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Artificial Intelligence
FDA
Biopharma
Clinical Trials
Pharmaceutical Industry
Oncology
Eli Lilly
Mergers and Acquisitions
Novo Nordisk
Drug Development
Drug Pricing
Biotechnology
Pfizer
Cell Therapy
Biotech
Gene Therapy
Patient Engagement
Alzheimer's Disease
Lung Cancer
Companion Diagnostics

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&D and device development. Available every Friday morning.

PublishesTwice weeklyEpisodes100Founded3 years ago
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Latest Episodes

The 2026 Fierce 50 includes people and organizations working on very different problems across biopharma and healthcare, from designing new proteins and developing cancer medicines to protecting vaccine science, improving health literacy and expandin... more

As Fierce Pharma Week approaches, the Fierce Pharma Marketing team is taking stock of some of the biggest trends reshaping how drugmakers and healthcare agencies reach audiences.

In this week’s episode of “The Top Line,” Fierce’s Ben Adams and Zoey... more

Earnings calls are a chance to catch up with the latest developments across Big Pharma and beyond, and last quarter was no different. From the rollout of AI to the oral GLP-1 battle between Novo Nordisk and Eli Lilly and new leadership at Sarepta and... more

Consumerization is changing how patients engage with healthcare, and pharma companies may need to rethink how they approach awareness, diagnosis and commercialization.

In this sponsored episode of The Top Line, host Irena Luo is joined by Rachel St... more

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Recent Guests

Rachel Stoll
Managing Partner of Growth and Innovation at Princeton10
Princeton10
Episode: How consumerization is reshaping pharma marketing (Sponsored)
Kevin Nalty
Vice President Strategy at Princeton10
Princeton10
Episode: How consumerization is reshaping pharma marketing (Sponsored)
Andy Deubler
Chief Business and Administrative Officer at Regeneron Genetics Center
Regeneron Genetics Center
Episode: A genomics library for the AI era
Kirti Prakash
Principal at ZS, focused on patient strategy and services
ZS
Episode: The next frontier in patient support: Connected data, AI and personalized engagement (Sponsored)
Asheesh Shukla
Principal at ZS, leads global patient strategy and services; leads ZS's Zaden platform
ZS
Episode: The next frontier in patient support: Connected data, AI and personalized engagement (Sponsored)
Karsten Munk Knudsen
Chief Financial Officer of Novo Nordisk
Novo Nordisk
Episode: Novo Nordisk’s CFO on the oral Wegovy rollout and beyond
Adam Shain
Vice President and Head of Business Transformation and Growth and Government Affairs Lead at Noble and Aptar Pharma Company
Noble and Aptar Pharma Company
Episode: Inside Noble’s connected approach to patient support (Sponsored)
Zee Zee Gueddar
Senior Director of Commercial Strategy for the Clinical Trial Financial Suite
IQVIA
Episode: Why modern clinical trials need a finance-first strategy (Sponsored)
Will Maddox
Editor, Fierce Biotech; co-author of the special report on emerging hubs
Fierce Biotech
Episode: 5 emerging biotech hubs

Hosts

Ayla Ellison
Host of The Top Line
Stephanie Butler
Host of The Top Line

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#46
United States/News/Business News
Apple Podcasts
#53
United Kingdom/News/Business News
Apple Podcasts
#161
Canada/News/Business News
Apple Podcasts
#111
France/News/Business News
Apple Podcasts
#175
Australia/News/Business News
Apple Podcasts
#210
Germany/News/Business News
Apple Podcasts
#212
Italy/News/Business News
Apple Podcasts
#24
South Korea/News/Business News
Apple Podcasts
#28
Hong Kong/News/Business News
Apple Podcasts
#30
Russia/News/Business News
Apple Podcasts
#32
Denmark/News/Business News
Apple Podcasts
#45
Belgium/News/Business News
Apple Podcasts
#47
Saudi Arabia/News/Business News
Apple Podcasts
#54
South Africa/News/Business News
Apple Podcasts
#57
Netherlands/News/Business News
Apple Podcasts
#58
Israel/News/Business News
Apple Podcasts
#68
China/News/Business News
Apple Podcasts
#73
Taiwan/News/Business News
Apple Podcasts
#77
Poland/News/Business News
Apple Podcasts
#81
Finland/News/Business News
Apple Podcasts
#82
Norway/News/Business News
Apple Podcasts
#93
Singapore/News/Business News
Apple Podcasts
#103
Switzerland/News/Business News
Apple Podcasts
#105
Mexico/News/Business News
Apple Podcasts
#108
India/News/Business News
Apple Podcasts
#114
Ireland/News/Business News
Apple Podcasts
#116
New Zealand/News/Business News
Apple Podcasts
#119
Sweden/News/Business News
Apple Podcasts
#123
Japan/News/Business News
Apple Podcasts
#145
Brazil/News/Business News
Apple Podcasts
#151
Austria/News/Business News
Apple Podcasts
#154
Hong Kong/News
Apple Podcasts
#162
Spain/News/Business News
Apple Podcasts
#192
United Arab Emirates/News/Business News
Apple Podcasts
#217
South Korea/News

Talking Points

Recent interactions between the hosts and their guests.

Novo Nordisk’s CFO on the oral Wegovy rollout and beyond
Q: Karsten, thank you so much for joining us on The Top Line. We're recording this just after Novo Nordisk has announced its second-quarter earnings, so let's start there.
We beat expectations for the second quarter, raised our full-year guidance, and highlighted strong volume growth from our GLP-1 franchise, with European rollout plans progressing and a focus on sustaining long-term growth.
Psychedelics, peptides and GLP-1s
Q: What happened with the peptide advisory committee meeting and the outcomes of the votes?
The committee approved six of seven peptide drugs, rejected one, and voting followed the same eight-to-six-to-one pattern with the same members voting the same way across all decisions, suggesting a pre-determined outcome rather than case-by-case deliberation.
Inside Noble’s connected approach to patient support (Sponsored)
Q: How has the approach to onboarding evolved with more therapies being self-administered at home?
There is a shift toward ensuring day-one experience is optimal, using a mix of hardware, digital tools, and ongoing engagement to keep patients on therapy and connected to care teams.
The next frontier in patient support: Connected data, AI and personalized engagement (Sponsored)
Q: Looking two to three years out, what will be fundamentally different, and what capability is essential?
Anticipatory patient support will become standard, with AI sensing and predicting risks to trigger proactive interventions before barriers arise. The baseline must be trust-first, with compliant, connected data ready for AI-driven engagement across the patient journey.
The next frontier in patient support: Connected data, AI and personalized engagement (Sponsored)
Q: What are the no-regret moves a pharma leader can start with now?
Start by organizing data into data products (foundational, enterprise-wide KPIs, fit-for-use case data products, and an AI-enabling layer). Also define personas for who consumes the data and design last-mile engagement within consent boundaries to ensure compliant, impactful actions.

Audience Metrics

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Frequently Asked Questions About The Top Line

What is The Top Line about and what kind of topics does it cover?

This show concentrates on biopharma, medtech, and healthcare business trends, blending industry news, deals, and science with strategic takeaways for practitioners. Episodes frequently explore data, AI, regulatory designations, clinical development, and market movements, often featuring sponsor-led conversations or editor analysis that translates complex topics into practical guidance for sponsors, researchers, and executives. Notable strengths include hands-on frameworks for modernizing operations, data governance, and patient-centric engagement, plus a track record of bringing together reporters and industry leaders to unpack high-stakes topics from FDA designations to M&A dynamics. Potential listeners who want concise, business-focused i... more

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Which podcasts are similar to The Top Line?

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1. The Readout Loud
2. BioCentury This Week
3. Biotech Hangout
4. WSJ's Take On the Week
5. The Indicator from Planet Money

How many episodes of The Top Line are there?

The Top Line launched 3 years ago and published 100 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Top Line?

Recent guests on The Top Line include:

1. Rachel Stoll
2. Kevin Nalty
3. Andy Deubler
4. Kirti Prakash
5. Asheesh Shukla
6. Karsten Munk Knudsen
7. Adam Shain
8. Zee Zee Gueddar

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