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NPP BrainPod

Springer Nature
Oxytocin
California Mice
Paraventricular Nucleus
Social Anxiety
Neuroscience
Caffeine
Coffee Consumption
Risk Aversion
Worry
Neuropsychopharmacology
Menstrual Cycle Affective Change
Dopamine Receptors
Gray Matter Volume
Nicotine
Addiction
Cannabis Lifetime Use
Endocannabinoid System
ADHD
E-Cigarettes
Cigarette Smoking

BrainPod is the podcast from the journal Neuropsychopharmacology, produced in association with Nature Publishing Group. Join us as we delve into the latest basic and clinical research that advance our understanding of the brain and behavior, featuring highlighted content from a top journal in fields of neuroscience, psychiatry, and pharmacology. For complete access to the original papers and revie... more

PublishesInfrequentlyEpisodes74Founded15 years ago
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Science

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Artwork for NPP BrainPod

Latest Episodes

There are a number of theories that have been studied to try to explain addiction and drug use escalation, and thus to also create animal models of that behavior that can then serve to help develop treatments. One theory for escalation is that people... more

Oxytocin has become known for having anti-anxiety and affiliative behavioral effects. That’s why clinicians and researchers are excited about using oxytocin as a potential therapeutic. 

Brian Trainor is a professor at UC Davis, and his lab has been ... more

Cannabis, which is increasingly legally available, both for therapeutic and recreational use, is now one of the most commonly used drugs worldwide. Of people who have ever used cannabis, studies vary, but they estimate that about 10-25 percent of peo... more

Worry seems like something most people do from time to time, but for some people, severe worry can become an overwhelming sensation, and for older adults later in life, severe worry has been associated with an increased risk of stroke and coronary he... more

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Recent Guests

Olivier George
Professor in the Department of Psychiatry, UC San Diego
University of California, San Diego
Episode: Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats
Brian Trainor
Professor at UC Davis and researcher on oxytocin
University of California, Davis
Episode: Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles
Audrey Krissman
Neuroscience graduate student and co-author of the study
University of California, Davis
Episode: Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles
Laurie Zawertailo
Senior scientist at the Center for Addiction and Mental Health and associate professor
University of Toronto
Episode: Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls
Kanwar Boparai
Postdoctoral researcher with a focus on brain studies
University of Toronto
Episode: Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls
Draulio Araujo
Professor at the Brain Institute in the University of Rio Grande Norte, Brazil, studying psychedelics and depression
University of Rio Grande Norte
Episode: Rapid and sustained antidepressant effects of vaporized N,N-Dimethyltryptamine: A Phase 2a clinical trial in Treatment-Resistant Depression.
Caitlin Orsini
Assistant professor in the Departments of Psychology and Neurology at UT Austin
University of Texas at Austin
Episode: Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats

Host

Cynthia Graeber
Host associated with Neuropsychopharmacology publications and related journals.

Reviews

4.2 out of 5 stars from 27 ratings
  • Robot vs Valley Girl

    What’s with the host’s robotic voice? She cannot be a real person. The I am to take seriously an interviewee who has all the gravitas of a cheerleader. Dull is putting it too kindly.

    Apple Podcasts
    2
    brainzmatter
    United States6 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Pacing and energy can feel flat at times; impact depends on the guest.
The host's gravitas is uneven; guests deserve stronger framing.
Sound and presentation occasionally detract from the science being discussed.
What's with the host's robotic voice? It undermines the interview.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#221
Finland/Science

Talking Points

Recent interactions between the hosts and their guests.

Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats
Q: What would you want colleagues in the field to take away from this paper?
No single theory is wrong; incentive salience is important early on, but long-term addiction likely involves a mix of mechanisms including hedonic allostasis and habit formation, depending on context and individual differences.
Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats
Q: What were the results of your study, and how did the cameras in the box deepen your understanding?
Initial data showed escalation with extended access, but tests for sensitization or tolerance did not predict higher intake; cameras revealed a predictive corner-approach pattern that correlated with later drug-taking and demonstrated an incubation of craving.
Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats
Q: So how did you set up your rat study to try to tease out different theories and potential influences?
They combined self-administration with extended access and a sensory-psychomotor protocol, then added pre-exposure video observations analyzed by machine learning to uncover predictive behavioral patterns beyond traditional measures.
Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles
Q: What do you think the field needs to understand better?
How oxytocin circuits are activated in different social contexts.
Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles
Q: Did anything in the results of this study surprise you?
The distinct electrophysiological signatures of oxytocin neurons in the anterior and posterior PVN were surprising.

Audience Metrics

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Frequently Asked Questions About NPP BrainPod

What is NPP BrainPod about and what kind of topics does it cover?

A science-focused show exploring cutting-edge neuroscience, psychiatry, and pharmacology research through expert interviews and paper summaries. Recent episodes emphasize neurobiological mechanisms, genetics of substance use, aging and worry, nicotine's neurodevelopmental effects, and ADHD pharmacology, often highlighting translational implications and innovative methodologies. The program tends to feature researchers and clinicians, offering deep dives into brain-behavior relationships and potential therapies, making it valuable for researchers, clinicians, and informed listeners who follow neuropharmacology developments. A standout characteristic is its strong ties to a top neuroscience journal, suggesting rigorous science curation and ac... more

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1. Science Magazine Podcast
2. Nature Podcast
3. TED Radio Hour
4. Hidden Brain
5. Inner Cosmos with David Eagleman

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NPP BrainPod launched 15 years ago and published 74 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on NPP BrainPod?

Recent guests on NPP BrainPod include:

1. Olivier George
2. Brian Trainor
3. Audrey Krissman
4. Laurie Zawertailo
5. Kanwar Boparai
6. Draulio Araujo
7. Caitlin Orsini

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