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Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production
Multiple Sclerosis
Mental Health
Chronic Illness
Friendship
Parenting
Community Support
Grief
Motherhood
Therapy
Vulnerability
Self-Care
Self-Acceptance
Support Groups
Personal Growth
Reality Television
Acceptance
Trauma
MS (multiple Sclerosis)
Support Systems
Parenting Challenges

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

PublishesWeeklyEpisodes118Founded2 years ago
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Personal JournalsHealth & FitnessSociety & Culture

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Artwork for MeSsy with Christina Applegate & Jamie Lynn Sigler

Latest Episodes

This week, Jamie sits down with Erin Moriarty. They discuss Erin's journey with Graves' disease while starring in "The Boys," the invisible toll chronic illnesses can take on your mental health, learning to advocate for yourself, and why vulnerabilit... more

This week, Jamie is joined by Summer House’s Mia Calabrese. She opens up about her journey with grief and what’s helped her to find joy again. They also discuss the Summer House scandal and Mia shares her thoughts on the reunion and bonus episode.

E... more

YouTube

This week, Jamie reads emails from listeners. She also discusses mom guilt, PMS and MS, letting people know how their actions affect you, and much more.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Enginee... more

YouTube

This week, we are revisiting conversations with some of our favorite Bravo men - Jesse Solomon, Carl Radke, and Andy Cohen. They share moments that were challenging, helped them grow, and changed their perspectives on life.

Executive Producers: Ch... more

YouTube

Key Facts

Accepts Guests
Accepts Sponsors
Contact Information
Podcast Host
Number of Listeners
Find out how many people listen to this podcast per episode and each month.

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Recent Guests

Carl Radke
Cast member of Summer House, cancer survivor, sober advocate
Loverboy (business owner)
Episode: Our Favorite Bravo Men
Jesse Solomon
Friend of the hosts, cancer survivor who shares his journey
Episode: Our Favorite Bravo Men
Aida Turturro
Actress known for The Sopranos role, public advocate for health and organizing
Actor and organizer
Episode: Aida Turturro
Lena Hall
Tony Award-winning actress and singer known for Hedwig and the Angry Inch
Episode: Lena Hall
Ana Maria Rodriguez
Psychologist; founder and CEO of Selva Wellness Collective; author
Selva Wellness Collective; Ana Maria Rodriguez (brand)
Episode: A Conversation with Jamie’s Therapist
Becca Tobin
Actor (Becca Tobin), introduced as one of Jamie and Christina's close friends
Entertainment
Episode: The Friendship Episode
Odette Annable
Actor (Odette Annable), introduced as one of Jamie and Christina's close friends
Entertainment
Episode: The Friendship Episode
Olivia Munn
Actress and guest on the episode
Actor/Public figure
Episode: Olivia Munn
Ryan Weiss
Coach, writer, speaker discussed in interview
Episode: How to Heal Your Relationship With Life

Hosts

Christina Applegate
Host with co-host; long-running public figure discussing MS, health, and advocacy
Jamie Lynn Sigler
Co-host; actress and caregiver perspectives, frequent discussion guest

Reviews

4.9 out of 5 stars from 6k ratings
  • Loved both your books

    Everyone should buy your books, so good

    Apple Podcasts
    5
    Beans13!$rr
    United States15 days ago
  • Question for Christina

    Excellent

    Apple Podcasts
    4
    Flying Burrito Brothers!
    United Statesa month ago
  • Thank you

    Best pod for improvement and not feeling alone

    Apple Podcasts
    5
    NickieSK09
    United Statesa month ago
  • Jamie and Cutter

    I don’t have a significant other, husband or boyfriend, but I do have brothers who are acting as my caregivers. This episode hit close to home because I recognize a lot of their challenges and struggles in what Cutter shared during your conversation. Jaime thanks for all the prep you did. Your questions were totally on point. You may have said it was couple’s therapy but I believe a better description is relationship strengthening. Thanks for the suggestions/advice and example of good, heal... more

    Apple Podcasts
    5
    Lisard01
    United Statesa month ago
  • Episode with Jamie Lynn’s husband is WOW!

    I’ve been listening to this podcast since they started it and absolutely love their pure honesty and I’m constantly shocked at all they have to go through, it’s eye opening! Today’s episode with Jaime Lynn’s husband was just SO incredibly beautiful! He’s so honest and supportive and hearing him speak about her is just the best thing! I was teary through the whole episode, you girls always get me too. His support and love is THE MOST beautiful thing! Thank you for sharing! And Jamie Lynn, y... more

    Apple Podcasts
    5
    lcpeebles
    United States2 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Critics note occasional strong language or interruptions but acknowledge emotional honesty and value for advocacy
Sponsorships are noticed but rarely disrupt the intimate conversation
Listeners praise the hosts' honesty, vulnerability, and supportive community
Fans value real-world coping tips and the candid discussion of MS and caregiving
Guests are seen as authentic, diverse, and relatable, strengthening the show's credibility

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

A Conversation with Jamie’s Therapist
Q: What impact did ketamine-assisted therapy have on Jamie's healing and what should people look for in a practitioner?
Ketamine therapy lowered the default mode's rigidity, opened up new pathways of thought, and allowed embodied experiences; look for proper certification, safety screening, medical supervision, and contraindications when seeking a practitioner.
A Conversation with Jamie’s Therapist
Q: Can you explain why EMDR was chosen for working with Jamie first and how the mechanics of EMDR work?
EMDR was chosen to address un-thawing stored trauma; it uses bilateral stimulation to access unconscious neural networks, reprocess memories, and reshape beliefs, often more efficiently than traditional talk therapy and enabling the body to heal itself through reprocessing.
The Impact of Inflammation with Dr. Will Cole
Q: Would you advise to begin in one area or the other, start slow because there's a lot of pitfalls?
It's important to meet patients where they're at and start with a plan they can consistently follow, focusing on manageable changes.
The Impact of Inflammation with Dr. Will Cole
Q: Can you just actually talk about what inflammation is? What is happening in the body?
Dr. Cole discusses the necessity of inflammation for bodily functions but emphasizes the problems caused by chronic inflammation and the importance of identifying underlying causes.
How Vulnerable Can I Be? with Craig Thomas
Q: What was it like navigating the challenges you faced as a parent?
Craig shares insights into the emotional rollercoaster of raising a child with Jacobson Syndrome, emphasizing the importance of community and advocacy in overcoming challenges.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

Two high-visibility hosts share vulnerable, candid conversations about navigating life with a chronic condition, balancing public attention with personal health journeys, and leaning on friendship and community for resilience. Episodes blend intimate storytelling, therapeutic conversations, and practical tips, often weaving sponsor reads into a conversational rhythm. Guests span actors, musicians, therapists, and creators who illuminate performance, wellness, trauma, caregiving, and advocacy, making the show a mix of raw honesty, humor, and actionable guidance for listeners facing illness or challenging life transitions. A standout is the consistent emphasis on real talk about MS, caregiving, and mental health, while spotlighting female fri... more

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1. Let's Talk Off Camera with Kelly Ripa
2. Dear Chelsea
3. I Choose Me with Jennie Garth
4. Making Space with Hoda Kotb
5. Literally! With Rob Lowe

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this podcast launched 2 years ago and published 118 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Carl Radke
2. Jesse Solomon
3. Aida Turturro
4. Lena Hall
5. Ana Maria Rodriguez
6. Becca Tobin
7. Odette Annable
8. Olivia Munn

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