
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
| Publishes | Twice weekly | Episodes | 147 | Founded | 3 years ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Personal JournalsHealth & FitnessSociety & Culture | |||

This week, Christina and Jamie are joined by Jack Osbourne for an honest conversation about growing up in the spotlight, getting sober at 17, and being diagnosed with MS at just 26. Jack opens up about how he's navigated life's challenges, the import... more
This week, Christina and Jamie read listener emails and discuss navigating life without a diagnosis, the challenges of parenting teenagers, learning to accept help, and the realities of getting older.
Executive Producers: Christina Applegate, Jamie ... more
In part two of their conversation, Jamie and Christina are joined by Dr. Marwa Kaisey, an Associate Professor of Neurology at Cedars-Sinai in Los Angeles.
Send us an email: www.messythepodcast.com/contact
Executive Producers: Christina Appl... more
Christina is finally back! This week, she returns to MeSsy and joins Jamie to catch up on everything that’s been going on in her life over the past six months.
Send us an email: www.messythepodcast.com/contact
Executive Producers: Christina... more
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Hi. After listening to your book months ago, I can’t stop thinking about Keiki (Christina).
I felt like you had possibly been misdiagnosed… and now to hear the news. I’m so very sorry you are going through a rude awakening. I think that you might have Lyme disease. Worth looking into, now back at square one. Use a doctor in MX or other countries as they are way more ahead of the game than the US!!! Love you Keiki. Keep your head up.
As a mysteriously sick girlie for 10 years, Christina’s journey makes me feel less alone. What a gift for people like me, who get diagnosed, misdiagnosed, or go undiagnosed. It’s a devastating and lonely place, and the only way to get through is to find people who understand. So grateful.
Please ask Christina
to have her implants removed! She has BII. I know because I’ve had the same issues and had them removed! Please! Help her understand Breast Implant Illness. Please
I was on deaths door but after removal I’m almost 100%
Might have Complex Regional Pain Syndrome. It’s what I developed & it is a very PAINFUL DISEASE.
I’m a long time fan but unfortunately I’m not writing as a fan. I have been misdiagnosed with what I have I live with pain everyday I have the same numbness and pain in my feet I can barely walk now I get worse and worse I’m 60 years old and my life sucks so I understand what your going though
Key themes from listener reviews, highlighting what works and what could be improved about the show.
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #12 | |
Apple Podcasts | #168 | |
Apple Podcasts | #14 | |
Apple Podcasts | #68 | |
Apple Podcasts | #204 | |
Apple Podcasts | #47 |
Recent interactions between the hosts and their guests.
Listeners, social reach, demographics and more for this podcast.
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MeSsy with Christina Applegate & Jamie Lynn Sigler features candid, vulnerable conversations centered on living with chronic illness (notably MS), grief, resilience, parenting, and personal growth. The hosts share real-life experiences, invite friends and guests from health, wellness, and entertainment to discuss tough topics with humor, honesty, and practical takeaways. A standout angle is the seamless integration of personal storytelling with advocacy and community support, often interwoven with sponsor messages that reinforce actionable guidance for listeners navigating chronic conditions. Potential listeners can expect relatable, no-holds-barred dialogue, actionable coping strategies, and a sense of shared experience that makes difficul... more
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this podcast launched 3 years ago and published 147 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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Recent guests on this podcast include:
1. Marwa Kaisey
2. Tiffani Thiessen
3. Emmanuelle Chriqui
4. Ana Rodriguez
5. Alberto Crane
6. Heather Dubrow
7. Lindsey Kraft
8. Ryan Weiss
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