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Artwork for Outperform Cancer

Outperform Cancer

Marybeth Gilliam
Gut Microbiome
Biomarker Testing
Immunotherapy
Sucralose
Precision Oncology
Cancer Vaccine
Biomarker-Guided Therapy
Arginine
Citrulline
Metastatic Breast Cancer
Tumor Sequencing
Cancer

Actionable, anti-cancer strategies found in peer-reviewed, scientific research to improve cancer outcomes.

PublishesMonthlyEpisodes17Founded3 years ago
Number of ListenersCategories
Alternative HealthMedicineHealth & Fitness

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Artwork for Outperform Cancer

Latest Episodes

In this episode of Outperform Cancer, Marybeth Gilliam speaks with Dr. Ryan Polselli, a fellowship-trained breast imaging radiologist and founder and CEO of MammoLink, about why breast cancer screening still fails too many women — and what can be don... more

A New Operating System for Cancer: How Sid Sijbrandij Is Outpacing an Evolving Disease

Going “Founder Mode” — And What Patients Can Do to Take Control of Their Own Care

What do you do when you’re told:

“There’s nothing more we can do”?

That’s the ... more

YouTube

What You’ll Learn

- What sulforaphane is and why it’s one of the most studied compounds in cancer research

- Why broccoli sprouts contain up to 100x more sulforaphane than mature broccoli

- How sulforaphane activates detoxification pathways like N... more

YouTube

In this episode, Marybeth speaks with Dr. Nathan Fowler, Chief Medical Officer of BostonGene and former Professor of Medicine at MD Anderson Cancer Center, about why biomarker testing is helping turn personalized medicine from an idea into a reality.... more

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Recent Guests

Sid Sijbrandij
Founder of GitLab, cancer patient
GitLab (founder)
Episode: A New Operating System for Cancer: How Sid Sijbrandij is Outpacing an Evolving Disease
Jed Fahey
Dr. Jed Fahey, nutritional biochemist specializing in plant-based compounds and sulforaphane
Johns Hopkins University
Episode: Can Broccoli Sprouts Fight Cancer? What 30 Years of Research Shows
Nathan Fowler
Dr. Nathan Fowler, Chief Medical Officer at BostonGene; former Professor of Medicine at MD Anderson Cancer Center
BostonGene; MD Anderson Cancer Center (former)
Episode: The Cancer Test Too Many Patients Still Aren't Getting — And Why It Matters
Teri Pollastro
Patient advocate and cancer survivor
Episode: 22 Years Metastatic: How Teri Pollastro Combined Standard Treatment, Cancer Vaccines & Self-Advocacy
Dr. Abby Overacre
PhD in microbiology and immunology; UC Pittsburgh Medical Center researcher focusing on microbiome-immune system interactions in cancer
University of Pittsburgh Medical Center
Episode: Dr. Abby Overacre — A Warning for Cancer Patients: Sucralose May Block Immunotherapy

Host

Mary Beth Gilliam
Host of Outperform Cancer

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Talking Points

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Can Broccoli Sprouts Fight Cancer? What 30 Years of Research Shows
Q: What is the most promising way to consume sulforaphane for cancer prevention or management?
Eating broccoli sprouts or broccoli-rich foods to obtain glucoraphanin with its activating enzyme (myrosinase) appears most effective, as sprouts provide both components; supplements can work but may require attention to dose, enzyme co-delivery, and individual gut microbiome for conversion, and should be discussed with a physician.
Dr. Abby Overacre — A Warning for Cancer Patients: Sucralose May Block Immunotherapy
Q: What practical steps can patients consider based on these findings?
Limit artificial sweeteners like sucralose where possible, focus on a fiber-rich whole-food diet to support a healthy gut microbiome, and consult clinicians about individualized strategies such as arginine/citrulline supplementation and potential microbiome-focused tests and therapies.
Dr. Abby Overacre — A Warning for Cancer Patients: Sucralose May Block Immunotherapy
Q: What immunotherapies were looked at, and were other drugs involved in the trials?
The common thread was anti-PD-1 therapies (e.g., nivolumab and pembrolizumab/Keytruda), often with additional agents in some trials, but the key link across cohorts was the impact of the gut microbiome on immunotherapy response.
Dr. Abby Overacre — A Warning for Cancer Patients: Sucralose May Block Immunotherapy
Q: Can you summarize the research this is referring to and what the big finding was?
We published in Cancer Discovery and found that artificial sweeteners, including sucralose, are detrimental to immunotherapy in cancer patients; in head-to-head comparisons with table sugar they performed worse, and this correlated with reduced immune response and poorer prognosis.

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Frequently Asked Questions About Outperform Cancer

What is Outperform Cancer about and what kind of topics does it cover?

Across recent episodes, the show centers on cancer biology, personalized medicine, and practical patient strategies, blending clinician-scientist insights with patient advocacy and real-world treatment narratives. Conversations frequently explore biomarker-driven care, immunotherapy, genomics, and emerging therapies, with a strong emphasis on actionable guidance for patients and care teams. A noteworthy pattern is pairing high-profile biotech and medical experts with patient perspectives to illuminate how research translates to real-world outcomes, including rapid diagnostics, vaccine-like approaches, and microbiome-related considerations. The show likely appeals to clinicians, researchers, biotech professionals, patient advocates, and educ... more

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Which podcasts are similar to Outperform Cancer?

These podcasts share a similar audience with Outperform Cancer:

1. Radical Remission Project ”Stories That Heal” Podcast
2. The Dr. K Show
3. Chris Beat Cancer: Heal With Nutrition & Natural Therapies
4. The Menopause and Cancer Podcast
5. The Proof with Simon Hill

How many episodes of Outperform Cancer are there?

Outperform Cancer launched 3 years ago and published 17 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Outperform Cancer?

Recent guests on Outperform Cancer include:

1. Sid Sijbrandij
2. Jed Fahey
3. Nathan Fowler
4. Teri Pollastro
5. Dr. Abby Overacre

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