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Artwork for The Lancet Oncology in conversation with

The Lancet Oncology in conversation with

The Lancet Group
Cancer Care
Head and Neck Cancer
Diffuse Intracranial Glioma
Global Cancer Surgery
Clinical Trials
Human Papillomavirus
Radiotherapy
Extranodal Extension
Standardization In Medicine
Valometastat
Immunotherapy
Multidisciplinary Workforce
Surgical Oncology
Cancer Research
Tissue Sampling
Glioma Treatment Approaches
Pandemic Impact On Healthcare
Human Papillomavirus Vaccine
Cervical Cancer
Stereotactic Body Radiotherapy

Editors at The Lancet Oncology, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy.

A monthly audio companion to the journal, this podcast covers a broad range of topics, from early-stage breast cancer treatment to mRNA vaccines, the access to essential cancer medicines for children to measuring ovarian toxici... more

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Life SciencesHealth & FitnessMedicineScience

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Artwork for The Lancet Oncology in conversation with

Latest Episodes

Kat Gourd, Acting Deputy Editor of The Lancet Oncology, is joined by Dr Linda Bi, Dr Ruchit Patel, Dr Chloe Gui, Dr Farshad Nassiri, and Dr Matija Snuderl, from institutions in the USA and Canada, to discuss two exciting papers on TERT expression and... more

Cheryl Reeves, Senior Editor at The Lancet Oncology, is joined by Dr Jinming Li, from the Department of Colorectal Surgery, Fudan University Shanghai Cancer Centre, Shanghai, China to discuss his international, multicohort, observational study on pat... more

Jamie Prowse, Senior Editor at The Lancet Oncology, is joined by Professor Abdalla Awidi (Founder and Director of Stem Cell Therapy Center, University of Jordan, Amman, Jordan) to discuss The Lancet Oncology's Cancer control in the Middle East Series... more

Katherine Gourd, Acting Deputy Editor at The Lancet Oncology, and Vania Wisdom, Senior Executive Editor at The Lancet and the journal's Oncology Ambassador, join Leon Terner to share some of their experiences, impressions and highlights from this yea... more

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Recent Guests

Dr. Jinming Li
Doctor from the Department of Colorectal Surgery, Fudan University, Shanghai Cancer Centre
Fudan University, Shanghai Cancer Centre
Episode: Jinming Li on patterns in genomic mutations among patients with early-onset colorectal cancer
Professor Richard Bryant
Professor from the University of Oxford, discussing prostate cancer biopsy approaches
University of Oxford
Episode: Richard Bryant on transperineal vs transrectal biopsy for prostate cancer
Dr. Ariana Znaor
Representative from the International Agency for Research on Cancer
International Agency for Research on Cancer
Episode: Ariana Znaor on cancer surveillance in the Eastern Mediterranean region
Yannick Romero
Doctor from the Union for International Cancer Control
Union for International Cancer Control
Episode: Yannick Romero on the changing landscape of national cancer control plans
Dr. Steven Horwitz
Co-author of papers on valometastat and its role in treating relapsed or refractory T-cell lymphoma
Memorial Sloan Kettering Cancer Center
Episode: Steven Horwitz on valemetostat for relapsed or refractory T-cell lymphoma
Zachary Zumsteg
Associate Professor at Cedars-Sinai Medical Center
Cedars-Sinai Medical Center
Episode: Zachary Zumsteg on early phase trial design for novel drug-radiotherapy combination
Professor May Abdel-Wahab
Director of the Division of Human Health, Department of Nuclear Science and Applications, at the International Atomic Energy Agency
International Atomic Energy Agency
Episode: May Abdel-Wahab and Andrew Scott on The Lancet Oncology Commission on Radiotherapy and Theranostics
Professor Andrew Scott
Director of the Department of Molecular Imaging and Therapy at Austin Health and Programme Head at the Olivia Newton John Cancer Research Institute
University of Melbourne and La Trobe University
Episode: May Abdel-Wahab and Andrew Scott on The Lancet Oncology Commission on Radiotherapy and Theranostics
Dr. Kanwal Raghav
Department of Gastrointestinal Medical Oncology
The University of Texas MD Anderson Cancer Center
Episode: Kanwal Raghav on trastuzumab deruxtecan in HER2-positive advanced colorectal cancer (DESTINY-CRC02)

Hosts

Kat Gourd
Acting Deputy Editor of The Lancet Oncology
Dr. Smriti Patodia
Senior Editor

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Talking Points

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Linda Bi, Ruchit Patel, Chloe Gui, Farshad Nassiri, and Matija Snuderl on TERT expression and TERT promoter mutations in meningiomas
Q: Finally, do you foresee your findings changing the current WHO classification of meningiomas?
While the findings are significant, any changes to the WHO classification will require broad consensus among clinicians and further prospective studies to validate findings.
Linda Bi, Ruchit Patel, Chloe Gui, Farshad Nassiri, and Matija Snuderl on TERT expression and TERT promoter mutations in meningiomas
Q: In view of the fact that most meningiomas are classified as benign non-cancerous tumors, why is it so important to profile these tumors so thoroughly and to ensure that they are classified accurately?
Accurate grading and profiling help guide treatment decisions, especially in cases where benign tumors show more aggressive behaviors that necessitate different management strategies.
Linda Bi, Ruchit Patel, Chloe Gui, Farshad Nassiri, and Matija Snuderl on TERT expression and TERT promoter mutations in meningiomas
Q: Was there anything that surprised you in your results?
They found a higher prevalence of TERT expression versus TERT promoter mutations, with significant implications for understanding tumor behavior and classifications.
Linda Bi, Ruchit Patel, Chloe Gui, Farshad Nassiri, and Matija Snuderl on TERT expression and TERT promoter mutations in meningiomas
Q: Could you please summarize the main findings of your two studies?
The studies revealed that up to one-third of meningiomas expressed TERT, linked to poorer outcomes, and that TERT expression was a more significant biomarker than TERT promoter mutations, which did not independently predict outcomes.
Linda Bi, Ruchit Patel, Chloe Gui, Farshad Nassiri, and Matija Snuderl on TERT expression and TERT promoter mutations in meningiomas
Q: Firstly, why did you decide to undertake these two research studies on TERT expression and TERT promoter mutations in meningiomas? Why were they needed?
The researchers observed inconsistencies in the prognostic implications of TERT mutations versus expression in meningiomas, prompting them to study the impact of these factors on patient outcomes and tumor classification.

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A series of conversations with leading researchers and medical professionals explore a diverse range of oncology topics, highlighting recent advancements in cancer research and treatment methodologies. Discussions cover significant issues, including genomic mutations in cancer patients, new therapies and drugs, cancer treatment protocols, and the challenges of cancer control on a global scale. The episodes delve into specifics such as prostate biopsy techniques, immunotherapy applications, and the effectiveness of various clinical trials, offering listeners a comprehensive understanding of contemporary oncology developments and their implications for patient care.

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1. NEJM This Week
2. JAMA Clinical Reviews
3. Harrison's PodClass: Internal Medicine Cases and Board Prep
4. Journal of Clinical Oncology (JCO) Podcast
5. ASCO Daily News

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Recent guests on The Lancet Oncology in conversation with include:

1. Dr. Jinming Li
2. Professor Richard Bryant
3. Dr. Ariana Znaor
4. Yannick Romero
5. Dr. Steven Horwitz
6. Zachary Zumsteg
7. Professor May Abdel-Wahab
8. Professor Andrew Scott

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