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Dr. GPCR Podcast

Dr. Yamina Berchiche
GPCR
Drug Discovery
Gpcrs
Pharmacology
G Protein-Coupled Receptors
Adhesion Gpcrs
GPCR Biology
Fluorescent Ligands
Adhesion GPCR Workshop
Data Analysis
Dr. Nicole Perry-Hauser
Nonprofit Organizations
Dr. GPCR Podcast
Celtarys Research
Neuroscience
Mexico City
Biotechnology
Science
Computational Chemistry
Olfactory Receptors

We bring you closer to dedicated scientists who work tirelessly to help understand GPCR pathophysiology.

PublishesTwice monthlyEpisodes231Founded6 years ago
Number of ListenersCategories
Life SciencesScience

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Artwork for Dr. GPCR Podcast

Latest Episodes

The biggest signal is not the same as the truest one. Jane Lamerdin and Gaurav Agrawal of Eurofins DiscoverX on what actually makes a GPCR assay trustworthy.

Overexpress a receptor and you get a big, convenient readout that drifts away from what hap... more

Adhesion GPCRs are the largest receptors in the human genome — and until recently, no one was certain they coupled to G proteins at all. Boucard is working to change that, one synapse at a time.

Antony Boucard didn't plan to be a scientist. He was h... more

Frizzled receptors look like GPCRs — but the field is split on whether they actually are. Gunnar Schulte has spent 25 years building the case, one receptor at a time.

Schulte is a professor at Karolinska Institute in Stockholm, where his lab investi... more

Same binding affinity. Same target. One compound worked in vivo. The other did nothing. The answer was how long each molecule stayed on the CRF receptor — seven hours versus fifteen minutes — and no one had thought to measure it.

Sam Hoare spent 15 ... more

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Recent Guests

Jane Lamerdin
VP for R&D at Eurofins DiscoverX
Eurofins DiscoverX
Episode: Building GPCR Assays That Reflect Real Biology
Gaurav Agrawal
Senior Director for Scientific Applications
Eurofins DiscoverX
Episode: Building GPCR Assays That Reflect Real Biology
Antony Boucard
Scientist focused on adhesion GPCRs and synapse formation
Boucard Lab, Mexico City
Episode: He Left Stanford to Decode Adhesion GPCRs - Antony Boucard
Gunnar Schulte
Professor at Karolinska Institute, GPCR researcher
Karolinska Institute
Episode: The GPCR Nobody Has Learned to Drug Yet — Schulte
Chia-Yi Lin
Team member, GeneTex International Office in Taiwan, leads sales/marketing and technical support
GeneTex
Episode: The GPCR Antibody Nobody Could Validate - GeneTex - Alexander Ball & Chia-Yi Lin
Alex Ball
Senior Scientist at GeneTex, involved in marketing, target selection, and QA collaboration
GeneTex
Episode: The GPCR Antibody Nobody Could Validate - GeneTex - Alexander Ball & Chia-Yi Lin
Beatriz Blanco
Neuroscientist; group leader studying adhesion GPCRs in Drosophila
University in Leipzig (Leipzig, Germany)
Episode: Three Adhesion GPCRs and No Rulebook - Beatriz Blanco
Charlotte Crauwels
PhD student focusing on computational GPCR design
Free University of Brussels (VUB)
Episode: Chimeric GPCRs: Why the Easy Designs Fail — Charlotte Crauwels
Tore Bengtsson
Professor in physiology at Stockholm University; entrepreneur and founder of Atroge and Cigri Therapeutics
Stockholm University; Atroge
Episode: The Beta-2 Agonist That Doesn't Stop Working — Tore Bengtsson

Host

Yamina Berchiche
Host of Dr. GPCR Podcast

Reviews

4.9 out of 5 stars from 27 ratings
  • All about GPCRs & insights into the personal world/views of researchers driving GPRR research

    Each and every episode absolutely worth listening !

    Apple Podcasts
    5
    GL_Science
    Germany4 years ago
  • Really enjoyable science podcast!

    Dr. Yamina Berchiche interviews leading GPCR scientists on this vibrant, entertaining podcast. I really appreciate the way the podcast educates and mentors, particularly towards junior scientists but also to the community as a whole. Yamina is a great interviewer, getting insight and personal history from her guests. Am very grateful for Dr GPCR livening up the week in these difficult times!

    Apple Podcasts
    5
    Sam @Pharmechanic
    United States6 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Each and every episode absolutely worth listening !
All about GPCRs & insights into the personal world/views of researchers driving GPRR research
Really enjoyable science podcast! Dr. Yamina Berchiche interviews leading GPCR scientists on this vibrant, entertaining podcast. I really appreciate the way the podcast educates and mentors, particularly towards junior scientists but also to the community as a whole. Yamina is a great interviewer, getting insight and personal history from her guests. Am very grateful for Dr GPCR livening up the week in these difficult times!

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Talking Points

Recent interactions between the hosts and their guests.

Building GPCR Assays That Reflect Real Biology
Q: What keeps you excited about the GPCR field?
They remain the largest target class with ongoing discoveries, and new ways to interrogate and modulate GPCR biology continue to emerge, keeping the field dynamic and full of potential for novel therapeutics.
The GPCR Nobody Has Learned to Drug Yet — Schulte
Q: But before we dive into that, can you please introduce yourself to us and tell us a little bit more about your career?
Gunnar Schulte introduces his background in biochemistry from Berlin, studies in Sweden at Karolinska, and his path through adenosine receptors to Frizzled GPCR research, including pivotal postdocs and collaborations that shaped his focus on Wnt signaling in the midbrain and development.
The Accident That Built the GPCR Field — Bob Lefkowitz
Q: Did you feel when you discovered that there would be a family of GPCRs, that all these receptors might look the same?
That moment was a Eureka for me; it was the realization that the beta receptor sharing a structural relationship with rhodopsin meant a broader family existed, which reshaped the whole field and validated years of effort.
The GPCR Antibody Nobody Could Validate - GeneTex - Alexander Ball & Chia-Yi Lin
Q: Why are recombinant monoclonals becoming more common in GPCR research, and what benefits do they offer researchers?
Recombinant monoclonals provide consistent sequences, scalable production, and reduced lot-to-lot variation, which helps researchers trust that a reagent will behave the same across experiments and over time, especially important for complex GPCR targets.
The GPCR Antibody Nobody Could Validate - GeneTex - Alexander Ball & Chia-Yi Lin
Q: In practice, what does GPCR antibody validation look like at GeneTex?
Validation is ongoing and structured around a five-pillar framework that includes genetic knockouts, orthogonal testing, endogenous expression sampling, side-by-side comparisons with established antibodies, and testing across multiple applications to ensure robust performance.

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Dr. GPCR Podcast launched 6 years ago and published 231 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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Recent guests on Dr. GPCR Podcast include:

1. Jane Lamerdin
2. Gaurav Agrawal
3. Antony Boucard
4. Gunnar Schulte
5. Chia-Yi Lin
6. Alex Ball
7. Beatriz Blanco
8. Charlotte Crauwels

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