Institute of Neuroimmunology and Multiple Sclerosis
Episode: Episode 441: The 2026 ACTRIMS Forum with Dr. Manuel Friese, Dr. Amit Bar-Or, and Dr. Haritha Desu
Dr. Haritha Desu
Postdoctoral neuroscientist focusing on immune cell interactions in MS.
Centre Hospitalier de l'Université de Montréal
Episode: Episode 441: The 2026 ACTRIMS Forum with Dr. Manuel Friese, Dr. Amit Bar-Or, and Dr. Haritha Desu
Dr. William Conte
MS specialist and principal investigator in the Phase 3 clinical trial for Tolebrutinib
Episode: Episode 440: An MS Specialist's Response to the FDA with Dr. William Conte
Dr. Bruce Bebo
Executive Vice President and Chief Research and Medical Affairs Officer at the National MS Society
National MS Society
Episode: Episode 439: Preventing MS with Dr. Bruce Bebo
Dr. Arman Eshaghi
Principal investigator of the study on MS subtypes
University College London
Episode: Episode 438: The Discovery of 2 MS Subtypes with Dr. Arman Eshaghi
David Mitchell
Founder of Patients for Affordable Drugs, cancer patient, and advocate for drug price reform
Patients for Affordable Drugs
Episode: Episode 437: Remembering David Mitchell
Amanda Montague
MS advocate and interim president and CEO of the Multiple Sclerosis Association of America
Multiple Sclerosis Association of America
Episode: Special Episode: Guiding the Future of MS Care: MS21 Consensus Recommendations for Improving MS Care to Relieve the Burden of Disease
Elisabeth G. Celius
Consultant neurologist with a special focus on MS at Oslo University Hospital, leader of the MS Research Group
Oslo University Hospital
Episode: Special Episode: Guiding the Future of MS Care: MS21 Consensus Recommendations for Improving MS Care to Relieve the Burden of Disease

Host

Jon Strum
Host of RealTalk MS, Jon Strum engages listeners with insightful discussions about multiple sclerosis and its management through expert interviews and real-life experiences from the MS community.

Reviews

4.7 out of 5 stars from 217 ratings
  • Use your voice

    Excellent podcast 10/28/25. US Const protects MS pts. Current admin disallows DOJ to prosecute. In this situation, ride your State & US Reps hard. Speak out loud about this. Strongly consider not only suing co but also Board Members of co personally. That’s where you will see change. Too often folks are unaware that Board Members jobs are demanded legally. Therefore, if they fail to esp deliberately to do their duties, they are in violation of most often reg law. Seek out an admin or reg attorne... more

    Apple Podcasts
    5
    Written Art
    United States4 months ago
  • Helpful and inspiring

    Wow- I can’t believe I just found out about this podcast! It is so informative and keeps me educated on so many things. The resources provided are super!

    Apple Podcasts
    5
    Bubblesforver123
    United States2 years ago
  • Episode after episode I come away feeling far better informed and empowered. Jon is gifted at breaking down the science in ways we can all understand. He also works very hard to deliver on topics that are close to many of our hearts in really important ways. Also his work before and during the podcast is only outdone by the "Session Notes" and the "Bonus Content" that make it so easy to access information, materials, research, etc. We are thrilled that he is so committed and so impactful.

    Podchaser
    5
    John Bradley
    3 years ago
  • Very insightful interviews.

    I just recently finsihed listening to the show 234, now although I do not have MS, I found the interview vey insightful, it gave me a different perspective that I did not have before. I had many amazing take aways and felt the show was informative. Just teaches you to always be considerate of others.

    Apple Podcasts
    5
    D Larson 2020
    United Kingdom4 years ago
  • This show is super engaging and extrmely informative.

    It's also very inspiring to listen to stories abouts other with MS and how they handle and manage themsleves and even thrive! It's motivational. Seeing the direction this show is heading is exciting and I am glad Jon's the host.

    Apple Podcasts
    5
    Anthony D N
    United Kingdom4 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Reviews highlight a strong sense of community fostered through shared experiences and advocacy discussions.
The podcast is praised for providing real-world insights and personal narratives that resonate deeply with the MS community.
The host is recognized for his skill in breaking down jargon and making science accessible to the lay audience.
People often mention the engaging interview style and the approachable way complex medical topics are discussed.
Listeners appreciate the informative and relatable content, making it a respected source for understanding multiple sclerosis.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Episode 441: The 2026 ACTRIMS Forum with Dr. Manuel Friese, Dr. Amit Bar-Or, and Dr. Haritha Desu
Q: How might your research help us develop treatments for people who already have active inflammation within their central nervous system?
The research focuses on identifying markers on peripheral immune cells that can be targeted to prevent them from causing further damage once they are in the brain.
Episode 441: The 2026 ACTRIMS Forum with Dr. Manuel Friese, Dr. Amit Bar-Or, and Dr. Haritha Desu
Q: For someone living with MS, what does it mean to change the focus from stopping the attacker, the immune system, to fortifying the house, protecting that nerve cell?
Changing the focus means understanding that once a diagnosis is established, prior adjustments may already have occurred in the nerve cells themselves, and research emphasizes the need to address these cellular changes.
Episode 440: An MS Specialist's Response to the FDA with Dr. William Conte
Q: What is the risk of doing nothing for patients with progressive MS?
Dr. Conte emphasizes that the consequences of under-treatment can lead to greater long-term disability compared to the potentially rare side effects of newer drugs, advocating for a balanced risk-benefit analysis.
Episode 440: An MS Specialist's Response to the FDA with Dr. William Conte
Q: How does using old definitions affect the evaluation of new innovative drugs like Tolebrutinib?
Dr. Conte suggests that reliance on outdated definitions hinders the understanding and evaluation of new treatment strategies for progressive MS, leading to complications in drug approval processes.
Episode 440: An MS Specialist's Response to the FDA with Dr. William Conte
Q: Can you explain the unmet need that Tolebrutinib was meant to fill?
Secondary progressive MS is characterized by slow-accumulating disability over time, often without relapses, leading to significant challenges for patients not effectively treated by existing therapies.

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Frequently Asked Questions About RealTalk MS

What is RealTalk MS about and what kind of topics does it cover?

This podcast focuses on multiple sclerosis (MS) by providing insightful discussions on the latest developments in research, treatment options, and the personal experiences of those living with MS. The content features interviews with healthcare professionals, researchers, and individuals navigating life with MS, discussing everything from clinical trial experiences to managing daily challenges related to the condition. This resource aims to empower listeners by equipping them with knowledge to better understand MS, advocate for themselves, and engage in informed discussions about their healthcare.

Notably, the podcast is characterized by its practical approach in addressing complex medical topics in an accessible manner, making it ideal fo... more

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To see how many followers or subscribers RealTalk MS has on Spotify and other platforms such as Castbox and Podcast Addict, simply upgrade your account. You'll also find viewership figures for their YouTube channel if they have one.

Which podcasts are similar to RealTalk MS?

These podcasts share a similar audience with RealTalk MS:

1. The MSing Link
2. MeSsy with Christina Applegate & Jamie Lynn Sigler
3. Living Well with Multiple Sclerosis
4. The Mel Robbins Podcast
5. Wiser Than Me with Julia Louis-Dreyfus

How many episodes of RealTalk MS are there?

RealTalk MS launched 8 years ago and published 496 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact RealTalk MS?

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Where can I see ratings and reviews for RealTalk MS?

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What guests have appeared on RealTalk MS?

Recent guests on RealTalk MS include:

1. Dr. Jeffrey Cohen
2. Dr. Manuel Friese
3. Dr. Haritha Desu
4. Dr. William Conte
5. Dr. Bruce Bebo
6. Dr. Arman Eshaghi
7. David Mitchell
8. Amanda Montague

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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