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Artwork for Neurology: Disease Deep Dive

Neurology: Disease Deep Dive

Practical Neurology
Clinical Trials
Parkinson's Disease
Cerebrovascular Inflammatory Conditions
Multiple Sclerosis
Neuroprotective Therapies
Alpha-Synuclein
Glp-1 Inhibitors
Personalized Medicine
Paramagnetic Rim Lesions
Mcdonald Criteria
Magnetic Resonance Imaging
Biomarkers
Glioma
Neuroimaging
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
IDH Mutations
Molecular Testing
Cleveland Clinic
Cedars-Sinai Medical Center

The field of neurology is vast and complex. This series provides thorough conversations with key expert physicians on neurologic conditions including the evolution of our understanding and treatment of these conditions.

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Artwork for Neurology: Disease Deep Dive

Latest Episodes

In this episode, Patrick J. Strollo Jr, MD, FACP, FCCP, FAASM, of the University of Pittsburgh Department of Medicine, Pittsburgh, PA, discusses the data from the phase 3 SynAIRgy clinical trial for AD109, an investigational once-nightly oral treatme... more

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This episode explores the real-world implementation of the Davos Alzheimer’s Collaborative Healthcare System Preparedness (DAC-SP) US Early Detection Program at Virtua Health, examining outcomes in identifying cognitive impairment, streamlining refer... more

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Elyse Perweiler, RN, MPP, Professor, Rowan–Virtua School of Osteopathic Medicine, Stratford, NJ, and Tim MacLeod, PhD, Program Director, Healthcare System Preparedness Program, Davos Alzheimer’s Collaborative (DAC), Toronto, Ontario, Canada, examine ... more

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This episode explores new evidence showing that paramagnetic rim lesions (PRLs) are highly prevalent early in multiple sclerosis (MS) and can differentiate MS from mimics with striking accuracy. Dr. Daniel Ontaneda, Cleveland Clinic Lerner College of... more

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Recent Guests

Patrick J. Strollo Jr.
Professor of medicine; sleep medicine researcher
University of Pittsburgh
Episode: Could a Novel Oral Therapy Change How Clinicians Treat Obstructive Sleep Apnea? Insights From the SynAIRgy Trial
Elyse Perweiler
Professor, Rowan–Virtua School of Osteopathic Medicine
Rowan–Virtua Health
Episode: Part II: Early Alzheimer Disease Detection through a Davos Alzheimer's Collaborative Initiative: Lessons from Real-World Implementation
Tim MacLeod
Program Director
Davos Alzheimer's Collaborative
Episode: Part II: Early Alzheimer Disease Detection through a Davos Alzheimer's Collaborative Initiative: Lessons from Real-World Implementation

Host

Joe Rusko
Editor-in-Chief of Practical Neurology

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Talking Points

Recent interactions between the hosts and their guests.

Could a Novel Oral Therapy Change How Clinicians Treat Obstructive Sleep Apnea? Insights From the SynAIRgy Trial
Q: Given the trial population and outcomes, where do you see Ad109 fitting into the treatment landscape if approved?
Ad109 could serve as salvage therapy for patients unable to accept or adhere to PAP, potentially complementing existing options like upper airway stimulation in selected cases. Its labeling and clinical use would be defined by the FDA, but the data suggest it could improve quality of life, reduce hypoxemia, and lessen snoring for a broad spectrum of OSA patients.
Could a Novel Oral Therapy Change How Clinicians Treat Obstructive Sleep Apnea? Insights From the SynAIRgy Trial
Q: Could you tell us how Ad109 works and what makes it different from existing treatments for sleep apnea?
Ad109 combines two agents to enhance neuromuscular activation of the upper airway: adamoxetine, a serotonin reuptake inhibitor that increases norepinephrine stores to boost airway muscle tone, and r-oxybutene, an antimuscarinic that decreases acetylcholine signaling. This dual mechanism targets the hypoglossal motor nucleus to improve airway stability during sleep, offering a pharmacologic option for patients who cannot tolerate PAP therapy.
Part II: Early Alzheimer Disease Detection through a Davos Alzheimer's Collaborative Initiative: Lessons from Real-World Implementation
Q: What outcomes have you observed after implementing the DAC Blueprint at the Rowan–Virtua Health Center?
We saw the patient population grow to over 71,000 primary care patients with the early detection program, and while screening increased, dementia diagnoses remained below the national average, underscoring the need for scalable workflows that move patients efficiently from primary care to neurology and to available treatments.
Detecting Multiple Sclerosis Earlier: PRLs and the Evolving McDonald Diagnostic Criteria
Q: How should neurologists communicate the meaning of PRLs to patients?
Neurologists should explain that PRLs indicate a specific type of lesion that is often present in multiple sclerosis and is associated with a higher degree of confidence in the diagnosis.
Detecting Multiple Sclerosis Earlier: PRLs and the Evolving McDonald Diagnostic Criteria
Q: What should neurologists request to utilize PRL detection effectively?
Neurologists should request high-quality MRI protocols that include phase imaging to facilitate accurate detection of paramagnetic rim lesions.

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Frequently Asked Questions About Neurology: Disease Deep Dive

What is Neurology: Disease Deep Dive about and what kind of topics does it cover?

The episodes center on cutting-edge neurology topics, with a strong emphasis on real-world clinical implementation and evolving diagnostic criteria. Coverage includes scalable workflows for early cognitive screening in Alzheimer's disease, the role of digital tools and interprofessional teams in health systems, advancing MRI-based markers for multiple sclerosis, and the integration of molecular testing and targeted therapies in glioma care. Across conversations, practical challenges such as billing, implementation science, and cross-system collaboration are highlighted, along with the push toward earlier, more precise diagnoses and personalized treatment strategies. The format tends to pair senior clinicians and researchers who share action... more

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1. Continuum Audio
2. Neurology® Podcast
3. 10% Happier with Dan Harris
4. The Rest Is Politics: US
5. Crime Junkie

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Neurology: Disease Deep Dive launched 3 years ago and published 14 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Neurology: Disease Deep Dive?

Recent guests on Neurology: Disease Deep Dive include:

1. Patrick J. Strollo Jr.
2. Elyse Perweiler
3. Tim MacLeod

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