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Epigenetics Podcast

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Epigenetics
Gene Regulation
Transcription Factors
DNA Methylation
Chromatin
Active Motif
Stem Cells
Chromatin Architecture
Chromatin Dynamics
Alzheimer's Disease
Histone Modifications
Drosophila
Cancer Biology
Aging
Chromatin Remodeling
Cell Biology
Genome Organization
Genome Stability
Gene Expression
Dnase Hypersensitive Sites

Discover the stories behind the science!

PublishesTwice monthlyEpisodes186Founded9 years ago
Number of ListenersCategories
Life SciencesScienceTechnology

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Artwork for Epigenetics Podcast

Latest Episodes

In this episode of the Epigenetics Podcast, we talked with Melanie Eckersley-Maslin from the Peter McCallum Cancer Center about her work on DPPA2 and DPPA4 as Chromatin Priming Factors.

During her PhD in David Spector’s lab at Cold Spring Harbor Lab... more

In this episode we speak with Luke Isbell, Senior Research Fellow and group leader at Adelaide University and the South Australian immunoGENomics Cancer Institute. We discuss his work on transcription factors, chromatin, and how epigenetic marks on h... more

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In this episode we speak with Rob Klose, Professor of Genetics at the University of Oxford, about how CpG islands help control gene expression and chromatin regulation during development.

We discuss how his lab connected CpG islands to histone modif... more

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In this episode of the Epigenetics Podcast, we talked with Onder Albayram from the Medical University of South Carolina about the role of the endocannabinoid system in brain aging and neuroprotection.

A major part of the conversation focuses on the ... more

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Recent Guests

Luke Isbel
Senior Research Fellow and Group Leader at the South Australian ImmunoGenomics Cancer Institute and the Adelaide Center for Epigenetics
South Australian ImmunoGenomics Cancer Institute; Adelaide Center for Epigenetics
Episode: How Chromatin Marks Shape Transcription Factor Function (Luke Isbel)
Rob Klose
Sheahan Professor of Genetics, Oxford University; epigenetics researcher focusing on CpG islands and Polycomb
University of Oxford
Episode: CpG Islands, Polycomb, and the Regulation of Transcription (Rob Klose)
Onder Albayram
Researcher studying endocannabinoid signaling in aging
Medical University of South Carolina
Episode: Epigenetics of the Cannabinoid System (Onder Albayram)
Kunal Rai
Professor of Genomic Medicine at MD Anderson Cancer Center; Scientific Director, Epigenomics Therapy Initiative
MD Anderson Cancer Center
Episode: Chromatin State Reprogramming in Cancer Progression (Kunal Rai)
Steffen Rulands
Professor, LMU Munich; theoretical physicist applying statistical physics to epigenetics
Ludwig Maximilian University of Munich
Episode: Statistical Physics Approaches to DNA Methylation and Aging (Steffen Rulands)
Alon Goren
Associate Professor at UC San Diego, Division of Precision Genomics; studies chromatin biology and technology development
University of California, San Diego
Episode: Antibodies, Automation, and the Fight for Reproducibility (Alon Goren)
Tomohisa Toda
Professor of Neural Epigenomics
Friedrich-Alexander University Erlangen-Nürnberg; Max-Planck Center for Physics and Medicine
Episode: Long-Term Maintenance of Neuronal Identity (Tomohisa Toda)
Tae-Kyung Kim
Professor, Neuroepigenetics Lab, Pohang University of Science and Technology (POSTECH)
Pohang University of Science and Technology (POSTECH)
Episode: Enhancer RNAs: Discovery and Function (Tae-Kyung Kim)
Peter Becker
Retired professor from the Biomedical Center Munich; chromatin biology expert
Biomedical Center Munich
Episode: Peter Becker: A Career in Chromatin — From ISWI to Dosage Compensation

Host

Stefan Dillinger
Primary host covering epigenetics topics with a broad range of guests; associated with industry collaboration.

Reviews

4.9 out of 5 stars from 100 ratings
  • Histones? Yes, histones.

    A fun epigenetics podcast that covers a wide array of topics. Fun to play in the lab during tissue culture!

    Apple Podcasts
    5
    Venus3PA
    Australia2 years ago
  • No rizz

    Love the show. Super interesting guest. But the host has no rizz. Feels like he’s reading off a script everytime.

    Apple Podcasts
    5
    PodcastEnjoyer69
    United States2 years ago
  • Excellent podcast

    Very informative interview. Stefan made it interesting and quite easy to understand on the growing topic of Epigenetics.

    Apple Podcasts
    5
    ship2shoreNJ
    United States8 years ago
  • fascinating guests

    Stefan gets some amazing guests to give some really great insight on the epi field and science in general.

    Apple Podcasts
    5
    GarBat
    United States8 years ago
  • Edith Heard

    Love this series. Great scientists have interesting stories about the field and how they found their way.

    Apple Podcasts
    5
    clutman
    United States8 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Guests are described as top researchers in epigenetics and related fields.
Hosts are commended for clear explanations and engaging interview style.
Listeners praise accessible depth and strong guest lineups.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

CpG Islands, Polycomb, and the Regulation of Transcription (Rob Klose)
Q: A question I like to ask every guest to start off our little podcast is, how did you become interested in biology in the first place and in pursuing a career in science?
Rob describes growing up in a rural Canadian town, fascination with the natural world, and a path through biology that led to studying DNA methylation, CpG islands, and later their role in regulating chromatin and transcription.
Epigenetics of the Cannabinoid System (Onder Albayram)
Q: So you said that there is almost the opposite effect between young and old mice; how gradual is the transition, and is there an age where the effect reverses or crosses over?
The lab is conducting comprehensive HUMMEN and rodent studies to map the overlap and trajectory; early data suggest a sharp decline in endocannabinoid signaling around mid-life, with a substantial reversal potential as age advances, indicating a complex, non-linear relation requiring more precise age windows for optimal effects.
Statistical Physics Approaches to DNA Methylation and Aging (Steffen Rulands)
Q: What is the central mechanism you identified for DNA methylation dynamics in development?
A feedback loop between DNA methylation deposition and chromatin conformation that self-organizes to produce a surprisingly simple global behavior, which can explain both how methylation spreads and how it relates to 3D genome structure.
Statistical Physics Approaches to DNA Methylation and Aging (Steffen Rulands)
Q: How did your background in physics influence your approach to biology and epigenetics?
It drives me to ask different questions and to seek simple, generic principles that can explain broad biological patterns, rather than focusing on highly specific locus-level details. This leads to models that connect one-dimensional methylation data to three-dimensional chromatin dynamics and time evolution.
From GAL4 to targeted DAM-ID: Tools for Studying Gene Expression In Vivo (Andrea Brand)
Q: Could you talk about how the GAL4 system matured and stands the test of time?
She explains that GAL4 continues to be widely used, with caveats about ectopic expression and the importance of having multiple complementary approaches to validate findings; the system has been extended to other organisms and remains a backbone for targeted gene expression in vivo.

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Frequently Asked Questions About Epigenetics Podcast

What is Epigenetics Podcast about and what kind of topics does it cover?

A deep, science-forward series exploring epigenetics, chromatin biology, and gene regulation through guest-led conversations with leading researchers. Across recent episodes, listeners hear theoretical and practical perspectives on DNA methylation, aging, neural identity, enhancer RNAs, chromatin remodeling, and 3D genome organization, often tying molecular mechanisms to development, brain function, and disease. Noteworthy traits include a strong emphasis on interdisciplinary methods (from physics-inspired models to cryo-EM and in vivo tools), long-form interviews that explore career trajectories, collaborative science, and the translational potential of epigenetic research. The show tends to attract researchers, clinicians, and graduate st... more

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1. Nature Podcast
2. Science Magazine Podcast
3. Think Fast Talk Smart: Communication Techniques
4. TED Talks Daily
5. 10% Happier with Dan Harris

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Epigenetics Podcast launched 9 years ago and published 186 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Epigenetics Podcast?

Recent guests on Epigenetics Podcast include:

1. Luke Isbel
2. Rob Klose
3. Onder Albayram
4. Kunal Rai
5. Steffen Rulands
6. Alon Goren
7. Tomohisa Toda
8. Tae-Kyung Kim

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