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Drug Development
Companion Diagnostics
Agilent Technologies
Precision Medicine
Adcs (antibody Drug Conjugates)
Oncology
Biotech
Next-Generation Sequencing
Immunohistochemistry
Women's Health Gap
Health Conditions Affecting Women
Sickle Cell Disease
Drug Approvals
Clinical Trials and Women's Inclusion
Women's Health Research
Radiology
Medical AI
Patient Psychosocial Health
CRISPR
Car-T Therapies

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&D and device development. Available every Friday morning.

PublishesTwice weeklyEpisodes100Founded3 years ago
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Latest Episodes

For more than a decade, CAR-T therapy has been the miracle of oncology, turning end-stage blood cancers into curable diseases. But the application of these engineered cell therapies is expanding to reset the immune system for patients living with lup... more

What does the future hold for sterile fill-finish CDMOs in a rapidly evolving market?

In this sponsored episode of The Top Line, Denis Johnson, CEO of Grand River Aseptic Manufacturing, discusses the capacity crunch facing U.S. sterile manufacturin... more

Though uncertainty still surrounds the Trump administration’s pharmaceutical import tariffs, the trade rhetoric set off a clear response across the industry in 2025. Drugmakers accelerated U.S. manufacturing plans, pushing production higher as compan... more

Biopharmaceutical innovation is advancing at an unprecedented pace, yet many patients still face barriers to accessing new medicines. In this episode of Health Matters, John O’Brien, president and CEO of the National Pharmaceutical Council, speaks wi... more

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Recent Guests

Dr. Harpreet Singh
Chief Medical Officer at Precision for Medicine and former FDA Oncology Division Director
Precision for Medicine
Episode: Autoimmune CAR-T: Navigating the FDA’s new regulatory playbook
Vinay Prasad
CBER Director at the FDA
FDA
Episode: Autoimmune CAR-T: Navigating the FDA’s new regulatory playbook
Denis Johnson
CEO of Grand River Aseptic Manufacturing with 25 years of experience in GMP manufacturing, focusing on sterile fill.
Grand River Aseptic Manufacturing
Episode: Inside the sterile fill capacity crunch (Sponsored)
Brady McKinney
Risk underwriter covering pharmaceuticals
Atradius
Episode: Trump's tariff threats, measured by manufacturing
James Waldron
Fierce Biotech reporter who led the annual report on clinical trial flops
Fierce Biotech
Episode: What were the biggest clinical trial flops of 2025?
Fraiser Kansteiner
Fierce Pharma reporter and participant in the discussion on clinical trial outcomes
Fierce Pharma
Episode: What were the biggest clinical trial flops of 2025?
Ajay Narasimha
Senior Vice President of Corporate Strategy and Business Development at Mirum Pharmaceuticals
Mirum Pharmaceuticals
Episode: How Mirum is Advancing Rare Disease Care Through Strategic M&A (Sponsored)
Gabriel Dardis
Scientific and communications strategist at RTI Health Solutions with more than eight years of experience
RTI Health Solutions
Episode: Why human expertise still matters in AI-driven med comms (Sponsored)
Frances Ramsey
Senior Information Services Specialist at RTI Health Solutions, with expertise in scientific evidence identification
RTI Health Solutions
Episode: Why human expertise still matters in AI-driven med comms (Sponsored)

Hosts

Ayla Ellison
Host of The Top Line, Editor-in-Chief at Fierce Pharma, and a prominent figure in health journalism.
Chris Hayden
Host of The Top Line and Producer at Fierce, contributing to insights on the biopharma industry.

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Talking Points

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Inside the sterile fill capacity crunch (Sponsored)
Q: What strategic investments and capital projects are on the horizon for you?
Grand River has made significant investments in a new facility and additional sterile filling lines to support growth.
Inside the sterile fill capacity crunch (Sponsored)
Q: How do you ensure a sterile fill finish success for your client's products?
Investing in the right equipment, processes, and people while preparing ahead for staffing is key.
Inside the sterile fill capacity crunch (Sponsored)
Q: What should the industry expect from the CDMO space in the next three years?
Increased demand for available capacity, limitation due to recent acquisitions of larger players, and a shift towards Isolator technology are expected trends.
Autoimmune CAR-T: Navigating the FDA’s new regulatory playbook
Q: What should sponsors pay attention to based on the article?
They should come prepared with clear monitoring plans and disease severity measures that mix both objective and subjective outcomes.
Autoimmune CAR-T: Navigating the FDA’s new regulatory playbook
Q: What development experience can be copied into autoimmune CAR-T programs from oncology?
Oncologists have figured out how to safely treat patients with these therapies, allowing for toxicity management to lend itself to autoimmune protocols.

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Frequently Asked Questions About The Top Line

What is The Top Line about and what kind of topics does it cover?

Exploring the dynamic landscape of the biopharma and medtech industries, discussions revolve around critical trends, innovations, and challenges facing these sectors each week. Journals dissect a range of topics, including mergers, marketing strategies, drug research and development, and advances in medical technology. The podcast frequently features insights from industry experts and leaders, offering listeners an in-depth look into the forces shaping the future of healthcare. Unique elements include episodes centered on women's leadership in life sciences and the evolving role of artificial intelligence in drug discovery and patient engagement.

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These podcasts share a similar audience with The Top Line:

1. BioCentury This Week
2. Bold Names
3. The Readout Loud
4. WSJ Your Money Briefing
5. WSJ's Take On the Week

How many episodes of The Top Line are there?

The Top Line launched 3 years ago and published 100 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Top Line?

Recent guests on The Top Line include:

1. Dr. Harpreet Singh
2. Vinay Prasad
3. Denis Johnson
4. Brady McKinney
5. James Waldron
6. Fraiser Kansteiner
7. Ajay Narasimha
8. Gabriel Dardis

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