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Intention to Treat

NEJM Group
Covid-19
Alzheimer's Disease
Parkinson's Disease
CAR T-Cell Therapy
Hypertrophic Cardiomyopathy
Gene Therapy
Race-Based Diagnosis
Alzheimer’s Disease
New England Journal Of Medicine
Medication Advances
Blood Cancers
H5N1 Bird Flu
Pulse Oximeter
Transmission Routes
Monoclonal Antibodies
Dementia
Patient-Centric Care
Race-Based Algorithms
Lymphoma
Dairy Cows

​Welcome to “Intention to Treat,” a podcast exploring the critical issues shaping medicine today. In a new 8-week series, The Race Equation, we confront harmful assumptions about race in clinical medicine—from diagnostic algorithms to guidelines—exploring how these practices took hold, why they endure, and what it will take to change them. ​

Hosted by health care journalist Rachel Gotbaum, the “I... more

PublishesWeeklyEpisodes48Founded3 years ago
Number of ListenersCategories
MedicineScienceHealth & Fitness

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Artwork for Intention to Treat

Latest Episodes

The use of race in medicine is harming patients. What is being done to move away from these practices and to change a culture of medicine based on the false premise that race is biological?

A full transcript of this episode is available at w... more

We now know that humans are more than 99.9% genetically alike. So why does medicine still link certain diseases to race? And what do genetics actually tell us about race, ancestry, and disease?

A full transcript of this episode is available at https... more

How did a drug for congestive heart failure get approved and marketed for Black people only?

A full transcript of this episode is available at www.nejm.org/doi/full/10.1056/NEJMp2601978.

The story of the pulse oximeter demonstrates that sometimes consideration of race is critical to diagnosis and treatment — as came starkly into light during the Covid-19 pandemic.

A full transcript of this episode is available at www.nejm.or... more

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Recent Guests

Joseph Graves
Professor of biology at North Carolina A&T State University
North Carolina A&T State University
Episode: The Myth of Race and Genetics
Sarah Tishkoff
Professor of genetics and biology at the University of Pennsylvania
University of Pennsylvania
Episode: The Myth of Race and Genetics
Dorothy Roberts
Professor of law and sociology, University of Pennsylvania
University of Pennsylvania
Episode: BiDil — The Story of the Black Pill
Noha Abalada
Founder, Roots Community Health
Roots Community Health, Oakland, CA
Episode: When Race Matters
Joelle Brevelle
Medical student
Washington State University
Episode: When Race Matters
Oleseni Bello
Patient advocate and survivor
Independent
Episode: When Race Matters
Abeya Trivedi
Pulmonologist
Rush University Medical Center
Episode: When Race Matters
Michael Lipnick
Professor of anesthesia and critical care
University of California, San Francisco; Open Oximetry Project
Episode: When Race Matters
Peter Sporn
Professor of medicine and critical care pulmonologist caring for veterans
Northwestern University, Jesse Brown VA Medical Center
Episode: Money and Misdiagnosis

Host

Rachel Gotbaum
Host of Intention to Treat, Rachel Gotbaum guides deep discussions of complex medical issues, providing insights from her background in journalism and her connection to the New England Journal of Medicine.

Reviews

4.7 out of 5 stars from 62 ratings
  • Surprising Informative

    I am a PhD epidemiologist trained 35 years ago and knew none of this and both shocked and saddened at the racist assumptions that inference medical thinking.

    Apple Podcasts
    3
    The horse with no nickname
    United Statesa month ago
  • Very interesting

    Discussion of important and relevant topics.

    Apple Podcasts
    5
    .><
    United Statesa year ago
  • Excellent

    Very excellent content and performance…

    Thank you for hard work.

    Apple Podcasts
    5
    kiahamid
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners appreciate the informative and engaging discussions, noting the high-quality content that spans both personal and technical aspects of medicine.
Reviews highlight the emotional depth of interviews, often relating personal stories to broader medical issues, making the content relatable and impactful.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

BiDil — The Story of the Black Pill
Q: I was curious if Keith Ferdinand had any regrets about helping get the drug approved.
He expressed concern about the approach but noted the fierce push from advocates and the goal of helping Black patients, while acknowledging the misalignment between clinical benefit and the marketing narrative.
BiDil — The Story of the Black Pill
Q: So what eventually happened with BIDAL after FDA approval in 2005?
The drug showed benefits in Black patients, but the marketing and pricing strategy, including insurance substitution with two cheaper generics, undermined its viability and suggested deeper issues with race-based indications.
BiDil — The Story of the Black Pill
Q: Dorothy, what do you think? Is there a role for race in biomedical research?
Race should never be used as a proxy for genetics; it can help study how racism affects health, but it must be contextualized within social determinants and environmental factors rather than treated as a biological category.
When Race Matters
Q: Why has it taken so long to change pulse oximeter testing and labeling?
The episode suggests delays stem from a combination of historical underestimation of skin pigmentation effects, limited real-world testing, and regulatory gaps that allowed manufacturers to self-validate data, leading to slow progress despite known risks.
Alzheimer’s Update, Part 2
Q: What does this mean for the research if having amyloid in the brain doesn't always lead to Alzheimer's?
Amyloid is necessary, but not sufficient to cause Alzheimer dementia.

Audience Metrics

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Frequently Asked Questions About Intention to Treat

What is Intention to Treat about and what kind of topics does it cover?

The content explored focuses on pressing and multifaceted issues within the medical field, ranging from innovative research breakthroughs to the emotional journeys of patients and their caregivers. Episodes often highlight personal narratives intertwined with scientific inquiry, creating an informative and empathetic perspective on healthcare advancements. Listeners can expect to encounter discussions on topics such as brain-computer interface technology for ALS patients, the implications of race in medical diagnoses, and the challenges surrounding long COVID, among others. This unique combination of personal stories with cutting-edge medical knowledge makes it a compelling resource for healthcare professionals and interested listeners alik... more

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Which podcasts are similar to Intention to Treat?

These podcasts share a similar audience with Intention to Treat:

1. JAMA Medical News
2. NEJM This Week
3. JAMA Editors' Summary
4. Annals On Call Podcast
5. Harrison's PodClass: Internal Medicine Cases and Board Prep

How many episodes of Intention to Treat are there?

Intention to Treat launched 3 years ago and published 48 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Intention to Treat?

Recent guests on Intention to Treat include:

1. Joseph Graves
2. Sarah Tishkoff
3. Dorothy Roberts
4. Noha Abalada
5. Joelle Brevelle
6. Oleseni Bello
7. Abeya Trivedi
8. Michael Lipnick

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