JAMAevidence JAMA Guide to Statistics and Methods

JAMA Network

Clinical Trials

Medical Image Analysis

Deep Learning

Genome-Wide Association Studies

Neural Networks

Machine Learning

Non-Parametric Statistical Analysis

Statistical Analysis

Immortal Time Bias

AI In Medicine

Target Trial Emulation

Bayesian Hierarchical Modeling

Randomized Clinical Trials

Ophthalmology

Dermatology

Sequential Multiple Assignment Randomized Trials

Treatment Effects

Statistics In Medicine

Adaptive Clinical Trials

Causal Inference

Interviews with authors of JAMA Guide to Statistics and Methods chapters about common and new statistics and methods used in clinical research and reported in medical journals.

50 ratings

Publishes	Monthly	Episodes	36	Founded	5 years ago
Categories	MedicineHealth & FitnessScience

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Latest Episodes

Nonparametric Statistical Analysis With Dr Lachin

John M. Lachin, ScD, Biostatistics Center, George Washington University, discusses Nonparametric Statistical Analysis with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Nonparametric Statistical Analysis

3 Apr 2025 • 11 min

The Use of Historical Controls in Clinical Trials, With Dr Althouse

Andrew D. Althouse, PhD, University of Pittsburgh School of Medicine discusses The Use of Historical Controls in Clinical Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• The Use of Historical Controls in Clinical T... more

6 Feb 2025 • 20 min

Futility in Clinical Trials With Dr Wendelberger

Barbara Wendelberger, PhD, Berry Consultants, discusses Futility in Clinical Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Futility in Clinical Trials

5 Dec 2024 • 15 min

Interim Analyses During Group Sequential Trials With Dr Meurer

William J. Meurer, MD, MS, University of Michigan Medical School, discusses Interim Analyses During Group Sequential Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Interim Analyses During Group Sequential Clinical... more

7 Nov 2024 • 16 min

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JAMA Medical NewsJAMA Network

JAMA Editors' SummaryJAMA Network

JAMA Clinical ReviewsJAMA Network

JAMAevidence Users' Guides to the Medical LiteratureJAMA Network

NEJM This WeekNEJM Group

Recent Guests

Dr. John Lachin

An emeritus research professor of bioinformatics and statistics at the Milken Institute School of Public Health at the George Washington University.

Milken Institute School of Public Health, George Washington University

Episode: Nonparametric Statistical Analysis With Dr Lachin

Andrew Althouse

Senior Principal Statistician at Medtronic, formerly with the University of Pittsburgh School of Medicine

Medtronic

Episode: The Use of Historical Controls in Clinical Trials, With Dr Althouse

Professor William Meurer

Professor of Emergency Medicine and Neurology at the University of Michigan at Ann Arbor, focusing on neurologic emergencies

University of Michigan

Episode: Interim Analyses During Group Sequential Trials With Dr Meurer

Professor Jerry Rotter

Director of the Institute for Translational Genomics and Population Sciences, Professor of Pediatrics and Human Genetics

Lundquist Institute at Harbor-UCLA Medical Center

Episode: Genome-Wide Association Studies With Dr Rotter

Dr. Anna McGlothlin

Director and Senior Statistical Scientist at Berry Consultants

Berry Consultants

Episode: Bayesian Hierarchical Models With Dr McGlothlin

Dr. Kelley Kidwell

Professor of biostatistics at the University of Michigan School of Public Health

University of Michigan

Episode: Sequential, Multiple Assignment, Randomized Trial Designs With Dr Kidwell

Miguel Hernán

Professor of Epidemiology and Biostatistics

Harvard TH Chan School of Public Health

Episode: Target Trial Emulation for Causal Inference From Observational Data With Dr Hernán

Dr. Larry Carin

a professor at Duke University in the Electrical and Computer Engineering Department with affiliations in computer science and statistics.

Duke University

Episode: On Deep Learning for Medical Image Analysis With Dr Carin

Kevin Weinfurt

Professor and interim chair in the Department of Population Health Sciences at Duke University School of Medicine, consultant for the FDA

Duke University School of Medicine

Episode: Patient-Reported Outcome Measures in Clinical Research With Drs Weinfurt and Reeve

Host

Dr. Roger Lewis

Senior Statistical Editor for JAMA and co-editor of the JAMA Guide to Statistics and Methods series.

Reviews

4.7 out of 5 stars from 50 ratings

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Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#205	United States/Health & Fitness/Medicine
Apple Podcasts	#144	Italy/Health & Fitness/Medicine
Apple Podcasts	#236	Chile/Top Podcasts
Apple Podcasts	#4	Chile/Health & Fitness/Medicine
Apple Podcasts	#4	Ukraine/Health & Fitness/Medicine
Apple Podcasts	#28	Ukraine/Health & Fitness

Talking Points

Recent interactions between the hosts and their guests.

Futility in Clinical Trials With Dr Wendelberger

Q: What problems does futility cause in the interpretation of the trial that has stopped early?

Futility does not indicate harm has occurred, but it leads to fewer data collected, less precise estimates, and reduced ability to identify subgroups.

Futility in Clinical Trials With Dr Wendelberger

Q: Why is futility important?

Futility protects participants and society by discouraging lengthy investigations into ineffective treatments and allows participants to pursue other options.

Futility in Clinical Trials With Dr Wendelberger

Q: What are the usual goals of trials in these settings?

The usual goals of clinical trials are to determine if there is a benefit of a specific treatment and to quantify that benefit.

Futility in Clinical Trials With Dr Wendelberger

Q: Can you explain what futility means in this context?

Futility refers to the likelihood that a trial will not meet its original goals, typically related to demonstrating treatment efficacy.

Interim Analyses During Group Sequential Trials With Dr Meurer

Q: So, when they provide a recommendation to the investigators to stop the trial, does the DSMB tell them why and isn't that unblinding?

The DSMB provides context to the investigators regarding whether the recommendation is due to futility or efficacy, which is a partial unblinding.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

This podcast presents detailed discussions with authors who contribute to an educational series dedicated to various statistical methods and techniques relevant to clinical research. The episodes cover a range of topics including clinical trial methodologies, statistical analyses, causal inference, and design considerations in medical research. Each episode seeks to enhance the understanding of statistical concepts among healthcare professionals and researchers, often featuring case studies that apply these methods in real-world contexts. The series aims to provide both foundational knowledge and advanced insights into the complexities involved in interpreting and conducting clinical studies.

What sets this podcast apart is its focus on br... more

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1. JAMA Medical News
2. JAMA Editors' Summary
3. JAMA Clinical Reviews
4. JAMAevidence Users' Guides to the Medical Literature
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this podcast launched 5 years ago and published 36 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Dr. John Lachin
2. Andrew Althouse
3. Professor William Meurer
4. Professor Jerry Rotter
5. Dr. Anna McGlothlin
6. Dr. Kelley Kidwell
7. Miguel Hernán
8. Dr. Larry Carin

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