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Artificial Intelligence
FDA
Biopharma
Clinical Trials
Pharmaceutical Industry
Oncology
Mergers and Acquisitions
Eli Lilly
Drug Development
Drug Pricing
Biotechnology
Pfizer
Cell Therapy
Biotech
Gene Therapy
Novo Nordisk
Patient Engagement
Alzheimer's Disease
Lung Cancer
Companion Diagnostics

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&D and device development. Available every Friday morning.

PublishesTwice weeklyEpisodes100Founded3 years ago
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Latest Episodes

The future of patient support may depend less on how much data organizations collect and more on how effectively they connect, govern and activate it. In this sponsored episode of The Top Line, host Stephanie Butler speaks with ZS principals Asheesh ... more

Novo Nordisk’s second-quarter earnings results this week were closely watched by analysts and investors eager to see whether the rollout of oral Wegovy could neutralize concerns about the pharma’s pipeline.

Fierce spoke to Novo’s chief financial of... more

The continued shift toward self-administered therapies is changing how pharmaceutical companies think about patient support. While access and affordability remain priorities, a growing share of industry attention is focused on the patient experience ... more

Is biotech taking a trip to the world of psychedelic drugs? Why is Novo Nordisk going after Eli Lilly’s Zepbound ads? And what are peptides?

This week on "The Top Line," Fierce's Zoey Becker, Will Maddox and Kevin Dunleavy chat about some of the b... more

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Recent Guests

Kirti Prakash
Principal at ZS, focused on patient strategy and services
ZS
Episode: The next frontier in patient support: Connected data, AI and personalized engagement (Sponsored)
Asheesh Shukla
Principal at ZS, leads global patient strategy and services; leads ZS's Zaden platform
ZS
Episode: The next frontier in patient support: Connected data, AI and personalized engagement (Sponsored)
Adam Shain
Vice President and Head of Business Transformation and Growth and Government Affairs Lead at Noble and Aptar Pharma Company
Noble and Aptar Pharma Company
Episode: Inside Noble’s connected approach to patient support (Sponsored)
Zee Zee Gueddar
Senior Director of Commercial Strategy for the Clinical Trial Financial Suite
IQVIA
Episode: Why modern clinical trials need a finance-first strategy (Sponsored)
Will Maddox
Editor, Fierce Biotech; co-author of the special report on emerging hubs
Fierce Biotech
Episode: 5 emerging biotech hubs
Josh JZ Schwartz
Vice President of North America Medical Affairs at BeOne Medicines
BeOne Medicines
Episode: Operating at the speed of science: The new medical affairs playbook (Sponsored)
Jalpa Shah
Leader in the medical and evidence practice at ZS
ZS
Episode: Operating at the speed of science: The new medical affairs playbook (Sponsored)
Justin Masterson
Senior Vice President of Human Sciences
The Directions Group
Episode: Decision readiness is the next AI advantage (Sponsored)
Fraiser Kansteiner
Fierce Pharma Senior Editor
Fierce Pharma Marketing / Fierce Pharma
Episode: A $10B deal, China trial scrutiny and highlights from ADA 2026

Hosts

Ayla Ellison
Host covering policy, market trends, and business implications in biopharma and medtech.
Kelly Hogan
Host focusing on industry trends, deal-making, and strategic insights within biotech and pharma media coverage.

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Psychedelics, peptides and GLP-1s
Q: What happened with the peptide advisory committee meeting and the outcomes of the votes?
The committee approved six of seven peptide drugs, rejected one, and voting followed the same eight-to-six-to-one pattern with the same members voting the same way across all decisions, suggesting a pre-determined outcome rather than case-by-case deliberation.
Inside Noble’s connected approach to patient support (Sponsored)
Q: How has the approach to onboarding evolved with more therapies being self-administered at home?
There is a shift toward ensuring day-one experience is optimal, using a mix of hardware, digital tools, and ongoing engagement to keep patients on therapy and connected to care teams.
The next frontier in patient support: Connected data, AI and personalized engagement (Sponsored)
Q: Looking two to three years out, what will be fundamentally different, and what capability is essential?
Anticipatory patient support will become standard, with AI sensing and predicting risks to trigger proactive interventions before barriers arise. The baseline must be trust-first, with compliant, connected data ready for AI-driven engagement across the patient journey.
The next frontier in patient support: Connected data, AI and personalized engagement (Sponsored)
Q: What are the no-regret moves a pharma leader can start with now?
Start by organizing data into data products (foundational, enterprise-wide KPIs, fit-for-use case data products, and an AI-enabling layer). Also define personas for who consumes the data and design last-mile engagement within consent boundaries to ensure compliant, impactful actions.
The next frontier in patient support: Connected data, AI and personalized engagement (Sponsored)
Q: What do you think is fundamentally changing right now in the way data is being generated, consumed, and trusted, and in the way pharma engages with patients?
The guests discuss four shifts: a healthcare mindset moving from post-event to proactive, real-time data streams to support timely interventions, greater interoperability and consumer-style engagement, and the need for trusted, semantically rich data to power AI agents. They emphasize that data must be governed and turned into actionable, ongoing insight rather than batch reports.

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Frequently Asked Questions About The Top Line

What is The Top Line about and what kind of topics does it cover?

A fast-moving, business-focused show that breaks down biopharma, medtech, and healthcare policy through interviews, expert analysis, and sponsor-driven conversations. Episodes frequently tackle pricing dynamics, regulatory shifts, supply-chain resilience, and go-to-market strategies for drugs, biologics, and medical devices. Notable throughlines include impact of tariffs and trade policy on global supply chains, rapid advances in RNA therapeutics and biomarker-driven trials, and the practical challenges of scaling manufacturing, clinical operations, and commercialization in a highly global, geopolitically nuanced landscape. The format blends newsroom-style reporting with in-depth guest discussions, offering listeners actionable takeaways fo... more

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2. The Readout Loud
3. Biotech Hangout
4. Masters of Scale
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The Top Line launched 3 years ago and published 100 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Top Line?

Recent guests on The Top Line include:

1. Kirti Prakash
2. Asheesh Shukla
3. Adam Shain
4. Zee Zee Gueddar
5. Will Maddox
6. Josh JZ Schwartz
7. Jalpa Shah
8. Justin Masterson

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