JAMAevidence JAMA Guide to Statistics and Methods

JAMA Network

Clinical Trials

Statistical Analysis

Medical Image Analysis

Deep Learning

Genome-Wide Association Studies

Neural Networks

Machine Learning

Non-Parametric Statistical Analysis

Factorial Clinical Trials

JAMA Network

Immortal Time Bias

AI In Medicine

Target Trial Emulation

Causal Inference

Bayesian Hierarchical Modeling

Randomized Clinical Trials

Dermatology

Ophthalmology

Sequential Multiple Assignment Randomized Trials

Biostatistics

Interviews with authors of JAMA Guide to Statistics and Methods chapters about common and new statistics and methods used in clinical research and reported in medical journals.

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Publishes	Infrequently	Episodes	41	Founded	6 years ago
Number of Listeners		Categories	ScienceHealth & FitnessMedicine

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Latest Episodes

Tipping Point Analysis: Assessing the Potential Impact of Missing Data With Dr Sims

Kendra D. Sims, PhD, postdoctoral associate in Epidemiology, Boston University, discusses Tipping Point Analysis: Assessing the Potential Impact of Missing Data with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Tipping Point... more

8 Jan 2026 • 10 min

YouTube

Instrumental Variables and Heterogeneous Treatment Effects With Dr Norton

Edward C. Norton, PhD, University of Michigan Health Management and Policy, discusses Instrumental Variables and Heterogeneous Treatment Effects with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Instrumental Variables and He... more

4 Sep 2025 • 18 min

YouTube

Factorial Clinical Trial Designs With Dr Ciolino

Jody D. Ciolino, PhD, Northwestern University, Feinberg School of Medicine discusses Factorial Clinical Trial Designs with JAMA Statistical Editor Roger J. Lewis, MD, PhD Related Content:

• Factorial Clinical Trial Designs

• Reporting of Factoria... more

7 Aug 2025 • 19 min

YouTube

JAMA Guide to Statistics and Methods: Assessing Unexpected Circumstances That Lead to Modifications in Clinical Trial Design, Conduct, or Analysis With Professor Brooks

Maria Mori Brooks, PhD, University of Pittsburgh School of Public Health, discusses "Assessing Unexpected Circumstances That Lead to Modifications in Clinical Trial Design, Conduct, or Analysis" in the JAMA Guide to Statistics and Methods series, wit... more

3 Jul 2025 • 16 min

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Recent Guests

Dr. Kendra Sims

Post-doctoral associate at the Boston University School of Public Health specializing in cardiovascular and cognitive health outcomes.

Boston University School of Public Health

Episode: Tipping Point Analysis: Assessing the Potential Impact of Missing Data With Dr Sims

Professor Edward Norton

An economist and the United Health Care Professor at the University of Michigan, involved in statistical methods and causal inference.

University of Michigan

Episode: Instrumental Variables and Heterogeneous Treatment Effects With Dr Norton

Dr. Jody Ciolino

Associate professor in the Department of Preventive Medicine within the Division of Biostatistics and Informatics

Northwestern University

Episode: Factorial Clinical Trial Designs With Dr Ciolino

Professor Maria Brooks

Professor at the University of Pittsburgh's Department of Epidemiology

University of Pittsburgh

Episode: JAMA Guide to Statistics and Methods: Assessing Unexpected Circumstances That Lead to Modifications in Clinical Trial Design, Conduct, or Analysis With Professor Brooks

Dr. John Lachin

An emeritus research professor of bioinformatics and statistics at the Milken Institute School of Public Health at the George Washington University.

Milken Institute School of Public Health, George Washington University

Episode: Nonparametric Statistical Analysis With Dr Lachin

Andrew Althouse

Senior Principal Statistician at Medtronic, formerly with the University of Pittsburgh School of Medicine

Medtronic

Episode: The Use of Historical Controls in Clinical Trials, With Dr Althouse

Professor William Meurer

Professor of Emergency Medicine and Neurology at the University of Michigan at Ann Arbor, focusing on neurologic emergencies

University of Michigan

Episode: Interim Analyses During Group Sequential Trials With Dr Meurer

Professor Jerry Rotter

Director of the Institute for Translational Genomics and Population Sciences, Professor of Pediatrics and Human Genetics

Lundquist Institute at Harbor-UCLA Medical Center

Episode: Genome-Wide Association Studies With Dr Rotter

Dr. Anna McGlothlin

Director and Senior Statistical Scientist at Berry Consultants

Berry Consultants

Episode: Bayesian Hierarchical Models With Dr McGlothlin

Host

Dr. Roger Lewis

Host and Senior Statistical Editor, known for his expertise in statistics and methods for clinical research, as well as editor of the JAMA Guide to Statistics and Methods series.

Reviews

4.7 out of 5 stars from 51 ratings

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Chart Rankings

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Apple Podcasts	#91	Australia/Health & Fitness/Medicine
Apple Podcasts	#25	Japan/Health & Fitness/Medicine
Apple Podcasts	#49	Ireland/Health & Fitness/Medicine
Apple Podcasts	#71	Poland/Health & Fitness/Medicine
Apple Podcasts	#159	South Korea/Health & Fitness/Medicine
Apple Podcasts	#166	Switzerland/Health & Fitness/Medicine

Talking Points

Recent interactions between the hosts and their guests.

Tipping Point Analysis: Assessing the Potential Impact of Missing Data With Dr Sims

Q: What are some of the limitations of tipping point analyses?

Tipping point analyses do not quantify the plausibility of a scenario related to missing data and rely on clinical judgment.

Tipping Point Analysis: Assessing the Potential Impact of Missing Data With Dr Sims

Q: Dr. Sims, in your article on tipping point analysis, you lay out some of the challenges that frequently exist when analyzing the results of clinical trials. Can you tell us about those?

Missing data in clinical trials are a significant issue as they often lead to biases when interpreting trial outcomes as those without follow-up may differ systematically from those with available data.

Instrumental Variables and Heterogeneous Treatment Effects With Dr Norton

Q: What do you think are the key takeaways from your article for our listeners?

Understand that while RCTs are ideal, they may not always be possible, and instrumental variables can help tease out causal effects from observational data, acknowledging that these effects may only apply to specific populations.

Instrumental Variables and Heterogeneous Treatment Effects With Dr Norton

Q: How does instrumental variable analysis adjust or account for the fact that some participants' treatments are affected by the instrumental variable and some aren't?

It focuses on the population that is influenced by the instrumental variable, termed 'compliers', to derive relevant treatment effects.

Instrumental Variables and Heterogeneous Treatment Effects With Dr Norton

Q: What is an instrumental variable and what does it allow us to do that we couldn't otherwise do with observational data?

An instrumental variable allows us to create a situation similar to randomization to analyze the impact of treatments in observational data, which would not be feasible in a randomized control trial.

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Focusing on the application of advanced statistical methods in clinical research, this podcast features in-depth discussions with experts who share insights on statistical techniques and methodologies critical for medical studies. Each episode presents varied discussions on topics such as factorial clinical trial designs, instrumental variables, non-parametric analysis, and the ramifications of unexpected events on trial design, illustrating the adaptability required within this field. Additionally, notable examples from real-world case studies enhance the practical understanding of these concepts, making this resource particularly valuable for professionals in health, academia, and medical research.

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this podcast launched 6 years ago and published 41 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Dr. Kendra Sims
2. Professor Edward Norton
3. Dr. Jody Ciolino
4. Professor Maria Brooks
5. Dr. John Lachin
6. Andrew Althouse
7. Professor William Meurer
8. Professor Jerry Rotter

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