Rephonic
Artwork for From First Principles
Cancer Therapy
Supernova
Spintronics
3I Atlas
Mars
NASA
Max Planck Institute
James Webb Space Telescope
Stellar Evolution
Moore's Law
Plastic Recycling
Bee Superfood
No-Sort Plastic
Human Longevity
Analog AI
Ancient Inscriptions
Earth's Rotation
Baby Solar System
Black Hole Collision
CRISPR Technology

We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.

PublishesDailyEpisodes21Founded3 months ago
Number of ListenersCategory
Science

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Artwork for From First Principles

Latest Episodes

After a packed week of Nobel Prize coverage, Lester and Krishna look back on how From First Principles began and why they built it as an “ESPN for Science.” They revisit 2025’s Medicine, Physics and Chemistry winners and discuss why fundamental resea... more

Hosted by Lester Nare and Krishna Choudhary, this one-episode special brings all three 2025 Nobel Prizes in the sciences into a single listen: Medicine (immune tolerance and FOXP3), Physics (macroscopic quantum tunneling in superconducting circuits),... more

Hosted by Lester Nare and Krishna Choudhary, this two-story, 2.5-hour special sets the table for Nobel Prize Week with deep dives into two recent Nobel-winning domains—gene editing (CRISPR) and gravitational waves (LIGO)—and how AI is accelerating bo... more

Hosted by Lester Nare and Krishna Choudhary, this story unpacks China’s DeepSeek R1 — a large language model trained for just $294,000 using restricted H800 GPUs. Published in Nature, DeepSeek shocked the AI community by matching frontier-level perfo... more

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Hosts

Lester Nare
Co-host discussing recent scientific breakthroughs and leading discussions on various topics in science and technology.
Krishna Choudhary
Co-host and resident PhD, bringing insights and detailed analysis on scientific topics, enhancing discussions with expert knowledge.

Reviews

5.0 out of 5 stars from 31 ratings
  • Great podcast

    The content of the show is GREAT A+. Please work on the thumping sound from one or both of the microphones and adjust the volume so both hosts are more balanced. Everyone interested in current science trends and topics should give this show a listen.

    Apple Podcasts
    4
    AtcNickel
    United States24 days ago
  • In depth, but not intimidating

    These guys go in depth with the science, but they hold your hand with the background. You come away actually understanding what happened. They’re also funny. Easy 5 star, would recommend.

    Apple Podcasts
    5
    Kmoney314159
    United Statesa month ago
  • Loved this.

    Was recommended this channel and absolutely loved the information and how directive it was. Anyone new please check all of them out. 5 star review easily! -shafer

    Apple Podcasts
    5
    ShaferGMoney
    United Statesa month ago

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#42
United States/Science
Apple Podcasts
#69
Canada/Science
Apple Podcasts
#152
United Kingdom/Science
Apple Podcasts
#148
Australia/Science
Apple Podcasts
#37
India/Science
Apple Podcasts
#37
United Arab Emirates/Science

Talking Points

Recent interactions between the hosts and their guests.

FFP EP. 11 | From Cells to Circuits to Crystals — 2025 Nobel Prizes Unpacked
Q: What does peripheral immune tolerance mean?
It is the mechanism that prevents our immune system from attacking our own body tissues.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
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Frequently Asked Questions About From First Principles

What is From First Principles about and what kind of topics does it cover?

Focused on making complex scientific topics accessible, this series presents engaging discussions around recent breakthroughs, technologies, and pressing issues in the fields of science and technology. Topics include advances in artificial intelligence, revolutionary healthcare therapies, environmental innovations, and exploration of cosmic phenomena. The hosts foster a relatable dialogue, breaking down difficult concepts into comprehensible language, which is likely to appeal to a broad audience interested in staying informed about the latest scientific developments without needing specialized education in the field. Notably, the podcast emphasizes the intersection of science and everyday life, encouraging listeners to consider how these a... more

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1. Decoder with Nilay Patel
2. StarTalk Radio
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How many episodes of From First Principles are there?

From First Principles launched 3 months ago and published 21 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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