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Two Disabled Dudes

The Dudes
Friedreich's Ataxia
Accessibility
Clinical Trials
Rare Disease Day
Rare Disease Community
Hope
Community Support
Uplifting Athletes
Duchenne Muscular Dystrophy
Rare Diseases
Disability
Newborn Screening
Spoon Theory
Telomere Biology Disorders
Chan Zuckerberg Initiative
Association For Creatine Deficiencies
Rare Disease
Patient Advocacy
Goal Setting
Resilience

The 2DD podcast is about setting sights beyond the challenges in your life and dreaming big, making a plan, and then executing like mad. You are guaranteed an emotional rollercoaster, and practical thoughts that you can apply to your life with this podcast. Hosts Sean and Kyle are both affected by a rare disease called Friedreich’s ataxia (FA). FA affects their balance and coordination, significan... more

PublishesWeeklyEpisodes307Founded10 years ago
Categories
Self-ImprovementBusinessEducationNon-Profit

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Artwork for Two Disabled Dudes

Latest Episodes

In this special 300th episode of the Two Disabled Dudes Podcast, Sean and Kyle reflect on nearly 10 years of podcasting, the challenges of creating 300 episodes, and the incredible community that has formed along the way. From forgotten recordings an... more

YouTube

Sean and Kyle kick off this episode with a conversation about smart technology, AI, and the growing tension between convenience and commercialization in everyday life. That discussion sets the stage for a powerful interview with Joshua Resnikoff , fo... more

YouTube

Part 2 continues Debbie Drell’s story, focusing on the real-life impact of caregiving, invisible illness, and the need for empathy.

Debbie highlights how much people take for granted—walking short distances, being in crowds, traveling, or getting th... more

YouTube

In this first part of the conversation, Sean and Kyle sit down with longtime friend and rare disease advocate Debbie Drell, whose connection to the space runs deep—both professionally and personally.

Debbie shares the story of her sister Alex, who w... more

YouTube

Key Facts

Accepts Guests
Contact Information
Podcast Host

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Recent Guests

Debbie Drell
Friend and advocate; sister to Alex, caregiver, and patient advocate
Advocate, caregiver for Alex with pulmonary hypertension
Episode: 298 - Invisible Illness, Unbreakable Bond: Part 2
Dr. Eric Mitchell
Founder/lead at Neurodiversity Consultants, psychologist/therapist
Neurodiversity Consultants
Episode: 296 - Support That Meets You Where You Are
Dylan Mitchell
Therapist-in-training; son of Eric Mitchell, neurodivergent individual
Neurodiversity Consultants (consulting group)
Episode: 296 - Support That Meets You Where You Are
Jake Marazzo
Panelist, storytelling/creative professional
Freelance/Advocacy
Episode: 293 - Rare Disease Day: This is What Advocacy Looks Like
Ashley Fox
Panelist, psychology background, Paralympic aspirations
UCSD; Rady Children's Hospital (as volunteer role)
Episode: 293 - Rare Disease Day: This is What Advocacy Looks Like
Javier Carrasco
Panelist, engineering student
University of Arizona
Episode: 293 - Rare Disease Day: This is What Advocacy Looks Like
Derek Ansel
Guest, Rare Disease CRO expert
Worldwide Clinical Trials
Episode: 292 - The Hidden System Behind Rare Disease Treatments
Joe Zinski
Data scientist focused on Castleman disease, invited guest
Castleman disease research group, University-affiliated nonprofit
Episode: 290 - Don’t Suffer Twice
John Crowley
CEO of BIO (Biotechnology Innovation Organization) and former Amicus Therapeutics CEO
BIO; Amicus Therapeutics
Episode: 289 - Re-release: From Dad to Advocate to CEO

Reviews

5.0 out of 5 stars from 220 ratings
  • I can relate

    Kyle and Sean talk about stuff that I think about all the time. Some pretty deep stuff, but always in an upbeat and hilarious way. I have taken some practical advice from this podcast. Thanks to the dudes!

    Apple Podcasts
    5
    BeExcellent9
    United Statesa year ago
  • Always Relevant Topics!

    Love how relatable your topics always are! Thank you for reminding us that we all grieve and that is part of the human condition. There’s always a good life to be had with Ataxia- just keep looking for the good… and you can adopt mine- you’ll even save on instate tuition!

    Apple Podcasts
    5
    gsiitjbf
    United Statesa year ago
  • Thoughtful

    You guys do your homework and ask compassionate and thought-provoking questions. I’ve found my new favorite podcast! Thank you.

    Apple Podcasts
    5
    creatine-mom
    United Statesa year ago
  • So relatable

    I have cerebellar ataxia and what I love most about this podcast is hearing two people who speak like I do talking about topics that I 100 percent identify with. It’s hard to find that when you have a rare disease. Great job, guys!

    Apple Podcasts
    5
    Sharon R1tr
    United States2 years ago
  • Great listen for anyone dealing with a disability

    I was able to meet Sean in Vegas at the annual ataxia conference this month for the National Ataxia Foundation. Let me just say that he is super nice. I love Kyle and Sean’s banter.

    The guests they they have on are relevant and knowledgeable I’ll learn a lot from this podcast!

    Apple Podcasts
    5
    jpars45
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Fans praise honesty, humor, and practical takeaways for living with disability.
Listeners value relatable, hopeful conversations with strong guest lineups.
The show is often described as uplifting, educational, and inspiring for caregivers and patients alike.
Guests are consistently seen as knowledgeable and impactful, with discussions that translate to real-life applications.

Talking Points

Recent interactions between the hosts and their guests.

299 - Building Hope From Broken Systems
Q: What was one surprising thing you learned about the healthcare system during your six to seven years building this?
A key realization was that policy and financial incentives, such as the MLR cap, created perverse incentives that hinder cost-saving care, underscoring the need for a model that aligns employer-backed funding with proactive, preventive genetics-based care.
299 - Building Hope From Broken Systems
Q: How does Sunstone Health actually work with employers to help families?
Sunstone Health acts as an end-to-end solution integrated into self-funded employer plans, using AI to identify patients with potential genetic conditions in claims data, performing trio-based genome sequencing, and delivering clinician-guided care reports, all without out-of-pocket costs to families.
299 - Building Hope From Broken Systems
Q: Give us context on what got you into the rare disease space.
Josh shares how his personal motivation—his child's recurring fevers and a failed search for answers—propelled him from bench science at Harvard to building Sunstone Health to shorten the diagnostic odyssey for families.
292 - The Hidden System Behind Rare Disease Treatments
Q: What is a CRO and why are they important in rare disease drug development?
A CRO is a contract research organization that partners with pharma and biotech to manage and execute clinical trials, provide regulatory support, data analysis, and global resources, helping smaller teams bring drugs through the development and approval process.
291 - Taking on the World’s Longest Stairway
Q: Can you describe to us exactly what this climb is?
It's the Niesen Stairway in Switzerland, the world's longest stairway; the plan is to rent access during the tram's off hours and climb it with a dedicated team, facing long, uneven steps and variable railings.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Gender Skew
Location
Interests
Professions
Age Range
Household Income
Social Media Reach

Frequently Asked Questions About Two Disabled Dudes

What is Two Disabled Dudes about and what kind of topics does it cover?

The show centers on navigating life with serious disabilities, turning obstacles into achievable goals, and pursuing meaningful impact through advocacy, innovation, and community. Episodes blend personal lived experience with expert insights—from rare diseases and disability inclusion to healthcare systems, funding, and accessibility—often anchored by stories of perseverance, practical strategies, and hopeful outcomes. A standout is the hosts' honest humor and willingness to tackle tough topics (privacy, pharma, policy) while highlighting actionable takeaways for listeners who want to improve their own situations or advance disability-related causes.

Note: this summary extrapolates from a pattern of guest expertise (caregiving, rare disease... more

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Which podcasts are similar to Two Disabled Dudes?

These podcasts share a similar audience with Two Disabled Dudes:

1. SmartLess
2. Radiolab

How many episodes of Two Disabled Dudes are there?

Two Disabled Dudes launched 10 years ago and published 307 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Two Disabled Dudes?

Recent guests on Two Disabled Dudes include:

1. Debbie Drell
2. Dr. Eric Mitchell
3. Dylan Mitchell
4. Jake Marazzo
5. Ashley Fox
6. Javier Carrasco
7. Derek Ansel
8. Joe Zinski

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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