Rephonic
Artwork for On The Pen GLP-1 News
Glp-1 Medications
Eli Lilly
Glp-1
Zepbound
Obesity
Novo Nordisk
Mounjaro
Wegovy
FDA
Terzepatide
Diabetes
Retatrutide
Obesity Medicine
Ozempic
Semaglutide
Weight Loss
Cagrisema
Medicare
Obesity Treatment
Type 2 Diabetes

On The Pen is the leading GLP-1 news podcast and platform covering obesity medicine, FDA actions, drug shortages, access policy, and the business of NuSH therapies. The podcast is in the top 1% of all podcasts globally, and On The Pen is a top Substack best-seller.

PublishesTwice weeklyEpisodes197Founded2 years ago
Number of ListenersCategories
MedicineHealth & Fitness

Listen to this Podcast

Artwork for On The Pen GLP-1 News

Latest Episodes

Millions of Medicare beneficiaries are about to gain access to GLP-1 weight loss medications for as little as $50 per month through the new Medicare Bridge Program, launching July 1. In this episode of On The Pen, Dave Knapp sits down with obesity me... more

ADA 2026 delivered a massive wave of obesity and diabetes data, and in this episode of On The Pen, Dave Knapp (@manonthemounjaro) sits down with Jen (@JcanNuSH) ​⁠ to break down the molecules, clinical trials, weight loss results, and safety signals ... more

Dave sits down with nurse practitioner and former Retatrutide clinical trial participant David White to break down the biggest obesity headlines from the 2026 American Diabetes Association Conference. Together, they explore the latest data on Retatru... more

Dave breaks down an unreported Expanded Access Pathway that Eli Lilly has quietly established for Retatrutide.

Key Facts

Accepts Guests
Accepts Sponsors
Contact Information
Podcast Host
Number of Listeners
Find out how many people listen to this podcast per episode and each month.

Recent Guests

Dr. Angela K. Fitch
Physician and obesity medicine advocate
Known Well (KnownWell Health)
Episode: How To Get $50 GLP-1
Jen Kanush
Guest expert discussed ADA 2026 findings and GLP-1 programs
X (formerly known for activity on social media)
Episode: What Comes After Zepbound? The Biggest ADA 2026 Obesity Drug Breakthroughs
David White
Nurse practitioner with deep involvement in GLP-1 trials and data analysis; self-described retatrutide glucagon nerd
Michigan, USA
Episode: Retatrutide Just Reached Bariatric Surgery Results
Beverly Chang
Endocrinologist, obesity specialist
Episode: Retatrutide, Multi Agonist Obesity Drugs, and the PBM Access War
Jen Kinnoosh
Expert following GLP-1 studies and obesity medications; active member of On The Pen community
Episode: The Next Two Weeks in GLP1 Are Huge, Here's Why
Kyler Ockey
Chief Product Officer at Shed
Shed
Episode: He Took Retatrutide 40mg and Proved a Point
Sabina Hemmi
Expert commentator from GLP-Winner
GLP-Winner
Episode: BPI STOPS TIRZEPATIDE Production, Second Major Pharmacy Out!
Spencer Nadolsky
Board-certified obesity medicine doctor
Vineyard (clinic)
Episode: Ozempic Personality With Dr Spencer Nadolsky
Dr. Ian Ellis
Physician and founder of VoaFit, ER physician
VoaFit
Episode: Zepbound Dosing: What Your Doctor Didn't Explain

Host

Dave Knapp
Host of On The Pen GLP-1 News; frequent presenter on GLP-1 market and policy topics; links with obesity medicine and access discussions.

Reviews

4.9 out of 5 stars from 596 ratings
  • On The Pen - THANK YOU!

    A+ Information

    Apple Podcasts
    5
    kjlebleu
    United Statesa month ago
  • Great source of unbiased info

    I enjoy listening to Dave keep me up to date on all things Glp-1. He is matter of fact, up to date, free of drama, and analyzes data very well and presents it in a way that the average PATIENT can understand. Thank you.

    Apple Podcasts
    5
    Jackbirdie
    United States2 months ago
  • Valuable podcast!! I rely on it 🌟

    I listen everyday. Best place to stay informed. Dave is not only keeping us informed but actively affecting change for us. Thanks Dave! Anne is also sharing info that we all need to hear.

    Apple Podcasts
    5
    Island Heart Vintage
    United States2 months ago
  • Best GLP-1 podcast

    This is by far the best GLP-1 podcast out there—and I’ve listened to MANY. Dave’s information is useful, reliable, and delivered in a way that lay people can understand it.

    Apple Podcasts
    5
    NonniPaints
    United States3 months ago
  • Health news

    I truly enjoy Dave bringing us the latest and greatest news when it comes to health and obesity news. He is so informative in this space.

    Apple Podcasts
    5
    Letiwilson
    United States3 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Dave Knapp is consistently seen as knowledgeable and trustworthy in GLP-1 news.
The show is praised for staying up-to-date and advocating for patient access during regulatory shifts.
Guests often highlight the host's ability to connect clinical relevance with market dynamics.
Listeners value the data-driven approach and clear explanations of complex policy.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

What Comes After Zepbound? The Biggest ADA 2026 Obesity Drug Breakthroughs
Q: What were Jen's biggest takeaways from ADA 2026 regarding tolerability and trial design?
Jen emphasized that tolerability remained a major hurdle even for phase three drugs, with some trials experiencing significant nausea and vomiting and rigid titration protocols that limited dose escalation. She also noted that trial designs need more flexible tolerability management and better reflection of real-world medication use, including reconsideration of placebo controls given the access to GLP-1 therapies outside trials.
Retatrutide Just Reached Bariatric Surgery Results
Q: How did retatrutide affect lipid profiles and inflammatory markers, and what does that imply for cardiovascular risk?
Triglycerides dropped around 40%, LDL reductions were substantial and likely greater than other incretin therapies, and hsCRP fell by roughly 60%, collectively indicating meaningful cardiovascular risk reduction beyond weight loss.
Retatrutide Just Reached Bariatric Surgery Results
Q: What were the key weight-loss findings in Triumph One at 80 weeks across the dose arms?
Four milligrams yielded about 19% weight loss, nine milligrams about 26%, and twelve milligrams around 28%, with extension showing continued gains towards 30% for higher doses.
The Next Two Weeks in GLP1 Are Huge, Here's Why
Q: What are your expectations for the Transcend study in diabetics, and how could the results reshape weight-loss expectations across populations?
Transcend has shown substantial weight loss in diabetics with the 40-week data, and the curves without a plateau suggest continued potential; if the results hold, diabetics could see significantly higher weight loss than non-diabetics, which would drive more disease-specific expectations and possibly new combination strategies.
The Next Two Weeks in GLP1 Are Huge, Here's Why
Q: How might real-world titration and dose changes influence how physicians prescribe these meds compared with trial protocols?
Clinicians will likely adopt more individualized titration strategies, adjusting doses based on tolerability and response, rather than sticking to fixed high-dose regimens; this could mean earlier dose reductions or stepwise adjustments to maintain weight loss while minimizing side effects.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
Location
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Frequently Asked Questions About On The Pen GLP-1 News

What is On The Pen GLP-1 News about and what kind of topics does it cover?

This show provides up-to-date, data-driven coverage of GLP-1 therapies, obesity medicine, FDA actions, drug access, and the evolving market landscape. Episodes mix regulatory shifts, pricing, and access with practical takeaways for clinicians, patients, and providers, often featuring medical experts, policy analysts, and industry commentators. A consistent strength is translating complex trial data and policy changes into actionable insights for real-world decision-making, with a clear focus on patient access and the business of obesity medicines. The format tends to blend quick news updates, in-depth market analysis, and expert perspectives, making it valuable for professionals tracking GLP-1 developments, sponsors seeking brand and though... more

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Which podcasts are similar to On The Pen GLP-1 News?

These podcasts share a similar audience with On The Pen GLP-1 News:

1. GLP-1 Hub: Support, Community, and Weight Loss
2. The Obesity Guide with Matthea Rentea MD
3. The Plus SideZ: A GLP-1 Guide to Metabolic Health
4. The Holistic GLP-1 Podcast with Elizabeth McGann
5. Your GLP-1 Bestie

How many episodes of On The Pen GLP-1 News are there?

On The Pen GLP-1 News launched 2 years ago and published 197 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on On The Pen GLP-1 News?

Recent guests on On The Pen GLP-1 News include:

1. Dr. Angela K. Fitch
2. Jen Kanush
3. David White
4. Beverly Chang
5. Jen Kinnoosh
6. Kyler Ockey
7. Sabina Hemmi
8. Spencer Nadolsky

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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