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Ground Truths

Eric Topol
Artificial Intelligence
Covid-19
Public Health
Long COVID
Cardiovascular Disease
Alzheimer's Disease
Lead Exposure
Healthcare
Aging
Obesity
Science Under Siege
CRISPR
Longevity
Chronic Diseases
Genome Editing
Anti-Vaccine Movement
Inflammation
Air Pollution
Lead Poisoning
Environmental Health

Facts, data, and analytics about biomedical matters. erictopol.substack.com

PublishesTwice monthlyEpisodes97Founded3 years ago
Number of ListenersCategories
Life SciencesHealth & FitnessMedicineScience

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Artwork for Ground Truths

Latest Episodes

Michael Lewis is one of the best storytellers of our era. You know and likely have read his books Moneyball, The Big Short, The Blind Side, Flash Boys, Liar’s Poker, and The Undoing Project, to name a few. He has long been one of my favorite authors.... more

In recent weeks the results (announced by press release) of 2 major placebo-controlled randomized trials—ZEUS, testing an interleukin-6 (IL-6) blocker vs inflammation, and HORIZON, testing a drug to lower Lp(a), indicated failure to achieve their pri... more

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This podcast is meant to complement my recent Ground Truths post Why Our Memory Slips After Age 50 which has all the relevant links to the 2 papers, key graphics, and other related publications. If you haven’t had a chance to read that, it would be h... more

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Deb Cohen is an award winning investigative journalist and correspondent who trained as a physician and has worked with the BBC and BMJ. She just published BAD INFLUENCE, a book which takes us deep into the wellness-industrial complex—the confluence ... more

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Recent Guests

Michael Lewis
Author and journalist
Author of Blockers
Episode: Michael Lewis: The NIH “Murder Mystery,” DOGE, and Our Government Immune System
Marios Georgakis
Physician-scientist, neurologist studying atherosclerosis and inflammation
University of Munich
Episode: Marios Georgakis: Why Did Two Major Clinical Trials for Heart Disease Fail?
Deborah Cohen
Investigative journalist and author of Bad Influence
BBC, BMJ, ITV
Episode: Deborah Cohen: The Wellness-Industrial Complex
Sarah Urbut
Instructors at Harvard Medical School, Broad Institute, and Mass General Hospital; MD, PhD; researcher on Aladynoulli
Harvard Medical School; Broad Institute; Mass General Hospital
Episode: Sarah Urbut: Predicting Your Health Arc
Patrick Hsu
Co-founder of the Arc Institute and Stanford faculty
Arc Institute, Stanford
Episode: Patrick Hsu: How Is AI Catalyzing Life Science?
Aaron Newman
Professor from Stanford who led the study
Stanford University
Episode: Aaron Newman: A Breakthrough Blood Test for Cancer
Elisa Port
Head of breast surgery at Mount Sinai Hospital
Mount Sinai Hospital
Episode: Elisa Port: Discuss THE BREAST ADVICE Book
Helen Pearson
Award-winning journalist and author of Beyond Belief
Nature
Episode: Helen Pearson: What Constitutes Real Medical Evidence?
Donald Milton
Internal medicine physician, Doctor of Public Health, distinguished professor at the University of Maryland
University of Maryland
Episode: Assessment of the Hantavirus with Prof Donald Milton

Host

Eric Topol
Host of Ground Truths

Reviews

4.8 out of 5 stars from 130 ratings
  • Awesome podcast

    After listening to the AI podcast and going over like AI etiquette and how adults and kids interact with AI, I found it very enlightening, but also humoristic at the same time due to the fact that I couldn’t stop thinking of hot tub Time Machine to the movie when the guy was rude to the auto drive car cab and the cab ended up filing a complaint and ended up wanting to terminate thus human for being rude and mean to the car and violent at the same time so yeah AI etiquette and the future of AI en... more

    Apple Podcasts
    5
    Dracg87
    United States5 months ago
  • Fascinating topics & real science

    This is so necessary these days. I started following Eric Topol when Covid started and I am so glad I did. The information he freely shared with the public probably saved my life (I am still a novid here at the end of 2025) and today’s episode with Dr. Gunter couldn’t have come at a better time. I have been fighting for MHT for more than a year now & hot flashes are currently killing me. Now I can take some of this information in to my next appointment. Thank you both!!

    Apple Podcasts
    5
    Meow4B
    United Statesa year ago
  • A Great Listen!

    Informative, interesting, and understandable! Dr. Topol’s podcast is so good!!

    Apple Podcasts
    5
    Lisa H O
    United Statesa year ago
  • Great podcast

    Great guests, information, and clarity. They explain complex medical concepts in plain language and improve how I think through issues.

    Apple Podcasts
    5
    Matthhjjj
    United Statesa year ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Thought-provoking coverage of emerging biomedical topics.
Energetic conversations with credible guests and a strong host presence.
Insightful, data-driven health science with clear storytelling.
Thoughtful exploration of AI in medicine with practical takeaways.
Accessible yet rigorous discussions that connect research to real world care.

Chart Rankings

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Talking Points

Recent interactions between the hosts and their guests.

Michael Lewis: The NIH “Murder Mystery,” DOGE, and Our Government Immune System
Q: What inspired you to frame the story as a murder mystery, and who did you consider as the prime suspect?
Lewis explains that the motive was to personify the tensions within federal funding for science, with suspects including figures close to the policy machinery; he emphasizes that the mystery format helps readers grasp the stakes and actors who shaped science policy under the Trump administration.
Aaron Newman: A Breakthrough Blood Test for Cancer
Q: What evidence supports the clinical relevance of the liquid biopsy approach in melanoma?
A cohort of pre-treatment melanoma patients showed strong correlations between blood ecotypes and tissue-based responses to immunotherapy, validating the prognostic value.
Aaron Newman: A Breakthrough Blood Test for Cancer
Q: How does the Liquid Ecotyper translate tissue findings into a blood test?
By mapping tissue ecotype signals to DNA methylation patterns in cell-free DNA and applying AI to extract the corresponding ecotype probabilities in blood, enabling noninvasive monitoring.
Aaron Newman: A Breakthrough Blood Test for Cancer
Q: What makes Spatial Ecotypes conserved across different cancers?
Nine distinct ecotypes emerge from integrating single-cell expression with spatial location, and these patterns persist across carcinoma and melanoma samples, suggesting fundamental organizational principles of the TME.
Aaron Newman: A Breakthrough Blood Test for Cancer
Q: How does the tumor microenvironment influence cancer therapy decisions beyond what a biopsy shows?
The microenvironment provides context about how cancer and immune cells interact, and spatial ecotypes reveal patterns that relate to therapy response; a blood-based readout could reflect these patterns over time, informing which treatments are more likely to work.

Audience Metrics

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Frequently Asked Questions About Ground Truths

What is Ground Truths about and what kind of topics does it cover?

The podcast centers on biomedical data, science, and medicine, with episodes often exploring cutting-edge research, AI in life sciences, and practical health implications. Guests range from physician-scientists and journalists to biotech leaders, covering topics like predictive health models, tumor microenvironments, AI-driven biology, evidence in medicine, sleep and neurodegeneration, and gut health. A standout trait is the blend of deep technical discussion with accessible storytelling, frequently connecting complex research to real-world clinical impact and patient outcomes. Listeners can expect rigorous analysis, energetic debates about new technologies, and thoughtful considerations of ethics, policy, and implementation in healthcare a... more

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These podcasts share a similar audience with Ground Truths:

1. The Ezra Klein Show
2. The Peter Attia Drive
3. Making Sense with Sam Harris
4. The Permanent Questions With David Brooks
5. Interesting Times

How many episodes of Ground Truths are there?

Ground Truths launched 3 years ago and published 97 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Ground Truths?

Recent guests on Ground Truths include:

1. Michael Lewis
2. Marios Georgakis
3. Deborah Cohen
4. Sarah Urbut
5. Patrick Hsu
6. Aaron Newman
7. Elisa Port
8. Helen Pearson

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