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Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production
Multiple Sclerosis
Mental Health
Chronic Illness
Friendship
Parenting
Community Support
Grief
Motherhood
Therapy
Vulnerability
Self-Care
Self-Acceptance
Support Groups
Personal Growth
Acceptance
Reality Television
Trauma
MS (multiple Sclerosis)
Parenting Challenges
Support Systems

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

PublishesWeeklyEpisodes121Founded2 years ago
Number of ListenersCategories
Health & FitnessPersonal JournalsSociety & Culture

Listen to this Podcast

Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

Latest Episodes

This week, Jamie reads listener emails and opens up about the feeling of all eyes on you when you're struggling, the anxiety of the lead up, caregiving, and more.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Aud... more

This week, Jamie sits down with journalist, author, and menopause advocate Tamsen Fadal. They discuss the physical and emotional realities of perimenopause, why so many women feel dismissed by the medical system, and how speaking honestly about agin... more

YouTube

This week, Jamie reads listener emails and discusses the invisible weight of living with chronic illness, the courage it takes to keep showing up, and the small moments that can bring us back to ourselves. She also shares the reminder she received fr... more

YouTube

This week, Jamie sits down with Erin Moriarty. They discuss Erin's journey with Graves' disease while starring in "The Boys," the invisible toll chronic illnesses can take on your mental health, learning to advocate for yourself, and why vulnerabilit... more

YouTube

Key Facts

Accepts Guests
Accepts Sponsors
Contact Information
Podcast Host
Number of Listeners
Find out how many people listen to this podcast per episode and each month.

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Recent Guests

Erin Moriarty
Actress known for The Boys
Episode: Erin Moriarty
Mia Calabrese
Reality television personality from Summer House, known for openness about grief
Summer House cast member
Episode: Mia Calabrese
Jesse Solomon
Friend of the hosts, cancer survivor who shares his journey
Episode: Our Favorite Bravo Men
Andy Cohen
Television host/producer, Bravo personality
Bravo
Episode: Our Favorite Bravo Men
Aida Turturro
Actress known for The Sopranos role, public advocate for health and organizing
Actor and organizer
Episode: Aida Turturro
Lena Hall
Tony Award-winning actress and singer known for Hedwig and the Angry Inch
Episode: Lena Hall
Ana Maria Rodriguez
Psychologist; founder and CEO of Selva Wellness Collective; author
Selva Wellness Collective; Ana Maria Rodriguez (brand)
Episode: A Conversation with Jamie’s Therapist
Becca Tobin
Actor (Becca Tobin), introduced as one of Jamie and Christina's close friends
Entertainment
Episode: The Friendship Episode
Odette Annable
Actor (Odette Annable), introduced as one of Jamie and Christina's close friends
Entertainment
Episode: The Friendship Episode

Hosts

Christina Applegate
Host with co-host; long-running public figure discussing MS, health, and advocacy
Jamie Lynn Sigler
Co-host; actress and caregiver perspectives, frequent discussion guest

Reviews

4.9 out of 5 stars from 6k ratings
  • Loved both your books

    Everyone should buy your books, so good

    Apple Podcasts
    5
    Beans13!$rr
    United Statesa month ago
  • Question for Christina

    Excellent

    Apple Podcasts
    4
    Flying Burrito Brothers!
    United States2 months ago
  • Thank you

    Best pod for improvement and not feeling alone

    Apple Podcasts
    5
    NickieSK09
    United States2 months ago
  • Jamie and Cutter

    I don’t have a significant other, husband or boyfriend, but I do have brothers who are acting as my caregivers. This episode hit close to home because I recognize a lot of their challenges and struggles in what Cutter shared during your conversation. Jaime thanks for all the prep you did. Your questions were totally on point. You may have said it was couple’s therapy but I believe a better description is relationship strengthening. Thanks for the suggestions/advice and example of good, heal... more

    Apple Podcasts
    5
    Lisard01
    United States2 months ago
  • Episode with Jamie Lynn’s husband is WOW!

    I’ve been listening to this podcast since they started it and absolutely love their pure honesty and I’m constantly shocked at all they have to go through, it’s eye opening! Today’s episode with Jaime Lynn’s husband was just SO incredibly beautiful! He’s so honest and supportive and hearing him speak about her is just the best thing! I was teary through the whole episode, you girls always get me too. His support and love is THE MOST beautiful thing! Thank you for sharing! And Jamie Lynn, y... more

    Apple Podcasts
    5
    lcpeebles
    United States3 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Critics note occasional strong language or interruptions but acknowledge emotional honesty and value for advocacy
Sponsorships are noticed but rarely disrupt the intimate conversation
Listeners praise the hosts' honesty, vulnerability, and supportive community
Fans value real-world coping tips and the candid discussion of MS and caregiving
Guests are seen as authentic, diverse, and relatable, strengthening the show's credibility

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Erin Moriarty
Q: When did symptoms start and how did filming intersect with illness?
Erin explains the onset of fatigue and numbness, the misdiagnoses, and how continuing work amid illness led to eventual diagnosis and treatment; highlights the difficulty of balancing health with demanding filming schedules.
Erin Moriarty
Q: So how did you get into acting and realize that could be your future?
Erin recounts starting at a young age, moving to LA for auditions, booking a role early on, and recognizing acting as a genuine source of joy that she wanted to pursue seriously.
Mia Calabrese
Q: What's next for Mia after Summer House?
She expresses a focus on living in the present and pursuing opportunities that feel like a true fit, aiming to stay connected with her core circle and be celebrated and loved.
Mia Calabrese
Q: How has grief impacted Mia and what has helped her cope?
She shares about her mother's passing, the intense grief she felt, and how therapy, cooking, and keeping memories alive through friends and recordings have helped her heal while still honoring her mom.
Mia Calabrese
Q: What drew Mia to New York and how did her early life shape her path?
Mia explains moving to New York for college, discovering a love for architecture and real estate, and the importance of staying true to herself rather than forcing a scripted image on screen.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
Location
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Age Range
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Social Media Reach

Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

Two high-visibility hosts share vulnerable, candid conversations about navigating life with a chronic condition, balancing public attention with personal health journeys, and leaning on friendship and community for resilience. Episodes blend intimate storytelling, therapeutic conversations, and practical tips, often weaving sponsor reads into a conversational rhythm. Guests span actors, musicians, therapists, and creators who illuminate performance, wellness, trauma, caregiving, and advocacy, making the show a mix of raw honesty, humor, and actionable guidance for listeners facing illness or challenging life transitions. A standout is the consistent emphasis on real talk about MS, caregiving, and mental health, while spotlighting female fri... more

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. Let's Talk Off Camera with Kelly Ripa
2. Making Space with Hoda Kotb
3. Wiser Than Me with Julia Louis-Dreyfus
4. Literally! With Rob Lowe
5. Reclaiming with Monica Lewinsky

How many episodes of this podcast are there?

this podcast launched 2 years ago and published 121 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Erin Moriarty
2. Mia Calabrese
3. Jesse Solomon
4. Andy Cohen
5. Aida Turturro
6. Lena Hall
7. Ana Maria Rodriguez
8. Becca Tobin

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