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Artwork for The Longevity Podcast: Optimizing HealthSpan & MindSpan

The Longevity Podcast: Optimizing HealthSpan & MindSpan

Dung Trinh
Alzheimer's Disease
Dementia
Glymphatic System
Circadian Rhythm
Cognitive Reserve
Cellular Senescence
MIND Diet
Communications Biology
Vagus Nerve
NAD Plus
Sleep
Sirtuins
Telomeres
Sitting
Swedish National March Cohort
Bayesian Brain
Default Mode Network
Gray Matter
Heart Rate Variability
Telomerase

Welcome to a new era of conversation—where artificial intelligence explores what it means to live longer and better. Created and guided by Dr. Trinh, The Longevity Podcast uses AI hosts to bring scientific discovery, health innovation, and human wisdom together. Through AI-driven discussions inspired by real research and medical insight, each episode reveals practical tools for optimizing your hea... more

PublishesDailyEpisodes376Founded5 years ago
Number of ListenersCategory
Health & Fitness

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Artwork for The Longevity Podcast: Optimizing HealthSpan & MindSpan

Latest Episodes

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Alzheimer’s doesn’t wait for a diagnosis to begin. The brain changes can start quietly for years, even a decade, while someone looks totally fine, passes cognitive tests, drives, works, and pays the same routine healthcare bills as ... more

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A tiny smudge in a century-old medical paper might be one of the most useful clues we have for Alzheimer’s disease prevention today. We trace that smudge back to 1907, when Alois Alzheimer documented not only plaques and tangles, bu... more

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Your medicine cabinet feels organized for a reason: we like to believe each pill has a single target and stays in its lane. Then we hit a finding that blows up that mental map. Millions of people take statins and other cholesterol d... more

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A clean diagnosis feels like an X-ray: obvious problem, obvious fix. Alzheimer’s disease is the opposite, and the arrival of disease-modifying anti-amyloid therapies like lecanemab and donanemab makes that gap impossible to ignore. ... more

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Recent Guests

Suzanne E. Schindler
Associate Professor of Neurology
Washington University School of Medicine in St. Louis
Episode: Alzheimer’s Before Symptoms
Christopher Weber
Director of Global Science Initiatives
Alzheimer's Association
Episode: Alzheimer’s Before Symptoms
Peter Gleibus
Chief of Neurology
Marcus Neuroscience Institute
Episode: Alzheimer’s Before Symptoms
Harriet Shellikens
Principal investigator of the Nature Communications Study
University College Cork and APC Microbiome Ireland
Episode: How Childhood Junk Food Rewires Appetite And How To Push Back
Dung Trinh
Internist and chief medical officer
Healthy Brain Clinic, Irvine, California
Episode: How Childhood Junk Food Rewires Appetite And How To Push Back
Monique Richard
Registered dietitian nutritionist and owner
Nutrition Insight
Episode: How Childhood Junk Food Rewires Appetite And How To Push Back
Andrea Zamet
Neuropsychologist and lead author of the study
Rush Alzheimer's Disease Center, Rush University
Episode: How Lifelong Learning Builds A Brain That Resists Dementia
Deng Trinh
Chief Medical Officer of the Healthy Brain Clinic
Healthy Brain Clinic, Irvine, California
Episode: How Lifelong Learning Builds A Brain That Resists Dementia

Reviews

5.0 out of 5 stars from 6 ratings
  • Science with Soul

    What I appreciate most about this podcast is how it bridges real science with humanity. The conversations are thoughtful, accessible, and rooted in research, yet never lose sight of compassion and lived experience. It expands how I think about longevity, not just as living longer, but as living better with clarity, vitality, and agency.

    Apple Podcasts
    5
    eliza warren
    United States5 months ago
  • Good stuff

    Right up my alley since I have a great interest in the brain coupled with a deep faith in God.

    Apple Podcasts
    5
    JSA1028
    United States6 months ago
  • Must listen podcast

    Very informative! Highly recommended!

    Apple Podcasts
    5
    soldier1047
    United States5 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Quality guests and clear explanations make the content trustworthy for sponsors.
Conversations translate complex biology into practical health steps.
Listeners appreciate science-backed, no-hype discussions on aging.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#139
New Zealand/Health & Fitness
Apple Podcasts
#227
Ireland/Health & Fitness

Talking Points

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Alzheimer’s Before Symptoms
Q: Why has it taken so long to build a radar for the brain, allowing detection of Alzheimer's disease decades before memory loss starts?
Historically, the brain was physically isolated from the rest of the body, making early biological changes invisible with existing tools; advanced biomarkers, blood tests, and digital assessments now enable earlier detection, shifting the timeline from reaction to prevention.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

This show centers on scientific research and practical strategies to extend healthspan and cognitive vitality. Episodes explore brain aging, sleep biology, autonomic regulation, and lifestyle factors that influence longevity, with a focus on actionable takeaways—ranging from sleep routines and breathing patterns to wearable metrics and evidence-based supplements. A notable strength is blending rigorous science with accessible explanations, using two-host dialogues to translate complex biology into usable guidance for everyday wellness and disease risk reduction. The format and topics suggest a thoughtful audience of health-conscious professionals and curious lifelong learners who want rigorous, evidence-informed insights without hype.

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. Metabolic Mind
2. Lifespan with Dr. David Sinclair
3. Knife Down
4. Race Against Mind: An Alzheimer's Prevention Investigation

How many episodes of this podcast are there?

this podcast launched 5 years ago and published 376 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Suzanne E. Schindler
2. Christopher Weber
3. Peter Gleibus
4. Harriet Shellikens
5. Dung Trinh
6. Monique Richard
7. Andrea Zamet
8. Deng Trinh

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