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Artwork for JAMAevidence JAMA Guide to Statistics and Methods

JAMAevidence JAMA Guide to Statistics and Methods

JAMA Network
Clinical Trials
Medical Image Analysis
Deep Learning
Genome-Wide Association Studies
Neural Networks
Machine Learning
Non-Parametric Statistical Analysis
Statistical Analysis
Immortal Time Bias
AI In Medicine
Target Trial Emulation
Bayesian Hierarchical Modeling
Randomized Clinical Trials
Ophthalmology
Dermatology
Sequential Multiple Assignment Randomized Trials
Treatment Effects
Statistics In Medicine
Adaptive Clinical Trials
Causal Inference

Interviews with authors of JAMA Guide to Statistics and Methods chapters about common and new statistics and methods used in clinical research and reported in medical journals.

PublishesMonthlyEpisodes36Founded5 years ago
Categories
MedicineHealth & FitnessScience

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Artwork for JAMAevidence JAMA Guide to Statistics and Methods

Latest Episodes

John M. Lachin, ScD, Biostatistics Center, George Washington University, discusses Nonparametric Statistical Analysis with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Nonparametric Statistical Analysis

Andrew D. Althouse, PhD, University of Pittsburgh School of Medicine discusses The Use of Historical Controls in Clinical Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• The Use of Historical Controls in Clinical T... more

Barbara Wendelberger, PhD, Berry Consultants, discusses Futility in Clinical Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Futility in Clinical Trials

William J. Meurer, MD, MS, University of Michigan Medical School, discusses Interim Analyses During Group Sequential Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Interim Analyses During Group Sequential Clinical... more

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Recent Guests

Dr. John Lachin
An emeritus research professor of bioinformatics and statistics at the Milken Institute School of Public Health at the George Washington University.
Milken Institute School of Public Health, George Washington University
Episode: Nonparametric Statistical Analysis With Dr Lachin
Andrew Althouse
Senior Principal Statistician at Medtronic, formerly with the University of Pittsburgh School of Medicine
Medtronic
Episode: The Use of Historical Controls in Clinical Trials, With Dr Althouse
Professor William Meurer
Professor of Emergency Medicine and Neurology at the University of Michigan at Ann Arbor, focusing on neurologic emergencies
University of Michigan
Episode: Interim Analyses During Group Sequential Trials With Dr Meurer
Professor Jerry Rotter
Director of the Institute for Translational Genomics and Population Sciences, Professor of Pediatrics and Human Genetics
Lundquist Institute at Harbor-UCLA Medical Center
Episode: Genome-Wide Association Studies With Dr Rotter
Dr. Anna McGlothlin
Director and Senior Statistical Scientist at Berry Consultants
Berry Consultants
Episode: Bayesian Hierarchical Models With Dr McGlothlin
Dr. Kelley Kidwell
Professor of biostatistics at the University of Michigan School of Public Health
University of Michigan
Episode: Sequential, Multiple Assignment, Randomized Trial Designs With Dr Kidwell
Miguel Hernán
Professor of Epidemiology and Biostatistics
Harvard TH Chan School of Public Health
Episode: Target Trial Emulation for Causal Inference From Observational Data With Dr Hernán
Dr. Larry Carin
a professor at Duke University in the Electrical and Computer Engineering Department with affiliations in computer science and statistics.
Duke University
Episode: On Deep Learning for Medical Image Analysis With Dr Carin
Kevin Weinfurt
Professor and interim chair in the Department of Population Health Sciences at Duke University School of Medicine, consultant for the FDA
Duke University School of Medicine
Episode: Patient-Reported Outcome Measures in Clinical Research With Drs Weinfurt and Reeve

Host

Dr. Roger Lewis
Senior Statistical Editor for JAMA and co-editor of the JAMA Guide to Statistics and Methods series.

Reviews

4.7 out of 5 stars from 50 ratings
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    a year ago

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Talking Points

Recent interactions between the hosts and their guests.

Futility in Clinical Trials With Dr Wendelberger
Q: What problems does futility cause in the interpretation of the trial that has stopped early?
Futility does not indicate harm has occurred, but it leads to fewer data collected, less precise estimates, and reduced ability to identify subgroups.
Futility in Clinical Trials With Dr Wendelberger
Q: Why is futility important?
Futility protects participants and society by discouraging lengthy investigations into ineffective treatments and allows participants to pursue other options.
Futility in Clinical Trials With Dr Wendelberger
Q: What are the usual goals of trials in these settings?
The usual goals of clinical trials are to determine if there is a benefit of a specific treatment and to quantify that benefit.
Futility in Clinical Trials With Dr Wendelberger
Q: Can you explain what futility means in this context?
Futility refers to the likelihood that a trial will not meet its original goals, typically related to demonstrating treatment efficacy.
Interim Analyses During Group Sequential Trials With Dr Meurer
Q: So, when they provide a recommendation to the investigators to stop the trial, does the DSMB tell them why and isn't that unblinding?
The DSMB provides context to the investigators regarding whether the recommendation is due to futility or efficacy, which is a partial unblinding.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

This podcast presents detailed discussions with authors who contribute to an educational series dedicated to various statistical methods and techniques relevant to clinical research. The episodes cover a range of topics including clinical trial methodologies, statistical analyses, causal inference, and design considerations in medical research. Each episode seeks to enhance the understanding of statistical concepts among healthcare professionals and researchers, often featuring case studies that apply these methods in real-world contexts. The series aims to provide both foundational knowledge and advanced insights into the complexities involved in interpreting and conducting clinical studies.

What sets this podcast apart is its focus on br... more

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1. JAMA Medical News
2. JAMA Editors' Summary
3. JAMA Clinical Reviews
4. JAMAevidence Users' Guides to the Medical Literature
5. NEJM This Week

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this podcast launched 5 years ago and published 36 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Dr. John Lachin
2. Andrew Althouse
3. Professor William Meurer
4. Professor Jerry Rotter
5. Dr. Anna McGlothlin
6. Dr. Kelley Kidwell
7. Miguel Hernán
8. Dr. Larry Carin

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