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Discovery Matters

Discovery Matters
Artificial Intelligence
Drug Discovery
Biotechnology
Lipid Nanoparticles
Personalized Medicine
Biomarkers
Cytiva
Antibody Drug Conjugates
RNA
Parkinson's Disease
Diagnostics
Synthetic Biology
Cancer Treatment
Hepatitis C
Protein A
Microbiome
Gene Editing
Cancer Research
Patient-Derived Organoids
Machine Learning

A collection of stories and insights on matters of discovery that advance life sciences. Brought to you by the curious people at Cytiva.

PublishesTwice monthlyEpisodes120Founded7 years ago
Number of ListenersCategories
ScienceLife Sciences

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Artwork for Discovery Matters

Latest Episodes

In this episode of Discovery Matters, we explore the science, stigma, and innovation behind one of medicine’s most misunderstood hormones. We are joined by Shalin Shah, CEO of Marius Pharmaceuticals, to unpack why testosterone plays a foundational ro... more

Oligonucleotides are moving beyond rare diseases—but scaling them is anything but simple. As therapies target larger patient populations, new synthesis technologies must stand up to real‑world manufacturing constraints, regulatory scrutiny, cost pres... more

YouTube

Global health has hit a low tide, but the story doesn’t end there. In this episode, we revisit Dr. Jerome Kim of the International Vaccine Institute to explore funding cuts, shifting power, and how regions like Africa and Europe are stepping up to re... more

What does real innovation in life sciences actually look like?

In this episode of Discovery Matters, we explore innovation from both a scientific and deeply human perspective. Guests Helena Strigård, CEO of Ventures Accelerated, and Lisa Lindström, ... more

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Recent Guests

Shalin Shah
CEO of Marius Pharmaceuticals
Marius Pharmaceuticals
Episode: 119. The truth about testosterone
Barry Cassie
Industry expert on oligonucleotides and manufacturing challenges
Independent industry veteran, formerly GSK and innovation center
Episode: 118. Oligos: new synthesis technologies
William Fong
VP, Wuxi Tides Division, peptide oligonucleotide development
Wuxi Tides Division, CRDMO industry
Episode: 118. Oligos: new synthesis technologies
Helena Strigård
Founder and CEO of Ventures Accelerated
Ventures Accelerated
Episode: 116. The beauty of innovation
Lisa Lindström
Entrepreneur, business reinvention leader at EY
EY (Ernst & Young)
Episode: 116. The beauty of innovation
Stephan Reisenberg
Group leader in genome engineering and repair
Max Planck Institute for Evolutionary Anthropology
Episode: 115. From synthetic guides to smart delivery
Adam Crow
Senior Manager, Nanomedicine Analytical Development Team
Cytiva
Episode: 115. From synthetic guides to smart delivery
Dr. TP. Singh
Pioneer in protein crystallography and structural biology
Episode: 114. Structural biology and crystallography
Professor Lawrence Steinman
Expert in inverse vaccines and neurological diseases.
Episode: 112. Best of 2025

Hosts

Dodie Axelson
Host with long-running involvement in Discovery Matters, often guiding conversations with industry and scientific leaders.
Conor McKechnie
Co-host and interview host, frequently engaging guests on topics spanning biotech manufacturing, delivery technologies, and biosciences.

Reviews

4.7 out of 5 stars from 80 ratings
  • Delightful

    Curiosity, fun and science mixed together. I love this podcast when I need to take a break yet still learn something new every time.

    Apple Podcasts
    5
    greymist girl
    United States6 years ago
  • A neat insight into the world of bioprocessing and biotech

    A really nice series of short snippets exploring different aspects of the bioprocessing and biotech industry.

    Apple Podcasts
    5
    Amex iPhone 4 user
    United Kingdom6 years ago
  • Biotech explained

    Such an insightful and entertaining podcast to guide us through the biotech world.

    Apple Podcasts
    5
    Dacarruda
    United States6 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

A really nice series of short snippets exploring different aspects of the bioprocessing and biotech industry.
Such an insightful and entertaining podcast to guide us through the biotech world.
Curiosity, fun and science mixed together. I love this podcast when I need to take a break yet still learn something new every time.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

118. Oligos: new synthesis technologies
Q: How do regulatory frameworks impact adoption of new oligo manufacturing methods?
Regulators evaluate safety and data robustness; while some schemes exist for early questions, the overall risk of new tech means sponsors must present strong, well-documented data to avoid delays in filings and launches.
118. Oligos: new synthesis technologies
Q: Can you explain why the delivery and manufacturing of oligonucleotides remains a bottleneck and how new technologies aim to address it?
Delivery bottlenecks largely stem from needing effective, safe transport of oligos to target tissues beyond liver, while manufacturing challenges involve scalingup production with consistent quality and managing complex analytics; new synthesis tech, modular processes, and data-driven control aim to make scale feasible while maintaining quality.
107. Engineering and preserving the microbiome
Q: How is the vault going to reshape the power dynamics and ethics of international research?
The model allows communities agency over their own biological resources, potentially leveling the playing field in biodiversity and resource access.
107. Engineering and preserving the microbiome
Q: So when did Harris have that aha moment when he realized that he and his team could target the toxin rather than the bacteria itself?
Harris realized that genetically, many bacteria are not so different, and targeting the toxins instead of killing the bacteria allows the non-harmful bacteria to coexist.
105. What is pain?
Q: How do we untangle the nuances when it comes to pain perception?
Understanding pain involves both biological variables like sex and social constructs like gender, complicating pain perception.

Audience Metrics

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Frequently Asked Questions About Discovery Matters

What is Discovery Matters about and what kind of topics does it cover?

This program frequently covers cutting-edge topics in life sciences, including bioprocessing, oligonucleotide manufacturing, gene editing delivery, vaccine security, and the role of AI in accelerating discovery. Guests span industry veterans, researchers, and leaders from major biotech and health organizations, offering practical perspectives on translation from lab to clinic, regulatory navigation, and the evolving biotech landscape. The show often blends human-centered narratives with technical detail, making it useful for listeners who want actionable insights on how scientific advances reach patients, funders, and partners. A notable strength is its ability to connect laboratory breakthroughs with real-world impact, governance, and mark... more

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Which podcasts are similar to Discovery Matters?

These podcasts share a similar audience with Discovery Matters:

1. Biotech Hangout
2. The Readout Loud
3. BioCentury This Week
4. Freakonomics Radio
5. The Daily

How many episodes of Discovery Matters are there?

Discovery Matters launched 7 years ago and published 120 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Discovery Matters?

Recent guests on Discovery Matters include:

1. Shalin Shah
2. Barry Cassie
3. William Fong
4. Helena Strigård
5. Lisa Lindström
6. Stephan Reisenberg
7. Adam Crow
8. Dr. TP. Singh

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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