
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
| Publishes | Weekly | Episodes | 87 | Founded | 2 years ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Health & FitnessPersonal JournalsSociety & Culture | |||

This week, Christina and Jamie are joined by Robert Iler, who starred on "The Sopranos" with Jamie. They discuss memories from their time on the show, his path to becoming sober, his friendship with Jamie, and much more.
Executive Producers: Christi... more
This week Christina and Jamie are joined by Craig Thomas, an author and Co-Creator, Executive Producer and Writer of How I Met Your Mother. He shares his experience raising a son with Jacobsen Syndrome, discusses the power of storytelling to make pe... more
This week, Christina and Jamie read listener emails and discuss aging, being able to express emotions authentically, where to turn when you’re feeling stuck, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick... more
This week, Christina and Jamie read listener emails and discuss dynamic disability, not being alone in your struggles, the meaning we attach to things, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audi... more
People also subscribe to these shows.




I just love listening to y’all on the podcast! I currently take Ocrevus which an infusion that I receive every 6 months. My brother and I both have MS, I am 52 and he is 55. I was 21 when I got blessed with the monster, he did not “catch” it until about 8 years ago! There were no medications available at first but I’ve taken probably about 4 others before landing on Ocrevus. My MS is visible as I use a walker or scooter to get around. My brother gets vision problems from his! I get UTIs oftentim... more
MeSsy has become my favorite podcast. At this point it’s the only one I listen to until I can catch up on all the episodes.
I don’t have MS or a chronic illness but I get so much out of it. It’s helped me recover from major surgery, be more aware of what others deal with on an ongoing basis, and laugh and cry with Christina and Jamie in all of their brilliant, vulnerable glory. Kudos to these two women for being willing to go there especially in an industry that can be so focused on appearan... more
Not even one minute into the podcast, you’re sure to hear Christina Applegate drop an f-bomb, and these are sprinkled throughout the podcast. I like the content, the relationship between the hosts, and the valuable information I get here, but the profanity has become so offensive and it is on every episode. Can’t two intelligent, compassionate women come up with an alternative to this word that has become so pervasive?
This podcast has made such a huge difference in my life! I love the connection between Christina and Jamie and truly feel like they are speaking to me on every episode. I was diagnosed with RRMS in 2008 and am now on disability. I am a 42 year old Mother and Grandmother who is still trying to find my new normal with all of these life changes. I always feel a lot better after listening to your show even though sometimes I will cry while I am laughing. Both of you are so open and raw about how you... more
I just found this podcast as I am living with cronic pain, waiting to be diagnosed maybe with ms, I don’t know… however listen to you guys it’s like a relief because I don’t feel alone, even when the waiting to be diagnosed is overwhelming. Thank you for being you and for showing as you are, we need more of this as we are all humans and vulnerability is a super power. Life is messy, and sweet at the same time! Keep going!
Key themes from listener reviews, highlighting what works and what could be improved about the show.
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #6 | |
Apple Podcasts | #146 | |
Apple Podcasts | #4 | |
Apple Podcasts | #123 | |
Apple Podcasts | #124 | |
Apple Podcasts | #21 |
Recent interactions between the hosts and their guests.
Listeners, social reach, demographics and more for this podcast.
| Listeners per Episode | |
|---|---|
| Gender Skew | |
| Location | |
| Interests | |
| Professions | |
| Age Range | |
| Household Income | |
| Social Media Reach |
This podcast offers an authentic and heartfelt exploration of life's challenges, particularly focusing on the experiences of living with multiple sclerosis (MS). The hosts, who candidly discuss their personal struggles and triumphs, foster a sense of community through their shared vulnerabilities. Topics often revolve around relationships, parenting, and the emotional toll of chronic illness, ensuring listeners feel understood and supported. Unique in its blend of humor and sincerity, each episode invites guests from various backgrounds, making it relatable to anyone grappling with life's unexpected difficulties. The hosts aim to inspire resilience and promote open conversations about pain, mental health, and personal growth, encouraging li... more
Rephonic provides a wide range of podcast stats for this podcast. We scanned the web and collated all of the information that we could find in our comprehensive podcast database. See how many people listen to this podcast and access YouTube viewership numbers, download stats, audience demographics, chart rankings, ratings, reviews and more.
Rephonic provides a full set of podcast information for three million podcasts, including the number of listeners. View further listenership figures for this podcast, including podcast download numbers and subscriber numbers, so you can make better decisions about which podcasts to sponsor or be a guest on. You will need to upgrade your account to access this premium data.
Rephonic provides comprehensive predictive audience data for this podcast, including gender skew, age, country, political leaning, income, professions, education level, and interests. You can access these listener demographics by upgrading your account.
To see how many followers or subscribers this podcast has on Spotify and other platforms such as Castbox and Podcast Addict, simply upgrade your account. You'll also find viewership figures for their YouTube channel if they have one.
These podcasts share a similar audience with this podcast:
1. Let's Talk Off Camera with Kelly Ripa
2. Sibling Revelry with Kate Hudson and Oliver Hudson
3. Reclaiming with Monica Lewinsky
4. Dear Chelsea
5. Literally! With Rob Lowe
this podcast launched 2 years ago and published 87 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
Our systems regularly scour the web to find email addresses and social media links for this podcast. We scanned the web and collated all of the contact information that we could find in our podcast database. But in the unlikely event that you can't find what you're looking for, our concierge service lets you request our research team to source better contacts for you.
Rephonic pulls ratings and reviews for this podcast from multiple sources, including Spotify, Apple Podcasts, Castbox, and Podcast Addict.
View all the reviews in one place instead of visiting each platform individually and use this information to decide if a show is worth pitching or not.
Rephonic provides full transcripts for episodes of this podcast. Search within each transcript for your keywords, whether they be topics, brands or people, and figure out if it's worth pitching as a guest or sponsor. You can even set-up alerts to get notified when your keywords are mentioned.
Recent guests on this podcast include:
1. Craig Thomas
2. Baylen Dupree
3. Megan Mullally
4. Cindy Locke
5. Fraser Olender
6. Dr. Daniel Amen
7. Ed Helms
8. Dr. Gretchen Hawley
To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.