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Artwork for MDS Podcast
Parkinson's Disease
Movement Disorders
Deep Brain Stimulation
Dystonia
Essential Tremor
Clinical Trials
Alpha-Synuclein
Neurology
Biomarkers
Progressive Supranuclear Palsy
Tremor
Tourette Syndrome
International Parkinson and Movement Disorder Society
Artificial Intelligence
Neuroimaging
Machine Learning
Stigma
Multiple System Atrophy
Chorea
Cognitive Impairment

Stay up to date on novel, clinically-relevant research findings in Parkinson's disease and other movement disorders. Each episode of the International Parkinson and Movement Disorder Society podcast discusses a relevant development in the field, including highlighted journal articles and interviews with the authors.

PublishesWeeklyEpisodes307Founded7 years ago
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Science

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Artwork for MDS Podcast

Latest Episodes

Dr. Sarah Camargos is joined by Dr. Rajeev Kumar to explore early research on targeting neuroinflammation in Huntington's disease. Dr. Kumar delves into the intricacies of the complement cascade, highlighting the pivotal role of C1q as the recognitio... more

Ms. Nicole Duff and Prof. Hae-Young Hawong discuss the benefits of Argentine tango in the rehabilitation of person's with Parkinson disease. The motor, non-motor, social, and quality of life gains are all explored; in addition to, the neuro-anatomica... more

YouTube

Dr. Norihito Uemura joins Prof. Tiago Outeiro to discuss perampanel, an AMPA receptor antagonist, and how it has been shown to block alpha-synuclein propagation and neurodegeneration in a mouse model of Lewy body disease. Dr. Uemura explains the mech... more

YouTube

Ms. Nicole Duff and Dr. Marjan Meinders discuss end of life preferences of people with Parkinson’s disease. Together they discuss the ways that end-of-life records could be sourced, as well as what information could be found in the end-of-life record... more

YouTube

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Recent Guests

Norihito Uemura
Researcher discussing the study
Kyoto University and Osaka Metropolitan University
Episode: Blocking alpha-synuclein propagation with perampanel
Marjan Meinders
Researcher
Radboud University Medical Center, Netherlands
Episode: End of life preferences of people with Parkinson's disease
Connie Marras
Professor of Neurology, University of Toronto; Movement Disorders Neurologist, University Health Network
University of Toronto; University Health Network
Episode: Quality of life in Parkinson’s disease
Delaram Safarpour
Movement disorder neurologist and DBS specialist
Oregon Health & Science University
Episode: New data to reframe the risks of DBS surgery for patients and providers
Sheng Wu
Functional neurosurgeon
Thomas Jefferson University
Episode: New data to reframe the risks of DBS surgery for patients and providers
Liana Rosenthal
Associate Professor of Neurology and Director of the Taxa Center at Johns Hopkins University School of Medicine
Johns Hopkins University
Episode: Ataxia Series: Treating cerebellar ataxia in 2026 - What's new?
David Goldstein
Researcher from NIH focusing on autonomic failure and catecholamine deficiency in synucleinopathies
National Institutes of Health (NIH)
Episode: Prodromal autonomic dysfunction in Lewy body diseases
Abhimanyu Mahajan
Researcher focused on autonomic dysfunction as an early biomarker in neurodegenerative diseases
Episode: Prodromal autonomic dysfunction in Lewy body diseases
Alison Yarnall
Professor of Geriatric Medicine; expert on cognitive and non-motor features of Lewy body diseases
Newcastle University (implied from context)
Episode: Prodromal autonomic dysfunction in Lewy body diseases

Hosts

Michele Matarazzo
Host of the MDS Podcast (leading host with focus on movement disorders and translational research)
Orlando Barsottini
Host of the MDS Podcast; neurology professional with ties to Brazilian institutions
Sara Schaefer
Host of the podcast episode

Reviews

4.8 out of 5 stars from 64 ratings
  • 雑音

    エピソードによって、プツプツプツと一定のリズムで雑音が混入しているものがある。

    Apple Podcasts
    2
    あちゃお19
    Japan7 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

High level, scholarly discussions with expert guests
Useful for researchers and clinicians seeking practical takeaways and future directions
Audio quality varies; some episodes include intermittent background noise

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#86
India/Science
Apple Podcasts
#119
China/Science
Apple Podcasts
#145
New Zealand/Science
Apple Podcasts
#164
Ukraine/Science
Apple Podcasts
#221
Brazil/Science

Talking Points

Recent interactions between the hosts and their guests.

Blocking alpha-synuclein propagation with perampanel
Q: What would be the next questions for your group and the future of this line of research?
Future work aims to determine whether the drug can move from animal models to clinical trials, assess efficacy in reducing spread in humans, and explore testing other molecules using the established model.
Blocking alpha-synuclein propagation with perampanel
Q: What were the main open questions from your earlier work that motivated this new study?
Previous work showed perampanel blocked activity-dependent uptake of alpha-synuclein fibrils in cultured neurons and mouse brains, but it remained unclear whether blocking the initial uptake would suppress subsequent transsynaptic spread.
Blocking alpha-synuclein propagation with perampanel
Q: Can you briefly explain what trans-synaptic propagation is and why you chose this process as a therapeutic target in this study?
Trans-synaptic propagation involves the spread of abnormal alpha-synuclein pathology along neural circuits through release and uptake between neurons, and targeting this process could slow disease progression by interrupting neuron-to-neuron transmission.
Quality of life in Parkinson’s disease
Q: Why did your team choose a qualitative approach to studying quality of life?
Because quality of life is subjective and variegated, and there was a lack of prior knowledge guiding how patients define it, making qualitative methods ideal to capture lived experiences and inform later quantitative measures.
New data to reframe the risks of DBS surgery for patients and providers
Q: What can be done to improve DBS referrals and patient comfort with the procedure?
Encourage earlier discussions about DBS, promote flexible multidisciplinary program models rather than a single rigid structure, and use communication strategies that normalize DBS as a viable option through education of both neurologists and general clinicians; emphasize that referral for evaluation does not commit a patient to surgery.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About MDS Podcast

What is MDS Podcast about and what kind of topics does it cover?

Across recent episodes, the show covers a broad span of movement disorders with a focus on Parkinson's disease, ataxias, dystonia, and related neurodegenerative conditions. Conversations often center on biomarkers, imaging, genetic etiologies, and clinical phenotypes, with an emphasis on translating research findings into practice, trial design, and multidisciplinary care. Noteworthy is the consistent involvement of clinicians and researchers from major institutions worldwide, plus a willingness to explore innovative methods (e.g., SCAN network theory, videography in phenotyping, immune pathways) that push beyond traditional motor symptom management. The format tends to pair clinical case discussions with expert interpretation, making it us... more

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Which podcasts are similar to MDS Podcast?

These podcasts share a similar audience with MDS Podcast:

1. Continuum Audio
2. Neurology® Podcast
3. Practical Neurology Podcast
4. Neurology Exam Prep Podcast
5. Navigating Neuropsychology

How many episodes of MDS Podcast are there?

MDS Podcast launched 7 years ago and published 307 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on MDS Podcast?

Recent guests on MDS Podcast include:

1. Norihito Uemura
2. Marjan Meinders
3. Connie Marras
4. Delaram Safarpour
5. Sheng Wu
6. Liana Rosenthal
7. David Goldstein
8. Abhimanyu Mahajan

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