Rephonic
Artwork for The Big Unlock
Artificial Intelligence
AI In Healthcare
Patient Care
Healthcare
Generative AI
Digital Transformation
Healthcare Innovation
Digital Health
Healthcare Technology
Healthcare System
Interoperability
Electronic Health Records
Clinical Informatics
Value-Based Care
Patient Engagement
Machine Learning
Women In Leadership
Telehealth
Data Analytics
Children's Hospital Of Philadelphia

THE BIG UNLOCK PODCAST is a Healthcare Digital Transformation Podcast. Stay Updated on Healthcare’s Digital Transformation Trends. Featuring C-suite Leaders and Insights on Digital Health Innovation. Explore Emerging Healthcare Technologies with Rohit Mahajan and Ritu M. Uberoy.

PublishesWeeklyEpisodes200Founded7 years ago
Number of ListenersCategory
Technology

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Artwork for The Big Unlock

Latest Episodes



The Big Unlock · Roy Schoenberg, M.D., CEO, Aileen and Founder and Executive Director, Amwell

In this episode, Dr. Roy Schoenberg, CEO of Aileen and Founder and Executive Director of Amwell, reflects on the evolution of telehealth and shares a bol... more

The Big Unlock · Michael Hasselberg, PhD, RN, Chief Transformation and Digital Officer, Nebraska Medicine

In this episode, Dr. Michael Hasselberg, Chief Transformation and Digital Officer at Nebraska Medicine, makes a compelling case that sustainable... more

The Big Unlock · Dr. Stephen K. Klasko, Executive in Residence, General Catalyst & Board Chair, DocGo, Teleflex

In this episode, Dr. Stephen K. Klasko, former CEO of Jefferson Health, Executive in Residence at General Catalyst, Board Chair at DocGo, ... more



The Big Unlock · Dr. Eric Stecker, Co-founder and Chief Medical Officer, Insight Health

In this episode, Dr. Eric Stecker, Co-founder and Chief Medical Officer at Insight Health, explores how autonomous AI agents are reshaping cardiovascular care ... more

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Recent Guests

Dr. Michael Hasselberg
Chief Transformation and Digital Officer at Nebraska Medicine
Nebraska Medicine
Episode: AI Leadership Starts with a Simplified, Integrated Tech Stack
Steve Klasko
Former CEO of Jefferson Health; advisor and investor; author
General Catalyst; SUMA Health; author of UnHealthcare
Episode: Healthcare Needs Real Disruption, Not Incremental Change
Dr. Stecker
Chief Medical Officer, co-founder of Insight Health
Insight Health
Episode: Autonomous AI Turning Evidence into Action
Rachel Feinman
Leader at Tampa General Hospital shaping digital health innovation
Tampa General Hospital
Episode: Moving Beyond Pilots to Scale Impact in Healthcare
Aditya Bansod
CTO and founder at Luma
Luma
Episode: Turning AI Hype into Healthcare Execution
Dr. Andrea Willis
Senior Vice President and Chief Medical Officer at BlueCross BlueShield of Tennessee
BlueCross BlueShield of Tennessee
Episode: Augmenting Care and Strengthening Trust with AI
Dr. Amit Phull
Chief Clinical Experience Officer at Doximity, Emergency Medicine Physician, and Adjunct Faculty at Northwestern University.
Doximity
Episode: AI Must Strengthen a Clinician’s “Spidey Sense,” Not Replace It
Greg Goldmacher
Associate VP of Clinical Research at Merck Research Laboratories
Merck Research Laboratories
Episode: AI Improves Endpoints and Evidence in Clinical Trials
Lisa Hunter
Senior Director of Federal Policy and Advocacy at the United States of Care
United States of Care
Episode: Rural Health Transformation and the Future of Patient-First Care

Hosts

Ritu M. Uberoy
Co-host and Managing Partner at Big Rio and Demo Consulting, with a focus on digital transformation in healthcare and technology.
Rohit Mahajan
Co-host and CEO of Demo Consulting and Big Rio, engaged in exploring and implementing digital health initiatives.

Chart Rankings

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Apple Podcasts
#226
Brazil/Technology

Talking Points

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Healthcare Needs Real Disruption, Not Incremental Change
Q: You've talked about health care at any address for years, telehealth, distributed care, and digital front doors—what's the core barrier to scaling this disruption?
The core barrier is the misaligned incentives and the inertia of existing business models across payers and providers; disruption is painful because it challenges the traditional lines of business that many stakeholders depend on, and without aligned incentives the system resists wholesale transformation.
Turning AI Hype into Healthcare Execution
Q: How should CIOs/CTOs measure success beyond time savings?
Success should be defined by improved patient outcomes and end-to-end workflow effectiveness, enabled by integrating tools that preserve context and by calibrating autonomy with governance and compliance controls that fit each health system's maturity.
Turning AI Hype into Healthcare Execution
Q: Where do you think AI can make the biggest initial dent in healthcare workflows?
Ambient, intelligent intake, and context-rich automation have the most immediate potential, especially when they can connect with scheduling, transportation, language services, and documentation within existing systems.
Turning AI Hype into Healthcare Execution
Q: Why isn't healthcare AI delivering what it's promised?
The core issue is execution and integration: AI tools often work in isolation and fail to connect with the broader clinical workflow, so context from handoffs and the healthcare infrastructure isn't preserved, limiting real-world impact.
Augmenting Care and Strengthening Trust with AI
Q: What kind of guardrails do you put in place to make sure that utilization management is done in a way that builds trust?
The company provides clear documentation for any denials to ensure transparency and understanding for providers and members.

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Frequently Asked Questions About The Big Unlock

What is The Big Unlock about and what kind of topics does it cover?

Focusing on the intersection of technology and healthcare, this podcast brings together insights from C-suite leaders and experts as they explore the ongoing digital transformation within the healthcare sector. It covers a variety of topics ranging from artificial intelligence applications in clinical settings to emerging healthcare technologies, providing a platform for thoughtful discussions on how digital innovations are reshaping patient care and health systems. Notable themes include the integration of AI in healthcare analytics, the importance of data interoperability, and the ethical considerations surrounding digital health solutions, which offers listeners a comprehensive understanding of the current landscape in healthcare technol... more

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1. The 229 Podcast
2. The a16z Show
3. The AI Daily Brief: Artificial Intelligence News and Analysis
4. All-In with Chamath, Jason, Sacks & Friedberg
5. Practical AI

How many episodes of The Big Unlock are there?

The Big Unlock launched 7 years ago and published 200 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Big Unlock?

Recent guests on The Big Unlock include:

1. Dr. Michael Hasselberg
2. Steve Klasko
3. Dr. Stecker
4. Rachel Feinman
5. Aditya Bansod
6. Dr. Andrea Willis
7. Dr. Amit Phull
8. Greg Goldmacher

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