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Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production
Multiple Sclerosis
Mental Health
Chronic Illness
Friendship
Parenting
Community Support
Grief
Motherhood
Therapy
Vulnerability
Self-Care
Self-Acceptance
Support Groups
Personal Growth
Reality Television
Acceptance
Trauma
MS (multiple Sclerosis)
Support Systems
Parenting Challenges

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

PublishesWeeklyEpisodes115Founded2 years ago
Number of ListenersCategories
Society & CulturePersonal JournalsHealth & Fitness

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Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

Latest Episodes

This week, we are revisiting conversations with some of our favorite Bravo men - Jesse Solomon, Carl Radke, and Andy Cohen. They share moments that were challenging, helped them grow, and changed their perspectives on life.

Executive Producers: Ch... more

YouTube

This week, Jamie sits down with the one and only Aida Turturro. They reflect on their years together on The Sopranos, and Aida discusses living with rheumatoid arthritis since childhood, perspective, and finding gratitude during difficult times.

Exe... more

YouTube

This week, Jamie reads listener emails and discusses what it means to feel seen, the complicated balance between grief and gratitude, and why you don’t have to be “perpetually positive” to keep moving forward.

Executive Producers: Christina Applegat... more

YouTube

This week, Jamie is joined by Tony Award-winning actress and singer Lena Hall. They discuss being present in grief, the power of healing, finding your way back to yourself, and more.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and A... more

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Key Facts

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Accepts Sponsors
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Recent Guests

Lena Hall
Tony Award-winning actress and singer known for Hedwig and the Angry Inch
Episode: Lena Hall
Martin Short
Renowned comedian and actor
Episode: Revisiting Our Convo with Martin Short
Ana Maria Rodriguez
Psychologist; founder and CEO of Selva Wellness Collective; author
Selva Wellness Collective; Ana Maria Rodriguez (brand)
Episode: A Conversation with Jamie’s Therapist
Becca Tobin
Actor (Becca Tobin), introduced as one of Jamie and Christina's close friends
Entertainment
Episode: The Friendship Episode
Odette Annable
Actor (Odette Annable), introduced as one of Jamie and Christina's close friends
Entertainment
Episode: The Friendship Episode
Olivia Munn
Actress and guest on the episode
Actor/Public figure
Episode: Olivia Munn
Carl Radke
Star of Summer House and author of Cake Eater
Summer House, Soft Bar and Cafe, More Life with Carl Radke
Episode: Carl Radke
Ryan Weiss
Coach, writer, speaker discussed in interview
Episode: How to Heal Your Relationship With Life
Martha Plimpton
Actor mentioned as hosting guest on the episode
Episode: We Don’t Want to Be Defined by This

Hosts

Christina Applegate
Host with co-host; long-running public figure discussing MS, health, and advocacy
Jamie Lynn Sigler
Co-host; actress and caregiver perspectives, frequent discussion guest

Reviews

4.9 out of 5 stars from 5.9k ratings
  • Episode with Jamie Lynn’s husband is WOW!

    I’ve been listening to this podcast since they started it and absolutely love their pure honesty and I’m constantly shocked at all they have to go through, it’s eye opening! Today’s episode with Jaime Lynn’s husband was just SO incredibly beautiful! He’s so honest and supportive and hearing him speak about her is just the best thing! I was teary through the whole episode, you girls always get me too. His support and love is THE MOST beautiful thing! Thank you for sharing! And Jamie Lynn, y... more

    Apple Podcasts
    5
    lcpeebles
    United Statesa month ago
  • With Husband Cutter

    Great episode

    Apple Podcasts
    5
    COTTONBALLS123
    United Statesa month ago
  • Raw and Real!

    I just discovered this podcast when Christina and Jamie took some time off. I have many episodes to go back to ! While I don’t have MS, Ive had chronic lyme for decades and am remission from lung cancer. I appreciate the raw and real talk, connections with actual people, the guests who share their stories, and the relatability of both ladies. While none of us with diagnoses and symptoms want to identify with what they are , it is refreshing to feel Im not alone in living with chronic anythin... more

    Apple Podcasts
    5
    Moongirl7364
    United States2 months ago
  • Learning to laugh, love , and heal

    I just listened to the Kelly Ripa interview and loved it very much. I enjoy watching Kelly and Mark every morning and their host chat segments at the beginning. I've enjoyed Kelly Ripa's book, Christina's book, and I will make sure to get Jamie's when it comes out. I enjoy Kelly and Christina's humor and it explains why I crushed on them and also wrote letters to them and they both replied to me. With Christina it was sharing my poems with her and Kelly it was musical instruments. We both had ... more

    Apple Podcasts
    5
    Phoenix Bliss
    United States2 months ago
  • Thank you

    Just thank you. I’m not here to write you my situation. But know you’ve helped me.

    Apple Podcasts
    5
    gov ins
    United States3 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Critics note occasional strong language or interruptions but acknowledge emotional honesty and value for advocacy
Sponsorships are noticed but rarely disrupt the intimate conversation
Listeners praise the hosts' honesty, vulnerability, and supportive community
Fans value real-world coping tips and the candid discussion of MS and caregiving
Guests are seen as authentic, diverse, and relatable, strengthening the show's credibility

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

A Conversation with Jamie’s Therapist
Q: What impact did ketamine-assisted therapy have on Jamie's healing and what should people look for in a practitioner?
Ketamine therapy lowered the default mode's rigidity, opened up new pathways of thought, and allowed embodied experiences; look for proper certification, safety screening, medical supervision, and contraindications when seeking a practitioner.
A Conversation with Jamie’s Therapist
Q: Can you explain why EMDR was chosen for working with Jamie first and how the mechanics of EMDR work?
EMDR was chosen to address un-thawing stored trauma; it uses bilateral stimulation to access unconscious neural networks, reprocess memories, and reshape beliefs, often more efficiently than traditional talk therapy and enabling the body to heal itself through reprocessing.
The Impact of Inflammation with Dr. Will Cole
Q: Would you advise to begin in one area or the other, start slow because there's a lot of pitfalls?
It's important to meet patients where they're at and start with a plan they can consistently follow, focusing on manageable changes.
The Impact of Inflammation with Dr. Will Cole
Q: Can you just actually talk about what inflammation is? What is happening in the body?
Dr. Cole discusses the necessity of inflammation for bodily functions but emphasizes the problems caused by chronic inflammation and the importance of identifying underlying causes.
How Vulnerable Can I Be? with Craig Thomas
Q: What was it like navigating the challenges you faced as a parent?
Craig shares insights into the emotional rollercoaster of raising a child with Jacobson Syndrome, emphasizing the importance of community and advocacy in overcoming challenges.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

Two high-visibility hosts share vulnerable, candid conversations about navigating life with a chronic condition, balancing public attention with personal health journeys, and leaning on friendship and community for resilience. Episodes blend intimate storytelling, therapeutic conversations, and practical tips, often weaving sponsor reads into a conversational rhythm. Guests span actors, musicians, therapists, and creators who illuminate performance, wellness, trauma, caregiving, and advocacy, making the show a mix of raw honesty, humor, and actionable guidance for listeners facing illness or challenging life transitions. A standout is the consistent emphasis on real talk about MS, caregiving, and mental health, while spotlighting female fri... more

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. Let's Talk Off Camera with Kelly Ripa
2. Literally! With Rob Lowe
3. Making Space with Hoda Kotb
4. Reclaiming with Monica Lewinsky
5. Wiser Than Me with Julia Louis-Dreyfus

How many episodes of this podcast are there?

this podcast launched 2 years ago and published 115 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Lena Hall
2. Martin Short
3. Ana Maria Rodriguez
4. Becca Tobin
5. Odette Annable
6. Olivia Munn
7. Carl Radke
8. Ryan Weiss

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