Rephonic
Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production
Multiple Sclerosis
Mental Health
Friendship
Chronic Illness
Therapy
Parenting Challenges
Emotional Support
Vulnerability
Health Struggles
Grief
Motherhood
Personal Struggles
Support Systems
Empathy
Chronic Illness Awareness
Body Image
Eating Disorders
Acting
Cancer
The Sopranos

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

PublishesWeeklyEpisodes97Founded2 years ago
Number of ListenersCategories
Health & FitnessSociety & CulturePersonal Journals

Listen to this Podcast

Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

Latest Episodes

This week, Christina and Jamie read listener emails and discuss Jamie’s recent trip, pregnancy and MS, asking for help, and more.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This ... more

YouTube

This week, Christina and Jamie are joined by Dr. Will Cole, a functional medicine expert. They discuss how to calm inflammation, medical gaslighting, the interactions between all our systems, and much more.

Executive Producers: Christina Applegate, ... more

YouTube

This week, Christina and Jamie read listener emails and discuss repeat reality stars, being a mother with MS, not blaming yourself, and more.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Win... more

YouTube

This week, Christina and Jamie read listener emails and discuss Christmas elves, setting goals, reclaiming your voice, and more.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This e... more

YouTube

Key Facts

Accepts Guests
Accepts Sponsors
Contact Information
Podcast Host
Number of Listeners
Find out how many people listen to this podcast per episode and each month.

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Recent Guests

Dr. Will Cole
Functional medicine expert and New York Times bestselling author
Episode: The Impact of Inflammation with Dr. Will Cole
Meg Josephson
Psychotherapist, licensed clinical social worker, and author
Self
Episode: Are You Mad At Me? with Meg Josephson
Rob Iler
Actor known for his role in The Sopranos
Episode: Robert Iler
Craig Thomas
Emmy-nominated producer and writer, creator of How I Met Your Mother
Episode: How Vulnerable Can I Be? with Craig Thomas
Baylen Dupree
A young woman living with Tourette syndrome, known for her openness and advocacy.
Beautifully Complex
Episode: It’s Okay to Be Yourself with Baylen Dupree
Megan Mullally
Actor and singer, best known for her role as Karen Walker on Will & Grace.
Episode: Megan Mullally
Cindy Locke
A fellow MS warrior and friend of Christina who shares her personal experiences with MS.
Episode: Do What You Can When You Can
Fraser Olender
Star of Below Deck and Chief Stew
Below Deck
Episode: Fraser Olender
Dr. Daniel Amen
Popular psychiatrist, CEO of Amen Clinics, author, and researcher.
Amen Clinics
Episode: Change Your Brain, Change Your Pain with Dr. Daniel Amen

Hosts

Christina Applegate
Co-host known for her open and honest approach to discussing life with multiple sclerosis, drawing on her own experiences and fostering connection.
Jamie Lynn Sigler
Co-host who shares her personal journey with multiple sclerosis, emphasizing community support and relatable life experiences.

Reviews

4.9 out of 5 stars from 5.7k ratings
  • This is such an important podcast. I look forward to it every week. Love you both! Thanks for keeping it real!

    Audible
    5
    Jennifer Burkhardt
    United States14 days ago
  • Thank you ❤️

    You ladies inspire me, make me laugh, make me cry, and help me process living with MS. I’ve since started my own MS journey Instagram page to share thoughts and feelings there after listening. Like Jamie, I kept my diagnosis a secret for years. I’m a wife, mother of 3, and own a wedding planning business. It takes courage to share what we go through, and I felt encouraged after listening to several episodes. Thank you for that and all that you share.

    Apple Podcasts
    5
    JRM075
    United Statesa month ago
  • Honest

    I’m completely enjoying listening to Christina and Jamie, both of whom I watched grow up on tv, be completely open and honest and INTERESTING!!!

    Apple Podcasts
    5
    Interplanet Janet B
    United Statesa month ago
  • Just what I needed to hear

    After 2+ years of progressively worsening symptoms, I finally got my MS diagnosis a few months ago. It happened suddenly and I’ve gone from being super active to mostly housebound and it’s been so difficult for me to explain just how much it’s impacted my daily life. I’m only a few episodes in, having just discovered the podcast this week, and hearing Christina talk about her experiences, soooo close to mine, has made me feel less alone in this. Less ‘dramatic’ about speaking on how awful I feel... more

    Apple Podcasts
    5
    Salsartstuff
    Australiaa month ago
  • Love you gals can’t wait for your books

    Love the podcast cause I love you gals! Good health in 2026!

    Apple Podcasts
    5
    Beans13!$rr
    United Statesa month ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

The podcast is praised for its ability to handle heavy topics with warmth and humor, contributing to its overall positive reception.
Some feel a disconnect if they are not directly affected by MS, suggesting the content may not always be universally relatable.
Listeners appreciate the raw honesty and vulnerability displayed by the hosts, finding comfort in their shared stories of living with MS.
There's a strong sense of community and support among listeners, with many finding solace in the shared experiences and insights.
The blend of humor and serious discussion about chronic illness resonates deeply, providing an engaging listening experience.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

The Impact of Inflammation with Dr. Will Cole
Q: Would you advise to begin in one area or the other, start slow because there's a lot of pitfalls?
It's important to meet patients where they're at and start with a plan they can consistently follow, focusing on manageable changes.
The Impact of Inflammation with Dr. Will Cole
Q: Can you just actually talk about what inflammation is? What is happening in the body?
Dr. Cole discusses the necessity of inflammation for bodily functions but emphasizes the problems caused by chronic inflammation and the importance of identifying underlying causes.
How Vulnerable Can I Be? with Craig Thomas
Q: What was it like navigating the challenges you faced as a parent?
Craig shares insights into the emotional rollercoaster of raising a child with Jacobson Syndrome, emphasizing the importance of community and advocacy in overcoming challenges.
It’s Okay to Be Yourself with Baylen Dupree
Q: What advice would you give to anyone that might be listening to this that has Tourette's or thinks they have Tourette's?
To not feel alone. We're so much more alike than we are different.
Fraser Olender
Q: What has been the hardest thing about being on television?
Fraser states that being on television has been the hardest and most doubted decision of his life, pushing him into maturity and forcing him to confront public perception.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
Location
Interests
Professions
Age Range
Household Income
Social Media Reach

Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

This show focuses on the candid experiences of two hosts living with multiple sclerosis (MS), exploring not only their personal struggles but also the broader emotional landscape of living with chronic illness. Episodes frequently feature their humorous yet heartfelt conversations that touch on topics such as coping strategies, community support, parenting challenges, and the importance of vulnerability. The hosts also engage with a variety of guests, including celebrities and experts, to discuss health and wellness, creating a diverse tapestry of insights that resonate with listeners navigating their own life challenges. Unique in its blend of humor and raw honesty, the content often provides a sense of belonging and understanding for thos... more

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. Let's Talk Off Camera with Kelly Ripa
2. Literally! With Rob Lowe
3. Sibling Revelry with Kate Hudson and Oliver Hudson
4. SmartLess
5. Armchair Expert with Dax Shepard

How many episodes of this podcast are there?

this podcast launched 2 years ago and published 97 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Dr. Will Cole
2. Meg Josephson
3. Rob Iler
4. Craig Thomas
5. Baylen Dupree
6. Megan Mullally
7. Cindy Locke
8. Fraser Olender

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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