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FDA
Artificial Intelligence
Biopharma
Clinical Trials
Pharmaceutical Industry
Oncology
Mergers and Acquisitions
Eli Lilly
Drug Pricing
Biotechnology
Drug Development
Pfizer
Cell Therapy
Gene Therapy
Alzheimer's Disease
Lung Cancer
Novo Nordisk
Patient Engagement
Women In Life Sciences
Layoffs

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&D and device development. Available every Friday morning.

PublishesTwice weeklyEpisodes100Founded3 years ago
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Artwork for The Top Line

Latest Episodes

It’s a pivotal year for RNA therapeutics pioneer Ionis Pharmaceuticals.

After transitioning from a partnering model to a full-ownership strategy following the 2024 approval of Tryngolza, the company is expecting an FDA decision to expand the drug ... more

Speed, precision, and visibility are critical to clinical trial success, and logistics plays a central role in delivering all three. In this interview, Manishaa O’Brien, director of commercial operations at Marken UPS Healthcare Precision Logistics, ... more

President Donald Trump has struck a deal with the UK that exempts prescription drugs imported to the United States from tariffs for three years. In exchange, Britain’s National Health Service will pay 25% more for new drugs. The question now is: Can ... more

Biomarkers are playing an increasingly critical role in shaping the future of oncology trials—and the pace of innovation is accelerating. In this sponsored episode of The Top Line, host Stephanie Butler sits down with Dr. Danielly Vicente, Associate ... more

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Recent Guests

Danielly Vicente
Associate Medical Director of Oncology and Hematology at Allucent
Allucent
Episode: Biomarkers are reshaping oncology trial design (Sponsored)
Dr. Dave Miller
Chief Scientific Officer at Austin Pharmaceuticals
Austin Pharmaceuticals
Episode: Fixing failed spray-dried formulations faster (Sponsored)
Kristen Pilkiewicz
EVP and Executive Creative Director at Sound Healthcare Communications
Sound Healthcare Communications
Episode: AI brings precision to pharma content decisions (Sponsored)
Matt Gline
CEO of Roivant
Roivant Sciences
Episode: Roivant’s CEO thinks China is a ‘red herring’
Rosemary Coates
Executive Director of the Reshoring Institute
Reshoring Institute
Episode: An update on the pharma industry’s reshoring effort
Olive McCormick
Director of Quality at Almac Clinical Services
Almac Clinical Services
Episode: Avoiding 11th hour surprises in clinical trials (Sponsored)
Jeff Jonker
President and Chief Operating Officer, Xaira
Xaira Therapeutics
Episode: What Xaira is building after its $1B fundraise
Ryley Poblete
Global Sciences Practice Area Leader at the architecture and design firm Gensler
Gensler
Episode: As AI evolves, the modern R&D lab is changing
Sue Bodine
President-elect of the American Physiological Society; Professor of Aging and Metabolism Research Program at the Oklahoma Medical Research Foundation
American Physiological Society; Oklahoma Medical Research Foundation
Episode: How physiology powers biotech innovation (Sponsored)

Hosts

Ayla Ellison
Host with insights into biopharma and medtech, bringing a journalistic perspective to industry trends.
Chris Hayden
Host and producer focused on pharmaceutical trends, providing analysis and news updates.
Irina Luo
Host connecting medical communications with strategic insights, focusing on the impact of AI and technology.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#42
United States/News/Business News
Apple Podcasts
#74
Canada/News/Business News
Apple Podcasts
#131
United Kingdom/News/Business News
Apple Podcasts
#30
France/News/Business News
Apple Podcasts
#77
Germany/News/Business News
Apple Podcasts
#156
Australia/News/Business News
Apple Podcasts
#23
Denmark/News/Business News
Apple Podcasts
#26
Belgium/News/Business News
Apple Podcasts
#45
Singapore/News/Business News
Apple Podcasts
#48
Russia/News/Business News
Apple Podcasts
#50
Israel/News/Business News
Apple Podcasts
#57
South Korea/News/Business News
Apple Podcasts
#58
Indonesia/News/Business News
Apple Podcasts
#59
Ireland/News/Business News
Apple Podcasts
#64
Ukraine/News/Business News
Apple Podcasts
#68
Taiwan/News/Business News
Apple Podcasts
#71
China/News/Business News
Apple Podcasts
#92
Norway/News/Business News
Apple Podcasts
#95
Switzerland/News/Business News
Apple Podcasts
#96
Japan/News/Business News
Apple Podcasts
#110
Poland/News/Business News
Apple Podcasts
#125
India/News/Business News
Apple Podcasts
#128
South Africa/News/Business News
Apple Podcasts
#130
Hong Kong/News/Business News
Apple Podcasts
#131
Philippines/News/Business News
Apple Podcasts
#143
Mexico/News/Business News
Apple Podcasts
#148
Spain/News/Business News
Apple Podcasts
#150
Sweden/News/Business News
Apple Podcasts
#156
New Zealand/News/Business News
Apple Podcasts
#163
Finland/News/Business News
Apple Podcasts
#173
Saudi Arabia/News/Business News
Apple Podcasts
#189
Netherlands/News/Business News
Apple Podcasts
#192
Austria/News/Business News
Apple Podcasts
#250
Brazil/News/Business News

Talking Points

Recent interactions between the hosts and their guests.

Roivant’s CEO thinks China is a ‘red herring’
Q: How is Roivant approaching licensing, particularly in China, and what milestones are coming for Brevastatinib?
Roivant hunts globally for licensing opportunities, including China, because of the abundance of programs. Brevastatinib, a dual JAK-1/TIK-2 inhibitor, is advancing in orphan indications with registrational data expected to support FDA filing and potential launch later this year.
Roivant’s CEO thinks China is a ‘red herring’
Q: Why do you see China as a red herring in the discovery space, and where do you think the real opportunities lie?
Because discovery has become commodity-like—antibody discovery can be readily sourced, so the premium shifts to late-stage clinical development, trial design, and indications. The real value is in how you run development and select targets, not in discovering the molecule itself.
AI brings precision to pharma content decisions (Sponsored)
Q: Can you expand a little bit more on how PerspectiveX is different from just using a general AI to evaluate content?
Kristen highlights that PerspectiveX is built specifically for healthcare communications, validated against pharma personas, regulatory constraints, and proprietary data, making it more nuanced and effective than general language models.
AI brings precision to pharma content decisions (Sponsored)
Q: I have a few questions for you today. First one, can you tell me about how Sound, a midsize healthcare communications company, has been navigating AI transformation?
Kristen explains that Sound views AI as an amplifier and accelerator for expertise, enabling faster content creation, tighter testing, and precision while embedding AI across the workflow with pharma-specific tools, governance, and training for teams.
An update on the pharma industry’s reshoring effort
Q: What drives the pace of reshoring for pharma, and where are the big opportunities?
Economics drive decisions; if more than half the cost of a product is labor, manufacturing won't be feasible in the US without automation. Mexico is highlighted as a cost-competitive option, while automation inside the US can unlock opportunities, especially for highly automated, mass-produced products.

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Frequently Asked Questions About The Top Line

What is The Top Line about and what kind of topics does it cover?

Focused on the biopharma and medtech sectors, this series offers listeners insights into key trends and developments within these dynamic industries. Episodes dive into topics such as regulatory issues, drug development, clinical trials, patient access, and industry challenges like tariff impacts and manufacturing capacity. The hosts leverage their journalistic backgrounds to analyze significant business news, mergers, acquisitions, and innovations, ensuring listeners stay informed about what shapes healthcare and pharmaceutical markets. Unique for its blend of rigorous analysis and accessibility, the series caters to professionals seeking a deeper understanding of these crucial fields.

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Which podcasts are similar to The Top Line?

These podcasts share a similar audience with The Top Line:

1. BioCentury This Week
2. The Readout Loud
3. Biotech Hangout
4. The Long Run with Luke Timmerman
5. Raising Health

How many episodes of The Top Line are there?

The Top Line launched 3 years ago and published 100 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Top Line?

Recent guests on The Top Line include:

1. Danielly Vicente
2. Dr. Dave Miller
3. Kristen Pilkiewicz
4. Matt Gline
5. Rosemary Coates
6. Olive McCormick
7. Jeff Jonker
8. Ryley Poblete

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