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We're not getting any younger... yet.

The Buck Institute
Aging
Geroscience
Immunology
Healthspan
Autophagy
Neurodegeneration
XPRIZE
Proteostasis
Proteins
Gene Therapy
Alzheimer's Disease
Proteomics
Chaperone-Mediated Autophagy
Tissue Repair
Cellular Rejuvenation
Next-Generation Sequencing
Aging Research
George Church
Cognitive Decline
Clinical Trials

Why do some of us age gracefully and others don’t? How do our bodies and minds experience aging at the cellular and molecular level? Why do we even age to begin with? And maybe most importantly, can we do anything about it? Join hosts Eric Verdin, CEO of the Buck Institute in California, and Brianna Stubbs, Director of Translational Science at the Buck, as they speak with some of the brightest sci... more

PublishesTwice monthlyEpisodes33Founded3 years ago
Number of ListenersCategories
ScienceHealth & FitnessLife SciencesMedicine

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Artwork for We're not getting any younger... yet.

Latest Episodes

In this episode, Buck scientist Brianna Stubbs joins Hanadie Yousef, Co-Founder of Juvena Therapeutics, to discuss the cutting-edge of longevity science. Dr. Yousef shares how Juvena is leveraging AI and the secretome—the proteins secreted by stem ce... more

YouTube

Eric Verdin sits down with Dr. Cynthia Kenyon, a true pioneer in the field of geroscience and the Vice President of Aging Research at Calico. Dr. Kenyon recounts the revolutionary discovery that aging is not merely a process of "wearing out," but is ... more

YouTube

What if the secret to a longer, healthier life isn’t found in a new supplement or a complex medical procedure, but in your cells' own innate ability to "take out the trash"? In this episode, host Eric Verdin is joined by Dr. Ana Maria Cuervo, a pione... more

YouTube

XPRIZE Healthspan Executive Director Jamie Justice joins Brianna Stubbs to discuss the $101 million race to restore 10 years of muscle, cognitive, and immune function within a single year. Moving past binary "alive or dead" metrics—famously called th... more

YouTube

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Recent Guests

Cynthia Kenyon
Dr. Cynthia Kenyon, Vice President at Calico
Calico
Episode: Cynthia Kenyon: Switching on Resilience
Ana Maria Cuervo
Physician-scientist specializing in aging, autophagy and CMA
Albert Einstein College of Medicine
Episode: Ana Maria Cuervo: Cellular Recycling
Jamie Justice
Executive Director of XPRIZE Healthspan
XPRIZE Foundation
Episode: Jamie Justice: The New Metrics of Functional Aging
Tony Wyss-Coray
A leading researcher in brain aging and neurodegeneration
Stanford University
Episode: Tony Wyss-Coray: Rejuvenating the Brain
George Church
Geneticist, and professor of genetics at Harvard Medical School, known for his work in aging research and gene therapy.
Harvard Medical School, Founding Director of the Wyss Institute
Episode: George Church: Rewriting The Rules of Aging

Host

Eric Verdin
CEO of the Buck Institute; co-host focusing on aging biology and translational implications.

Reviews

5.0 out of 5 stars from 85 ratings
  • Awesome podcast

    The exact pod cast I was looking for. Thank you very much.

    Apple Podcasts
    5
    maery
    United Statesa year ago
  • Fascinating content!

    Not the same old trending topic! Covered many aspects of longevity and hope for attainable avenues of health span and lifespan.

    Thank you!!!

    Apple Podcasts
    5
    Fat Chat kat
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Very engaging and accessible; great mix of science and practical takeaways.
Keeps evolving; consistently deep dives into cutting-edge aging science and therapies.
High-quality guests with actionable insights for researchers and sponsors.

Chart Rankings

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Talking Points

Recent interactions between the hosts and their guests.

Cynthia Kenyon: Switching on Resilience
Q: What is the significance of the insulin/IGF-1 signaling pathway in aging, and how has this shaped translational research?
Insulin and IGF-1 signaling act as master regulators of aging across species; modulating this pathway can extend lifespan and improve healthspan, informing translational efforts and drug development that aim to target these pathways in humans.
Cynthia Kenyon: Switching on Resilience
Q: Why do model organisms matter, and what are the advantages of studying aging in worms or other animals?
Model organisms are cheaper, reproduce quickly, and allow complete genetic manipulation, making it possible to uncover conserved aging mechanisms that translate to humans, thus accelerating the whole research enterprise.
Ana Maria Cuervo: Cellular Recycling
Q: What is chaperone-mediated autophagy and how is it different from other autophagy pathways?
CMA selectively targets specific damaged proteins using chaperones to guide them to lysosomes for degradation, unlike bulk autophagy which non-selectively sequesters cytoplasmic material; CMA offers precision in protein quality control with broad relevance to aging and disease.
Ana Maria Cuervo: Cellular Recycling
Q: How does proteostasis relate to aging and disease?
Proteostasis is the cellular quality-control system that ensures proteins are correctly folded and located; when it fails, damaged proteins accumulate and contribute to neurodegenerative and metabolic diseases, making proteostasis a central hallmark of aging.
Ana Maria Cuervo: Cellular Recycling
Q: What drew you to the field of aging?
Cuervo explains that her interest grew from clinical rotations in geriatrics and the lack of effective aging interventions in Spain at the time, which motivated her to pursue research to understand and eventually improve aging at the cellular level.

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Frequently Asked Questions About We're not getting any younger... yet.

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A thoughtful science-focused series exploring aging from cellular to systemic levels, often featuring leading researchers and clinicians. Topics frequently center on proteostasis, autophagy, healthspan, immunology, and emerging biomarkers, with an emphasis on translational potential and practical lifestyle factors. Noteworthy is the guests' blend of cutting-edge research and real-world applications, plus a recurring interest in therapies and interventions that could extend functional years rather than merely increasing lifespan.

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Which podcasts are similar to We're not getting any younger... yet.?

These podcasts share a similar audience with We're not getting any younger... yet.:

1. STEM-Talk
2. The Peter Attia Drive
3. Longevity by Design
4. Moonshots with Peter Diamandis
5. Pivot

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We're not getting any younger... yet. launched 3 years ago and published 33 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on We're not getting any younger... yet.?

Recent guests on We're not getting any younger... yet. include:

1. Cynthia Kenyon
2. Ana Maria Cuervo
3. Jamie Justice
4. Tony Wyss-Coray
5. George Church

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