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Artwork for Neurology: Disease Deep Dive

Neurology: Disease Deep Dive

Practical Neurology
Parkinson's Disease
Cerebrovascular Inflammatory Conditions
Clinical Trials
Neuroprotective Therapies
Alpha-Synuclein
Glp-1 Inhibitors
Personalized Medicine
Biomarkers
Amyotrophic Lateral Sclerosis
Secondary CNS Vasculitis
Primary CNS Vasculitis
Massachusetts General Hospital
SOD1 Gene Mutation
Gene Therapy
FDA
Harvard Medical School

The field of neurology is vast and complex. This series provides thorough conversations with key expert physicians on neurologic conditions including the evolution of our understanding and treatment of these conditions.

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Artwork for Neurology: Disease Deep Dive

Latest Episodes

Merit Cudkowicz, MD, Julieanne Professor of Neurology, Harvard Medical School, Boston, MA, discusses the evolving landscape of treatment for ALS, including FDA-approved disease-modifying therapies, the importance of genetic testing, the emergence of ... more

Abbas Kharal, MD, MPH, Neurologist at Cleveland Clinic Neurological Institute, Cleveland, OH, provides a review of cerebrovascular inflammatory conditions, with an emphasis on diagnostic challenges, the evolving treatment landscape, and the use of im... more

Mark Stacy, MD, William E. Murray Professor of Neurology, Medical University of South Carolina, Charleston, SC, discusses the evolving therapeutic landscape for Parkinson disease, highlighting promising advances in neuroprotective therapies, biomarke... more

Welcome to Neurology: Disease Deep Dive. In this episode, Dr. Beth McQuiston, MD, RD, Medical Director at Abbott Laboratories, and Dr. David Okonkwo, MD, PhD, Professor of Neurological Surgery, Clinical Director of the Brain Trauma Research Center, a... more

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Advances in ALS: New Targets, Trials, and Care Strategies
Q: What are some of the promising new therapies that you're looking at that are in clinical trial stage?
There are global trials for gene therapies targeting rare mutations as well as trials for sporadic ALS that focus on cellular pathways and protein targets like TDP43.
Advances in ALS: New Targets, Trials, and Care Strategies
Q: What about managing patient and caregiver expectations about treatment options?
There are effective options and promising research for ALS, and it's important to communicate both current treatment availability and emerging therapies, while considering the patients' quality of life.
Advances in ALS: New Targets, Trials, and Care Strategies
Q: How are you currently approaching prescribing treatments for someone who's newly diagnosed?
There are several FDA-approved drugs for ALS including Rilazole and Radekava, which have proven benefits. It's crucial to discuss the pros and cons of each treatment based on individual patient circumstances.
The Evolving Therapeutic Landscape for Parkinson Disease
Q: What else are you excited about in the field right now?
He expresses enthusiasm for personalized medicine and integrating patient care with biomarker data and health optimization strategies.
The Evolving Therapeutic Landscape for Parkinson Disease
Q: Can you tell us a little bit about notable clinical trials in this field?
Dr. Stacy describes various trials focusing on repurposing existing medications, studying GLP-1 agonists, and innovative trial methods including home evaluations.

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1. Practical Neurology Podcast
2. Continuum Audio
3. Neurology® Podcast
4. Neurology Exam Prep Podcast
5. Neurology Minute

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Neurology: Disease Deep Dive launched 2 years ago and published 8 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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