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Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production
Multiple Sclerosis
Mental Health
Chronic Illness
Friendship
Parenting
Community Support
Grief
Motherhood
Therapy
Vulnerability
Self-Care
Self-Acceptance
Support Groups
Personal Growth
Acceptance
Reality Television
Trauma
MS (multiple Sclerosis)
Support Systems
Parenting Challenges

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

PublishesTwice weeklyEpisodes147Founded3 years ago
Number of ListenersCategories
Personal JournalsHealth & FitnessSociety & Culture

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Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

Latest Episodes

This week, Christina and Jamie are joined by Jack Osbourne for an honest conversation about growing up in the spotlight, getting sober at 17, and being diagnosed with MS at just 26. Jack opens up about how he's navigated life's challenges, the import... more

This week, Christina and Jamie read listener emails and discuss navigating life without a diagnosis, the challenges of parenting teenagers, learning to accept help, and the realities of getting older.

Executive Producers: Christina Applegate, Jamie ... more

YouTube

In part two of their conversation, Jamie and Christina are joined by Dr. Marwa Kaisey, an Associate Professor of Neurology at Cedars-Sinai in Los Angeles.

Send us an email: www.messythepodcast.com/contact

Executive Producers: Christina Appl... more

YouTube

Christina is finally back! This week, she returns to MeSsy and joins Jamie to catch up on everything that’s been going on in her life over the past six months.

Send us an email: www.messythepodcast.com/contact

Executive Producers: Christina... more

YouTube

Key Facts

Accepts Guests
Accepts Sponsors
Contact Information
Podcast Host
Number of Listeners
Find out how many people listen to this podcast per episode and each month.

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Recent Guests

Marwa Kaisey
Associate Professor of Neurology specializing in multiple sclerosis care, teaching and research
Cedars-Sinai
Episode: Christina Is Back (Part 2) with Dr. Marwa Kaisey
Tiffani Thiessen
Actor, author, and host with more than three decades of experience in the entertainment industry
Episode: Learning to Love Every Version of Yourself with Tiffani Thiessen
Emmanuelle Chriqui
Actress and friend; invited guest
Episode: What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui
Ana Rodriguez
Personal therapist, regular contributor to the series
Therapy practice (as described in episode)
Episode: How to Live With What You Can’t Control with Ana Rodriguez
Alberto Crane
Jiu Jitsu champion, movement scientist
Martial arts instructor, speaker
Episode: The Hardest Fight Is Learning to Rest with Alberto Crane
Heather Dubrow
Actress, author, TV personality, entrepreneur, podcaster
Episode: Stop Apologizing for Wanting More with Heather Dubrow
Lindsey Kraft
Pianist, songwriter, storyteller and actor; wrote a one-woman musical
Various theater and music projects including a Ben Folds collaboration
Episode: There Is Beauty Within All of This Pain with Lindsey Kraft
Ryan Weiss
Friend and guest on Living With It, host of Waking Up With Ryan
Waking Up With Ryan podcast
Episode: Falling Apart to Come Back Together with Ryan Weiss
Cat Cohen
Award-winning comedian, actor, singer and writer
Broad Strokes (Off-Broadway show)
Episode: Thank God I’m So Neurotic with Cat Cohen

Hosts

Christina Applegate
Co-host with Jamie Lynn Sigler, engaging in vulnerable conversations about MS, health, and life; frequently shares personal experiences and advocacy.
Jamie Lynn Sigler
Co-host with Christina Applegate, guiding conversations about MS, motherhood, grief, and resilience; shares personal perspectives and actively engages guests.

Reviews

4.9 out of 5 stars from 6.1k ratings
  • Look into..

    Hi. After listening to your book months ago, I can’t stop thinking about Keiki (Christina).

    I felt like you had possibly been misdiagnosed… and now to hear the news. I’m so very sorry you are going through a rude awakening. I think that you might have Lyme disease. Worth looking into, now back at square one. Use a doctor in MX or other countries as they are way more ahead of the game than the US!!! Love you Keiki. Keep your head up.

    Apple Podcasts
    5
    Snc4
    United States13 days ago
  • This makes me feel seen

    As a mysteriously sick girlie for 10 years, Christina’s journey makes me feel less alone. What a gift for people like me, who get diagnosed, misdiagnosed, or go undiagnosed. It’s a devastating and lonely place, and the only way to get through is to find people who understand. So grateful.

    Apple Podcasts
    5
    stephhhhhhlllll
    United States14 days ago
  • Please Help Christina!

    Please ask Christina

    to have her implants removed! She has BII. I know because I’ve had the same issues and had them removed! Please! Help her understand Breast Implant Illness. Please

    I was on deaths door but after removal I’m almost 100%

    Apple Podcasts
    5
    Qb41
    United States14 days ago
  • Misdiagnosis

    Might have Complex Regional Pain Syndrome. It’s what I developed & it is a very PAINFUL DISEASE.

    Apple Podcasts
    5
    Ironhorse2180
    United States14 days ago
  • Living with pain

    I’m a long time fan but unfortunately I’m not writing as a fan. I have been misdiagnosed with what I have I live with pain everyday I have the same numbness and pain in my feet I can barely walk now I get worse and worse I’m 60 years old and my life sucks so I understand what your going though

    Apple Podcasts
    5
    Daryl Lepree
    United States14 days ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Many relate to MS and other chronic illnesses, finding validation and practical tips.
Episodes are seen as relatable, hopeful, and community-focused, often helping listeners feel less alone.
Guests are valued for sharing authentic experiences and actionable guidance.
Listeners praise the show's honesty and transparency, noting it as a supportive space for chronic illness stories.
Some feedback about host dynamics includes appreciation for empathy, with occasional critiques about interruptions or tone.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Learning to Love Every Version of Yourself with Tiffani Thiessen
Q: What is your perspective around rejection and how to deal with it?
Thiessen says it is okay to be upset because it shows someone cared. She views rejection as an inevitable part of life, encourages people to give their best effort, and lets go of auditions by tearing up the sides afterward.
Learning to Love Every Version of Yourself with Tiffani Thiessen
Q: How did you navigate all of those choppy waters all these 45 years?
Thiessen says there is no special recipe: she has experienced dry periods and doubts, but still finds joy in acting, credits some luck and her reputation, and enjoys working with younger performers.
Christina Is Back (Part 2) with Dr. Marwa Kaisey
Q: What are some important questions that somebody can ask their neurologist or MS specialist if they have doubts about their diagnosis?
Ask what the diagnosis is based on, whether it relies on symptoms, MRI findings, or spinal-fluid results, and request to review the MRI images. If doubt remains, seek an MS specialist's second opinion.
Christina Is Back (Part 2) with Dr. Marwa Kaisey
Q: Why is MS misdiagnosis fairly common?
There is no single definitive MS test; clinicians assess a changing set of criteria, and common symptoms and MRI findings can have causes other than MS.
The Hardest Fight Is Learning to Rest with Alberto Crane
Q: How did rest become a core part of his routine?
He learned to rest intentionally as part of recovery, using interflow, breath control, and mobility work to stay connected and capable.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

MeSsy with Christina Applegate & Jamie Lynn Sigler features candid, vulnerable conversations centered on living with chronic illness (notably MS), grief, resilience, parenting, and personal growth. The hosts share real-life experiences, invite friends and guests from health, wellness, and entertainment to discuss tough topics with humor, honesty, and practical takeaways. A standout angle is the seamless integration of personal storytelling with advocacy and community support, often interwoven with sponsor messages that reinforce actionable guidance for listeners navigating chronic conditions. Potential listeners can expect relatable, no-holds-barred dialogue, actionable coping strategies, and a sense of shared experience that makes difficul... more

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These podcasts share a similar audience with this podcast:

1. Let's Talk Off Camera with Kelly Ripa
2. Sibling Revelry with Kate Hudson and Oliver Hudson
3. Making Space with Hoda Kotb
4. Joy 101 with Hoda Kotb
5. I Choose Me with Jennie Garth

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this podcast launched 3 years ago and published 147 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Marwa Kaisey
2. Tiffani Thiessen
3. Emmanuelle Chriqui
4. Ana Rodriguez
5. Alberto Crane
6. Heather Dubrow
7. Lindsey Kraft
8. Ryan Weiss

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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