Rephonic
Artwork for MDS Podcast
Parkinson's Disease
Movement Disorders
Deep Brain Stimulation
Dystonia
Essential Tremor
Clinical Trials
Neurology
Progressive Supranuclear Palsy
Biomarkers
Tremor
Alpha-Synuclein
Tourette Syndrome
International Parkinson and Movement Disorder Society
Artificial Intelligence
Neuroimaging
Machine Learning
Multiple System Atrophy
Stigma
Chorea
Cognitive Impairment

Stay up to date on novel, clinically-relevant research findings in Parkinson's disease and other movement disorders. Each episode of the International Parkinson and Movement Disorder Society podcast discusses a relevant development in the field, including highlighted journal articles and interviews with the authors.

PublishesWeeklyEpisodes299Founded7 years ago
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Science

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Artwork for MDS Podcast

Latest Episodes

Genetic ataxias have many non-motor features, such as fatigue, sleep disorders, and cognitive dysfunction. In this episode, Dr. Orlando Barsottini and Dr. Christofer Stephen discuss the most common non-motor symptoms and how to approach them.

Dr. Michele Matarazzo sits down with Dr. Rebecca Wallings to discuss how two of the most important genetic forms for Parkinson's disease, LRRK2 and GBA1, influence immune response to bacterial simulation. Their discussion highlights a potential link ... more

YouTube

In this episode, Dr. Orlando Barsottini and Dr. Malco Rossi discuss the main imaging findings and clues for the the diagnosis of genetic and sporadic ataxias.

YouTube

In this episode Dr. Hugo Morales Briceno and Dr. Ai Huey Tan discuss how to approach deafness-dystonia syndrome and its etiological differential diagnoses. Read the discussed case.

YouTube

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Recent Guests

Rebecca Wallings
Researcher
Indiana University, Indianapolis
Episode: Modulating the peripheral immune response: LRRK2 and GBA1 mutations
Ai Huey Tan
Movement Disorder Specialist at the University of Malaya
University of Malaya
Episode: What is it? A young boy with deafness and twisting limb movements
Divyani Garg
Assistant Professor at Department of Neurology, All India Institute of Medical Sciences, New Delhi
All India Institute of Medical Sciences
Episode: Ataxia Series: Recognizing sporadic ataxias
Mattia Rosso
Fellow in movement disorders, co-founder of the Neurohumanities Network
Yale School of Medicine; Neurohumanities Network
Episode: History of Movement Disoders: The influence of videography
José Luiz Pedroso
Associate Professor of Neurology
Federal University of São Paulo
Episode: Ataxia Series: Deconstructing late-onset idiopathic ataxia
Hesheng Liu
Professor, Changping Laboratory
Changping Laboratory, Beijing
Episode: Rethinking Parkinson’s: The Somato-Cognitive Action Network (SCAN) hypothesis
Bart van de Warrenburg
Professor of Neurology and Head of the Experts Center for Rare and Genetic Movement Disorders
Rathboum University Medical Center (Radboud University Medical Center)
Episode: Ataxia Series: The ataxia exam - Phenomenology, classification, and a practical diagnostic roadmap
Susan Fox
Author, University of Toronto Western Hospital
University of Toronto Western Hospital
Episode: Revisiting the 2015 MDS clinical diagnostic criteria for Parkinson's disease
Claudia Trenkwalder
Author, Paracelsus Elena Hospital in Kassel and University Medical Centre in Göttingen
Paracelsus Elena Hospital; University Medical Centre Göttingen
Episode: Revisiting the 2015 MDS clinical diagnostic criteria for Parkinson's disease

Hosts

Sara Schaefer
Deputy editor and host of the podcast, involved in various scientific discussions and editorial tasks.
Sarah Camargos
Host and associate editor contributing insights on patient care and treatment modalities.

Reviews

4.8 out of 5 stars from 62 ratings
  • 雑音

    エピソードによって、プツプツプツと一定のリズムで雑音が混入しているものがある。

    Apple Podcasts
    2
    あちゃお19
    Japan7 years ago

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Apple Podcasts
#66
Saudi Arabia/Science
Apple Podcasts
#121
Spain/Science
Apple Podcasts
#181
Colombia/Science
Apple Podcasts
#222
Ukraine/Science
Apple Podcasts
#222
Poland/Science
Apple Podcasts
#228
Brazil/Science

Talking Points

Recent interactions between the hosts and their guests.

Modulating the peripheral immune response: LRRK2 and GBA1 mutations
Q: How did the LRRK2 mutations differ in their response compared with GBA1 mutations when treated with a Gcase activator?
LRRK2-mutant PBMCs showed a robust increase in MHC-II antigen presentation when treated with a Gcase activator, suggesting enhanced antigen processing and presentation, whereas GBA mutation carriers did not exhibit the same response, indicating different regulatory dynamics between these two genes.
Modulating the peripheral immune response: LRRK2 and GBA1 mutations
Q: What did you find about the immune responses of GBA-1 mutation carriers when exposed to Pseudomonas aeruginosa?
GBA-1 mutation carriers showed an increased inflammatory cytokine secretion in response to the bacterial challenge, aligning with the notion of heightened inflammatory signaling in some genetic forms of PD.
Modulating the peripheral immune response: LRRK2 and GBA1 mutations
Q: Could you briefly explain how the study groups were selected and what you aimed to compare across them?
We compared PBMC responses from individuals with LRRK2 mutations, GBA1 mutations, idiopathic PD, and healthy controls to see how these genetic backgrounds shape immune responses to a real-world bacterial stimulus, with the goal of understanding gene-by-environment interactions in immune function relevant to Parkinson's.
Ataxia Series: Neuroimaging patterns not to miss in ataxia
Q: How do you see advanced MRI techniques and nuclear imaging shaping earlier diagnosis, disease monitoring, and future clinical trials in ataxia?
Advanced MRI and nuclear imaging will move toward quantitative biomarkers that track progression and treatment response, enabling earlier diagnosis, better patient stratification, and more sensitive outcome measures in trials.
Ataxia Series: Neuroimaging patterns not to miss in ataxia
Q: Can you name a few animal-shape imaging signs and how you use them in practice without biasing the diagnosis?
Signs such as the shrimp sign, hot cross band sign, catapult-like or panda faces can aid recognition but must be interpreted with caution and in conjunction with the overall clinical and laboratory context to avoid misdiagnosis.

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Frequently Asked Questions About MDS Podcast

What is MDS Podcast about and what kind of topics does it cover?

Programming includes insightful discussions surrounding recent advancements in the field of movement disorders, particularly focusing on Parkinson's disease. Episodes cover a range of topics from clinical case studies to psychological aspects influencing patient experiences, such as shame in Parkinson's patients, integrating palliative care in neurological settings, and innovative research on probiotics affecting Parkinson's symptoms. Unique features include in-depth interviews with leading experts and researchers, giving listeners a comprehensive understanding of the latest clinical practices and challenges in the management of movement disorders. This podcast is an essential resource for healthcare professionals and enthusiasts aiming for... more

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1. Continuum Audio
2. Neurology® Podcast
3. JAMA Clinical Reviews
4. The Curbsiders Internal Medicine Podcast
5. Core IM | Internal Medicine Podcast

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MDS Podcast launched 7 years ago and published 299 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on MDS Podcast?

Recent guests on MDS Podcast include:

1. Rebecca Wallings
2. Ai Huey Tan
3. Divyani Garg
4. Mattia Rosso
5. José Luiz Pedroso
6. Hesheng Liu
7. Bart van de Warrenburg
8. Susan Fox

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