
The 2DD podcast is about setting sights beyond the challenges in your life and dreaming big, making a plan, and then executing like mad. You are guaranteed an emotional rollercoaster, and practical thoughts that you can apply to your life with this podcast. Hosts Sean and Kyle are both affected by a rare disease called Friedreich’s ataxia (FA). FA affects their balance and coordination, significan... more
| Publishes | Weekly | Episodes | 307 | Founded | 10 years ago |
|---|---|---|---|---|---|
| Categories | Self-ImprovementBusinessEducationNon-Profit | ||||

In this special 300th episode of the Two Disabled Dudes Podcast, Sean and Kyle reflect on nearly 10 years of podcasting, the challenges of creating 300 episodes, and the incredible community that has formed along the way. From forgotten recordings an... more
Sean and Kyle kick off this episode with a conversation about smart technology, AI, and the growing tension between convenience and commercialization in everyday life. That discussion sets the stage for a powerful interview with Joshua Resnikoff , fo... more
Part 2 continues Debbie Drell’s story, focusing on the real-life impact of caregiving, invisible illness, and the need for empathy.
Debbie highlights how much people take for granted—walking short distances, being in crowds, traveling, or getting th... more
In this first part of the conversation, Sean and Kyle sit down with longtime friend and rare disease advocate Debbie Drell, whose connection to the space runs deep—both professionally and personally.
Debbie shares the story of her sister Alex, who w... more
Kyle and Sean talk about stuff that I think about all the time. Some pretty deep stuff, but always in an upbeat and hilarious way. I have taken some practical advice from this podcast. Thanks to the dudes!
Love how relatable your topics always are! Thank you for reminding us that we all grieve and that is part of the human condition. There’s always a good life to be had with Ataxia- just keep looking for the good… and you can adopt mine- you’ll even save on instate tuition!
You guys do your homework and ask compassionate and thought-provoking questions. I’ve found my new favorite podcast! Thank you.
I have cerebellar ataxia and what I love most about this podcast is hearing two people who speak like I do talking about topics that I 100 percent identify with. It’s hard to find that when you have a rare disease. Great job, guys!
I was able to meet Sean in Vegas at the annual ataxia conference this month for the National Ataxia Foundation. Let me just say that he is super nice. I love Kyle and Sean’s banter.
The guests they they have on are relevant and knowledgeable I’ll learn a lot from this podcast!
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The show centers on navigating life with serious disabilities, turning obstacles into achievable goals, and pursuing meaningful impact through advocacy, innovation, and community. Episodes blend personal lived experience with expert insights—from rare diseases and disability inclusion to healthcare systems, funding, and accessibility—often anchored by stories of perseverance, practical strategies, and hopeful outcomes. A standout is the hosts' honest humor and willingness to tackle tough topics (privacy, pharma, policy) while highlighting actionable takeaways for listeners who want to improve their own situations or advance disability-related causes.
Note: this summary extrapolates from a pattern of guest expertise (caregiving, rare disease... more
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Two Disabled Dudes launched 10 years ago and published 307 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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Recent guests on Two Disabled Dudes include:
1. Debbie Drell
2. Dr. Eric Mitchell
3. Dylan Mitchell
4. Jake Marazzo
5. Ashley Fox
6. Javier Carrasco
7. Derek Ansel
8. Joe Zinski
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