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Artwork for Core Memory

Core Memory

Ashlee Vance
Artificial Intelligence
Neuroscience
Neuralink
Biotechnology
Silicon Valley
Openai
Technology
China
Spacex
Aging
AI In Drug Discovery
Epigenetic Reprogramming
Brain-Computer Interface
Connectome
United States
Consciousness
Retinal Prosthesis
Podcasting
Longevity Medicine
Gene Editing

Core Memory is a podcast about science and technology hosted by best-selling author and filmmaker Ashlee Vance. Vance has spent the past two decades chronicling advances in science and tech for publications like The Economist, The New York Times and Bloomberg Businessweek. Along with the stories, he's written best-selling books like Elon Musk’s biography, made an Emmy-nominated tech TV show watche... more

PublishesWeeklyEpisodes89Founded2 years ago
Number of ListenersCategories
TechnologyScience

Listen to this Podcast

Artwork for Core Memory

Latest Episodes

This episode is nerd catnip unlike anything I’ve ever seen before.

Ashlee sat down with Seamus Blackley, who you might know as the man who talked Microsoft into building the Xbox. Nowadays, you can find Blackley in a Pasadena laboratory making the w... more

We have been promised glorious gene therapies for decades. This is supposed to be the stuff of reprogramming the body to blunt or cure diseases with something approaching a permanent fix. While gene therapy progress has been made, treatments remain r... more

Over the past five years, Alex Colville has become one of the most influential figures in the longevity and aging fields.

There’s a decent chance you have not heard of him, which is a bit by design. Unlike many longevity gurus, Colville does not see... more

Every couple of days, a new AI-meets-biotech startup sends me a pitch, and the pitches all sound the same. AI is amazing, and it can now tame biology. We’re on the cusp of producing new cures for diseases at a rapid rate, and these startups know just... more

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Recent Guests

Seamus Blackley
Physicist, inventor, engineer, and Xbox co-creator
Pacific Light and Hologram / Xbox
Episode: The Xbox Nearly Destroyed Him - EP 87 Seamus Blackley
Adrian Veres
Co-founder and Chief Science Officer
Dyno Therapeutics
Episode: Gene Therapies That Work? - EP 86 Adrian Veres
Alex Colville
Co-founder and General Partner at Age One (longevity-focused VC)
Age One
Episode: The Realest Longevity Guru - EP 85 Alex Colville
Abhi Mahajan
Biotech researcher, formerly at Noetic and OpenAI Foundation
OpenAI Foundation; Noetic
Episode: AI Will Cure Us All!! Or Not!! - EP 84 Abhi Mahajan
Alan Eustace
Skydiver and engineer, former Google/DEC executive, space and ocean technology pioneer
Independent, formerly Google, Paragon/WorldView connections mentioned in episode
Episode: The Google Engineer Who Set The Skydiving Record At 58 - EP 83 Alan Eustace
Ben Woodington
CEO and co-founder of Coherence
Coherence
Episode: An Implant That Tracks And Treats Cancer Tumors - EP 82 Ben Woodington
Ashlee Vance
Author, filmmaker, founder/CEO of Core Memory
Core Memory
Episode: Inside The Media Marvel That Is TBPN
Prineha Narang
Professor at UCLA, quantum scientist
University of California, Los Angeles (UCLA)
Episode: Quantum Everything Explained - EP 81 Prineha Narang
Chris Power
Founder and CEO of Hadrian
Hadrian
Episode: He Came From Oz To Save American Manufacturing - EP 80 Chris Power

Hosts

Ashlee Vance
Host with coreMemory branding; best-selling author and filmmaker; focus on tech storytelling and interviews with industry leaders.
Kylie Robison
Co-host referenced in intros and credits; journalist and contributor with tech reporting experience.

Reviews

4.9 out of 5 stars from 116 ratings
  • Extraordinarily Authentic

    I stumbled across this podcast because, for about a year, I had been following a really good tech reporter, Kylie Robison, on Twitter.

    I found her writing to be refreshingly authentic in a sea of hype.

    She tweeted about a podcast she was part of, so I gave it a listen and discovered Ashlee Vance. Again, I found his approach to talking about technology to be genuinely authentic. There’s a real excitement in the way he shares what he’s learned.

    It’s hard to find podcasts like this where you fee... more

    Apple Podcasts
    5
    ShaunMcDonnell
    United States4 months ago
  • My new favorite podcast

    Love the depth and personality Ashlee and Kylie bring to my favorite topics in technology and AI!

    Apple Podcasts
    5
    bfioca
    United States4 months ago
  • Philosophy nerd loves the show

    Hi!

    Philosophy has long pondered whether the mind is a machine, what that would mean, and how we would know (check out philosophy of mind, cognitive science, etc.). I got all my degrees in philosophy (spare me the jokes!). I've been fascinated with AI, talked about it with engineer friends, read about it, used it, etc., and this podcast has become my resource for bridging some of the gaps in my understanding of what's afoot, both globally and locally. I'm from the Bay Area and have watched tec... more

    Apple Podcasts
    5
    c'estmoi,jessa
    United States5 months ago
  • Indoor oxygen levels finally optimal

    This review is review is most relevant for indoor gardening enthusiasts, but hope others will find it helpful too.

    I’d been struggling for about a year with low oxygen in my home office, and brought in some indoor plants to fix the problem.

    As many do, I opted for peace lilies, but despite following every top voted recommendation on Reddit was barely keeping them alive, oxygen levels remained low.

    While looking for new tech news content I stumbled across Core Memory. I tuned in while getti... more

    Apple Podcasts
    5
    Abbabba6555
    United States5 months ago
  • My favorite podcast

    This is the one

    Apple Podcasts
    5
    tarnesen
    United States8 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners appreciate the hosts' ability to translate cutting-edge tech into accessible narratives.
Show draws favorable comparisons for high-quality guests and offerings beyond typical tech podcasts.
Fans value depth, practicality, and candidness in interviews with industry leaders.
Listeners praise authenticity and clear communication about complex tech topics.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#174
Israel/Technology
Apple Podcasts
#249
India/Technology

Talking Points

Recent interactions between the hosts and their guests.

The Realest Longevity Guru - EP 85 Alex Colville
Q: What could be the most exciting near-term development in the field?
A trend toward trials designed to assess aging broadly rather than a single disease, and the potential for systemic interventions (like RNA-based or replacement therapies) to start showing measurable benefits in humans within the next decade.
The Realest Longevity Guru - EP 85 Alex Colville
Q: Do you see real progress translating these therapies to humans, or is it mostly hype?
The guest argues that while progress is challenging and expensive, there are credible, datadriven paths—such as GLP-1s and reprogramming approaches—that are moving toward human trials, with regulatory and logistical hurdles being the main bottlenecks.
The Realest Longevity Guru - EP 85 Alex Colville
Q: What did you see in 2014 that made you excited about aging research?
Colville highlights the small but active research community and pivotal papers showing aging is modifiable, with early demonstrations in worms and subsequent work hinting at meaningful lifespan extension, which suggested real translational potential rather than mere theory.
Gene Therapies That Work? - EP 86 Adrian Veres
Q: What about cost; can these therapies become affordable and scalable?
Cost has been driven by manufacturing and dose requirements. We are seeing cost reductions from two angles: more efficient capsids that require lower doses, and improved manufacturing—potentially plant-based or automated bioreactors aided by AI. Early projections suggest thousands to tens of thousands per dose, with ongoing optimization driving costs down further.
Gene Therapies That Work? - EP 86 Adrian Veres
Q: Why is delivery the bottleneck, and how does your capsid engineering change that?
Delivery is hard because you must get the therapeutic payload inside the right cells while avoiding off-target organs like the liver. By engineering the viral capsid with AI-guided design, we can detarget the liver and improve distribution to the brain, muscle, or eye, expanding the therapeutic window and enabling broader applications.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
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Interests
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Frequently Asked Questions About Core Memory

What is Core Memory about and what kind of topics does it cover?

A tech-focused interview show that features deep-dive conversations with founders, researchers, and leaders across hardware, AI, biotech, and space. Episodes spotlight building new companies, scaling hardware, and navigating policy, regulation, and global supply chains, often with behind-the-scenes anecdotes and practical takeaways for builders and executives. A distinctive element is the mix of candid dialogue between two hosts and a rotating roster of high-profile guests, delivering accessible yet thorough explorations of cutting-edge technology, industry shifts, and strategic decision-making. Sponsorship mentions are common, and the format tends to blend big-picture context with on-the-ground execution stories, making it valuable for lis... more

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Which podcasts are similar to Core Memory?

These podcasts share a similar audience with Core Memory:

1. Dwarkesh Podcast
2. Sourcery
3. No Priors: Artificial Intelligence | Technology | Startups
4. Training Data
5. Uncapped with Jack Altman

How many episodes of Core Memory are there?

Core Memory launched 2 years ago and published 89 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Core Memory?

Recent guests on Core Memory include:

1. Seamus Blackley
2. Adrian Veres
3. Alex Colville
4. Abhi Mahajan
5. Alan Eustace
6. Ben Woodington
7. Ashlee Vance
8. Prineha Narang

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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