
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
| Publishes | Weekly | Episodes | 97 | Founded | 2 years ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Health & FitnessSociety & CulturePersonal Journals | |||

This week, Christina and Jamie read listener emails and discuss Jamie’s recent trip, pregnancy and MS, asking for help, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This ... more
This week, Christina and Jamie are joined by Dr. Will Cole, a functional medicine expert. They discuss how to calm inflammation, medical gaslighting, the interactions between all our systems, and much more.
Executive Producers: Christina Applegate, ... more
This week, Christina and Jamie read listener emails and discuss repeat reality stars, being a mother with MS, not blaming yourself, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Win... more
This week, Christina and Jamie read listener emails and discuss Christmas elves, setting goals, reclaiming your voice, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This e... more
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This is such an important podcast. I look forward to it every week. Love you both! Thanks for keeping it real!
You ladies inspire me, make me laugh, make me cry, and help me process living with MS. I’ve since started my own MS journey Instagram page to share thoughts and feelings there after listening. Like Jamie, I kept my diagnosis a secret for years. I’m a wife, mother of 3, and own a wedding planning business. It takes courage to share what we go through, and I felt encouraged after listening to several episodes. Thank you for that and all that you share.
I’m completely enjoying listening to Christina and Jamie, both of whom I watched grow up on tv, be completely open and honest and INTERESTING!!!
After 2+ years of progressively worsening symptoms, I finally got my MS diagnosis a few months ago. It happened suddenly and I’ve gone from being super active to mostly housebound and it’s been so difficult for me to explain just how much it’s impacted my daily life. I’m only a few episodes in, having just discovered the podcast this week, and hearing Christina talk about her experiences, soooo close to mine, has made me feel less alone in this. Less ‘dramatic’ about speaking on how awful I feel... more
Love the podcast cause I love you gals! Good health in 2026!
Key themes from listener reviews, highlighting what works and what could be improved about the show.
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #12 | |
Apple Podcasts | #194 | |
Apple Podcasts | #12 | |
Apple Podcasts | #98 | |
Apple Podcasts | #192 | |
Apple Podcasts | #70 |
Recent interactions between the hosts and their guests.
Listeners, social reach, demographics and more for this podcast.
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This show focuses on the candid experiences of two hosts living with multiple sclerosis (MS), exploring not only their personal struggles but also the broader emotional landscape of living with chronic illness. Episodes frequently feature their humorous yet heartfelt conversations that touch on topics such as coping strategies, community support, parenting challenges, and the importance of vulnerability. The hosts also engage with a variety of guests, including celebrities and experts, to discuss health and wellness, creating a diverse tapestry of insights that resonate with listeners navigating their own life challenges. Unique in its blend of humor and raw honesty, the content often provides a sense of belonging and understanding for thos... more
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1. Let's Talk Off Camera with Kelly Ripa
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4. SmartLess
5. Armchair Expert with Dax Shepard
this podcast launched 2 years ago and published 97 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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Recent guests on this podcast include:
1. Dr. Will Cole
2. Meg Josephson
3. Rob Iler
4. Craig Thomas
5. Baylen Dupree
6. Megan Mullally
7. Cindy Locke
8. Fraser Olender
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