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The Cancer Letter

The Cancer Letter
National Cancer Institute
FDA
National Institutes Of Health
Vinay Prasad
Richard Pazdur
HPV
Financial Toxicity
Cancer Centers
ASCO
The Cancer Letter
Intermediate Endpoints
NCI
Oncology
Anthony Letai
Cervical Cancer
City Of Hope
Multi-Cancer Detection (MCD)
The Wistar Institute
Christianacare Graham Cancer Center
Early Onset Colorectal Cancer

The Cancer Letter, an independent weekly news publication, has been the leading source for information on the issues that shape oncology since 1973. With a dedicated audience of oncology’s leaders, The Cancer Letter stays on top of breaking news and advances in oncology, providing authoritative, award-winning coverage of the development of cancer therapies, drug regulation, legislation, cancer res... more

PublishesTwice weeklyEpisodes92Foundeda year ago
Number of ListenersCategories
Health & FitnessMedicine

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Artwork for The Cancer Letter

Latest Episodes

The oncology community is still riding the high of the success of daraxonrasib—the first drug to show real promise in treating metastatic pancreatic cancer. The drug doubled overall survival for patients in the phase III RASolute-302 trial.

At the s... more

At the American Society of Clinical Oncology annual meeting, the plenary sessions are one of the main events. A handful of clinical research studies are chosen from the thousands that are presented at the conference to represent the biggest achieveme... more

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While every agency under HHS, particularly FDA, has seen historic leadership shakeups and massive cuts to personnel and funding over the course of the second Trump administration—NCI has been spared, even getting a small raise, under the direction of... more

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In last week’s issue of The Cancer Letter, the cover story featured something special: The first de novo book published by The Cancer History Project. The book, “Backwater to Blockbuster: St. Jude Children’s Research Hospital,” co-written by Charles ... more

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Recent Guests

Marcel van den Brink
President of City of Hope, microbiome researcher
City of Hope
Episode: As FDA’s wheels almost entirely come off, NCI remains sturdy—a cancer moonshot may even be on the horizon
Amarintha Curtis
Medical Director Gibbs Cancer Center and Research Institute; PI Upstate Carolina NCORP
Gibbs Cancer Center and Research Institute; Upstate Carolina NCORP
Episode: The Directors: NCORP PIs discuss the growing complexity of regulatory oversight in clinical cancer research
Jeffrey Berenberg
Co-PI Hawaii Minority and Underserved NCORP; core clinical member for translational and clinical research
Hawaii NCORP; University of Hawaii Cancer Center
Episode: The Directors: NCORP PIs discuss the growing complexity of regulatory oversight in clinical cancer research
John Byrd
Director of UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs at the University of Pittsburgh
UPMC Hillman Cancer Center; University of Pittsburgh
Episode: The Directors: Byrd and Chapman speak about avoiding catastrophism and using bridge funding to keep labs open
Andrew Chapman
Director of the Sidney Kimmel Cancer Center at Jefferson Health; Executive Vice President of Oncology Services
Sidney Kimmel Cancer Center at Jefferson Health
Episode: The Directors: Byrd and Chapman speak about avoiding catastrophism and using bridge funding to keep labs open
Nicholas Petrelli
Co-director of the Bridge Program, ChristianaCare
ChristianaCare
Episode: With early-onset colorectal cancer on the rise, CRC screening is no longer just your parents’ problem
Cameron Rathmell
Former director of NCI, CEO at Ohio State James Cancer Center
The Ohio State University James Cancer Center
Episode: With early-onset colorectal cancer on the rise, CRC screening is no longer just your parents’ problem
John Alexander
Co-director of the Bridge Program at the Osuccc James
Osuccc James
Episode: With early-onset colorectal cancer on the rise, CRC screening is no longer just your parents’ problem
Richard Goldberg
Contributor of guest editorial on early onset cancer
The Cancer Letter
Episode: With early-onset colorectal cancer on the rise, CRC screening is no longer just your parents’ problem

Hosts

Paul Goldberg
Host of The Cancer Letter Podcast
Jacqueline Cobb
Associate Editor of The Cancer Letter
Robert A. Winn
Host of The Cancer Letter podcast

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In The Headlines: Kimryn Rathmell, ASCO, and “an important time in cancer research”
Q: What is your message to junior faculty members about staying in the field given funding pressures?
The advice focuses on doubling down on bold, innovative ideas, leveraging opportunities in early career grants, and maintaining enthusiasm for a meaningful career path in cancer research, especially as new funding streams and collaboration opportunities emerge.
In The Headlines: Is early detection always good? Inside NCI’s MCD feasibility trial.
Q: How might the rapid evolution of testing technology affect the trial's relevance by the time results are available?
Researchers acknowledge that technology can evolve quickly, which could render initial endpoints less relevant and require adaptive or ongoing assessment to stay aligned with current capabilities.
In The Headlines: Is early detection always good? Inside NCI’s MCD feasibility trial.
Q: What are the main design challenges of a tri-arm Vanguard-type trial where one arm tests a modality, another arm tests a different modality, and a control group is involved?
Key concerns include whether participants in the control group will seek testing outside the study, how to prevent bias, and how to ensure the trial can still yield meaningful conclusions about mortality versus survival endpoints.
In The Headlines: Is early detection always good? Inside NCI’s MCD feasibility trial.
Q: Is early detection always good, especially when discussing very early stages where outcomes are not yet known?
The hosts and researchers explain that early detection can be beneficial in some contexts but can also cause harm in others due to uncertainties at the earliest stages, hence the need for careful evaluation of benefits versus harms.
In the Headlines: MD Anderson’s Pisters on doing “something gigantic for pediatric cancer”
Q: And how did the idea for the collaboration between MD Anderson and Texas Children's come about?
The idea emerged from a long-held belief in the speaker's career that unifying programs, education, and research across two top institutions could create the largest pediatric oncology effort in the nation, culminating in a joint facility.

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Frequently Asked Questions About The Cancer Letter

What is The Cancer Letter about and what kind of topics does it cover?

A weekly, in-depth look at oncology news, policy, funding, and care delivery from a publication that serves oncology leaders. Episodes center on how new research, regulatory developments, and funding decisions shape patient care and cancer centers, often featuring interviews with senior researchers, center directors, and industry/health-policy experts. Notable threads include translational partnerships between research institutes and cancer centers, the latest in screening and early-detection trials, workforce development and diversity in leadership, and practical implications of funding cycles and policy changes for researchers and clinicians. The show often blends reporting with expert commentary, giving listeners a clear sense of how mac... more

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Which podcasts are similar to The Cancer Letter?

These podcasts share a similar audience with The Cancer Letter:

1. The Peter Attia Drive
2. Good Hang with Amy Poehler
3. Up First from NPR
4. NPR News Now
5. The Daily Show: Ears Edition

How many episodes of The Cancer Letter are there?

The Cancer Letter launched a year ago and published 92 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact The Cancer Letter?

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What guests have appeared on The Cancer Letter?

Recent guests on The Cancer Letter include:

1. Marcel van den Brink
2. Amarintha Curtis
3. Jeffrey Berenberg
4. John Byrd
5. Andrew Chapman
6. Nicholas Petrelli
7. Cameron Rathmell
8. John Alexander

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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