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Artwork for NPP BrainPod

NPP BrainPod

Springer Nature
Oxytocin
California Mice
Paraventricular Nucleus
Social Anxiety
Neuroscience
Caffeine
Coffee Consumption
Depression
Risk Aversion
Worry
Neuropsychopharmacology
Menstrual Cycle Affective Change
Dopamine Receptors
Gray Matter Volume
Nicotine
Addiction
Cannabis Lifetime Use
Endocannabinoid System
ADHD
E-Cigarettes

BrainPod is the podcast from the journal Neuropsychopharmacology, produced in association with Nature Publishing Group. Join us as we delve into the latest basic and clinical research that advance our understanding of the brain and behavior, featuring highlighted content from a top journal in fields of neuroscience, psychiatry, and pharmacology. For complete access to the original papers and revie... more

PublishesInfrequentlyEpisodes76Founded15 years ago
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Science

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Artwork for NPP BrainPod

Latest Episodes

Problematic alcohol use frequently occurs in conjunction with anxiety disorders. Between 20 to 40 percent of individuals with anxiety disorders are also diagnosed with alcohol use disorder. Anxiety can lead people to use alcohol to self-medicate, and... more

Insomnia and depression are two serious and debilitating conditions. Insomnia on its own is linked to an increase in suicide risk, and insomnia can also exacerbate the severity of depression.

Andrea Goldstein-Piekarski, assistant professor in the de... more

There are a number of theories that have been studied to try to explain addiction and drug use escalation, and thus to also create animal models of that behavior that can then serve to help develop treatments. One theory for escalation is that people... more

Oxytocin has become known for having anti-anxiety and affiliative behavioral effects. That’s why clinicians and researchers are excited about using oxytocin as a potential therapeutic. 

Brian Trainor is a professor at UC Davis, and his lab has been ... more

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Recent Guests

Joshua Gray
Associate professor, Department of Psychology, Uniformed Services University
Uniformed Services University
Episode: Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders
Olivier George
Professor in the Department of Psychiatry, UC San Diego
University of California, San Diego
Episode: Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats
Brian Trainor
Professor at UC Davis and researcher on oxytocin
University of California, Davis
Episode: Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles
Audrey Krissman
Neuroscience graduate student and co-author of the study
University of California, Davis
Episode: Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles
Laurie Zawertailo
Senior scientist at the Center for Addiction and Mental Health and associate professor
University of Toronto
Episode: Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls
Kanwar Boparai
Postdoctoral researcher with a focus on brain studies
University of Toronto
Episode: Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls
Draulio Araujo
Professor at the Brain Institute in the University of Rio Grande Norte, Brazil, studying psychedelics and depression
University of Rio Grande Norte
Episode: Rapid and sustained antidepressant effects of vaporized N,N-Dimethyltryptamine: A Phase 2a clinical trial in Treatment-Resistant Depression.
Caitlin Orsini
Assistant professor in the Departments of Psychology and Neurology at UT Austin
University of Texas at Austin
Episode: Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats

Host

Cynthia Graeber
Host of episodes focusing on neuropsychopharmacology research and clinical implications.

Reviews

4.2 out of 5 stars from 27 ratings
  • Robot vs Valley Girl

    What’s with the host’s robotic voice? She cannot be a real person. The I am to take seriously an interviewee who has all the gravitas of a cheerleader. Dull is putting it too kindly.

    Apple Podcasts
    2
    brainzmatter
    United States6 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Delivery may come across as formal or clinical to some listeners.
Listeners note rigorous scientific discussion and clear explanations.
Sometimes pacing can feel dense for non-specialists.
Guests are high-caliber researchers delivering translational insight.

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Talking Points

Recent interactions between the hosts and their guests.

Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders
Q: What are the potential implications for brain targets and treatments?
The analysis highlighted specific genes and brain regions with increased expression, suggesting targets for drug development or repurposing, and the plan to test real-world drug effects in electronic health records to prioritize which targets to take into clinical trials.
Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders
Q: What did you find about directionality between anxiety and alcohol use?
We found evidence for bidirectional causality in both directions, indicating that anxiety can lead to heavier drinking and that heavy drinking can sensitize individuals to anxiety, reinforcing a cycle that may be hard to break.
Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders
Q: Did anything in your results surprise you?
I was surprised by how extensive the genetic overlap turned out to be, which challenges the older view that these disorders are largely distinct and supports the idea of a general psychiatric risk factor influencing multiple conditions.
Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia
Q: So what did you decide to do and why?
We recognized CBT-I improves sleep and depressive symptoms, which implies a shared neurobiological mechanism. We conducted a treatment trial with people having both insomnia and depression, measuring brain activity before and after CBT-I to see if changes in frontolimbic circuits accompany mood improvements.
Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats
Q: What would you want colleagues in the field to take away from this paper?
No single theory is wrong; incentive salience is important early on, but long-term addiction likely involves a mix of mechanisms including hedonic allostasis and habit formation, depending on context and individual differences.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About NPP BrainPod

What is NPP BrainPod about and what kind of topics does it cover?

The show explores cutting-edge brain and behavior research through conversations with leading scientists. Recent episodes span sleep and mood—examining how cognitive-behavioral therapy for insomnia modulates frontal-limbic activity and mood—and extend to addiction neuroscience, oxytocin's neural circuits, cannabis genetics, and worry in aging. A notable throughline is translating basic findings into clinical or translational perspectives, including objective sleep metrics, predictive behavior, and AI-assisted insights. The format often centers on clear explanations of complex experiments, step-by-step study designs, and practical implications for treatment, diagnosis, or future research, with a strong emphasis on neuropharmacology and psych... more

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Which podcasts are similar to NPP BrainPod?

These podcasts share a similar audience with NPP BrainPod:

1. Nature Podcast
2. Unexpected Elements
3. Short Wave
4. JAMA Medical News
5. The Daily

How many episodes of NPP BrainPod are there?

NPP BrainPod launched 15 years ago and published 76 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on NPP BrainPod?

Recent guests on NPP BrainPod include:

1. Joshua Gray
2. Olivier George
3. Brian Trainor
4. Audrey Krissman
5. Laurie Zawertailo
6. Kanwar Boparai
7. Draulio Araujo
8. Caitlin Orsini

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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