
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
| Publishes | Twice weekly | Episodes | 142 | Founded | 3 years ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Personal JournalsHealth & FitnessSociety & Culture | |||

This week, Jamie is joined by her friend, actress Emmanuelle Chriqui. They talk about grief, the friendships that carry us through hard times, getting older, learning to separate your self-worth from your career, and more.
Executive Producers: Chri... more
This week, Jamie reads listener emails and discusses parenting with MS, learning to embrace mobility aids, and navigating unsolicited advice and comparisons.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio E... more
In the final episode of Living With It, Jamie sits down with her therapist, Ana Rodriguez, to talk about what it really means to heal when life doesn’t go according to plan. They explore grief, resilience, uncertainty, and the ways we avoid our feeli... more
This week, Jamie sits down with jiu-jitsu champion and former UFC fighter Alberto Crane to talk about how his MS diagnosis forced him to redefine what it means to be strong. Alberto opens up about learning to slow down, embrace rest, and why sometime... more
People also subscribe to these shows.





I recently discovered this podcast a few months ago. I have many episodes to go back to ! While I don’t have MS, Ive had chronic lyme for decades and am remission from lung cancer. I appreciate the raw and real talk, connections with actual people, the guests who share their stories, and the relatability of both ladies. While none of us with diagnoses and symptoms want to identify with what they are , it is refreshing to feel Im not alone in living with chronic anything while continuing to b... more
Miss her so much
I am so missing Christina, does Anyone know when she will return???
Some things evolve and change and grow in awesome ways. Some things zig when they shoulda zagged.
What the heck is happening with this podcast? Yikes! MeSsy has become a mess.
I loved your conversation with Myriam Sandler of Mothercould! Thanks to you both!
Key themes from listener reviews, highlighting what works and what could be improved about the show.
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #36 | |
Apple Podcasts | #75 | |
Apple Podcasts | #186 | |
Apple Podcasts | #94 | |
Apple Podcasts | #189 | |
Apple Podcasts | #30 |
Recent interactions between the hosts and their guests.
Listeners, social reach, demographics and more for this podcast.
| Listeners per Episode | |
|---|---|
| Gender Skew | |
| Location | |
| Interests | |
| Professions | |
| Age Range | |
| Household Income | |
| Social Media Reach |
MeSsy with Christina Applegate & Jamie Lynn Sigler features candid, vulnerable conversations centered on living with chronic illness (notably MS), grief, resilience, parenting, and personal growth. The hosts share real-life experiences, invite friends and guests from health, wellness, and entertainment to discuss tough topics with humor, honesty, and practical takeaways. A standout angle is the seamless integration of personal storytelling with advocacy and community support, often interwoven with sponsor messages that reinforce actionable guidance for listeners navigating chronic conditions. Potential listeners can expect relatable, no-holds-barred dialogue, actionable coping strategies, and a sense of shared experience that makes difficul... more
Rephonic provides a wide range of podcast stats for this podcast. We scanned the web and collated all of the information that we could find in our comprehensive podcast database. See how many people listen to this podcast and access YouTube viewership numbers, download stats, audience demographics, chart rankings, ratings, reviews and more.
Rephonic provides a full set of podcast information for four million podcasts, including the number of listeners. View further listenership figures for this podcast, including podcast download numbers and subscriber numbers, so you can make better decisions about which podcasts to sponsor or be a guest on. You will need to upgrade your account to access this premium data.
Rephonic provides comprehensive predictive audience data for this podcast, including gender skew, age, country, political leaning, income, professions, education level, and interests. You can access these listener demographics by upgrading your account.
To see how many followers or subscribers this podcast has on Spotify and other platforms such as Castbox and Podcast Addict, simply upgrade your account. You'll also find viewership figures for their YouTube channel if they have one.
These podcasts share a similar audience with this podcast:
1. Let's Talk Off Camera with Kelly Ripa
2. Sibling Revelry with Kate Hudson and Oliver Hudson
3. Making Space with Hoda Kotb
4. Literally! With Rob Lowe
5. All There Is with Anderson Cooper
this podcast launched 3 years ago and published 142 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
Our systems regularly scour the web to find email addresses and social media links for this podcast. We scanned the web and collated all of the contact information that we could find in our podcast database. But in the unlikely event that you can't find what you're looking for, our concierge service lets you request our research team to source better contacts for you.
Rephonic pulls ratings and reviews for this podcast from multiple sources, including Spotify, Apple Podcasts, Castbox, and Podcast Addict.
View all the reviews in one place instead of visiting each platform individually and use this information to decide if a show is worth pitching or not.
Rephonic provides full transcripts for episodes of this podcast. Search within each transcript for your keywords, whether they be topics, brands or people, and figure out if it's worth pitching as a guest or sponsor. You can even set-up alerts to get notified when your keywords are mentioned.
Recent guests on this podcast include:
1. Emmanuelle Chriqui
2. Ana Rodriguez
3. Alberto Crane
4. Heather Dubrow
5. Lindsey Kraft
6. Ryan Weiss
7. Cat Cohen
8. Kelsey Chittick
To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.